4H1SA

Crystal structure of a truncated soluble form of human cd73 with ecto-5'-nucleotidase activity
Total Genus 173
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
173
sequence length
523
structure length
521
Chain Sequence
WELTILHTNDVHSRLEQTSEDSSKCVNASRCMGGVARLFTKVQQIRRAEPNVLLLDAGDQYQGTIWFTVYKGAEVAHFMNALRYDAMALGNHEFDNGVEGLIEPLLKEAKFPILSANIKAKGPLASQISGLYLPYKVLPVGDEVVGIVGYTSKETPFLSNPGTNLVFEDEITALQPEVDKLKTLNVNKIIALGHSGFEMDKLIAQKVRGVDVVVGGHSNTFLYTGNPPSKEVPAGKYPFIVTSDDGRKVPVVQAYAFGKYLGYLKIEFDERGNVISSHGNPILLNSSIPEDPSIKADINKWRIKLDNYQELGKTIVYLDGSSQSCRFRECNMGNLICDAMINNNLRHTDEMFWNHVSMCILNGGGIRSPIDERNNGTITWENLAAVLPFGGTFDLVQLKGSTLKKAFEHSVHRYGQSTGEFLQVGGIHVVYDLSRKPGDRVVKLDVLCTKCRVPSYDPLKMDEVYKVILPNFLANGGDGFQMIKDELLRHDSGDQDINVVSTYISKMKVIYPAVEGRIKFS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Crystal structure of a soluble form of human CD73 with ecto-5'-nucleotidase activity.
pubmed doi rcsb
molecule tags Hydrolase
molecule keywords 5'-nucleotidase
total genus 173
structure length 521
sequence length 523
chains with identical sequence B
ec nomenclature ec 3.1.3.5: 5'-nucleotidase.
pdb deposition date 2012-09-11

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00149 Metallophos Calcineurin-like phosphoesterase
A PF02872 5_nucleotid_C 5'-nucleotidase, C-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.21.10 Alpha Beta 4-Layer Sandwich Purple Acid Phosphatase; chain A, domain 2 Purple Acid Phosphatase; chain A, domain 2 4h1sA01
3.90.780.10 Alpha Beta Alpha-Beta Complex 5'-nucleotidase; domain 2 5'-Nucleotidase, C-terminal domain 4h1sA02
4TUIA 2HYOA 5B8IA 3QG5C 1HPUA 1WARA 2WDCA 4ORBA 4IL1A 4TUGA 1NNWA 2XMOA 4MOYA 2QFRA 3RL4A 4ORCA 3P71C 1UTEA 2KKNA 2WDDA 4V0XA 4HD0A 3ZTVA 3QFOA 4WWLA 3IVDA 3H60A 3K7VC 5JPFA 1WAO1 4DT2A 3C9FA 2R17A 3KBPA 1KBPA 4MOVA 5JPEA 3HVQA 1USHA 1QFCA 2USHA 3FGAC 2QJCA 3H61A 2O8AA 1XZWA 3H64A 1JK7A 1S8EA 1M63A 3TGHA 4B2OA 