4GS7D

Structure of the interleukin-15 quaternary complex
Total Genus 14
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
14
sequence length
67
structure length
67
Chain Sequence
ITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPSLKCIRDP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Mechanistic and structural insight into the functional dichotomy between IL-2 and IL-15.
pubmed doi rcsb
molecule tags Immune system
source organism Homo sapiens
molecule keywords Interleukin-15
total genus 14
structure length 67
sequence length 67
ec nomenclature
pdb deposition date 2012-08-27
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.20.28.230 Mainly Beta Single Sheet Rubrerythrin, domain 2 Rubrerythrin, domain 2 4gs7D01
2B5ID 1Z92B 4GS7D 2Z3RB 3NFPI 2PSMC 2Z3QB 2ERSA 3IU3I 2ERJA
chains in the Genus database with same CATH superfamily
2AYJA 2GMGA 1YK5A 1I50L 1IRNA 4V196 1PFWA 2A68D 3S15L 4ZN1B 3S1RL 3LWRB 3S2HL 4ZN3B 1SFOL 1DVBA 4UY81 1LKMA 2EY4E 2RFKB 2M4VA 4A3EL 1ODHA 4A3CL 2M6OA 5DM61 1QCVA 1NXGA 2B63L 4C3HL 5MLC3 5MGNA 3HOZL 3WWNB 2L0ZA 1C09A 2CKAA 4U671 1F4LA 3HOUL 4AI1A 2XJVA 4Y52L 3H99A 3VPBE 3GTML 4AR3A 1I3QL 4JAEA 3MQKB 1RYTA 1TWFL 1I6HL 2Z3QB 1T9QA 3S17L 3GTQL 1Z92B 3H0GL 3PWFA 5C4XL 2WAQP 1B2JA 2J9UB 2V3BB 3KYWA 3S2DL 3B0AB 1LTLA 4AHWA 3H97A 2KN9A 3S16L 4A3BL 2HR5A 5M5WL 4GS7D 3A44A 4LHNA 1RB9A 1WJVA 1ZRPA 4E6YA 5AI2A 1IU6A 1NNQA 1RDGA 1RWDA 4JAFA 4AI0A 2XJRA 1LKOA 2M6PA 5MFZA 2E2JL 5EINC 2V0FA 2NVYL 2CR8A 1QYBA 1YUXA 5C44L 3GTJL 2Y0SP 3KYUA 2PYAA 1BQ9A 2PPTA 1SMMA 4ME3A 3LWPB 5MFPA 2XJPA 2M4YA 4QIWP 1BFYA 3PIO1 4AHXA 1R0IA 1IW7D 3IU3I 1TWGL 4A3ML 5M3FL 4K9FA 2JA6L 4BY7L 2E2HL 3HOXL 2ERSA 2JA7L 3P2AA 5IYDL 4BY1L 1YK4A 2NVTL 3PZAA 5MF6A 3FKIL 1BE7A 4XXBB 1RDVA 2A6ED 2PVXA 5K2ME 4G6BA 2PVEA 3NFPI 4BBRL 2H12A 2JI1A 1NXEA 4A93L 1JYBA 4JADA 3KYXA 2A6HD 1R0HA 1DX8A 3RZTA 2AQCA 1YUZA 3LWOB 2APOB 3GTOL 4AR4A 1LKPA 2LCQA 1R0GA 7RXNA 5H1Sc 5M3ML 4C3JL 5DM71 1S24A 1RYQA 3S14L 5JVG1 1FHHA 5JVH1 6RXNA 1TWAL 1P7PA 3LWVB 2AUSB 3PO3L 4BBSL 2A69D 5FJ8L 2XJSA 1K83L 1CADA 2KKDA 3MPSA 