4I06A

Crystal structure of human arginase-2 complexed with inhibitor 14
Total Genus 116
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
116
sequence length
306
structure length
306
Chain Sequence
HSVAVIGAPFSQGQKRKGVEHGPAAIREAGLMKRLSSLGCHLKDFGDLSFTPVPKDDLYNNLIVNPRSVGLANQELAEVVSRAVSDGYSCVTLGGDHSLAIGTISGHARHCPDLCVVWVDAHADINTPLTTSSGNLHGQPVSFLLRELQDKVPQLPGFSWIKPCISSASIVYIGLRDVDPPEHFILKNYDIQYFSMRDIDRLGIQKVMERTFDLLIGKRQRPIHLSFDIDAFDPTLAPATGTPVVGGLTYREGMYIAEEIHNTGLLSALDLVEVNPQLATSEEEAKTTANLAVDVIASSFGQTREG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase
molecule keywords Arginase-2, mitochondrial
publication title Discovery of (R)-2-Amino-6-borono-2-(2-(piperidin-1-yl)ethyl)hexanoic Acid and Congeners As Highly Potent Inhibitors of Human Arginases I and II for Treatment of Myocardial Reperfusion Injury.
pubmed doi rcsb
source organism Homo sapiens
total genus 116
structure length 306
sequence length 306
chains with identical sequence B, C
ec nomenclature ec 3.5.3.1: Arginase.
pdb deposition date 2012-11-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00491 Arginase Arginase family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.10 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Ureohydrolase domain 4i06A00
4MYKA 1WVAA 2RLAA 4Q40A 4MYFA 2EIVA 4Q41A 3SKKA 3SL1A 1GQ7A 3CEVA 3RLAA 4Q42A 4IXVA 1R1OA 3PZLA 4FCKA 4HWWA 4Q3RC 1ZPGA 1T5GA 4RHIA 3DJ8A 4Q3QA 1HQXA 3TH7A 4Q3PA 2CEVA 2PLLA 4Q3UA 4HZEA 1P8PA 3THJA 3THEA 4CEVA 3MFWA 1CEVA 1P8MA 1WOHA 1P8RA 1WVBA 3MMRA 1GQ6A 3NIPA 3LHLA 4GWDA 4IU1A 1T4SA 1WOIA 4MYNA 1T5FA 4Q3SA 4GWCA 4FCIA 3M1RA 4RHKA 1HQFA 3F80A 1XFKA 1TBLA 3E8QA 4MXRA 2PHAA 1P8NA 4GSMA 4IE2A 4IE1A 2ZAVA 5CEVA 3LP7A 1HQHA 4G3HA 4RHJA 3E9BA 5RLAA 5HJAA 1D3VA 1ZPEA 4IXUA 1TA1A 2EF5A 1P8SA 4Q3VA 3THHA 3KV2A 1T4RA 4GSZA 1HQ5A 3SL0A 2AEBA 4RHLA 4I06A 3SJTA 3GMZA 4Q3RA 4DZ4A 1T4TA 2A0MA 4IU5A 3TF3A 1T4PA 5HJ9A 4RLAA 3E6KA 1RLAA 4RHMA 4Q3TA 2EF4A 1WOGA 1P8QA 4HXQA 3NIQA 4IU4A 1HQGA 3E8ZA 1P8OA 3E6VA 4GSVA 4MYLA 3GN0A 4ITYA 3MFVA 3NIOA 1PQ3A 4IU0A 1TBJA 3LP4A 2PHOA 4IE3A 3MJLA 1TBHA 4RHQA