4O5GA 2JOGA 3K7WC 4DHLA 1HO5A 2Z72A 4LACC 1QHWA 4KBPA 3ICFA 2AHDA 4FBWA 4H1SA 3RQZA 1Z2XA 3H63A 3N5UA 1UF3A 4DSYA 3DSDA 1S70A 1W24A 2HYPA 4ZX2A 3EGGA 2Z06A 5F3WA 1Z2WA 1OIDA 3IB7A 3C5WC 3H67A 3E7BA 2YVTA 3H69A 3QFKA 3ZU0A 3V4YA 4H2GA 3QFMA 4JA7A 4M0VA 4Q7FA 4FBKA 4O4KA 4I5NC 2WDFA 2GJUA 3H62B 4V0VA 4XPNA 5INBA 3GVEA 2DFJA 1IT6A 2IE3C 2Q8UA 2A22A 3EGHA 4NZVA 4O24A 5GTUA 2QFPA 1S3NA 2NPPC 4UT3A 4LTYA 1AUIA 1T71A 1T70A 3H66A 4F0ZA 2CV9A 4UT2A 4V0WA 1OIEA 5DNYA 1U32A 5J28A 4LU9A 1HP1A 2BQ8X 4H2FA 4H2IA 4OR9A 4ORAA 3QFNA 3E7AA 5HPEA 3DW8C 3RL3A 4FCXA 4MP0A 1OI8A 2BCDA 2IE4C 4UWQA 1TCOA 2WDEA 3THOB 1SU1A 2BDXA 2NXFA 5C1VA 4JA9A 1MF8A 2HY1A 2P6BA 4UT3B 1II7A 2O8GA 3AV0A 4O43A 1G5BA 1V73A 2NYLC 3PSNA 4H2BA 4FBQA 3CK2A 3LL8A 2Z1AA 1FJMA 4IYPC 4YKEA 4J6OA 3THNA 4H1YP 2IAEC 3JYFA 3RL5A 4I5LC 5JJTA 3IVEA 1S3MA 4G9JA 2ZBMA 4ZVZA 3H68A 2NYMC 3AUZA 3T1IA 1XM7A 4KKZA 5EQVA 3PSOA 5IOHA 3IB8A 1S3LA 3DSCA 1S95A
chains in the Genus database with same CATH superfamily
4TUIA 2HYOA 5B8IA 3QG5C 1HPUA 1WARA 2WDCA 4ORBA 4IL1A 4TUGA 1NNWA 2XMOA 4MOYA 2QFRA 3RL4A 4ORCA 3P71C 1UTEA 2KKNA 2WDDA 4V0XA 4HD0A 3ZTVA 3QFOA 4WWLA 3IVDA 3H60A 3K7VC 5JPFA 1WAO1 4DT2A 3C9FA 2R17A 3KBPA 1KBPA 4MOVA 5JPEA 3HVQA 1USHA 1QFCA 2USHA 3FGAC 2QJCA 3H61A 2O8AA 1XZWA 3H64A 1JK7A 1S8EA 1M63A 3TGHA 4B2OA 4O5GA 2JOGA 3K7WC 4DHLA 1HO5A 2Z72A 4LACC 1QHWA 4KBPA 3ICFA 2AHDA 4FBWA 4H1SA 3RQZA 3FLOA 1Z2XA 3H63A 3N5UA 1UF3A 4DSYA 3DSDA 1S70A 1W24A 2HYPA 4ZX2A 3EGGA 2Z06A 5F3WA 1Z2WA 1OIDA 3IB7A 3C5WC 3H67A 3E7BA 2YVTA 3H69A 3QFKA 3ZU0A 3V4YA 4H2GA 3QFMA 4JA7A 4M0VA 4Q7FA 4FBKA 4O4KA 4I5NC 2WDFA 2GJUA 3H62B 4V0VA 4XPNA 5INBA 3E0JA 3GVEA 2DFJA 1IT6A 2IE3C 2Q8UA 2A22A 3EGHA 4NZVA 4O24A 5GTUA 2QFPA 1S3NA 2NPPC 4UT3A 4LTYA 1AUIA 1T71A 3D03A 1T70A 3H66A 4F0ZA 2CV9A 4UT2A 4V0WA 1OIEA 5DNYA 1U32A 5J28A 4LU9A 1HP1A 2BQ8X 4H2FA 4H2IA 4OR9A 4ORAA 3QFNA 3E7AA 5HPEA 3DW8C 3RL3A 4FCXA 4MP0A 1OI8A 2BCDA 2IE4C 4UWQA 1TCOA 2WDEA 