4AHYA 3HOYL 3K7AL 5C3EL 1FHMA 2R93L 4AR5A 3PO2L 1TWHL 4YWMA 4A3IL 4YWLA 2B5ID 1E8JA 4AYBP 3S1QL 1SMUA 4A3LL 4TVMA 8RXNA 3K35A 4A3GL 3HJYB 2JA8L 3QQCE 3WWLA 2NYDA 1OWCA 4RXNA 3GTKL 3KYVA 3GTGL 1IROA 2MS3A 1VZHA 1T9PA 2WB1P 5C4JL 3RZDL 4AR6A 5GAEc 1R0JA 3HKZP 2QL0A 4A3DL 2ERJA 1Y1WL 1B2OA 3PKJA 5GADc 5GAHc 3B08B 3P8BA 4C3IL 3MSUA 5IY0A 3FDJA 2XJQA 3RZOL 1H7VA 2ZIXA 1B13A 5M5YL 3I4NL 2PSMC 1S2ZA 5AI3A 1OWBA 3H9BA 5FLML 1TWCL 1VZIA 3HOWL 2NVXL 2JI3A 1R9TL 2JA5L 3RZ6A 3H3VM 1PZXA 4B8CD 5IYBL 1B71A 4LHLA 4XGHA 1BRFA 2XJTA 2E2IL 2Z3RB 4A3JL 1VZGA 5GAGc 2RDVA 3M4OL 3ZG6A 4POFA 5M5XL 1S30A 1R0FA 2CKCA 3PKIA 1QQTA 5EIOC 2VUML 2YU9L 1WCML 2V0EA 4POGA 1VCXA 4TPUA 3I4ML 1PFVA 3GTLL 4X6AL 2R92L 3GTPL 4AI3A 3HJWB 3S1NL 2C6BA 3RYGA 2R7ZL 3HOVL 5AN9H 5IP7L 2K2DA 2NVQL 1Y1VL 1YV1A 3KYYA 3PL5A 1SMWA 3H9CA 3S1ML 1PFUA 3SS2A 1T9OA 4WFN1 1IU5A 4C2M1 3M3YL 2C6AA 3J7Z1 4AHZA 4BXXL 1BQ8A 2DSXA 3QVDA 2VL6A 3PIP1 5IP9L 2BE5D 3HAXC 2JI2A 4A3KL 2XJUA 3J7Y1 4Y7NL 1CAAA 2O5JD 5IYCL 4A3FL 2PMZP 1PFYA 2HVYC 4JAGA 3LNLA 3LPEB 4AI2A 3CQZL 5RXNA 3JR7A 3LWQB
chains in the Genus database with same CATH topology
2AYJA 1YUZA 4GS7D 4AR4A 2JI3A 1LKPA 3A44A 2GMGA 3RZ6A 1YK5A 4B8CD 2LCQA 1R0GA 7RXNA 4LHNA 5H1Sc 1IRNA 4V196 1B71A 1RB9A 1WJVA 1ZRPA 4LHLA 4E6YA 4XGHA 1BRFA 5AI2A 1IU6A 1NNQA 2XJTA 2A68D 5DM71 1RDGA 4ZN1B 1S24A 1RWDA 1RYQA 4JAFA 4AI0A 2XJRA 1LKOA 2M6PA 2Z3RB 5JVG1 1VZGA 5MFZA 1FHHA 5GAGc 2RDVA 5JVH1 6RXNA 3ZG6A 4ZN3B 5EINC 1DVBA 2V0FA 2A69D 4UY81 2CR8A 1LKMA 1QYBA 1YUXA 2XJSA 4POFA 2M4VA 1ODHA 1CADA 1S30A 2KKDA 3MPSA 4AHYA 3KYUA 1R0FA 2CKCA 2PYAA 2M6OA 1BQ9A 2PPTA 1QCVA 5DM61 1NXGA 1SMMA 4ME3A 3PKIA 5EIOC 5MFPA 2V0EA 1FHMA 5MLC3 4AR5A 2XJPA 5MGNA 2M4YA 4POGA 1VCXA 4YWMA 4TPUA 4YWLA 2B5ID 1E8JA 1BFYA 3WWNB 2L0ZA 3PIO1 1SMUA 4AHXA 1C09A 2CKAA 1IW7D 1R0IA 3IU3I 4TVMA 4AI3A 8RXNA 4U671 4AI1A 2C6BA 3K35A 3RYGA 2XJVA 3VPBE 5AN9H 4K9FA 4AR3A 3QQCE 3WWLA 2K2DA 4JAEA 1RYTA 1YV1A 2NYDA 3KYYA 2Z3QB 2ERSA 1OWCA 1SMWA 1T9QA 3P2AA 3SS2A 4RXNA 3KYVA 1IROA 1T9OA 4WFN1 2MS3A 1IU5A 1VZHA 1T9PA 4AR6A 1YK4A 2C6AA 3PZAA 1Z92B 4AHZA 5MF6A 