4GYVA

Crystal structure of the dh domain of farp2
Total Genus 96
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
96
sequence length
216
structure length
216
Chain Sequence
GPHMEDEAYFIAKEILATERTYLKDLEVITVWFRSVLIKEEAMPAALMALLFSNIDPVYEFHRGFLHEVEQRLALWEGPSSAHLKGDHQRIGDILLRNMRQLKEFTSYFQRHDEVLTELEKATKHCKKLEAVYKEFELQKVCYLPLNTFLLKPVQRLVHYRLLLSRLCAHYSPGHRDYADCHEALKAITEVTTELQQSLTRLENLQKLTELQRDLV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords FERM, RhoGEF and pleckstrin domain-containing protein 2
publication title Structural Basis for Autoinhibition of the Guanine Nucleotide Exchange Factor FARP2.
pubmed doi rcsb
source organism Mus musculus
molecule tags Signaling protein
total genus 96
structure length 216
sequence length 216
chains with identical sequence B, C, D, E, F, G, H, I
ec nomenclature
pdb deposition date 2012-09-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00621 RhoGEF RhoGEF domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.900.10 Mainly Alpha Up-down Bundle Dbl Homology Domain; Chain A Dbl homology (DH) domain 4gyvA00
3KY9A 1BY1A 4D0NB 1LB1A 2VRWB 5FI0A 1FOEA 4D0OA 3KZ1A 1DBHA 1KZ7A 5JHHA 3T06A 1KI1B 2DFKA 3GF9A 1KZGA 5FI1A 4MT7A 3BJIA 2PZ1A 1RJ2A 2NZ8B 3ODXA 4GZUA 3P6AA 1XCGA 4YONA 1XD4A 1TXDA 3ODOA 2DX1A 1NTYA 2KR9A 2RGNB 3QBVB 2Z0QA 1X86A 1F5XA 4GOUA 4GYVA 3JV3A 5JHGA 3EO2A 3ODWA 3MPXA 3KSYA
chains in the Genus database with same CATH superfamily
3KY9A 1BY1A 4D0NB 1LB1A 2VRWB 5FI0A 1FOEA 4D0OA 3KZ1A 1DBHA 1KZ7A 5JHHA 3T06A 1KI1B 2DFKA 3GF9A 1KZGA 5FI1A 4MT7A 3BJIA 2PZ1A 1RJ2A 2NZ8B 3ODXA 4GZUA 3P6AA 1XCGA 4YONA 1XD4A 1TXDA 3ODOA 2DX1A 1NTYA 2KR9A 2RGNB 3QBVB 2Z0QA 1X86A 1F5XA 4GOUA 4GYVA 3JV3A 5JHGA 3EO2A 3ODWA 3MPXA 3KSYA
chains in the Genus database with same CATH topology
3KY9A 1BY1A 4D0NB 1LB1A 2VRWB 5FI0A 1FOEA 4D0OA 3KZ1A 1DBHA 1KZ7A 5JHHA 3T06A 1KI1B 2DFKA 3GF9A 1KZGA 5FI1A 4MT7A 3BJIA 2PZ1A 1RJ2A 2NZ8B 3ODXA 4GZUA 3P6AA 1XCGA 4YONA 1XD4A 1TXDA 3ODOA 2DX1A 1NTYA 2KR9A 2RGNB 3QBVB 2Z0QA 1X86A 1F5XA 4GOUA 4GYVA 3JV3A 5JHGA 3EO2A 3ODWA 3MPXA 3KSYA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3KY9 A;  1BY1 A;  4D0N B;  1LB1 A;  2VRW B;  5FI0 A;  1FOE A;  4D0O A;  3KZ1 A;  1DBH A;  1KZ7 A;  5JHH A;  3T06 A;  1KI1 B;  2DFK A;  3GF9 A;  1KZG A;  5FI1 A;  4MT7 A;  3BJI A;  2PZ1 A;  1RJ2 A;  2NZ8 B;  3ODX A;  4GZU A;  3P6A A;  1XCG A;  4YON A;  1XD4 A;  1TXD A;  3ODO A;  2DX1 A;  1NTY A;  2KR9 A;  2RGN B;  3QBV B;  2Z0Q A;  1X86 A;  1F5X A;  4GOU A;  4GYV A;  3JV3 A;  5JHG A;  3EO2 A;  3ODW A;  3MPX A;  3KSY A; 
#chains in the Genus database with same CATH topology
 3KY9 A;  1BY1 A;  4D0N B;  1LB1 A;  2VRW B;  5FI0 A;  1FOE A;  4D0O A;  3KZ1 A;  1DBH A;  1KZ7 A;  5JHH A;  3T06 A;  1KI1 B;  2DFK A;  3GF9 A;  1KZG A;  5FI1 A;  4MT7 A;  3BJI A;  2PZ1 A;  1RJ2 A;  2NZ8 B;  3ODX A;  4GZU A;  3P6A A;  1XCG A;  4YON A;  1XD4 A;  1TXD A;  3ODO A;  2DX1 A;  1NTY A;  2KR9 A;  2RGN B;  3QBV B;  2Z0Q A;  1X86 A;  1F5X A;  4GOU A;  4GYV A;  3JV3 A;  5JHG A;  3EO2 A;  3ODW A;  3MPX A;  3KSY A; 
#chains in the Genus database with same CATH homology
 3KY9 A;  1BY1 A;  4D0N B;  1LB1 A;  2VRW B;  5FI0 A;  1FOE A;  4D0O A;  3KZ1 A;  1DBH A;  1KZ7 A;  5JHH A;  3T06 A;  1KI1 B;  2DFK A;  3GF9 A;  1KZG A;  5FI1 A;  4MT7 A;  3BJI A;  2PZ1 A;  1RJ2 A;  2NZ8 B;  3ODX A;  4GZU A;  3P6A A;  1XCG A;  4YON A;  1XD4 A;  1TXD A;  3ODO A;  2DX1 A;  1NTY A;  2KR9 A;  2RGN B;  3QBV B;  2Z0Q A;  1X86 A;  1F5X A;  4GOU A;  4GYV A;  3JV3 A;  5JHG A;  3EO2 A;  3ODW A;  3MPX A;  3KSY A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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