2ZO9B 3THOB 1SU1A 2BDXA 2NXFA 5C1VA 2YEQA 4JA9A 1MF8A 2HY1A 2P6BA 4UT3B 1II7A 2O8GA 3AV0A 4O43A 1G5BA 1V73A 2NYLC 3PSNA 4H2BA 4FBQA 3CK2A 3LL8A 2Z1AA 1FJMA 4IYPC 4YKEA 4J6OA 3THNA 4H1YP 2IAEC 3JYFA 3RL5A 4I5LC 5JJTA 2ZOAA 3IVEA 1S3MA 4G9JA 2ZBMA 4ZVZA 3H68A 2NYMC 3AUZA 3T1IA 1XM7A 4KKZA 5EQVA 2DXNA 3PSOA 2DXLA 5IOHA 3IB8A 1S3LA 3DSCA 1S95A
chains in the Genus database with same CATH topology
4TUIA 2HYOA 5B8IA 3QG5C 1HPUA 1WARA 2WDCA 4ORBA 4IL1A 4TUGA 1NNWA 2XMOA 4MOYA 2QFRA 3RL4A 4ORCA 3P71C 1UTEA 2KKNA 2WDDA 4V0XA 4HD0A 3ZTVA 3QFOA 4WWLA 3IVDA 3H60A 3K7VC 5JPFA 1WAO1 4DT2A 3C9FA 2R17A 3KBPA 1KBPA 4MOVA 5JPEA 3HVQA 1USHA 1QFCA 2USHA 3FGAC 2QJCA 3H61A 2O8AA 1XZWA 3H64A 1JK7A 1S8EA 1M63A 3TGHA 4B2OA 4O5GA 2JOGA 3K7WC 4DHLA 1HO5A 2Z72A 4LACC 1QHWA 4KBPA 3ICFA 2AHDA 4FBWA 4H1SA 3RQZA 3FLOA 1Z2XA 3H63A 3N5UA 1UF3A 4DSYA 3DSDA 1S70A 1W24A 2HYPA 4ZX2A 3EGGA 2Z06A 5F3WA 1Z2WA 1OIDA 3IB7A 3C5WC 3H67A 3E7BA 2YVTA 3H69A 3QFKA 3ZU0A 3V4YA 4H2GA 3QFMA 4JA7A 4M0VA 4Q7FA 4FBKA 4O4KA 4I5NC 2WDFA 2GJUA 3H62B 4V0VA 4XPNA 5INBA 3E0JA 3GVEA 2DFJA 1IT6A 2IE3C 2Q8UA 2A22A 3EGHA 4NZVA 4O24A 5GTUA 2QFPA 1S3NA 2NPPC 4UT3A 4LTYA 1AUIA 1T71A 3D03A 1T70A 3H66A 4F0ZA 2CV9A 4UT2A 4V0WA 1OIEA 5DNYA 1U32A 5J28A 4LU9A 1HP1A 2BQ8X 4H2FA 4H2IA 4OR9A 4ORAA 3QFNA 3E7AA 5HPEA 3DW8C 3RL3A 4FCXA 4MP0A 1OI8A 2BCDA 2IE4C 4UWQA 1TCOA 2WDEA 2ZO9B 3THOB 1SU1A 2BDXA 2NXFA 5C1VA 2YEQA 4JA9A 1MF8A 2HY1A 2P6BA 4UT3B 1II7A 2O8GA 3AV0A 4O43A 1G5BA 1V73A 2NYLC 3PSNA 4H2BA 4FBQA 3CK2A 3LL8A 2Z1AA 1FJMA 4IYPC 4YKEA 4J6OA 3THNA 4H1YP 2IAEC 3JYFA 3RL5A 4I5LC 5JJTA 2ZOAA 3IVEA 1S3MA 4G9JA 2ZBMA 4ZVZA 3H68A 2NYMC 3AUZA 3T1IA 1XM7A 4KKZA 5EQVA 2DXNA 3PSOA 2DXLA 5IOHA 3IB8A 1S3LA 3DSCA 1S95A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4TUI A;  2HYO A;  5B8I A;  3QG5 C;  1HPU A;  1WAR A;  2WDC A;  4ORB A;  4IL1 A;  4TUG A;  1NNW A;  2XMO A;  4MOY A;  2QFR A;  3RL4 A;  4ORC A;  3P71 C;  1UTE A;  2KKN A;  2WDD