5GAEc 3J7Z1 1R0JA 1BQ8A 3PWFA 2QL0A 2DSXA 1BE7A 4XXBB 1RDVA 2ERJA 3QVDA 2VL6A 3PIP1 2BE5D 2JI2A 1B2OA 2A6ED 2XJUA 3PKJA 2PVXA 5GADc 5GAHc 1B2JA 3B08B 3P8BA 3J7Y1 2J9UB 5K2ME 2V3BB 3MSUA 4G6BA 1CAAA 5IY0A 3KYWA 2PVEA 3NFPI 2O5JD 2H12A 2JI1A 1NXEA 3B0AB 1LTLA 2XJQA 1JYBA 4AHWA 2ZIXA 1H7VA 1B13A 4JAGA 3LNLA 3LPEB 2PSMC 4JADA 4AI2A 1S2ZA 5AI3A 5RXNA 3KYXA 2KN9A 1OWBA 2HR5A 2A6HD 1R0HA 1VZIA 1DX8A 3RZTA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2B5I D;  1Z92 B;  4GS7 D;  2Z3R B;  3NFP I;  2PSM C;  2Z3Q B;  2ERS A;  3IU3 I;  2ERJ A; 
#chains in the Genus database with same CATH topology
 2AYJ A;  2GMG A;  1YK5 A;  1I50 L;  1IRN A;  4V19 6;  1PFW A;  2A68 D;  3S15 L;  4ZN1 B;  3S1R L;  3LWR B;  3S2H L;  4ZN3 B;  1SFO L;  1DVB A;  4UY8 1;  1LKM A;  2EY4 E;  2RFK B;  2M4V A;  4A3E L;  1ODH A;  4A3C L;  2M6O A;  5DM6 1;  1QCV A;  1NXG A;  2B63 L;  4C3H L;  5MLC 3;  5MGN A;  3HOZ L;  3WWN B;  2L0Z A;  1C09 A;  2CKA A;  4U67 1;  1F4L A;  3HOU L;  4AI1 A;  2XJV A;  4Y52 L;  3H99 A;  3VPB E;  3GTM L;  4AR3 A;  1I3Q L;  4JAE A;  3MQK B;  1RYT A;  1TWF L;  1I6H L;  2Z3Q B;  1T9Q A;  3S17 L;  3GTQ L;  1Z92 B;  3H0G L;  3PWF A;  5C4X L;  2WAQ P;  1B2J A;  2J9U B;  2V3B B;  3KYW A;  3S2D L;  3B0A B;  1LTL A;  4AHW A;  3H97 A;  2KN9 A;  3S16 L;  4A3B L;  2HR5 A;  5M5W L;  4GS7 D;  3A44 A;  4LHN A;  1RB9 A;  1WJV A;  1ZRP A;  4E6Y A;  5AI2 A;  1IU6 A;  1NNQ A;  1RDG A;  1RWD A;  4JAF A;  4AI0 A;  2XJR A;  1LKO A;  2M6P A;  5MFZ A;  2E2J L;  5EIN C;  2V0F A;  2NVY L;  2CR8 A;  1QYB A;  1YUX A;  5C44 L;  3GTJ L;  2Y0S P;  3KYU A;  2PYA A;  1BQ9 A;  2PPT A;  1SMM A;  4ME3 A;  3LWP B;  5MFP A;  2XJP A;  2M4Y A;  4QIW P;  1BFY A;  3PIO 1;  4AHX A;  1R0I A;  1IW7 D;  3IU3 I;  1TWG L;  4A3M L;  5M3F L;  4K9F A;  2JA6 L;  4BY7 L;  2E2H L;  3HOX L;  2ERS A;  2JA7 L;  3P2A A;  5IYD L;  4BY1 L;  1YK4 A;  2NVT L;  3PZA A;  5MF6 A;  3FKI L;  1BE7 A;  4XXB B;  1RDV A;  2A6E D;  2PVX A;  5K2M E;  4G6B A;  2PVE A;  3NFP I;  4BBR L;  2H12 A;  2JI1 A;  1NXE A;  4A93 L;  1JYB A;  4JAD A;  3KYX A;  2A6H D;  1R0H