4HMHC

Crystal structure of tankyrase 2 in complex with 7,3-dihydroxyflavone
Total Genus 1
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
1
sequence length
47
structure length
47
Chain Sequence
MAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Transferase
molecule keywords Tankyrase-2
publication title Screening and structural analysis of flavones inhibiting tankyrases.
pubmed doi rcsb
source organism Homo sapiens
total genus 1
structure length 47
sequence length 47
ec nomenclature ec 2.4.2.30: NAD(+) ADP-ribosyltransferase.
pdb deposition date 2012-10-18
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.1620.50 Alpha Beta 3-Layer(aba) Sandwich YefM-like fold YefM-like fold 4hmhC00
4L0IC 4L0TC 4HLFC 4HKIC 4L10C 4HLHC 4HL5C 4KZLC 4L09C 5ADTB 4UI8C 5ADRB 4UVPB 4L0VC 4UI3C 4HKNC 4L2KC 4UI4C 5C5RC 4HLGC 4UI7C 4L2GC 5FPFC 5ADSB 4L2FC 4L0BC 5ADQB 4L0SC 4L33C 5C5PC 4HLKC 4L34C 4UI6C 4HLMC 4L31C 5C5QC 4KZQC 4KZUC 4HMHC 4UI5C 4HKKB 4L32C
chains in the Genus database with same CATH superfamily
4L0IC 4L0TC 3KH2E 2ZIXB 3HRYA 4HLFC 4HKIC 4L10C 4HLHC 4ZLXA 4HL5C 4KZLC 4ZM2A 4L09C 5ADTB 4UI8C 5ADRB 4UVPB 3HS2A 3OEIA 4L0VC 3G5OA 4UI3C 4HKNC 4L2KC 4UI4C 3K6QA 2ODKA 5C5RC 4HLGC 4UI7C 3CTOA 2A6QA 4L2GC 5FPFC 5ADSB 4L2FC 4L0BC 3HJ6A 5ADQB 4L0SC 4L33C 5C5PC 3K33B 4HLKC 4L34C 4UI6C 3OEIE 4HLMC 4L31C 3D55A 5C5QC 4KZQC 4KZUC 4HMHC 4UI5C 4ZM0A 4HKKB 4L32C
chains in the Genus database with same CATH topology
4L0IC 4L0TC 2ZIXB 4HLFC 4HKIC 4L10C 4HLHC 4HL5C 4KZLC 4L09C 5ADTB 4UI8C 5ADRB 4UVPB 4L0VC 4UI3C 4HKNC 4L2KC 4UI4C 5C5RC 4HLGC 4UI7C 4L2GC 5FPFC 5ADSB 4L2FC 4L0BC 3HJ6A 5ADQB 4L0SC 4L33C 5C5PC 4HLKC 4L34C 4UI6C 4HLMC 4L31C 5C5QC 4KZQC 4KZUC 4HMHC 4UI5C 4HKKB 4L32C
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4L0I C;  4L0T C;  4HLF C;  4HKI C;  4L10 C;  4HLH C;  4HL5 C;  4KZL C;  4L09 C;  5ADT B;  4UI8 C;  5ADR B;  4UVP B;  4L0V C;  4UI3 C;  4HKN C;  4L2K C;  4UI4 C;  5C5R C;  4HLG C;  4UI7 C;  4L2G C;  5FPF C;  5ADS B;  4L2F C;  4L0B C;  5ADQ B;  4L0S C;  4L33 C;  5C5P C;  4HLK C;  4L34 C;  4UI6 C;  4HLM C;  4L31 C;  5C5Q C;  4KZQ C;  4KZU C;  4HMH C;  4UI5 C;  4HKK B;  4L32 C; 
#chains in the Genus database with same CATH topology
 4L0I C;  4L0T C;  3KH2 E;  2ZIX B;  3HRY A;  4HLF C;  4HKI C;  4L10 C;  4HLH C;  4ZLX A;  4HL5 C;  4KZL C;  4ZM2 A;  4L09 C;  5ADT B;  4UI8 C;  5ADR B;  4UVP B;  3HS2 A;  3OEI A;  4L0V C;  3G5O A;  4UI3 C;  4HKN C;  4L2K C;  4UI4 C;  3K6Q A;  2ODK A;  5C5R C;  4HLG C;  4UI7 C;  3CTO A;  2A6Q A;  4L2G C;  5FPF C;  5ADS B;  4L2F C;  4L0B C;  3HJ6 A;  5ADQ B;  4L0S C;  4L33 C;  5C5P C;  3K33 B;  4HLK C;  4L34 C;  4UI6 C;  3OEI E;  4HLM C;  4L31 C;  3D55 A;  5C5Q C;  4KZQ C;  4KZU C;  4HMH C;  4UI5 C;  4ZM0 A;  4HKK B;  4L32 C; 
#chains in the Genus database with same CATH homology
 4L0I C;  4L0T C;  2ZIX B;  4HLF C;  4HKI C;  4L10 C;  4HLH C;  4HL5 C;  4KZL C;  4L09 C;  5ADT B;  4UI8 C;  5ADR B;  4UVP B;  4L0V C;  4UI3 C;  4HKN C;  4L2K C;  4UI4 C;  5C5R C;  4HLG C;  4UI7 C;  4L2G C;  5FPF C;  5ADS B;  4L2F C;  4L0B C;  3HJ6 A;  5ADQ B;  4L0S C;  4L33 C;  5C5P C;  4HLK C;  4L34 C;  4UI6 C;  4HLM C;  4L31 C;  5C5Q C;  4KZQ C;  4KZU C;  4HMH C;  4UI5 C;  4HKK B;  4L32 C; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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