4H5XA

Human plk1-pbd with a glycerol bound at the phophopeptide binding site
Total Genus 71
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
71
sequence length
222
structure length
222
Chain Sequence
CHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Thymoquinone Blocks pSer/pThr Recognition by Plk1 Polo-Box Domain As a Phosphate Mimic
pubmed doi rcsb
source organism Homo sapiens
molecule tags Transferase
molecule keywords Serine/threonine-protein kinase PLK1
total genus 71
structure length 222
sequence length 222
chains with identical sequence B
ec nomenclature ec 2.7.11.21: Polo kinase.
pdb deposition date 2012-09-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00659 POLO_box POLO box duplicated region
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 4h5xA02
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 4h5xA01
4H71A 1Q4KA 4DFWA 2OJXA 5DMVC 4O9WA 4O56A 4X9RA 4E9CA 2N19A 3P34A 4X9VA 5DNJA 5J19A 4O6WA 3C5LA 1UMWA 4RS6A 3BZIA 1Q4OA 3P37A 4RCPA 4HABA 4WHKA 4X9WA 4LKMA 3FVHA 3P2ZA 4LKLA 4HY2A 4E9DA 4WHHA 3RQ7A 3P2WA 4XB0A 3HIHA 4E67A 3Q1IA 4H5XA 4YYPA 4J7BB 5DMSA 3P35A 3HIKA 3P36A 5LHZA 2OGQA 4HCOA 4WHLA
chains in the Genus database with same CATH superfamily
1P49A 4H71A 4CXKA 4DFWA 5AJ9A 4E9CA 2N19A 4X9VA 4O6WA 1E1ZP 3C5LA 1UMWA 4RCPA 1E33P 4LKMA 3P2ZA 4LKLA 4WHHA 3RQ7A 4CYRA 2I9XA 1F32A 3HMJG 3P35A 3HIKA 3GYVA 4G7NA 4HCOA 3GYWA 1Q4KA 2OJXA 4O9WA 1AUKA 5DNJA 1N2LA 4RS6A 1Q4OA 4FDIA 4WHKA 4X9WA 3FVHA 4HY2A 1A87A 3HIHA 3Q1IA 4N7ZA 4YYPA 4J7BB 1FSUA 4NK7A 3P36A 4N7VA 1F34B 2I9ZA 5DMVC 4O56A 3LM3A 4X9RA 1HDHA 4CXSA 3P34A 4HABA 4CYSA 2QZUA 3ED4A 4CXUA 2E50A 2VKZG 4XB0A 4E67A 4H5XA 3LXQA 5DAYA 2OGQA 2IA9A 3HFDA 1E3CP 1E2SP 1N2KA 3KDRA 5J19A 3BZIA 3P37A 4FDJA 4E9DA 3P2WA 3FS3A 2UV8G 4NKBA 5DMSA 4N9JA 1E2TA 5LHZA 4WHLA
chains in the Genus database with same CATH topology
4H71A 1Q4KA 4DFWA 2OJXA 5DMVC 4O9WA 4O56A 4X9RA 4E9CA 2N19A 3P34A 4X9VA 5DNJA 5J19A 4O6WA 3C5LA 1UMWA 4RS6A 3BZIA 1Q4OA 3P37A 4RCPA 4HABA 4WHKA 4X9WA 4LKMA 3FVHA 3P2ZA 4LKLA 4HY2A 4E9DA 4WHHA 3RQ7A 3P2WA 4XB0A 3HIHA 4E67A 3Q1IA 4H5XA 4YYPA 4J7BB 5DMSA 3P35A 3HIKA 3P36A 5LHZA 2OGQA 4HCOA 4WHLA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4H71 A;  1Q4K A;  4DFW A;  2OJX A;  5DMV C;  4O9W A;  4O56 A;  4X9R A;  4E9C A;  2N19 A;  3P34 A;  4X9V A;  5DNJ A;  5J19 A;  4O6W A;  3C5L A;  1UMW A;  4RS6 A;  3BZI A;  1Q4O A;  3P37 A;  4RCP A;  4HAB A;  4WHK A;  4X9W A;  4LKM A;  3FVH A;  3P2Z A;  4LKL A;  4HY2 A;  4E9D A;  4WHH A;  3RQ7 A;  3P2W A;  4XB0 A;  3HIH A;  4E67 A;  3Q1I A;  4H5X A;  4YYP A;  4J7B B;  5DMS A;  3P35 A;  3HIK A;  3P36 A;  5LHZ A;  2OGQ A;  4HCO A;  4WHL A; 
#chains in the Genus database with same CATH topology
 1P49 A;  4H71 A;  4CXK A;  4DFW A;  5AJ9 A;  4E9C A;  2N19 A;  4X9V A;  4O6W A;  1E1Z P;  3C5L A;  1UMW A;  4RCP A;  1E33 P;  4LKM A;  3P2Z A;  4LKL A;  4WHH A;  3RQ7 A;  4CYR A;  2I9X A;  1F32 A;  3HMJ G;  3P35 A;  3HIK A;  3GYV A;  4G7N A;  4HCO A;  3GYW A;  1Q4K A;  2OJX A;  4O9W A;  1AUK A;  5DNJ A;  1N2L A;  4RS6 A;  1Q4O A;  4FDI A;  4WHK A;  4X9W A;  3FVH A;  4HY2 A;  1A87 A;  3HIH A;  3Q1I A;  4N7Z A;  4YYP A;  4J7B B;  1FSU A;  4NK7 A;  3P36 A;  4N7V A;  1F34 B;  2I9Z A;  5DMV C;  4O56 A;  3LM3 A;  4X9R A;  1HDH A;  4CXS A;  3P34 A;  4HAB A;  4CYS A;  2QZU A;  3ED4 A;  4CXU A;  2E50 A;  2VKZ G;  4XB0 A;  4E67 A;  4H5X A;  3LXQ A;  5DAY A;  2OGQ A;  2IA9 A;  3HFD A;  1E3C P;  1E2S P;  1N2K A;  3KDR A;  5J19 A;  3BZI A;  3P37 A;  4FDJ A;  4E9D A;  3P2W A;  3FS3 A;  2UV8 G;  4NKB A;  5DMS A;  4N9J A;  1E2T A;  5LHZ A;  4WHL A; 
#chains in the Genus database with same CATH homology
 4H71 A;  1Q4K A;  4DFW A;  2OJX A;  5DMV C;  4O9W A;  4O56 A;  4X9R A;  4E9C A;  2N19 A;  3P34 A;  4X9V A;  5DNJ A;  5J19 A;  4O6W A;  3C5L A;  1UMW A;  4RS6 A;  3BZI A;  1Q4O A;  3P37 A;  4RCP A;  4HAB A;  4WHK A;  4X9W A;  4LKM A;  3FVH A;  3P2Z A;  4LKL A;  4HY2 A;  4E9D A;  4WHH A;  3RQ7 A;  3P2W A;  4XB0 A;  3HIH A;  4E67 A;  3Q1I A;  4H5X A;  4YYP A;  4J7B B;  5DMS A;  3P35 A;  3HIK A;  3P36 A;  5LHZ A;  2OGQ A;  4HCO A;  4WHL A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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