A;  1DX8 A;  3RZT A;  2AQC A;  1YUZ A;  3LWO B;  2APO B;  3GTO L;  4AR4 A;  1LKP A;  2LCQ A;  1R0G A;  7RXN A;  5H1S c;  5M3M L;  4C3J L;  5DM7 1;  1S24 A;  1RYQ A;  3S14 L;  5JVG 1;  1FHH A;  5JVH 1;  6RXN A;  1TWA L;  1P7P A;  3LWV B;  2AUS B;  3PO3 L;  4BBS L;  2A69 D;  5FJ8 L;  2XJS A;  1K83 L;  1CAD A;  2KKD A;  3MPS A;  4AHY A;  3HOY L;  3K7A L;  5C3E L;  1FHM A;  2R93 L;  4AR5 A;  3PO2 L;  1TWH L;  4YWM A;  4A3I L;  4YWL A;  2B5I D;  1E8J A;  4AYB P;  3S1Q L;  1SMU A;  4A3L L;  4TVM A;  8RXN A;  3K35 A;  4A3G L;  3HJY B;  2JA8 L;  3QQC E;  3WWL A;  2NYD A;  1OWC A;  4RXN A;  3GTK L;  3KYV A;  3GTG L;  1IRO A;  2MS3 A;  1VZH A;  1T9P A;  2WB1 P;  5C4J L;  3RZD L;  4AR6 A;  5GAE c;  1R0J A;  3HKZ P;  2QL0 A;  4A3D L;  2ERJ A;  1Y1W L;  1B2O A;  3PKJ A;  5GAD c;  5GAH c;  3B08 B;  3P8B A;  4C3I L;  3MSU A;  5IY0 A;  3FDJ A;  2XJQ A;  3RZO L;  1H7V A;  2ZIX A;  1B13 A;  5M5Y L;  3I4N L;  2PSM C;  1S2Z A;  5AI3 A;  1OWB A;  3H9B A;  5FLM L;  1TWC L;  1VZI A;  3HOW L;  2NVX L;  2JI3 A;  1R9T L;  2JA5 L;  3RZ6 A;  3H3V M;  1PZX A;  4B8C D;  5IYB L;  1B71 A;  4LHL A;  4XGH A;  1BRF A;  2XJT A;  2E2I L;  2Z3R B;  4A3J L;  1VZG A;  5GAG c;  2RDV A;  3M4O L;  3ZG6 A;  4POF A;  5M5X L;  1S30 A;  1R0F A;  2CKC A;  3PKI A;  1QQT A;  5EIO C;  2VUM L;  2YU9 L;  1WCM L;  2V0E A;  4POG A;  1VCX A;  4TPU A;  3I4M L;  1PFV A;  3GTL L;  4X6A L;  2R92 L;  3GTP L;  4AI3 A;  3HJW B;  3S1N L;  2C6B A;  3RYG A;  2R7Z L;  3HOV L;  5AN9 H;  5IP7 L;  2K2D A;  2NVQ L;  1Y1V L;  1YV1 A;  3KYY A;  3PL5 A;  1SMW A;  3H9C A;  3S1M L;  1PFU A;  3SS2 A;  1T9O A;  4WFN 1;  1IU5 A;  4C2M 1;  3M3Y L;  2C6A A;  3J7Z 1;  4AHZ A;  4BXX L;  1BQ8 A;  2DSX A;  3QVD A;  2VL6 A;  3PIP 1;  5IP9 L;  2BE5 D;  3HAX C;  2JI2 A;  4A3K L;  2XJU A;  3J7Y 1;  4Y7N L;  1CAA A;  2O5J D;  5IYC L;  4A3F L;  2PMZ P;  1PFY A;  2HVY C;  4JAG A;  3LNL A;  3LPE B;  4AI2 A;  3CQZ L;  5RXN A;  3JR7 A;  3LWQ B; 
#chains in the Genus database with same CATH homology