A;  4V0X A;  4HD0 A;  3ZTV A;  3QFO A;  4WWL A;  3IVD A;  3H60 A;  3K7V C;  5JPF A;  1WAO 1;  4DT2 A;  3C9F A;  2R17 A;  3KBP A;  1KBP A;  4MOV A;  5JPE A;  3HVQ A;  1USH A;  1QFC A;  2USH A;  3FGA C;  2QJC A;  3H61 A;  2O8A A;  1XZW A;  3H64 A;  1JK7 A;  1S8E A;  1M63 A;  3TGH A;  4B2O A;  4O5G A;  2JOG A;  3K7W C;  4DHL A;  1HO5 A;  2Z72 A;  4LAC C;  1QHW A;  4KBP A;  3ICF A;  2AHD A;  4FBW A;  4H1S A;  3RQZ A;  1Z2X A;  3H63 A;  3N5U A;  1UF3 A;  4DSY A;  3DSD A;  1S70 A;  1W24 A;  2HYP A;  4ZX2 A;  3EGG A;  2Z06 A;  5F3W A;  1Z2W A;  1OID A;  3IB7 A;  3C5W C;  3H67 A;  3E7B A;  2YVT A;  3H69 A;  3QFK A;  3ZU0 A;  3V4Y A;  4H2G A;  3QFM A;  4JA7 A;  4M0V A;  4Q7F A;  4FBK A;  4O4K A;  4I5N C;  2WDF A;  2GJU A;  3H62 B;  4V0V A;  4XPN A;  5INB A;  3GVE A;  2DFJ A;  1IT6 A;  2IE3 C;  2Q8U A;  2A22 A;  3EGH A;  4NZV A;  4O24 A;  5GTU A;  2QFP A;  1S3N A;  2NPP C;  4UT3 A;  4LTY A;  1AUI A;  1T71 A;  1T70 A;  3H66 A;  4F0Z A;  2CV9 A;  4UT2 A;  4V0W A;  1OIE A;  5DNY A;  1U32 A;  5J28 A;  4LU9 A;  1HP1 A;  2BQ8 X;  4H2F A;  4H2I A;  4OR9 A;  4ORA A;  3QFN A;  3E7A A;  5HPE A;  3DW8 C;  3RL3 A;  4FCX A;  4MP0 A;  1OI8 A;  2BCD A;  2IE4 C;  4UWQ A;  1TCO A;  2WDE A;  3THO B;  1SU1 A;  2BDX A;  2NXF A;  5C1V A;  4JA9 A;  1MF8 A;  2HY1 A;  2P6B A;  4UT3 B;  1II7 A;  2O8G A;  3AV0 A;  4O43 A;  1G5B A;  1V73 A;  2NYL C;  3PSN A;  4H2B A;  4FBQ A;  3CK2 A;  3LL8 A;  2Z1A A;  1FJM A;  4IYP C;  4YKE A;  4J6O A;  3THN A;  4H1Y P;  2IAE C;  3JYF A;  3RL5 A;  4I5L C;  5JJT A;  3IVE A;  1S3M A;  4G9J A;  2ZBM A;  4ZVZ A;  3H68 A;  2NYM C;  3AUZ A;  3T1I A;  1XM7 A;  4KKZ A;  5EQV A;  3PSO A;  5IOH A;  3IB8 A;  1S3L A;  3DSC A;  1S95 A; 
#chains in the Genus database with same CATH topology