chains in the Genus database with same CATH superfamily
4MYKA 1WVAA 2RLAA 4Q40A 4MYFA 5G0XA 2EIVA 4Q41A 3EW8A 4BZ8A 3SKKA 3SL1A 1GQ7A 1T64A 3CEVA 3RLAA 4QA4A 5THVA 4Q42A 4IXVA 1R1OA 3PZLA 4FCKA 4HWWA 4BZ6A 3MZ4A 4Q3RC 4ZUMA 5EFJD 3Q9EA 1ZPGA 1T5GA 3MZ6A 4RHIA 3ZNSA 3C10A 1C3SA 3DJ8A 4Q3QA 1HQXA 3TH7A 5G0JA 4Q3PA 2V5WA 1W22A 2GH6A 5THUA 2CEVA 2PLLA 4Q3UA 4QA6A 4HZEA 5DC7A 1P8PA 5G12A 4CBTA 5A2SA 2VQQA 3THJA 5EF7A 3THEA 3EZTA 4CEVA 2VQVA 5G0IA 4QA7A 3MFWA 1CEVA 1P8MA 1WOHA 1P8RA 3C0ZA 5D1BA 1WVBA 3MMRA 1GQ6A 5EFHA 5G0YA 3NIPA 5DC5A 2VQWG 3LHLA 3Q9FA 3SFFA 5DC8A 4GWDA 4A69A 5EFGA 4IU1A 5EFBD 3F06A 1T4SA 2VCGA 1WOIA 4ZUOA 5G1CA 5G17A 1ZZ1A 4MYNA 1T5FA 5IX0A 4ZUPA 4Q3SA 4RN1A 4GWCA 3C0YA 5ICNB 4CQFA 4FCIA 4QA5A 3M1RA 4RHKA 1HQFA 3F80A 1XFKA 5EFKB 4BKXB 5G13A 1TBLA 4BZ5A 3E8QA 3ZNRA 4MXRA 2PHAA 1P8NA 4GSMA 4IE2A 4IE1A 2ZAVA 5EEFA 4RN0A 5CEVA 1ZZ3A 3LP7A 2VQMA 5G1BA 1HQHA 5G11A 4ZUQA 4QA3A 3MAXA 5G1AA 4G3HA 5D1CA 4RHQA 1C3RA 4RHJA 3E9BA 5RLAA 5HJAA 1D3VA 3Q9BA 1T69A 4BZ7A 1VKGA 1ZPEA 4IXUA 1TA1A 5G0HA 2EF5A 1P8SA 1C3PA 3MZ7A 5EF8A 4Q3VA 5THSA 3THHA 4QA0A 3KV2A 1T4RA 4GSZA 3MZ3A 1HQ5A 3SL0A 2AEBA 4RHLA 4I06A 4LY1A 3GMZA 4Q3RA 3SJTA 3EZPA 5FCWA 1T4TA 4DZ4A 2A0MA 4QA1A 3F0RA 4RN2A 4IU5A 5EFNA 3EWFA 1ZZ0A 1T4PA 3MENA 4LXZA 3TF3A 4QA2A 5EEKA 5HJ9A 4ZUNA 4RLAA 4CBYA 3E6KA 1RLAA 4RHMA 5G0GA 4Q3TA 5D1DA 2EF4A 1WOGA 1P8QA 4HXQA 3NIQA 5THTA 1T67A 4IU4A 5EEIA 5G10A 3RQDA 3SFHA 1HQGA 3E8ZA 1P8OA 3E6VA 4GSVA 4ZURA 5BWZA 5EENA 2VQJA 4BZ9A 2V5XA 4MYLA 3GN0A 5EEMA 5IWGA 5DC6A 4ITYA 3MFVA 3NIOA 5FUEA 1PQ3A 4IU0A 1TBJA 3LP4A 2PHOA 4IE3A 2VQOA 5JI5A 5LI3A 3MJLA 3F07A 1TBHA 5G3WA 3Q9CA
chains in the Genus database with same CATH topology
