4HXQA

Crystal structure of human arginase-1 complexed with inhibitor 14
Total Genus 118
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
118
sequence length
314
structure length
314
Chain Sequence
SRTIGIIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKEQECDVKDYGDLPFADIPNDSPFQIVKNPRSVGKASEQLAGKVAEVKKNGRISLVLGGDHSLAIGSISGHARVHPDLGVIWVDAHTDINTPLTTTSGNLHGQPVSFLLKELKGKIPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYILKTLGIKYFSMTEVDRLGIGKVMEETLSYLLGRKKRPIHLSFDVDGLDPSFTPATGTPVVGGLTYREGLYITEEIYKTGLLSGLDIMEVNPSLGKTPEEVTRTVNTAVAITLACFGLAREGNHKPIDYL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase/hydrolase inhibitor
molecule keywords Arginase-1
publication title Discovery of (R)-2-Amino-6-borono-2-(2-(piperidin-1-yl)ethyl)hexanoic Acid and Congeners As Highly Potent Inhibitors of Human Arginases I and II for Treatment of Myocardial Reperfusion Injury.
pubmed doi rcsb
source organism Homo sapiens
total genus 118
structure length 314
sequence length 314
chains with identical sequence B
ec nomenclature ec 3.5.3.1: Arginase.
pdb deposition date 2012-11-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00491 Arginase Arginase family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.10 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Ureohydrolase domain 4hxqA00
4MYNA 5HJ9A 1P8OA 3LHLA 3E6KA 3M1RA 1T4PA 3SL0A 1HQFA 3GN0A 3SL1A 3NIQA 4GWDA 4RHMA 3MMRA 1PQ3A 4MYKA 3KV2A 1TBJA 4Q3QA 1P8RA 4Q3RC 1P8MA 2AEBA 4IXVA 1WOHA 2PHAA 3MFWA 2EF4A 1HQXA 1TBHA 4IXUA 4GSZA 4Q3VA 1P8PA 4MYFA 4Q42A 1WOIA 4HZEA 1T4RA 1XFKA 4Q3UA 1WVAA 2PHOA 4RLAA 4HWWA 1T5FA 1T4SA 4Q3RA 4RHIA 4MYLA 1P8NA 4IU4A 4RHKA 4FCIA 4MXRA 4ITYA 3PZLA 5HJAA 3NIOA 4HXQA 4RHLA 3E6VA 1D3VA 1TA1A 3THHA 3SKKA 1HQ5A 3MJLA 4RHJA 1ZPEA 2RLAA 4Q41A 2A0MA 2EF5A 3E9BA 3SJTA 4FCKA 1HQHA 3DJ8A 4Q3PA 2EIVA 1WVBA 4IE2A 4DZ4A 3THEA 1CEVA 3E8ZA 3F80A 1HQGA 2PLLA 3MFVA 3TF3A 4I06A 1WOGA 4IU0A 2ZAVA 4IE1A 3LP4A 1P8SA 3E8QA 1P8QA 1ZPGA 4GSMA 4Q3SA 4Q3TA 4IU5A 3NIPA 1RLAA 2CEVA 1R1OA 5CEVA 4Q40A 3THJA 4GSVA 3GMZA 4GWCA 3TH7A 4IU1A 4CEVA 5RLAA 1GQ6A 1TBLA 3LP7A 4G3HA 4RHQA 1GQ7A 1T4TA 3RLAA 4IE3A 1T5GA 3CEVA
chains in the Genus database with same CATH superfamily