 4TUI A;  2HYO A;  5B8I A;  3QG5 C;  1HPU A;  1WAR A;  2WDC A;  4ORB A;  4IL1 A;  4TUG A;  1NNW A;  2XMO A;  4MOY A;  2QFR A;  3RL4 A;  4ORC A;  3P71 C;  1UTE A;  2KKN A;  2WDD A;  4V0X A;  4HD0 A;  3ZTV A;  3QFO A;  4WWL A;  3IVD A;  3H60 A;  3K7V C;  5JPF A;  1WAO 1;  4DT2 A;  3C9F A;  2R17 A;  3KBP A;  1KBP A;  4MOV A;  5JPE A;  3HVQ A;  1USH A;  1QFC A;  2USH A;  3FGA C;  2QJC A;  3H61 A;  2O8A A;  1XZW A;  3H64 A;  1JK7 A;  1S8E A;  1M63 A;  3TGH A;  4B2O A;  4O5G A;  2JOG A;  3K7W C;  4DHL A;  1HO5 A;  2Z72 A;  4LAC C;  1QHW A;  4KBP A;  3ICF A;  2AHD A;  4FBW A;  4H1S A;  3RQZ A;  3FLO A;  1Z2X A;  3H63 A;  3N5U A;  1UF3 A;  4DSY A;  3DSD A;  1S70 A;  1W24 A;  2HYP A;  4ZX2 A;  3EGG A;  2Z06 A;  5F3W A;  1Z2W A;  1OID A;  3IB7 A;  3C5W C;  3H67 A;  3E7B A;  2YVT A;  3H69 A;  3QFK A;  3ZU0 A;  3V4Y A;  4H2G A;  3QFM A;  4JA7 A;  4M0V A;  4Q7F A;  4FBK A;  4O4K A;  4I5N C;  2WDF A;  2GJU A;  3H62 B;  4V0V A;  4XPN A;  5INB A;  3E0J A;  3GVE A;  2DFJ A;  1IT6 A;  2IE3 C;  2Q8U A;  2A22 A;  3EGH A;  4NZV A;  4O24 A;  5GTU A;  2QFP A;  1S3N A;  2NPP C;  4UT3 A;  4LTY A;  1AUI A;  1T71 A;  3D03 A;  1T70 A;  3H66 A;  4F0Z A;  2CV9 A;  4UT2 A;  4V0W A;  1OIE A;  5DNY A;  1U32 A;  5J28 A;  4LU9 A;  1HP1 A;  2BQ8 X;  4H2F A;  4H2I A;  4OR9 A;  4ORA A;  3QFN A;  3E7A A;  5HPE A;  3DW8 C;  3RL3 A;  4FCX A;  4MP0 A;  1OI8 A;  2BCD A;  2IE4 C;  4UWQ A;  1TCO A;  2WDE A;  2ZO9 B;  3THO B;  1SU1 A;  2BDX A;  2NXF A;  5C1V A;  2YEQ A;  4JA9 A;  1MF8 A;  2HY1 A;  2P6B A;  4UT3 B;  1II7 A;  2O8G A;  3AV0 A;  4O43 A;  1G5B A;  1V73 A;  2NYL C;  3PSN A;  4H2B A;  4FBQ A;  3CK2 A;  3LL8 A;  2Z1A A;  1FJM A;  4IYP C;  4YKE A;  4J6O A;  3THN A;  4H1Y P;  2IAE C;  3JYF A;  3RL5 A;  4I5L C;  5JJT A;  2ZOA A;  3IVE A;  1S3M A;  4G9J A;  2ZBM A;  4ZVZ A;  3H68 A;  2NYM C;  3AUZ A;  3T1I A;  1XM7 A;  4KKZ A;  5EQV A;  2DXN A;  3PSO A;  2DXL A;  5IOH A;  3IB8 A;  1S3L A;  3DSC A;  1S95 A; 
#chains in the Genus database with same CATH homology
