4GYLA

The e142l mutant of the amidase from geobacillus pallidus showing the result of michael addition of acrylamide at the active site cysteine
Total Genus 122
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
122
sequence length
340
structure length
340
Chain Sequence
MRHGDISSSHDTVGIAVVNYKMPRLHTKAEVIENAKKIADMVVGMKQGLPGMDLVVFPEYSTMGIMYDQDEMFATAASIPGEETAIFAEACKKADTWGVFSLTGEKHEDHPNKAPYNTLVLINNKGEIVQKYRKIIPWCPILGWYPGDTTYVTEGPKGLKISLIVCDDGNYPEIWRDCAMKGAELIVRCQGYMYPAKEQQIMMAKAMAWANNTYVAVANATGFDGVYSYFGHSAIIGFDGRTLGECGTEENGIQYAEVSISQIRDFRKNAQSQNHLFKLLHRGYTGLINSGEGDRGVAECPFDFYRTWVLDAEKARENVEKITRSTVGTAECPIQGIPNE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase
molecule keywords Aliphatic amidase
publication title The mechanism of the amidases: mutating the glutamate adjacent to the catalytic triad inactivates the enzyme due to substrate mispositioning.
pubmed doi rcsb
source organism Bacillus sp.
total genus 122
structure length 340
sequence length 340
ec nomenclature ec 3.5.1.4: Amidase.
pdb deposition date 2012-09-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00795 CN_hydrolase Carbon-nitrogen hydrolase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.110.10 Alpha Beta 4-Layer Sandwich Nitrilase/N-carbamoyl-D-aminoacid amidohydrolase Carbon-nitrogen hydrolase 4gylA00
4IZUA 4CYFA 2E11A 5H8JA 3HKXA 1EMSA 3ILVA 3IW3A 2GGLA 2VHIA 3SEZA 4IZWA 3KI8A 4CYGA 1UF5A 5H8IA 4F4HA 4KZFA 4CYYA 4IZTA 2VHHA 1UF7A 4GYLA 2W1VA 2E2LA 5H8KA 3IVZA 2UXYA 1ERZA 2DYUA 1F89A 3N05A 4GYNA 2GGKA 4HG3A 3DLAA 4H5UA 5KHAA 5H8LA 2DYVA 3SDBA 3WUYA 4IZVA 3SYTA 4HGDA 3KLCA 1FO6A 5JQNA 1UF4A 3SEQA 4LF0A 2E2KA 4IZSA 3P8KA 2PLQA 1J31A 3SZGA 1UF8A 4HG5A
chains in the Genus database with same CATH superfamily
4IZUA 4CYFA 2E11A 5H8JA 3HKXA 1EMSA 3ILVA 3IW3A 2GGLA 2VHIA 3SEZA 4IZWA 3KI8A 4CYGA 1UF5A 5H8IA 4F4HA 4KZFA 4CYYA 4IZTA 2VHHA 1UF7A 4GYLA 2W1VA 2E2LA 5H8KA 3IVZA 2UXYA 1ERZA 2DYUA 1F89A 3N05A 4GYNA 2GGKA 4HG3A 3DLAA 4H5UA 5KHAA 5H8LA 2DYVA 3SDBA 3WUYA 4IZVA 3SYTA 4HGDA 3KLCA 1FO6A 5JQNA 1UF4A 3SEQA 4LF0A 2E2KA 4IZSA 3P8KA 2PLQA 1J31A 3SZGA 1UF8A 4HG5A
chains in the Genus database with same CATH topology
4IZUA 4CYFA 2E11A 5H8JA 3HKXA 1EMSA 3ILVA 3IW3A 2GGLA 2VHIA 3SEZA 4IZWA 3KI8A 4CYGA 1UF5A 5H8IA 4F4HA 4KZFA 4CYYA 4IZTA 2VHHA 1UF7A 4GYLA 2W1VA 2E2LA 5H8KA 3IVZA 2UXYA 1ERZA 2DYUA 1F89A 3N05A 4GYNA 2GGKA 4HG3A 3DLAA 4H5UA 5KHAA 5H8LA 2DYVA 3SDBA 3WUYA 4IZVA 3SYTA 4HGDA 3KLCA 1FO6A 5JQNA 1UF4A 3SEQA 4LF0A 2E2KA 4IZSA 3P8KA 2PLQA 1J31A 3SZGA 1UF8A 4HG5A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4IZU A;  4CYF A;  2E11 A;  5H8J A;  3HKX A;  1EMS A;  3ILV A;  3IW3 A;  2GGL A;  2VHI A;  3SEZ A;  4IZW A;  3KI8 A;  4CYG A;  1UF5 A;  5H8I A;  4F4H A;  4KZF A;  4CYY A;  4IZT A;  2VHH A;  1UF7 A;  4GYL A;  2W1V A;  2E2L A;  5H8K A;  3IVZ A;  2UXY A;  1ERZ A;  2DYU A;  1F89 A;  3N05 A;  4GYN A;  2GGK A;  4HG3 A;  3DLA A;  4H5U A;  5KHA A;  5H8L A;  2DYV A;  3SDB A;  3WUY A;  4IZV A;  3SYT A;  4HGD A;  3KLC A;  1FO6 A;  5JQN A;  1UF4 A;  3SEQ A;  4LF0 A;  2E2K A;  4IZS A;  3P8K A;  2PLQ A;  1J31 A;  3SZG A;  1UF8 A;  4HG5 A; 
#chains in the Genus database with same CATH topology
 4IZU A;  4CYF A;  2E11 A;  5H8J A;  3HKX A;  1EMS A;  3ILV A;  3IW3 A;  2GGL A;  2VHI A;  3SEZ A;  4IZW A;  3KI8 A;  4CYG A;  1UF5 A;  5H8I A;  4F4H A;  4KZF A;  4CYY A;  4IZT A;  2VHH A;  1UF7 A;  4GYL A;  2W1V A;  2E2L A;  5H8K A;  3IVZ A;  2UXY A;  1ERZ A;  2DYU A;  1F89 A;  3N05 A;  4GYN A;  2GGK A;  4HG3 A;  3DLA A;  4H5U A;  5KHA A;  5H8L A;  2DYV A;  3SDB A;  3WUY A;  4IZV A;  3SYT A;  4HGD A;  3KLC A;  1FO6 A;  5JQN A;  1UF4 A;  3SEQ A;  4LF0 A;  2E2K A;  4IZS A;  3P8K A;  2PLQ A;  1J31 A;  3SZG A;  1UF8 A;  4HG5 A; 
#chains in the Genus database with same CATH homology
 4IZU A;  4CYF A;  2E11 A;  5H8J A;  3HKX A;  1EMS A;  3ILV A;  3IW3 A;  2GGL A;  2VHI A;  3SEZ A;  4IZW A;  3KI8 A;  4CYG A;  1UF5 A;  5H8I A;  4F4H A;  4KZF A;  4CYY A;  4IZT A;  2VHH A;  1UF7 A;  4GYL A;  2W1V A;  2E2L A;  5H8K A;  3IVZ A;  2UXY A;  1ERZ A;  2DYU A;  1F89 A;  3N05 A;  4GYN A;  2GGK A;  4HG3 A;  3DLA A;  4H5U A;  5KHA A;  5H8L A;  2DYV A;  3SDB A;  3WUY A;  4IZV A;  3SYT A;  4HGD A;  3KLC A;  1FO6 A;  5JQN A;  1UF4 A;  3SEQ A;  4LF0 A;  2E2K A;  4IZS A;  3P8K A;  2PLQ A;  1J31 A;  3SZG A;  1UF8 A;  4HG5 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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