4H1SA

Crystal structure of a truncated soluble form of human cd73 with ecto-5'-nucleotidase activity
Total Genus 173
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
173
sequence length
523
structure length
521
Chain Sequence
WELTILHTNDVHSRLEQTSEDSSKCVNASRCMGGVARLFTKVQQIRRAEPNVLLLDAGDQYQGTIWFTVYKGAEVAHFMNALRYDAMALGNHEFDNGVEGLIEPLLKEAKFPILSANIKAKGPLASQISGLYLPYKVLPVGDEVVGIVGYTSKETPFLSNPGTNLVFEDEITALQPEVDKLKTLNVNKIIALGHSGFEMDKLIAQKVRGVDVVVGGHSNTFLYTGNPPSKEVPAGKYPFIVTSDDGRKVPVVQAYAFGKYLGYLKIEFDERGNVISSHGNPILLNSSIPEDPSIKADINKWRIKLDNYQELGKTIVYLDGSSQSCRFRECNMGNLICDAMINNNLRHTDEMFWNHVSMCILNGGGIRSPIDERNNGTITWENLAAVLPFGGTFDLVQLKGSTLKKAFEHSVHRYGQSTGEFLQVGGIHVVYDLSRKPGDRVVKLDVLCTKCRVPSYDPLKMDEVYKVILPNFLANGGDGFQMIKDELLRHDSGDQDINVVSTYISKMKVIYPAVEGRIKFS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Crystal structure of a soluble form of human CD73 with ecto-5'-nucleotidase activity.
pubmed doi rcsb
molecule tags Hydrolase
molecule keywords 5'-nucleotidase
total genus 173
structure length 521
sequence length 523
chains with identical sequence B
ec nomenclature ec 3.1.3.5: 5'-nucleotidase.
pdb deposition date 2012-09-11

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00149 Metallophos Calcineurin-like phosphoesterase
A PF02872 5_nucleotid_C 5'-nucleotidase, C-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.21.10 Alpha Beta 4-Layer Sandwich Purple Acid Phosphatase; chain A, domain 2 Purple Acid Phosphatase; chain A, domain 2 4h1sA01
3.90.780.10 Alpha Beta Alpha-Beta Complex 5'-nucleotidase; domain 2 5'-Nucleotidase, C-terminal domain 4h1sA02
5IOHA 2YVTA 4G9JA 1WAO1 2IE3C 1S8EA 4MOVA 1NNWA 1S3MA 4V0WA 1S3LA 4JA7A 2NPPC 3KBPA 1Z2XA 3K7VC 1UTEA 4H1YP 4IYPC 3JYFA 3AV0A 4ORCA 1QHWA 2A22A 2BDXA 1QFCA 3ZU0A 5J28A 4UT3B 2WDEA 4J6OA 3DW8C 3THOB 2QFPA 3IVDA 1M63A 1HO5A 4O5GA 4LTYA 2QFRA 3ICFA 2GJUA 4O24A 3H68A 4O4KA 2IAEC 3H69A 2BQ8X 1G5BA 3DSCA 4HD0A 4H2FA 