4HTPA

Crystal structure of the dbd domain of human dna ligase iv bound to artemis peptide
Total Genus 82
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
82
sequence length
231
structure length
221
Chain Sequence
SQTVASHVPFADLCSTLERIQKSKGRAEKIRHFREFLDSWRKFHDALHKNHKDVTDSFYPAMRLILPQLERERMAYGIKETMLAKLYIELLNLPRDGKDALKLLNYGDFAMIAYFVLKPRCLQKGSLTIQQVNDLLDSIASNNSAKRKDLIKKSLLQLITQSSALEQKWLIRMIIKDLKLGVSQQTIFSVFHNDAAELHNVTTDLEKVCRQLHDPSVGLSD
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Ligase/hydrolase
molecule keywords DNA ligase 4
publication title Structural Basis of DNA Ligase IV-Artemis Interaction in Nonhomologous End-Joining.
pubmed doi rcsb
source organism Homo sapiens
total genus 82
structure length 221
sequence length 231
chains with identical sequence B
ec nomenclature ec 6.5.1.1: DNA ligase (ATP).
pdb deposition date 2012-11-01

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF04675 DNA_ligase_A_N DNA ligase N terminus
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.3260.10 Mainly Alpha Orthogonal Bundle DNA ligase i, domain 1 DNA ligase, ATP-dependent, N-terminal domain 4htpA00
2HIXA 3GDEA 3RR5A 3W1BA 3W1GA 3L2PA 2HIVA 4HTOA 4EQ5A 4HTPA 2CFMA 1X9NA 3W5OA
chains in the Genus database with same CATH superfamily
2HIXA 3GDEA 3RR5A 3W1BA 3W1GA 3L2PA 2HIVA 4HTOA 4EQ5A 4HTPA 2CFMA 1X9NA 3W5OA
chains in the Genus database with same CATH topology
2HIXA 3GDEA 3RR5A 3W1BA 3W1GA 3L2PA 2HIVA 4HTOA 4EQ5A 4HTPA 2CFMA 1X9NA 3W5OA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2HIX A;  3GDE A;  3RR5 A;  3W1B A;  3W1G A;  3L2P A;  2HIV A;  4HTO A;  4EQ5 A;  4HTP A;  2CFM A;  1X9N A;  3W5O A; 
#chains in the Genus database with same CATH topology
 2HIX A;  3GDE A;  3RR5 A;  3W1B A;  3W1G A;  3L2P A;  2HIV A;  4HTO A;  4EQ5 A;  4HTP A;  2CFM A;  1X9N A;  3W5O A; 
#chains in the Genus database with same CATH homology
 2HIX A;  3GDE A;  3RR5 A;  3W1B A;  3W1G A;  3L2P A;  2HIV A;  4HTO A;  4EQ5 A;  4HTP A;  2CFM A;  1X9N A;  3W5O A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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