3Q9BA 5G11A 2GH6A 4QA5A 5EFBD 1ZZ0A 4MYNA 2VQMA 5HJ9A 1P8OA 3LHLA 5G0YA 5G13A 3E6KA 3MZ7A 5G10A 5DC6A 3M1RA 1T4PA 4ZUQA 5A2SA 3SL0A 1HQFA 4CQFA 3GN0A 4CBYA 3SL1A 3NIQA 4GWDA 4RHMA 5EFGA 1C3RA 3MMRA 4RN2A 3EZPA 1PQ3A 5G0JA 3MAXA 4MYKA 5G1CA 5G0GA 3EW8A 3KV2A 5THVA 1TBJA 4Q3QA 1P8RA 4Q3RC 5DC7A 1P8MA 2AEBA 4IXVA 1WOHA 2PHAA 5D1DA 5EEKA 3MFWA 2EF4A 1HQXA 3ZNSA 3ZNRA 1TBHA 3EZTA 4IXUA 4GSZA 5EENA 5G1BA 4BZ7A 5EF8A 4QA3A 4Q3VA 2V5XA 1P8PA 4MYFA 4QA0A 4Q42A 5EFKB 1WOIA 4QA6A 3Q9EA 4HZEA 1T4RA 1XFKA 5G1AA 4Q3UA 1WVAA 2PHOA 2VCGA 4RLAA 4HWWA 1C3SA 2VQJA 1T5FA 1T4SA 4Q3RA 4RHIA 5EFNA 3MENA 4MYLA 1P8NA 5EEIA 3C0ZA 1ZZ3A 5G0XA 3C10A 4ZURA 4IU4A 5DC8A 5EEFA 4RHKA 4FCIA 4LY1A 4MXRA 4BZ9A 4ITYA 3PZLA 5IWGA 3SFHA 5THTA 1W22A 5HJAA 3Q9CA 3NIOA 4HXQA 4RHLA 3E6VA 1D3VA 1TA1A 4ZUOA 3THHA 4RN1A 3SKKA 1HQ5A 3MJLA 4RHJA 3F0RA 5THSA 1ZPEA 4BKXB 2RLAA 4Q41A 2A0MA 2EF5A 2V5WA 3E9BA 3Q9FA 1HQHA 4FCKA 5G17A 3SJTA 3DJ8A 5BWZA 4Q3PA 5G0IA 2EIVA 1WVBA 4IE2A 1T69A 4BZ6A 2VQWG 4DZ4A 5THUA 1CEVA 1ZZ1A 3E8ZA 1VKGA 1HQGA 3F80A 4RN0A 3THEA 2PLLA 4ZUMA 4LXZA 3C0YA 4CBTA 3EWFA 5ICNB 2VQQA 1T64A 3MFVA 4ZUNA 3TF3A 2VQOA 4I06A 5LI3A 1WOGA 4IU0A 5EEMA 2ZAVA 1C3PA 3MZ4A 3LP4A 3MZ6A 1P8SA 4IE1A 5G12A 4A69A 5FCWA 3E8QA 3MZ3A 1P8QA 1ZPGA 4GSMA 5DC5A 5G3WA 3F06A 3F07A 4Q3SA 4Q3TA 5IX0A 4IU5A 3NIPA 1RLAA 2CEVA 1R1OA 5CEVA 4Q40A 4QA7A 4QA1A 4QA4A 5EF7A 3THJA 4QA2A 5JI5A 4GSVA 4BZ8A 3GMZA 4GWCA 5D1BA 5D1CA 5FUEA 3TH7A 4IU1A 4CEVA 3SFFA 5RLAA 4BZ5A 5EFJD 1GQ6A 1TBLA 3LP7A 4G3HA 4RHQA 1T67A 1GQ7A 1T4TA 5G0HA 3RLAA 4IE3A 5EFHA 4ZUPA 1T5GA 3CEVA 2VQVA 3RQDA
chains in the Genus database with same CATH topology
4MYNA 5HJ9A 1P8OA 3LHLA 3E6KA 3M1RA 1T4PA 3SL0A 1HQFA 3GN0A 3SL1A 3NIQA 4GWDA 4RHMA 3MMRA 1PQ3A 4MYKA 3KV2A 1TBJA 4Q3QA 1P8RA 4Q3RC 1P8MA 2AEBA 4IXVA 1WOHA 2PHAA 3MFWA 2EF4A 1HQXA 1TBHA 4IXUA 4GSZA 4Q3VA 1P8PA 4MYFA 4Q42A 1WOIA 4HZEA 1T4RA 1XFKA 4Q3UA 1WVAA 2PHOA 4RLAA 4HWWA 1T5FA 1T4SA 4Q3RA 4RHIA 4MYLA 1P8NA 4IU4A 4RHKA 4FCIA 4MXRA 4ITYA 3PZLA 5HJAA 3NIOA 4HXQA 4RHLA 3E6VA 1D3VA 1TA1A 3THHA 3SKKA 1HQ5A 3MJLA 4RHJA 1ZPEA 2RLAA 4Q41A 2A0MA 2EF5A 3E9BA 3SJTA 4FCKA 1HQHA 3DJ8A 4Q3PA 2EIVA 1WVBA 4IE2A 4DZ4A 3THEA 1CEVA 3E8ZA 3F80A 1HQGA 2PLLA 3MFVA 3TF3A 4I06A 1WOGA 4IU0A 2ZAVA 4IE1A 3LP4A 1P8SA 3E8QA 1P8QA 1ZPGA 4GSMA 4Q3SA 4Q3TA 4IU5A 3NIPA 1RLAA 2CEVA 1R1OA 5CEVA 4Q40A 3THJA 4GSVA 3GMZA 4GWCA 3TH7A 4IU1A 4CEVA 5RLAA 1GQ6A 1TBLA 3LP7A 4G3HA 4RHQA 1GQ7A 1T4TA 3RLAA 4IE3A 1T5GA 3CEVA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4MYN A;  5HJ9 A;  1P8O A;  3LHL A;  3E6K A;  3M1R A;  1T4P A;  3SL0 A;  1HQF A;  3GN0 A;  3SL1 A;  3NIQ A;  4GWD A;  4RHM A;  3MMR A;  1PQ3 A;  4MYK A;  