5C1VA 4DT2A 3H62B 1TCOA 4B2OA 3PSOA 2IE4C 3HVQA 4MOYA 3QFKA 3H61A 1T71A 4H2BA 1JK7A 2DFJA 3C5WC 2CV9A 4H1SA 4V0XA 5JPFA 5JPEA 1KBPA 5JJTA 1OIEA 1HPUA 2USHA 1OIDA 1W24A 5EQVA 2ZBMA 1XZWA 1XM7A 2Z72A 3RL4A 1II7A 4IL1A 3DSDA 3QFOA 4ZX2A 5INBA 4I5NC 5HPEA 3CK2A 4FCXA 1WARA 1Z2WA 2NXFA 2WDCA 4WWLA 2P6BA 3LL8A 2HYPA 4ORBA 4XPNA 3EGHA 4OR9A 3RL5A 2Z1AA 1USHA 3TGHA 3THNA 4MP0A 1SU1A 1S95A 4LACC 3H60A 2WDFA 1AUIA 3C9FA 3N5UA 3H63A 4UT3A 1U32A 3AUZA 4FBWA 3RL3A 2XMOA 2QJCA 3K7WC 2R17A 4FBQA 2JOGA 4H2GA 4ORAA 1IT6A 4LU9A 2Q8UA 1OI8A 4H2IA 4Q7FA 2KKNA 4DHLA 4JA9A 4V0VA 4KBPA 3IVEA 4TUGA 2WDDA 3T1IA 3E7BA 3H66A 3IB7A 4ZVZA 4UWQA 4UT2A 4O43A 1HP1A 4FBKA 4F0ZA 4KKZA 3FGAC 2HYOA 4I5LC 3GVEA 2NYLC 1FJMA 2AHDA 3PSNA 3QFMA 3QG5C 5F3WA 1T70A 2HY1A 1UF3A 3IB8A 3E7AA 1V73A 3H64A 3RQZA 3P71C 3H67A 1MF8A 4M0VA 3QFNA 5GTUA 1S70A 4NZVA 3V4YA 4YKEA 4TUIA 5DNYA 2NYMC 4DSYA 2O8AA 3ZTVA 3EGGA 2O8GA 2BCDA 2Z06A 1S3NA 5B8IA
chains in the Genus database with same CATH superfamily
5IOHA 2YVTA 4G9JA 1WAO1 2IE3C 1S8EA 4MOVA 2DXNA 1NNWA 1S3MA 4V0WA 1S3LA 4JA7A 2NPPC 3KBPA 1Z2XA 3K7VC 1UTEA 4H1YP 4IYPC 2ZOAA 3JYFA 3AV0A 4ORCA 1QHWA 2A22A 2BDXA 1QFCA 3ZU0A 5J28A 4UT3B 2WDEA 4J6OA 3DW8C 3THOB 2QFPA 3IVDA 1M63A 1HO5A 4O5GA 4LTYA 2ZO9B 2QFRA 3ICFA 2GJUA 4O24A 3H68A 4O4KA 2IAEC 3H69A 2BQ8X 1G5BA 3DSCA 4HD0A 4H2FA 5C1VA 4DT2A 3H62B 1TCOA 2DXLA 3PSOA 2IE4C 3HVQA 4B2OA 4MOYA 3QFKA 3H61A 1T71A 3D03A 4H2BA 1JK7A 2DFJA 3C5WC 2CV9A 4H1SA 4V0XA 5JPFA 5JPEA 1KBPA 5JJTA 1OIEA 1HPUA 2USHA 1OIDA 1W24A 5EQVA 2ZBMA 1XZWA 3E0JA 1XM7A 2Z72A 3RL4A 1II7A 4IL1A 3DSDA 3QFOA 4ZX2A 5INBA 4I5NC 5HPEA 3CK2A 4FCXA 1WARA 1Z2WA 2NXFA 2WDCA 4WWLA 2P6BA 3LL8A 2HYPA 4ORBA 4XPNA 3EGHA 4OR9A 3RL5A 2Z1AA 1USHA 3TGHA 3THNA 4MP0A 1SU1A 1S95A 4LACC 3H60A 2WDFA 1AUIA 3C9FA 3N5UA 3H63A 4UT3A 1U32A 3AUZA 4FBWA 3RL3A 2XMOA 2QJCA 3K7WC 2R17A 4FBQA 2JOGA 4H2GA 4ORAA 1IT6A 4LU9A 2Q8UA 1OI8A 4H2IA 4Q7FA 2KKNA 4DHLA 4JA9A 4V0VA 4KBPA 3IVEA 