4MYKA 1WVAA 2RLAA 4Q40A 4MYFA 2EIVA 4Q41A 3SKKA 3SL1A 1GQ7A 3CEVA 3RLAA 4Q42A 4IXVA 1R1OA 3PZLA 4FCKA 4HWWA 4Q3RC 1ZPGA 1T5GA 4RHIA 3DJ8A 4Q3QA 1HQXA 3TH7A 4Q3PA 2CEVA 2PLLA 4Q3UA 4HZEA 1P8PA 3THJA 3THEA 4CEVA 3MFWA 1CEVA 1P8MA 1WOHA 1P8RA 1WVBA 3MMRA 1GQ6A 3NIPA 3LHLA 4GWDA 4IU1A 1T4SA 1WOIA 4MYNA 1T5FA 4Q3SA 4GWCA 4FCIA 3M1RA 4RHKA 1HQFA 3F80A 1XFKA 1TBLA 3E8QA 4MXRA 2PHAA 1P8NA 4GSMA 4IE2A 4IE1A 2ZAVA 5CEVA 3LP7A 1HQHA 4G3HA 4RHJA 3E9BA 5RLAA 5HJAA 1D3VA 1ZPEA 4IXUA 1TA1A 2EF5A 1P8SA 4Q3VA 3THHA 3KV2A 1T4RA 4GSZA 1HQ5A 3SL0A 2AEBA 4RHLA 4I06A 3SJTA 3GMZA 4Q3RA 4DZ4A 1T4TA 2A0MA 4IU5A 3TF3A 1T4PA 5HJ9A 4RLAA 3E6KA 1RLAA 4RHMA 4Q3TA 2EF4A 1WOGA 1P8QA 4HXQA 3NIQA 4IU4A 1HQGA 3E8ZA 1P8OA 3E6VA 4GSVA 4MYLA 3GN0A 4ITYA 3MFVA 3NIOA 1PQ3A 4IU0A 1TBJA 3LP4A 2PHOA 4IE3A 3MJLA 1TBHA 4RHQA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4MYK A;  1WVA A;  2RLA A;  4Q40 A;  4MYF A;  2EIV A;  4Q41 A;  3SKK A;  3SL1 A;  1GQ7 A;  3CEV A;  3RLA A;  4Q42 A;  4IXV A;  1R1O A;  3PZL A;  4FCK A;  4HWW A;  4Q3R C;  1ZPG A;  1T5G A;  4RHI A;  3DJ8 A;  4Q3Q A;  1HQX A;  3TH7 A;  4Q3P A;  2CEV A;  2PLL A;  4Q3U A;  4HZE A;  1P8P A;  3THJ A;  3THE A;  4CEV A;  3MFW A;  1CEV A;  1P8M A;  1WOH A;  1P8R A;  1WVB A;  3MMR A;  1GQ6 A;  3NIP A;  3LHL A;  4GWD A;  4IU1 A;  1T4S A;  1WOI A;  4MYN A;  1T5F A;  4Q3S A;  4GWC A;  4FCI A;  3M1R A;  4RHK A;  1HQF A;  3F80 A;  1XFK A;  1TBL A;  3E8Q A;  4MXR A;  2PHA A;  1P8N A;  4GSM A;  4IE2 A;  4IE1 A;  2ZAV A;  5CEV A;  3LP7 A;  1HQH A;  4G3H A;  4RHJ A;  3E9B A;  5RLA A;  5HJA A;  1D3V A;  1ZPE A;  4IXU A;  1TA1 A;  2EF5 A;  1P8S A;  4Q3V A;  3THH A;  3KV2 A;  1T4R A;  4GSZ A;  1HQ5 A;  3SL0 A;  2AEB A;  4RHL A;  4I06 A;  3SJT A;  3GMZ A;  4Q3R A;  4DZ4 A;  1T4T A;  2A0M A;  4IU5 A;  3TF3 A;  1T4P A;  5HJ9 A;  4RLA A;  3E6K A;  1RLA A;  4RHM A;  4Q3T A;  2EF4 A;  1WOG A;  1P8Q A;  4HXQ A;  3NIQ A;  4IU4 A;  1HQG A;  3E8Z A;  1P8O A;  3E6V A;  4GSV A;  4MYL A;  3GN0 A;  4ITY A;  3MFV A;  3NIO A;  1PQ3 A;  4IU0 A;  1TBJ A;  3LP4 A;  2PHO A;  4IE3 A;  3MJL A;  1TBH A;  4RHQ A; 