 2AYJ A;  1YUZ A;  4GS7 D;  4AR4 A;  2JI3 A;  1LKP A;  3A44 A;  2GMG A;  3RZ6 A;  1YK5 A;  4B8C D;  2LCQ A;  1R0G A;  7RXN A;  4LHN A;  5H1S c;  1IRN A;  4V19 6;  1B71 A;  1RB9 A;  1WJV A;  1ZRP A;  4LHL A;  4E6Y A;  4XGH A;  1BRF A;  5AI2 A;  1IU6 A;  1NNQ A;  2XJT A;  2A68 D;  5DM7 1;  1RDG A;  4ZN1 B;  1S24 A;  1RWD A;  1RYQ A;  4JAF A;  4AI0 A;  2XJR A;  1LKO A;  2M6P A;  2Z3R B;  5JVG 1;  1VZG A;  5MFZ A;  1FHH A;  5GAG c;  2RDV A;  5JVH 1;  6RXN A;  3ZG6 A;  4ZN3 B;  5EIN C;  1DVB A;  2V0F A;  2A69 D;  4UY8 1;  2CR8 A;  1LKM A;  1QYB A;  1YUX A;  2XJS A;  4POF A;  2M4V A;  1ODH A;  1CAD A;  1S30 A;  2KKD A;  3MPS A;  4AHY A;  3KYU A;  1R0F A;  2CKC A;  2PYA A;  2M6O A;  1BQ9 A;  2PPT A;  1QCV A;  5DM6 1;  1NXG A;  1SMM A;  4ME3 A;  3PKI A;  5EIO C;  5MFP A;  2V0E A;  1FHM A;  5MLC 3;  4AR5 A;  2XJP A;  5MGN A;  2M4Y A;  4POG A;  1VCX A;  4YWM A;  4TPU A;  4YWL A;  2B5I D;  1E8J A;  1BFY A;  3WWN B;  2L0Z A;  3PIO 1;  1SMU A;  4AHX A;  1C09 A;  2CKA A;  1IW7 D;  1R0I A;  3IU3 I;  4TVM A;  4AI3 A;  8RXN A;  4U67 1;  4AI1 A;  2C6B A;  3K35 A;  3RYG A;  2XJV A;  3VPB E;  5AN9 H;  4K9F A;  4AR3 A;  3QQC E;  3WWL A;  2K2D A;  4JAE A;  1RYT A;  1YV1 A;  2NYD A;  3KYY A;  2Z3Q B;  2ERS A;  1OWC A;  1SMW A;  1T9Q A;  3P2A A;  3SS2 A;  4RXN A;  3KYV A;  1IRO A;  1T9O A;  4WFN 1;  2MS3 A;  1IU5 A;  1VZH A;  1T9P A;  4AR6 A;  1YK4 A;  2C6A A;  3PZA A;  1Z92 B;  4AHZ A;  5MF6 A;  5GAE c;  3J7Z 1;  1R0J A;  1BQ8 A;  3PWF A;  2QL0 A;  2DSX A;  1BE7 A;  4XXB B;  1RDV A;  2ERJ A;  3QVD A;  2VL6 A;  3PIP 1;  2BE5 D;  2JI2 A;  1B2O A;  2A6E D;  2XJU A;  3PKJ A;  2PVX A;  5GAD c;  5GAH c;  1B2J A;  3B08 B;  3P8B A;  3J7Y 1;  2J9U B;  5K2M E;  2V3B B;  3MSU A;  4G6B A;  1CAA A;  5IY0 A;  3KYW A;  2PVE A;  3NFP I;  2O5J D;  2H12 A;  2JI1 A;  1NXE A;  3B0A B;  1LTL A;  2XJQ A;  1JYB A;  4AHW A;  2ZIX A;  1H7V A;  1B13 A;  4JAG A;  3LNL A;  3LPE B;  2PSM C;  4JAD A;  4AI2 A;  1S2Z A;  5AI3 A;  5RXN A;  3KYX A;  2KN9 A;  1OWB A;  2HR5 A;  2A6H D;  1R0H A;  1VZI A;  1DX8 A;  3RZT A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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