4HREA

Crystal structure of p11/annexin a2 heterotetramer in complex with smarca3 peptide
Total Genus 131
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
131
sequence length
338
structure length
338
Chain Sequence
STVHEILCKLSLEGDHSTPPSAYGSVKPYTNFDAERDALNIETAVKTKGVDEVTIVNILTNRSNVQRQDIAFAYQRRTKKELPSALKSALSGHLETVILGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQELQEINRVYKEMYKTDLEKDIISDTSGDFRKLMVALAKGRRAEDGSVIDYELIDQDARELYDAGVKRKGTDVPKWISIMTERSVCHLQKVFERYKSYSPYDMLESIKKEVKGDLENAFLNLVQCIQNKPLYFADRLYDSMKGKGTRDKVLIRIMVSRSEVDMLKIRSEFKRKYGKSLYYYIQQDTKGDYQKALLYLCGGDD
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Annexin A2
publication title SMARCA3, a Chromatin-Remodeling Factor, Is Required for p11-Dependent Antidepressant Action.
pubmed doi rcsb
source organism Mus musculus
molecule tags Calcium-binding protein
total genus 131
structure length 338
sequence length 338
chains with identical sequence B, C, D
ec nomenclature
pdb deposition date 2012-10-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00191 Annexin Annexin
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.220.10 Mainly Alpha Orthogonal Bundle Annexin V; domain 1 Annexin 4hreA04
1.10.220.10 Mainly Alpha Orthogonal Bundle Annexin V; domain 1 Annexin 4hreA01
1.10.220.10 Mainly Alpha Orthogonal Bundle Annexin V; domain 1 Annexin 4hreA02
1.10.220.10 Mainly Alpha Orthogonal Bundle Annexin V; domain 1 Annexin 4hreA03
1AVHA 1AVRA 1XJLA 2II2A 1HVGA 1DM5A 1W7BA 1HVFA 1ANWA 2IICA 1AXNA 1ANNA 1AOWA 1W3WA 1ALAA 2HYVA 1A8BA 1G5NA 2HYUA 4EVHA 1HVEA 1A8AA 4MDUA 1YIIA 1BC1A 2H0KA 4MDVA 1HAKA 1N42A 2IE7A 3BRXA 1BC0A 4EVFA 1I4AA 2ZOCA 1M9IA 4X9PA 2H0MA 1N44A 1N41A 1N00A 2RANA 1AEIA 1AIIA 1BCZA 1BCYA 1W45A 1AVCA 2IE6A 1SAVA 2HYWA 1ANXA 2XO2A 1DK5A 1YJ0A 2XO3A 4HREA 1BO9A 1MCXA 1YCNA 1BC3A 2ZHIA 1HM6A 1BCWA 2Q4CA 1HVDA 2ZHJA 2H0LA
chains in the Genus database with same CATH superfamily
1DM5A 1W3WA 3LTLA 3USYA 1HVEA 4EVHA 1BC1A 2R09A 1HAKA 1N42A 4EVFA 3AO0A 4JXHA 1I4AA 1R8QE 2ZOCA 1R4AE 4X9PA 1N00A 2R0DA 1AIIA 1BCYA 3ABQA 1SAVA 1ANXA 1LKVX 2XO2A 1YJ0A 4JMOA 4HREA 1BO9A 3ABRA 1HM6A 1AVHA 1UPTB 1AVRA 2IICA 1AXNA 4JWLA 2HYUA 1ALAA 1A8BA 1G5NA 2H0KA 4MDVA 3BRXA 3TW5A 2H0MA 4OIYA 1N41A 1C1KA 4FHRB 4FQ0C 3SWVA 1AVCA 3USWA 2QEZA 4D7RA 1DK5A 4KN4X 4C0AA 4JMIA 2ZHIA 1XT0B 1HVDA 3ABSA 2VXGA 2H0LA 2II2A 1W7BA 3SOHB 1HVFA 1ANWA 4Q2SA 1ANNA 1A8AA 4MDUA 1YIIA 4C7PA 1BC0A 1R8SE 4JK1X 1S9DE 1M9IA 4D7QA 1N44A 2RANA 1AEIA 1BCZA 4KMUX 1W45A 1RE0B 3L8NA 3ANYA 3HJLA 1XJLA 1YGMA 1HVGA 2HSNA 4A4PA 4Z21A 1AOWA 2HYVA 3AJCA 1KU1A 1R8ME 2IE7A 4L5MA 3ABOA 1PBVA 1QC7A 1BC9A 1XSZA 4KN7X 2K6XA 2IE6A 2HYWA 1Q8DA 2XO3A 1MCXA 1YCNA 1BC3A 2OY9A 1BCWA 2Q4CA 2ZHJA
chains in the Genus database with same CATH topology