#chains in the Genus database with same CATH topology
 4MYK A;  1WVA A;  2RLA A;  4Q40 A;  4MYF A;  5G0X A;  2EIV A;  4Q41 A;  3EW8 A;  4BZ8 A;  3SKK A;  3SL1 A;  1GQ7 A;  1T64 A;  3CEV A;  3RLA A;  4QA4 A;  5THV A;  4Q42 A;  4IXV A;  1R1O A;  3PZL A;  4FCK A;  4HWW A;  4BZ6 A;  3MZ4 A;  4Q3R C;  4ZUM A;  5EFJ D;  3Q9E A;  1ZPG A;  1T5G A;  3MZ6 A;  4RHI A;  3ZNS A;  3C10 A;  1C3S A;  3DJ8 A;  4Q3Q A;  1HQX A;  3TH7 A;  5G0J A;  4Q3P A;  2V5W A;  1W22 A;  2GH6 A;  5THU A;  2CEV A;  2PLL A;  4Q3U A;  4QA6 A;  4HZE A;  5DC7 A;  1P8P A;  5G12 A;  4CBT A;  5A2S A;  2VQQ A;  3THJ A;  5EF7 A;  3THE A;  3EZT A;  4CEV A;  2VQV A;  5G0I A;  4QA7 A;  3MFW A;  1CEV A;  1P8M A;  1WOH A;  1P8R A;  3C0Z A;  5D1B A;  1WVB A;  3MMR A;  1GQ6 A;  5EFH A;  5G0Y A;  3NIP A;  5DC5 A;  2VQW G;  3LHL A;  3Q9F A;  3SFF A;  5DC8 A;  4GWD A;  4A69 A;  5EFG A;  4IU1 A;  5EFB D;  3F06 A;  1T4S A;  2VCG A;  1WOI A;  4ZUO A;  5G1C A;  5G17 A;  1ZZ1 A;  4MYN A;  1T5F A;  5IX0 A;  4ZUP A;  4Q3S A;  4RN1 A;  4GWC A;  3C0Y A;  5ICN B;  4CQF A;  4FCI A;  4QA5 A;  3M1R A;  4RHK A;  1HQF A;  3F80 A;  1XFK A;  5EFK B;  4BKX B;  5G13 A;  1TBL A;  4BZ5 A;  3E8Q A;  3ZNR A;  4MXR A;  2PHA A;  1P8N A;  4GSM A;  4IE2 A;  4IE1 A;  2ZAV A;  5EEF A;  4RN0 A;  5CEV A;  1ZZ3 A;  3LP7 A;  2VQM A;  5G1B A;  1HQH A;  5G11 A;  4ZUQ A;  4QA3 A;  3MAX A;  5G1A A;  4G3H A;  5D1C A;  4RHQ A;  1C3R A;  4RHJ A;  3E9B A;  5RLA A;  5HJA A;  1D3V A;  3Q9B A;  1T69 A;  4BZ7 A;  1VKG A;  1ZPE A;  4IXU A;  1TA1 A;  5G0H A;  2EF5 A;  1P8S A;  1C3P A;  3MZ7 A;  5EF8 A;  4Q3V A;  5THS A;  3THH A;  4QA0 A;  3KV2 A;  1T4R A;  4GSZ A;  3MZ3 A;  1HQ5 A;  3SL0 A;  2AEB A;  4RHL A;  4I06 A;  4LY1 A;  3GMZ A;  4Q3R A;  3SJT A;  3EZP A;  5FCW A;  1T4T A;  4DZ4 A;  2A0M A;  4QA1 A;  3F0R A;  4RN2 A;  4IU5 A;  5EFN A;  3EWF A;  1ZZ0 A;  1T4P A;  3MEN A;  4LXZ A;  3TF3 A;  4QA2 A;  5EEK A;  5HJ9 A;  4ZUN A;  4RLA A;  4CBY A;  3E6K A;  1RLA A;  4RHM A;  5G0G A;  4Q3T A;  5D1D A;  2EF4 A;  1WOG A;  1P8Q A;  4HXQ A;  3NIQ A;  5THT A;  1T67 A;  4IU4 A;  5EEI A;  5G10 A;  3RQD A;  3SFH A;  1HQG A;  3E8Z A;  1P8O A;  3E6V A;  4GSV A;  4ZUR A;  5BWZ A;  5EEN A;  2VQJ A;  4BZ9 A;  2V5X A;  4MYL A;  3GN0 A;  5EEM A;  5IWG A;  5DC6 A;  4ITY A;  3MFV A;  3NIO A;  5FUE A;  1PQ3 A;  4IU0 A;  1TBJ A;  3LP4 A;  2PHO A;  4IE3 A;  2VQO A;  5JI5 A;  5LI3 A;  3MJL A;  3F07 A;  1TBH A;  5G3W A;  3Q9C A; 
#chains in the Genus database with same CATH homology
 4MYK A;  1WVA A;  2RLA A;  4Q40 A;  4MYF A;  2EIV A;  4Q41 A;  3SKK A;  3SL1 A;  1GQ7 A;  3CEV A;  3RLA A;  4Q42 A;  4IXV A;  1R1O A;  3PZL A;  4FCK A;  4HWW A;  4Q3R C;  1ZPG A;  1T5G A;  4RHI A;  3DJ8 A;  4Q3Q A;  1HQX A;  3TH7 A;  4Q3P A;  2CEV A;  2PLL A;  4Q3U A;  4HZE A;  1P8P A;  3THJ A;  3THE A;  4CEV A;  3MFW A;  1CEV A;  1P8M A;  1WOH A;  1P8R A;  1WVB A;  3MMR A;  1GQ6 A;  3NIP A;  3LHL A;  4GWD A;  4IU1 A;  1T4S A;  1WOI A;  4MYN A;  1T5F A;  4Q3S A;  4GWC A;  4FCI A;  3M1R A;  4RHK A;  1HQF A;  3F80 A;  1XFK A;  1TBL A;  3E8Q A;  4MXR A;  2PHA A;  1P8N A;  4GSM A;  4IE2 A;  4IE1 A;  2ZAV A;  5CEV A;  3LP7 A;  1HQH A;  4G3H A;  4RHJ A;  3E9B A;  5RLA A;  5HJA A;  1D3V A;  1ZPE A;  4IXU A;  1TA1 A;  2EF5 A;  1P8S A;  4Q3V A;  3THH A;  3KV2 A;  1T4R A;  4GSZ A;  1HQ5 A;  3SL0 A;  2AEB A;  4RHL A;  4I06 A;  3SJT A;  3GMZ A;  4Q3R A;  4DZ4 A;  1T4T A;  2A0M A;  4IU5 A;  3TF3 A;  1T4P A;  5HJ9 A;  4RLA A;  3E6K A;  1RLA A;  4RHM A;  4Q3T A;  2EF4 A;  1WOG A;  1P8Q A;  4HXQ A;  3NIQ A;  4IU4 A;  1HQG A;  3E8Z A;  1P8O A;  3E6V A;  4GSV A;  4MYL A;  3GN0 A;  4ITY A;  3MFV A;  3NIO A;  1PQ3 A;  4IU0 A;  1TBJ A;  3LP4 A;  2PHO A;  4IE3 A;  3MJL A;  1TBH A;  4RHQ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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