4HKIC

Tankyrase 2 in complex with flavone
Total Genus 1
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
1
sequence length
47
structure length
47
Chain Sequence
MAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Transferase
molecule keywords Tankyrase-2
publication title Screening and structural analysis of flavones inhibiting tankyrases.
pubmed doi rcsb
source organism Homo sapiens
total genus 1
structure length 47
sequence length 47
chains with identical sequence D
ec nomenclature ec 2.4.2.30: NAD(+) ADP-ribosyltransferase.
pdb deposition date 2012-10-15
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.1620.50 Alpha Beta 3-Layer(aba) Sandwich YefM-like fold YefM-like fold 4hkiC00
4UI6C 4HLHC 4L09C 4L33C 5ADSB 4L2FC 4HKKB 4HLMC 4L0BC 4KZUC 4UI5C 4UI7C 4HLFC 4L0VC 4L31C 5C5PC 5C5QC 4L32C 4HMHC 4L2GC 4HKNC 4L34C 4UI4C 4L2KC 4UI8C 4KZQC 4L0IC 4L10C 4HLGC 4L0SC 4HL5C 5ADRB 5C5RC 5ADTB 4L0TC 5ADQB 4KZLC 4UI3C 4UVPB 5FPFC 4HKIC 4HLKC
chains in the Genus database with same CATH superfamily
3D55A 4UI6C 4HLHC 4L09C 2ZIXB 4L33C 4ZM0A 5ADSB 4L2FC 4HKKB 4HLMC 4L0BC 3OEIA 3KH2E 4KZUC 4UI5C 4UI7C 4HLFC 4L0VC 4L31C 5C5PC 5C5QC 3HRYA 4L32C 4HMHC 3G5OA 4L2GC 4ZLXA 3K33B 3K6QA 4HKNC 3HS2A 5FPFC 2A6QA 4L34C 4UI4C 4L2KC 4UI8C 4KZQC 2ODKA 4L0IC 4L10C 4HLGC 4L0SC 4HL5C 5ADRB 5C5RC 3HJ6A 4L0TC 4ZM2A 4KZLC 5ADTB 5ADQB 4UI3C 4UVPB 3CTOA 4HKIC 3OEIE 4HLKC
chains in the Genus database with same CATH topology
4UI6C 4HLHC 4L09C 2ZIXB 4L33C 5ADSB 4L2FC 4HKKB 4HLMC 4L0BC 4KZUC 4UI5C 4UI7C 4HLFC 4L0VC 4L31C 5C5PC 5C5QC 4L32C 4HMHC 4L2GC 4HKNC 4L34C 4UI4C 4L2KC 4UI8C 4KZQC 4L0IC 4L10C 4HLGC 4L0SC 4HL5C 5ADRB 5C5RC 3HJ6A 4L0TC 5ADTB 4KZLC 5ADQB 4UI3C 4UVPB 5FPFC 4HKIC 4HLKC
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4UI6 C;  4HLH C;  4L09 C;  4L33 C;  5ADS B;  4L2F C;  4HKK B;  4HLM C;  4L0B C;  4KZU C;  4UI5 C;  4UI7 C;  4HLF C;  4L0V C;  4L31 C;  5C5P C;  5C5Q C;  4L32 C;  4HMH C;  4L2G C;  4HKN C;  4L34 C;  4UI4 C;  4L2K C;  4UI8 C;  4KZQ C;  4L0I C;  4L10 C;  4HLG C;  4L0S C;  4HL5 C;  5ADR B;  5C5R C;  5ADT B;  4L0T C;  5ADQ B;  4KZL C;  4UI3 C;  4UVP B;  5FPF C;  4HKI C;  4HLK C; 
#chains in the Genus database with same CATH topology
 3D55 A;  4UI6 C;  4HLH C;  4L09 C;  2ZIX B;  4L33 C;  4ZM0 A;  5ADS B;  4L2F C;  4HKK B;  4HLM C;  4L0B C;  3OEI A;  3KH2 E;  4KZU C;  4UI5 C;  4UI7 C;  4HLF C;  4L0V C;  4L31 C;  5C5P C;  5C5Q C;  3HRY A;  4L32 C;  4HMH C;  3G5O A;  4L2G C;  4ZLX A;  3K33 B;  3K6Q A;  4HKN C;  3HS2 A;  5FPF C;  2A6Q A;  4L34 C;  4UI4 C;  4L2K C;  4UI8 C;  4KZQ C;  2ODK A;  4L0I C;  4L10 C;  4HLG C;  4L0S C;  4HL5 C;  5ADR B;  5C5R C;  3HJ6 A;  4L0T C;  4ZM2 A;  4KZL C;  5ADT B;  5ADQ B;  4UI3 C;  4UVP B;  3CTO A;  4HKI C;  3OEI E;  4HLK C; 
#chains in the Genus database with same CATH homology
 4UI6 C;  4HLH C;  4L09 C;  2ZIX B;  4L33 C;  5ADS B;  4L2F C;  4HKK B;  4HLM C;  4L0B C;  4KZU C;  4UI5 C;  4UI7 C;  4HLF C;  4L0V C;  4L31 C;  5C5P C;  5C5Q C;  4L32 C;  4HMH C;  4L2G C;  4HKN C;  4L34 C;  4UI4 C;  4L2K C;  4UI8 C;  4KZQ C;  4L0I C;  4L10 C;  4HLG C;  4L0S C;  4HL5 C;  5ADR B;  5C5R C;  3HJ6 A;  4L0T C;  5ADT B;  4KZL C;  5ADQ B;  4UI3 C;  4UVP B;  5FPF C;  4HKI C;  4HLK C; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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