4GYVA

Crystal structure of the dh domain of farp2
Total Genus 96
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
96
sequence length
216
structure length
216
Chain Sequence
b'GPHMEDEAYFIAKEILATERTYLKDLEVITVWFRSVLIKEEAMPAALMALLFSNIDPVYEFHRGFLHEVEQRLALWEGPSSAHLKGDHQRIGDILLRNMRQLKEFTSYFQRHDEVLTELEKATKHCKKLEAVYKEFELQKVCYLPLNTFLLKPVQRLVHYRLLLSRLCAHYSPGHRDYADCHEALKAITEVTTELQQSLTRLENLQKLTELQRDLV'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords FERM, RhoGEF and pleckstrin domain-containing protein 2
publication title Structural Basis for Autoinhibition of the Guanine Nucleotide Exchange Factor FARP2.
pubmed doi rcsb
source organism Mus musculus
molecule tags Signaling protein
total genus 96
structure length 216
sequence length 216
chains with identical sequence B, C, D, E, F, G, H, I
ec nomenclature
pdb deposition date 2012-09-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00621 RhoGEF RhoGEF domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.900.10 Mainly Alpha Up-down Bundle Dbl Homology Domain; Chain A Dbl homology (DH) domain 4gyvA00
1NTYA 2DX1A 3ODWA 2NZ8B 2VRWB 5FI1A 3JV3A 3GF9A 3ODOA 1TXDA 1DBHA 1KZ7A 3T06A 4YONA 4GOUA 3P6AA 1BY1A 3QBVB 4D0OA 1F5XA 3MPXA 2PZ1A 3KSYA 2KR9A 5JHHA 4D0NB 3BJIA 1KI1B 3KZ1A 1LB1A 4GZUA 4MT7A 2RGNB 4GYVA 5FI0A 3ODXA 2DFKA 1FOEA 1XCGA 5JHGA 1KZGA 2Z0QA 1RJ2A 3KY9A 1X86A 1XD4A 3EO2A
chains in the Genus database with same CATH superfamily
1NTYA 2DX1A 3ODWA 2NZ8B 2VRWB 5FI1A 3JV3A 3GF9A 3ODOA 1TXDA 1DBHA 1KZ7A 3T06A 4YONA 4GOUA 3P6AA 1BY1A 3QBVB 4D0OA 1F5XA 3MPXA 2PZ1A 3KSYA 2KR9A 5JHHA 4D0NB 3BJIA 1KI1B 3KZ1A 1LB1A 4GZUA 4MT7A 2RGNB 4GYVA 5FI0A 3ODXA 2DFKA 1FOEA 1XCGA 5JHGA 1KZGA 2Z0QA 1RJ2A 3KY9A 1X86A 1XD4A 3EO2A
chains in the Genus database with same CATH topology
1NTYA 2DX1A 3ODWA 2NZ8B 2VRWB 5FI1A 3JV3A 3GF9A 3ODOA 1TXDA 1DBHA 1KZ7A 3T06A 4YONA 4GOUA 3P6AA 1BY1A 3QBVB 4D0OA 1F5XA 3MPXA 2PZ1A 3KSYA 2KR9A 5JHHA 4D0NB 3BJIA 1KI1B 3KZ1A 1LB1A 4GZUA 4MT7A 2RGNB 4GYVA 5FI0A 3ODXA 2DFKA 1FOEA 1XCGA 5JHGA 1KZGA 2Z0QA 1RJ2A 3KY9A 1X86A 1XD4A 3EO2A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1NTY A;  2DX1 A;  3ODW A;  2NZ8 B;  2VRW B;  5FI1 A;  3JV3 A;  3GF9 A;  3ODO A;  1TXD A;  1DBH A;  1KZ7 A;  3T06 A;  4YON A;  4GOU A;  3P6A A;  1BY1 A;  3QBV B;  4D0O A;  1F5X A;  3MPX A;  2PZ1 A;  3KSY A;  2KR9 A;  5JHH A;  4D0N B;  3BJI A;  1KI1 B;  3KZ1 A;  1LB1 A;  4GZU A;  4MT7 A;  2RGN B;  4GYV A;  5FI0 A;  3ODX A;  2DFK A;  1FOE A;  1XCG A;  5JHG A;  1KZG A;  2Z0Q A;  1RJ2 A;  3KY9 A;  1X86 A;  1XD4 A;  3EO2 A; 
#chains in the Genus database with same CATH topology
 1NTY A;  2DX1 A;  3ODW A;  2NZ8 B;  2VRW B;  5FI1 A;  3JV3 A;  3GF9 A;  3ODO A;  1TXD A;  1DBH A;  1KZ7 A;  3T06 A;  4YON A;  4GOU A;  3P6A A;  1BY1 A;  3QBV B;  4D0O A;  1F5X A;  3MPX A;  2PZ1 A;  3KSY A;  2KR9 A;  5JHH A;  4D0N B;  3BJI A;  1KI1 B;  3KZ1 A;  1LB1 A;  4GZU A;  4MT7 A;  2RGN B;  4GYV A;  5FI0 A;  3ODX A;  2DFK A;  1FOE A;  1XCG A;  5JHG A;  1KZG A;  2Z0Q A;  1RJ2 A;  3KY9 A;  1X86 A;  1XD4 A;  3EO2 A; 
#chains in the Genus database with same CATH homology
 1NTY A;  2DX1 A;  3ODW A;  2NZ8 B;  2VRW B;  5FI1 A;  3JV3 A;  3GF9 A;  3ODO A;  1TXD A;  1DBH A;  1KZ7 A;  3T06 A;  4YON A;  4GOU A;  3P6A A;  1BY1 A;  3QBV B;  4D0O A;  1F5X A;  3MPX A;  2PZ1 A;  3KSY A;  2KR9 A;  5JHH A;  4D0N B;  3BJI A;  1KI1 B;  3KZ1 A;  1LB1 A;  4GZU A;  4MT7 A;  2RGN B;  4GYV A;  5FI0 A;  3ODX A;  2DFK A;  1FOE A;  1XCG A;  5JHG A;  1KZG A;  2Z0Q A;  1RJ2 A;  3KY9 A;  1X86 A;  1XD4 A;  3EO2 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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