4TUGA 2WDDA 3T1IA 3FLOA 3E7BA 3H66A 3IB7A 4ZVZA 4UWQA 4UT2A 4O43A 1HP1A 4FBKA 4F0ZA 4KKZA 3FGAC 2HYOA 4I5LC 3GVEA 2NYLC 1FJMA 2AHDA 3PSNA 3QFMA 3QG5C 5F3WA 1T70A 2YEQA 2HY1A 1UF3A 3IB8A 3E7AA 1V73A 3H64A 3RQZA 3P71C 3H67A 1MF8A 4M0VA 3QFNA 5GTUA 1S70A 4NZVA 3V4YA 4YKEA 4TUIA 5DNYA 2NYMC 4DSYA 2O8AA 3ZTVA 3EGGA 2O8GA 2BCDA 2Z06A 1S3NA 5B8IA
chains in the Genus database with same CATH topology
5IOHA 2YVTA 4G9JA 1WAO1 2IE3C 1S8EA 4MOVA 2DXNA 1NNWA 1S3MA 4V0WA 1S3LA 4JA7A 2NPPC 3KBPA 1Z2XA 3K7VC 1UTEA 4H1YP 4IYPC 2ZOAA 3JYFA 3AV0A 4ORCA 1QHWA 2A22A 2BDXA 1QFCA 3ZU0A 5J28A 4UT3B 2WDEA 4J6OA 3DW8C 3THOB 2QFPA 3IVDA 1M63A 1HO5A 4O5GA 4LTYA 2ZO9B 2QFRA 3ICFA 2GJUA 4O24A 3H68A 4O4KA 2IAEC 3H69A 2BQ8X 1G5BA 3DSCA 4HD0A 4H2FA 5C1VA 4DT2A 3H62B 1TCOA 2DXLA 3PSOA 2IE4C 3HVQA 4B2OA 4MOYA 3QFKA 3H61A 1T71A 3D03A 4H2BA 1JK7A 2DFJA 3C5WC 2CV9A 4H1SA 4V0XA 5JPFA 5JPEA 1KBPA 5JJTA 1OIEA 1HPUA 2USHA 1OIDA 1W24A 5EQVA 2ZBMA 1XZWA 3E0JA 1XM7A 2Z72A 3RL4A 1II7A 4IL1A 3DSDA 3QFOA 4ZX2A 5INBA 4I5NC 5HPEA 3CK2A 4FCXA 1WARA 1Z2WA 2NXFA 2WDCA 4WWLA 2P6BA 3LL8A 2HYPA 4ORBA 4XPNA 3EGHA 4OR9A 3RL5A 2Z1AA 1USHA 3TGHA 3THNA 4MP0A 1SU1A 1S95A 4LACC 3H60A 2WDFA 1AUIA 3C9FA 3N5UA 3H63A 4UT3A 1U32A 3AUZA 4FBWA 3RL3A 2XMOA 2QJCA 3K7WC 2R17A 4FBQA 2JOGA 4H2GA 4ORAA 1IT6A 4LU9A 2Q8UA 1OI8A 4H2IA 4Q7FA 2KKNA 4DHLA 4JA9A 4V0VA 4KBPA 3IVEA 4TUGA 2WDDA 3T1IA 3FLOA 3E7BA 3H66A 3IB7A 4ZVZA 4UWQA 4UT2A 4O43A 1HP1A 4FBKA 4F0ZA 4KKZA 3FGAC 2HYOA 4I5LC 3GVEA 2NYLC 1FJMA 2AHDA 3PSNA 3QFMA 3QG5C 5F3WA 1T70A 2YEQA 2HY1A 1UF3A 3IB8A 3E7AA 1V73A 3H64A 3RQZA 3P71C 3H67A 1MF8A 4M0VA 3QFNA 5GTUA 1S70A 4NZVA 3V4YA 4YKEA 4TUIA 5DNYA 2NYMC 4DSYA 2O8AA 3ZTVA 3EGGA 2O8GA 2BCDA 2Z06A 1S3NA 5B8IA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5IOH A;  2YVT A;  4G9J A;  1WAO 1;  2IE3 C;  1S8E A;  4MOV A;  1NNW A;  1S3M A;  4V0W A;  1S3L A;  4JA7 A;  2NPP C;  3KBP A;  1Z2X A;  3K7V C;  1UTE A;  4H1Y P;  4IYP C;  3JYF