3KV2 A;  1TBJ A;  4Q3Q A;  1P8R A;  4Q3R C;  1P8M A;  2AEB A;  4IXV A;  1WOH A;  2PHA A;  3MFW A;  2EF4 A;  1HQX A;  1TBH A;  4IXU A;  4GSZ A;  4Q3V A;  1P8P A;  4MYF A;  4Q42 A;  1WOI A;  4HZE A;  1T4R A;  1XFK A;  4Q3U A;  1WVA A;  2PHO A;  4RLA A;  4HWW A;  1T5F A;  1T4S A;  4Q3R A;  4RHI A;  4MYL A;  1P8N A;  4IU4 A;  4RHK A;  4FCI A;  4MXR A;  4ITY A;  3PZL A;  5HJA A;  3NIO A;  4HXQ A;  4RHL A;  3E6V A;  1D3V A;  1TA1 A;  3THH A;  3SKK A;  1HQ5 A;  3MJL A;  4RHJ A;  1ZPE A;  2RLA A;  4Q41 A;  2A0M A;  2EF5 A;  3E9B A;  3SJT A;  4FCK A;  1HQH A;  3DJ8 A;  4Q3P A;  2EIV A;  1WVB A;  4IE2 A;  4DZ4 A;  3THE A;  1CEV A;  3E8Z A;  3F80 A;  1HQG A;  2PLL A;  3MFV A;  3TF3 A;  4I06 A;  1WOG A;  4IU0 A;  2ZAV A;  4IE1 A;  3LP4 A;  1P8S A;  3E8Q A;  1P8Q A;  1ZPG A;  4GSM A;  4Q3S A;  4Q3T A;  4IU5 A;  3NIP A;  1RLA A;  2CEV A;  1R1O A;  5CEV A;  4Q40 A;  3THJ A;  4GSV A;  3GMZ A;  4GWC A;  3TH7 A;  4IU1 A;  4CEV A;  5RLA A;  1GQ6 A;  1TBL A;  3LP7 A;  4G3H A;  4RHQ A;  1GQ7 A;  1T4T A;  3RLA A;  4IE3 A;  1T5G A;  3CEV A; 
#chains in the Genus database with same CATH topology
 3Q9B A;  5G11 A;  2GH6 A;  4QA5 A;  5EFB D;  1ZZ0 A;  4MYN A;  2VQM A;  5HJ9 A;  1P8O A;  3LHL A;  5G0Y A;  5G13 A;  3E6K A;  3MZ7 A;  5G10 A;  5DC6 A;  3M1R A;  1T4P A;  4ZUQ A;  5A2S A;  3SL0 A;  1HQF A;  4CQF A;  3GN0 A;  4CBY A;  3SL1 A;  3NIQ A;  4GWD A;  4RHM A;  5EFG A;  1C3R A;  3MMR A;  4RN2 A;  3EZP A;  1PQ3 A;  5G0J A;  3MAX A;  4MYK A;  5G1C A;  5G0G A;  3EW8 A;  3KV2 A;  5THV A;  1TBJ A;  4Q3Q A;  1P8R A;  4Q3R C;  5DC7 A;  1P8M A;  2AEB A;  4IXV A;  1WOH A;  2PHA A;  5D1D A;  5EEK A;  3MFW A;  2EF4 A;  1HQX A;  3ZNS A;  3ZNR A;  1TBH A;  3EZT A;  4IXU A;  4GSZ A;  5EEN A;  5G1B A;  4BZ7 A;  5EF8 A;  4QA3 A;  4Q3V A;  2V5X A;  1P8P A;  4MYF A;  4QA0 A;  4Q42 A;  5EFK B;  1WOI A;  4QA6 A;  3Q9E A;  4HZE A;  1T4R A;  1XFK A;  5G1A A;  4Q3U A;  1WVA A;  2PHO A;  2VCG A;  4RLA A;  4HWW A;  1C3S A;  2VQJ A;  1T5F A;  1T4S A;  4Q3R A;  4RHI A;  5EFN A;  3MEN A;  4MYL A;  1P8N A;  5EEI A;  3C0Z A;  1ZZ3 A;  5G0X A;  3C10 A;  4ZUR A;  4IU4 A;  5DC8 A;  5EEF A;  4RHK A;  4FCI A;  4LY1 A;  4MXR A;  4BZ9 A;  4ITY A;  3PZL A;  5IWG A;  3SFH A;  5THT A;  1W22 A;  5HJA A;  3Q9C A;  3NIO A;  4HXQ A;  4RHL A;  3E6V A;  1D3V A;  1TA1 A;  4ZUO A;  3THH A;  4RN1 A;  3SKK A;  1HQ5 A;  3MJL A;  4RHJ A;  3F0R A;  5THS A;  1ZPE A;  4BKX B;  2RLA A;  4Q41 A;  2A0M