1AVHA 1AVRA 1XJLA 2II2A 1HVGA 1DM5A 1W7BA 1HVFA 1ANWA 2IICA 1AXNA 1ANNA 1AOWA 1W3WA 1ALAA 2HYVA 1A8BA 1G5NA 2HYUA 4EVHA 1HVEA 1A8AA 4MDUA 1YIIA 1BC1A 2H0KA 4MDVA 1HAKA 1N42A 2IE7A 3BRXA 1BC0A 4EVFA 1I4AA 2ZOCA 1M9IA 4X9PA 2H0MA 1N44A 1N41A 1N00A 2RANA 1AEIA 1AIIA 1BCZA 1BCYA 1W45A 1AVCA 2IE6A 1SAVA 2HYWA 1ANXA 2XO2A 1DK5A 1YJ0A 2XO3A 4HREA 1BO9A 1MCXA 1YCNA 1BC3A 2ZHIA 1HM6A 1BCWA 2Q4CA 1HVDA 2ZHJA 2H0LA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1AVH A;  1AVR A;  1XJL A;  2II2 A;  1HVG A;  1DM5 A;  1W7B A;  1HVF A;  1ANW A;  2IIC A;  1AXN A;  1ANN A;  1AOW A;  1W3W A;  1ALA A;  2HYV A;  1A8B A;  1G5N A;  2HYU A;  4EVH A;  1HVE A;  1A8A A;  4MDU A;  1YII A;  1BC1 A;  2H0K A;  4MDV A;  1HAK A;  1N42 A;  2IE7 A;  3BRX A;  1BC0 A;  4EVF A;  1I4A A;  2ZOC A;  1M9I A;  4X9P A;  2H0M A;  1N44 A;  1N41 A;  1N00 A;  2RAN A;  1AEI A;  1AII A;  1BCZ A;  1BCY A;  1W45 A;  1AVC A;  2IE6 A;  1SAV A;  2HYW A;  1ANX A;  2XO2 A;  1DK5 A;  1YJ0 A;  2XO3 A;  4HRE A;  1BO9 A;  1MCX A;  1YCN A;  1BC3 A;  2ZHI A;  1HM6 A;  1BCW A;  2Q4C A;  1HVD A;  2ZHJ A;  2H0L A; 
#chains in the Genus database with same CATH topology
 1DM5 A;  1W3W A;  3LTL A;  3USY A;  1HVE A;  4EVH A;  1BC1 A;  2R09 A;  1HAK A;  1N42 A;  4EVF A;  3AO0 A;  4JXH A;  1I4A A;  1R8Q E;  2ZOC A;  1R4A E;  4X9P A;  1N00 A;  2R0D A;  1AII A;  1BCY A;  3ABQ A;  1SAV A;  1ANX A;  1LKV X;  2XO2 A;  1YJ0 A;  4JMO A;  4HRE A;  1BO9 A;  3ABR A;  1HM6 A;  1AVH A;  1UPT B;  1AVR A;  2IIC A;  1AXN A;  4JWL A;  2HYU A;  1ALA A;  1A8B A;  1G5N A;  2H0K A;  4MDV A;  3BRX A;  3TW5 A;  2H0M A;  4OIY A;  1N41 A;  1C1K A;  4FHR B;  4FQ0 C;  3SWV A;  1AVC A;  3USW A;  2QEZ A;  4D7R A;  1DK5 A;  4KN4 X;  4C0A A;  4JMI A;  2ZHI A;  1XT0 B;  1HVD A;  3ABS A;  2VXG A;  2H0L A;  2II2 A;  1W7B A;  3SOH B;  1HVF A;  1ANW A;  4Q2S A;  1ANN A;  1A8A A;  4MDU A;  1YII A;  4C7P A;  1BC0 A;  1R8S E;  4JK1 X;  1S9D E;  1M9I A;  4D7Q A;  1N44 A;  2RAN A;  1AEI A;  1BCZ A;  4KMU X;  1W45 A;  1RE0 B;  3L8N A;  3ANY A;  3HJL A;  1XJL A;  1YGM A;  1HVG A;  2HSN A;  4A4P A;  4Z21 A;  1AOW A;  2HYV A;  3AJC A;  1KU1 A;  1R8M E;  2IE7 A;  4L5M A;  3ABO A;  1PBV A;  1QC7 A;  1BC9 A;  1XSZ A;  4KN7 X;  2K6X A;  2IE6 A;  2HYW A;  1Q8D A;  2XO3 A;  1MCX A;  1YCN A;  1BC3 A;  2OY9 A;  1BCW A;  2Q4C A;  2ZHJ A; 
#chains in the Genus database with same CATH homology
 1AVH A;  1AVR A;  1XJL A;  2II2 A;  1HVG A;  1DM5 A;  1W7B A;  1HVF A;  1ANW A;  2IIC A;  1AXN A;  1ANN A;  1AOW A;  1W3W A;  1ALA A;  2HYV A;  1A8B A;  1G5N A;  2HYU A;  4EVH A;  1HVE A;  1A8A A;  4MDU A;  1YII A;  1BC1 A;  2H0K A;  4MDV A;  1HAK A;  1N42 A;  2IE7 A;  3BRX A;  1BC0 A;  4EVF A;  1I4A A;  2ZOC A;  1M9I A;  4X9P A;  2H0M A;  1N44 A;  1N41 A;  1N00 A;  2RAN A;  1AEI A;  1AII A;  1BCZ A;  1BCY A;  1W45 A;  1AVC A;  2IE6 A;  1SAV A;  2HYW A;  1ANX A;  2XO2 A;  1DK5 A;  1YJ0 A;  2XO3 A;  4HRE A;  1BO9 A;  1MCX A;  1YCN A;  1BC3 A;  2ZHI A;  1HM6 A;  1BCW A;  2Q4C A;  1HVD A;  2ZHJ A;  2H0L A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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