A;  3AV0 A;  4ORC A;  1QHW A;  2A22 A;  2BDX A;  1QFC A;  3ZU0 A;  5J28 A;  4UT3 B;  2WDE A;  4J6O A;  3DW8 C;  3THO B;  2QFP A;  3IVD A;  1M63 A;  1HO5 A;  4O5G A;  4LTY A;  2QFR A;  3ICF A;  2GJU A;  4O24 A;  3H68 A;  4O4K A;  2IAE C;  3H69 A;  2BQ8 X;  1G5B A;  3DSC A;  4HD0 A;  4H2F A;  5C1V A;  4DT2 A;  3H62 B;  1TCO A;  4B2O A;  3PSO A;  2IE4 C;  3HVQ A;  4MOY A;  3QFK A;  3H61 A;  1T71 A;  4H2B A;  1JK7 A;  2DFJ A;  3C5W C;  2CV9 A;  4H1S A;  4V0X A;  5JPF A;  5JPE A;  1KBP A;  5JJT A;  1OIE A;  1HPU A;  2USH A;  1OID A;  1W24 A;  5EQV A;  2ZBM A;  1XZW A;  1XM7 A;  2Z72 A;  3RL4 A;  1II7 A;  4IL1 A;  3DSD A;  3QFO A;  4ZX2 A;  5INB A;  4I5N C;  5HPE A;  3CK2 A;  4FCX A;  1WAR A;  1Z2W A;  2NXF A;  2WDC A;  4WWL A;  2P6B A;  3LL8 A;  2HYP A;  4ORB A;  4XPN A;  3EGH A;  4OR9 A;  3RL5 A;  2Z1A A;  1USH A;  3TGH A;  3THN A;  4MP0 A;  1SU1 A;  1S95 A;  4LAC C;  3H60 A;  2WDF A;  1AUI A;  3C9F A;  3N5U A;  3H63 A;  4UT3 A;  1U32 A;  3AUZ A;  4FBW A;  3RL3 A;  2XMO A;  2QJC A;  3K7W C;  2R17 A;  4FBQ A;  2JOG A;  4H2G A;  4ORA A;  1IT6 A;  4LU9 A;  2Q8U A;  1OI8 A;  4H2I A;  4Q7F A;  2KKN A;  4DHL A;  4JA9 A;  4V0V A;  4KBP A;  3IVE A;  4TUG A;  2WDD A;  3T1I A;  3E7B A;  3H66 A;  3IB7 A;  4ZVZ A;  4UWQ A;  4UT2 A;  4O43 A;  1HP1 A;  4FBK A;  4F0Z A;  4KKZ A;  3FGA C;  2HYO A;  4I5L C;  3GVE A;  2NYL C;  1FJM A;  2AHD A;  3PSN A;  3QFM A;  3QG5 C;  5F3W A;  1T70 A;  2HY1 A;  1UF3 A;  3IB8 A;  3E7A A;  1V73 A;  3H64 A;  3RQZ A;  3P71 C;  3H67 A;  1MF8 A;  4M0V A;  3QFN A;  5GTU A;  1S70 A;  4NZV A;  3V4Y A;  4YKE A;  4TUI A;  5DNY A;  2NYM C;  4DSY A;  2O8A A;  3ZTV A;  3EGG A;  2O8G A;  2BCD A;  2Z06 A;  1S3N A;  5B8I A; 
#chains in the Genus database with same CATH topology