 4TUI A;  2HYO A;  5B8I A;  3QG5 C;  1HPU A;  1WAR A;  2WDC A;  4ORB A;  4IL1 A;  4TUG A;  1NNW A;  2XMO A;  4MOY A;  2QFR A;  3RL4 A;  4ORC A;  3P71 C;  1UTE A;  2KKN A;  2WDD A;  4V0X A;  4HD0 A;  3ZTV A;  3QFO A;  4WWL A;  3IVD A;  3H60 A;  3K7V C;  5JPF A;  1WAO 1;  4DT2 A;  3C9F A;  2R17 A;  3KBP A;  1KBP A;  4MOV A;  5JPE A;  3HVQ A;  1USH A;  1QFC A;  2USH A;  3FGA C;  2QJC A;  3H61 A;  2O8A A;  1XZW A;  3H64 A;  1JK7 A;  1S8E A;  1M63 A;  3TGH A;  4B2O A;  4O5G A;  2JOG A;  3K7W C;  4DHL A;  1HO5 A;  2Z72 A;  4LAC C;  1QHW A;  4KBP A;  3ICF A;  2AHD A;  4FBW A;  4H1S A;  3RQZ A;  3FLO A;  1Z2X A;  3H63 A;  3N5U A;  1UF3 A;  4DSY A;  3DSD A;  1S70 A;  1W24 A;  2HYP A;  4ZX2 A;  3EGG A;  2Z06 A;  5F3W A;  1Z2W A;  1OID A;  3IB7 A;  3C5W C;  3H67 A;  3E7B A;  2YVT A;  3H69 A;  3QFK A;  3ZU0 A;  3V4Y A;  4H2G A;  3QFM A;  4JA7 A;  4M0V A;  4Q7F A;  4FBK A;  4O4K A;  4I5N C;  2WDF A;  2GJU A;  3H62 B;  4V0V A;  4XPN A;  5INB A;  3E0J A;  3GVE A;  2DFJ A;  1IT6 A;  2IE3 C;  2Q8U A;  2A22 A;  3EGH A;  4NZV A;  4O24 A;  5GTU A;  2QFP A;  1S3N A;  2NPP C;  4UT3 A;  4LTY A;  1AUI A;  1T71 A;  3D03 A;  1T70 A;  3H66 A;  4F0Z A;  2CV9 A;  4UT2 A;  4V0W A;  1OIE A;  5DNY A;  1U32 A;  5J28 A;  4LU9 A;  1HP1 A;  2BQ8 X;  4H2F A;  4H2I A;  4OR9 A;  4ORA A;  3QFN A;  3E7A A;  5HPE A;  3DW8 C;  3RL3 A;  4FCX A;  4MP0 A;  1OI8 A;  2BCD A;  2IE4 C;  4UWQ A;  1TCO A;  2WDE A;  2ZO9 B;  3THO B;  1SU1 A;  2BDX A;  2NXF A;  5C1V A;  2YEQ A;  4JA9 A;  1MF8 A;  2HY1 A;  2P6B A;  4UT3 B;  1II7 A;  2O8G A;  3AV0 A;  4O43 A;  1G5B A;  1V73 A;  2NYL C;  3PSN A;  4H2B A;  4FBQ A;  3CK2 A;  3LL8 A;  2Z1A A;  1FJM A;  4IYP C;  4YKE A;  4J6O A;  3THN A;  4H1Y P;  2IAE C;  3JYF A;  3RL5 A;  4I5L C;  5JJT A;  2ZOA A;  3IVE A;  1S3M A;  4G9J A;  2ZBM A;  4ZVZ A;  3H68 A;  2NYM C;  3AUZ A;  3T1I A;  1XM7 A;  4KKZ A;  5EQV A;  2DXN A;  3PSO A;  2DXL A;  5IOH A;  3IB8 A;  1S3L A;  3DSC A;  1S95 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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