4HY2A

Crystal structure of plk1 polo-box domain in complex with pl-42
Total Genus 69
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
69
sequence length
223
structure length
215
Chain Sequence
HLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Development of cyclic peptomer inhibitors targeting the polo-box domain of polo-like kinase 1.
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Homo sapiens
molecule keywords Serine/threonine-protein kinase PLK1
total genus 69
structure length 215
sequence length 223
ec nomenclature ec 2.7.11.21: Polo kinase.
pdb deposition date 2012-11-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00659 POLO_box POLO box duplicated region
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 4hy2A02
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 4hy2A01
4LKLA 4O56A 5J19A 2OGQA 3P2ZA 3P35A 4E9CA 4RS6A 4YYPA 3P37A 4H5XA 4E67A 3HIHA 4HCOA 3Q1IA 5DMVC 3BZIA 4XB0A 5DNJA 4X9RA 4RCPA 3C5LA 4WHHA 3P2WA 3P34A 2OJXA 1UMWA 4J7BB 4DFWA 4WHKA 5DMSA 3HIKA 4HY2A 4X9VA 3RQ7A 4O6WA 4LKMA 2N19A 3FVHA 4WHLA 4HABA 4O9WA 1Q4OA 3P36A 1Q4KA 4X9WA 4H71A 5LHZA 4E9DA
chains in the Genus database with same CATH superfamily
1E3CP 4YYPA 3P37A 4NKBA 3BZIA 3P34A 4N7ZA 1P49A 1E2SP 4X9VA 1HDHA 3FVHA 3HMJG 4FDIA 1AUKA 4E9DA 4LKLA 3P2ZA 3P35A 5LHZA 4E9CA 1A87A 5DMVC 5DNJA 3LM3A 3P2WA 4DFWA 2UV8G 4HY2A 4N7VA 3KDRA 4O6WA 5AJ9A 4LKMA 2I9XA 3ED4A 4X9WA 1F34B 4O56A 4CXSA 4H5XA 1E1ZP 4E67A 4HCOA 3Q1IA 1F32A 1N2KA 4N9JA 4XB0A 4CYSA 2IA9A 3GYWA 4RCPA 3C5LA 4WHHA 4CXUA 1UMWA 2I9ZA 5DMSA 3LXQA 5DAYA 4FDJA 1N2LA 4CYRA 4WHLA 2QZUA 1Q4OA 3P36A 4NK7A 5J19A 1E2TA 2OGQA 4RS6A 3HIHA 3GYVA 4X9RA 4CXKA 2OJXA 4J7BB 3FS3A 4WHKA 2E50A 3HIKA 2VKZG 4G7NA 3RQ7A 2N19A 4HABA 4O9WA 1E33P 1FSUA 1Q4KA 4H71A 3HFDA
chains in the Genus database with same CATH topology
4LKLA 4O56A 5J19A 2OGQA 3P2ZA 3P35A 4E9CA 4RS6A 4YYPA 3P37A 4H5XA 4E67A 3HIHA 4HCOA 3Q1IA 5DMVC 3BZIA 4XB0A 5DNJA 4X9RA 4RCPA 3C5LA 4WHHA 3P2WA 3P34A 2OJXA 1UMWA 4J7BB 4DFWA 4WHKA 5DMSA 3HIKA 4HY2A 4X9VA 3RQ7A 4O6WA 4LKMA 2N19A 3FVHA 4WHLA 4HABA 4O9WA 1Q4OA 3P36A 1Q4KA 4X9WA 4H71A 5LHZA 4E9DA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4LKL A;  4O56 A;  5J19 A;  2OGQ A;  3P2Z A;  3P35 A;  4E9C A;  4RS6 A;  4YYP A;  3P37 A;  4H5X A;  4E67 A;  3HIH A;  4HCO A;  3Q1I A;  5DMV C;  3BZI A;  4XB0 A;  5DNJ A;  4X9R A;  4RCP A;  3C5L A;  4WHH A;  3P2W A;  3P34 A;  2OJX A;  1UMW A;  4J7B B;  4DFW A;  4WHK A;  5DMS A;  3HIK A;  4HY2 A;  4X9V A;  3RQ7 A;  4O6W A;  4LKM A;  2N19 A;  3FVH A;  4WHL A;  4HAB A;  4O9W A;  1Q4O A;  3P36 A;  1Q4K A;  4X9W A;  4H71 A;  5LHZ A;  4E9D A; 
#chains in the Genus database with same CATH topology
 1E3C P;  4YYP A;  3P37 A;  4NKB A;  3BZI A;  3P34 A;  4N7Z A;  1P49 A;  1E2S P;  4X9V A;  1HDH A;  3FVH A;  3HMJ G;  4FDI A;  1AUK A;  4E9D A;  4LKL A;  3P2Z A;  3P35 A;  5LHZ A;  4E9C A;  1A87 A;  5DMV C;  5DNJ A;  3LM3 A;  3P2W A;  4DFW A;  2UV8 G;  4HY2 A;  4N7V A;  3KDR A;  4O6W A;  5AJ9 A;  4LKM A;  2I9X A;  3ED4 A;  4X9W A;  1F34 B;  4O56 A;  4CXS A;  4H5X A;  1E1Z P;  4E67 A;  4HCO A;  3Q1I A;  1F32 A;  1N2K A;  4N9J A;  4XB0 A;  4CYS A;  2IA9 A;  3GYW A;  4RCP A;  3C5L A;  4WHH A;  4CXU A;  1UMW A;  2I9Z A;  5DMS A;  3LXQ A;  5DAY A;  4FDJ A;  1N2L A;  4CYR A;  4WHL A;  2QZU A;  1Q4O A;  3P36 A;  4NK7 A;  5J19 A;  1E2T A;  2OGQ A;  4RS6 A;  3HIH A;  3GYV A;  4X9R A;  4CXK A;  2OJX A;  4J7B B;  3FS3 A;  4WHK A;  2E50 A;  3HIK A;  2VKZ G;  4G7N A;  3RQ7 A;  2N19 A;  4HAB A;  4O9W A;  1E33 P;  1FSU A;  1Q4K A;  4H71 A;  3HFD A; 
#chains in the Genus database with same CATH homology
 4LKL A;  4O56 A;  5J19 A;  2OGQ A;  3P2Z A;  3P35 A;  4E9C A;  4RS6 A;  4YYP A;  3P37 A;  4H5X A;  4E67 A;  3HIH A;  4HCO A;  3Q1I A;  5DMV C;  3BZI A;  4XB0 A;  5DNJ A;  4X9R A;  4RCP A;  3C5L A;  4WHH A;  3P2W A;  3P34 A;  2OJX A;  1UMW A;  4J7B B;  4DFW A;  4WHK A;  5DMS A;  3HIK A;  4HY2 A;  4X9V A;  3RQ7 A;  4O6W A;  4LKM A;  2N19 A;  3FVH A;  4WHL A;  4HAB A;  4O9W A;  1Q4O A;  3P36 A;  1Q4K A;  4X9W A;  4H71 A;  5LHZ A;  4E9D A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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