 5IOH A;  2YVT A;  4G9J A;  1WAO 1;  2IE3 C;  1S8E A;  4MOV A;  2DXN A;  1NNW A;  1S3M A;  4V0W A;  1S3L A;  4JA7 A;  2NPP C;  3KBP A;  1Z2X A;  3K7V C;  1UTE A;  4H1Y P;  4IYP C;  2ZOA A;  3JYF A;  3AV0 A;  4ORC A;  1QHW A;  2A22 A;  2BDX A;  1QFC A;  3ZU0 A;  5J28 A;  4UT3 B;  2WDE A;  4J6O A;  3DW8 C;  3THO B;  2QFP A;  3IVD A;  1M63 A;  1HO5 A;  4O5G A;  4LTY A;  2ZO9 B;  2QFR A;  3ICF A;  2GJU A;  4O24 A;  3H68 A;  4O4K A;  2IAE C;  3H69 A;  2BQ8 X;  1G5B A;  3DSC A;  4HD0 A;  4H2F A;  5C1V A;  4DT2 A;  3H62 B;  1TCO A;  2DXL A;  3PSO A;  2IE4 C;  3HVQ A;  4B2O A;  4MOY A;  3QFK A;  3H61 A;  1T71 A;  3D03 A;  4H2B A;  1JK7 A;  2DFJ A;  3C5W C;  2CV9 A;  4H1S A;  4V0X A;  5JPF A;  5JPE A;  1KBP A;  5JJT A;  1OIE A;  1HPU A;  2USH A;  1OID A;  1W24 A;  5EQV A;  2ZBM A;  1XZW A;  3E0J A;  1XM7 A;  2Z72 A;  3RL4 A;  1II7 A;  4IL1 A;  3DSD A;  3QFO A;  4ZX2 A;  5INB A;  4I5N C;  5HPE A;  3CK2 A;  4FCX A;  1WAR A;  1Z2W A;  2NXF A;  2WDC A;  4WWL A;  2P6B A;  3LL8 A;  2HYP A;  4ORB A;  4XPN A;  3EGH A;  4OR9 A;  3RL5 A;  2Z1A A;  1USH A;  3TGH A;  3THN A;  4MP0 A;  1SU1 A;  1S95 A;  4LAC C;  3H60 A;  2WDF A;  1AUI A;  3C9F A;  3N5U A;  3H63 A;  4UT3 A;  1U32 A;  3AUZ A;  4FBW A;  3RL3 A;  2XMO A;  2QJC A;  3K7W C;  2R17 A;  4FBQ A;  2JOG A;  4H2G A;  4ORA A;  1IT6 A;  4LU9 A;  2Q8U A;  1OI8 A;  4H2I A;  4Q7F A;  2KKN A;  4DHL A;  4JA9 A;  4V0V A;  4KBP A;  3IVE A;  4TUG A;  2WDD A;  3T1I A;  3FLO A;  3E7B A;  3H66 A;  3IB7 A;  4ZVZ A;  4UWQ A;  4UT2 A;  4O43 A;  1HP1 A;  4FBK A;  4F0Z A;  4KKZ A;  3FGA C;  2HYO A;  4I5L C;  3GVE A;  2NYL C;  1FJM A;  2AHD A;  3PSN A;  3QFM A;  3QG5 C;  5F3W A;  1T70 A;  2YEQ A;  2HY1 A;  1UF3 A;  3IB8 A;  3E7A A;  1V73 A;  3H64 A;  3RQZ A;  3P71 C;  3H67 A;  1MF8 A;  4M0V A;  3QFN A;  5GTU A;  1S70 A;  4NZV A;  3V4Y A;  4YKE A;  4TUI A;  5DNY A;  2NYM C;  4DSY A;  2O8A A;  3ZTV A;  3EGG A;  2O8G A;  2BCD A;  2Z06 A;  1S3N A;  5B8I A; 
#chains in the Genus database with same CATH homology