A;  2EF5 A;  2V5W A;  3E9B A;  3Q9F A;  1HQH A;  4FCK A;  5G17 A;  3SJT A;  3DJ8 A;  5BWZ A;  4Q3P A;  5G0I A;  2EIV A;  1WVB A;  4IE2 A;  1T69 A;  4BZ6 A;  2VQW G;  4DZ4 A;  5THU A;  1CEV A;  1ZZ1 A;  3E8Z A;  1VKG A;  1HQG A;  3F80 A;  4RN0 A;  3THE A;  2PLL A;  4ZUM A;  4LXZ A;  3C0Y A;  4CBT A;  3EWF A;  5ICN B;  2VQQ A;  1T64 A;  3MFV A;  4ZUN A;  3TF3 A;  2VQO A;  4I06 A;  5LI3 A;  1WOG A;  4IU0 A;  5EEM A;  2ZAV A;  1C3P A;  3MZ4 A;  3LP4 A;  3MZ6 A;  1P8S A;  4IE1 A;  5G12 A;  4A69 A;  5FCW A;  3E8Q A;  3MZ3 A;  1P8Q A;  1ZPG A;  4GSM A;  5DC5 A;  5G3W A;  3F06 A;  3F07 A;  4Q3S A;  4Q3T A;  5IX0 A;  4IU5 A;  3NIP A;  1RLA A;  2CEV A;  1R1O A;  5CEV A;  4Q40 A;  4QA7 A;  4QA1 A;  4QA4 A;  5EF7 A;  3THJ A;  4QA2 A;  5JI5 A;  4GSV A;  4BZ8 A;  3GMZ A;  4GWC A;  5D1B A;  5D1C A;  5FUE A;  3TH7 A;  4IU1 A;  4CEV A;  3SFF A;  5RLA A;  4BZ5 A;  5EFJ D;  1GQ6 A;  1TBL A;  3LP7 A;  4G3H A;  4RHQ A;  1T67 A;  1GQ7 A;  1T4T A;  5G0H A;  3RLA A;  4IE3 A;  5EFH A;  4ZUP A;  1T5G A;  3CEV A;  2VQV A;  3RQD A; 
#chains in the Genus database with same CATH homology
 4MYN A;  5HJ9 A;  1P8O A;  3LHL A;  3E6K A;  3M1R A;  1T4P A;  3SL0 A;  1HQF A;  3GN0 A;  3SL1 A;  3NIQ A;  4GWD A;  4RHM A;  3MMR A;  1PQ3 A;  4MYK A;  3KV2 A;  1TBJ A;  4Q3Q A;  1P8R A;  4Q3R C;  1P8M A;  2AEB A;  4IXV A;  1WOH A;  2PHA A;  3MFW A;  2EF4 A;  1HQX A;  1TBH A;  4IXU A;  4GSZ A;  4Q3V A;  1P8P A;  4MYF A;  4Q42 A;  1WOI A;  4HZE A;  1T4R A;  1XFK A;  4Q3U A;  1WVA A;  2PHO A;  4RLA A;  4HWW A;  1T5F A;  1T4S A;  4Q3R A;  4RHI A;  4MYL A;  1P8N A;  4IU4 A;  4RHK A;  4FCI A;  4MXR A;  4ITY A;  3PZL A;  5HJA A;  3NIO A;  4HXQ A;  4RHL A;  3E6V A;  1D3V A;  1TA1 A;  3THH A;  3SKK A;  1HQ5 A;  3MJL A;  4RHJ A;  1ZPE A;  2RLA A;  4Q41 A;  2A0M A;  2EF5 A;  3E9B A;  3SJT A;  4FCK A;  1HQH A;  3DJ8 A;  4Q3P A;  2EIV A;  1WVB A;  4IE2 A;  4DZ4 A;  3THE A;  1CEV A;  3E8Z A;  3F80 A;  1HQG A;  2PLL A;  3MFV A;  3TF3 A;  4I06 A;  1WOG A;  4IU0 A;  2ZAV A;  4IE1 A;  3LP4 A;  1P8S A;  3E8Q A;  1P8Q A;  1ZPG A;  4GSM A;  4Q3S A;  4Q3T A;  4IU5 A;  3NIP A;  1RLA A;  2CEV A;  1R1O A;  5CEV A;  4Q40 A;  3THJ A;  4GSV A;  3GMZ A;  4GWC A;  3TH7 A;  4IU1 A;  4CEV A;  5RLA A;  1GQ6 A;  1TBL A;  3LP7 A;  4G3H A;  4RHQ A;  1GQ7 A;  1T4T A;  3RLA A;  4IE3 A;  1T5G A;  3CEV A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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