 5IOH A;  2YVT A;  4G9J A;  1WAO 1;  2IE3 C;  1S8E A;  4MOV A;  2DXN A;  1NNW A;  1S3M A;  4V0W A;  1S3L A;  4JA7 A;  2NPP C;  3KBP A;  1Z2X A;  3K7V C;  1UTE A;  4H1Y P;  4IYP C;  2ZOA A;  3JYF A;  3AV0 A;  4ORC A;  1QHW A;  2A22 A;  2BDX A;  1QFC A;  3ZU0 A;  5J28 A;  4UT3 B;  2WDE A;  4J6O A;  3DW8 C;  3THO B;  2QFP A;  3IVD A;  1M63 A;  1HO5 A;  4O5G A;  4LTY A;  2ZO9 B;  2QFR A;  3ICF A;  2GJU A;  4O24 A;  3H68 A;  4O4K A;  2IAE C;  3H69 A;  2BQ8 X;  1G5B A;  3DSC A;  4HD0 A;  4H2F A;  5C1V A;  4DT2 A;  3H62 B;  1TCO A;  2DXL A;  3PSO A;  2IE4 C;  3HVQ A;  4B2O A;  4MOY A;  3QFK A;  3H61 A;  1T71 A;  3D03 A;  4H2B A;  1JK7 A;  2DFJ A;  3C5W C;  2CV9 A;  4H1S A;  4V0X A;  5JPF A;  5JPE A;  1KBP A;  5JJT A;  1OIE A;  1HPU A;  2USH A;  1OID A;  1W24 A;  5EQV A;  2ZBM A;  1XZW A;  3E0J A;  1XM7 A;  2Z72 A;  3RL4 A;  1II7 A;  4IL1 A;  3DSD A;  3QFO A;  4ZX2 A;  5INB A;  4I5N C;  5HPE A;  3CK2 A;  4FCX A;  1WAR A;  1Z2W A;  2NXF A;  2WDC A;  4WWL A;  2P6B A;  3LL8 A;  2HYP A;  4ORB A;  4XPN A;  3EGH A;  4OR9 A;  3RL5 A;  2Z1A A;  1USH A;  3TGH A;  3THN A;  4MP0 A;  1SU1 A;  1S95 A;  4LAC C;  3H60 A;  2WDF A;  1AUI A;  3C9F A;  3N5U A;  3H63 A;  4UT3 A;  1U32 A;  3AUZ A;  4FBW A;  3RL3 A;  2XMO A;  2QJC A;  3K7W C;  2R17 A;  4FBQ A;  2JOG A;  4H2G A;  4ORA A;  1IT6 A;  4LU9 A;  2Q8U A;  1OI8 A;  4H2I A;  4Q7F A;  2KKN A;  4DHL A;  4JA9 A;  4V0V A;  4KBP A;  3IVE A;  4TUG A;  2WDD A;  3T1I A;  3FLO A;  3E7B A;  3H66 A;  3IB7 A;  4ZVZ A;  4UWQ A;  4UT2 A;  4O43 A;  1HP1 A;  4FBK A;  4F0Z A;  4KKZ A;  3FGA C;  2HYO A;  4I5L C;  3GVE A;  2NYL C;  1FJM A;  2AHD A;  3PSN A;  3QFM A;  3QG5 C;  5F3W A;  1T70 A;  2YEQ A;  2HY1 A;  1UF3 A;  3IB8 A;  3E7A A;  1V73 A;  3H64 A;  3RQZ A;  3P71 C;  3H67 A;  1MF8 A;  4M0V A;  3QFN A;  5GTU A;  1S70 A;  4NZV A;  3V4Y A;  4YKE A;  4TUI A;  5DNY A;  2NYM C;  4DSY A;  2O8A A;  3ZTV A;  3EGG A;  2O8G A;  2BCD A;  2Z06 A;  1S3N A;  5B8I A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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