4I5LC

Structural mechanism of trimeric pp2a holoenzyme involving pr70: insight for cdc6 dephosphorylation
Total Genus 111
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
111
sequence length
295
structure length
295
Chain Sequence
DEKVFTKELDQWIEQLNECKQLSESQVKSLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAPRRG
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
molecule tags Hydrolase/toxin
molecule keywords Serine/threonine-protein phosphatase 2A 65 kDa regulatory su
publication title Structure of the Ca(2+)-dependent PP2A heterotrimer and insights into Cdc6 dephosphorylation.
pubmed doi rcsb
source organism Homo sapiens
total genus 111
structure length 295
sequence length 295
chains with identical sequence F
ec nomenclature ec 3.1.3.16: Protein-serine/threonine phosphatase.
pdb deposition date 2012-11-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
C PF00149 Metallophos Calcineurin-like phosphoesterase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.21.10 Alpha Beta 4-Layer Sandwich Purple Acid Phosphatase; chain A, domain 2 Purple Acid Phosphatase; chain A, domain 2 4i5lC00
4KBPA 2Q8UA 3RL4A 2GJUA 2NPPC 3EGHA 1G5BA 2BDXA 4OR9A 3IB8A 4JA9A 2O8GA 1T70A 2XMOA 4Q7FA 3N5UA 2NXFA 3KBPA 1S95A 1S70A 4KKZA 3PSNA 4LU9A 4O4KA 3RL3A 3RQZA 4JA7A 2Z72A 3K7WC 3H68A 1OI8A 2IAEC 2QFPA 1WARA 4UT2A 2QJCA 2R17A 5F3WA 4H2FA 2HYOA 4O5GA 5HPEA 4TUGA 2A22A 2USHA 4ORBA 3RL5A 4V0XA 3PSOA 4ZX2A 4F0ZA 3GVEA 3H69A 1II7A 3QFOA 2CV9A 4WWLA 1NNWA 1Z2XA 1W24A 3FGAC 4H2IA 5B8IA 1HO5A 2IE4C 3H64A 4FBKA 4H1SA 5EQVA 3THNA 4NZVA 3H60A 2Z1AA 2NYLC 2HY1A 2JOGA 5INBA 3ZU0A 1HPUA 3IVEA 1SU1A 2NYMC 2KKNA 1QFCA 1T71A 3QG5C 3DSCA 5IOHA 3EGGA 5DNYA 3T1IA 4B2OA 5JJTA 2WDFA 3IVDA 2Z06A 4ZVZA 1JK7A 3E7AA 1USHA 4LACC 3V4YA 4LTYA 5J28A 2O8AA 1QHWA 1XM7A 3ICFA 1TCOA 2YVTA 4H1YP 4H2GA 4HD0A 4UT3B 2BCDA 3QFNA 1KBPA 3QFKA 4UWQA 1S3MA 4MOYA 4V0WA 4FCXA 5JPFA 3ZTVA 2DFJA 1XZWA 4IL1A 2ZBMA 4M0VA 4H2BA 3TGHA 4IYPC 4TUIA 1OIDA 3P71C 5C1VA 1UTEA 1OIEA 4MOVA 3H67A 3THOB 2WDCA 3E7BA 1MF8A 1U32A 2HYPA 1AUIA 4I5NC 4J6OA 1WAO1 1IT6A 4MP0A 4UT3A 3H63A 4I5LC 3H66A 3CK2A 4O43A 4DSYA 3H61A 3IB7A 2BQ8X 3HVQA 3JYFA 4FBQA 3C5WC 4ORCA 3AUZA 2IE3C 2AHDA 3H62B 4V0VA 3QFMA 1FJMA 4YKEA 3DW8C 2WDEA 2WDDA 4G9JA 4FBWA 4DT2A 1Z2WA 1S3NA 1M63A 4ORAA 2QFRA 1UF3A 3C9FA 3K7VC 3LL8A 5JPEA 4XPNA 2P6BA 5GTUA 4O24A 1S8EA 3DSDA 1V73A 4DHLA 3AV0A 1S3LA 1HP1A
chains in the Genus database with same CATH superfamily
4KBPA 2Q8UA 3RL4A 2GJUA 2NPPC 3EGHA 1G5BA 2BDXA 4OR9A 3IB8A 4JA9A 2O8GA 1T70A 2XMOA 4Q7FA 3N5UA 2NXFA 3KBPA 1S95A 1S70A 4KKZA 3PSNA 4LU9A 4O4KA 3RL3A 3RQZA 4JA7A 2Z72A 3K7WC 3H68A 1OI8A 2IAEC 2DXLA 1WARA 2QFPA 2ZO9B 4UT2A 2QJCA 2R17A 5F3WA 4H2FA 2HYOA 4O5GA 5HPEA 4TUGA 2A22A 2USHA 4ORBA 3RL5A 4V0XA 3PSOA 4ZX2A 4F0ZA 3GVEA 3H69A 1II7A 3QFOA 2CV9A 3D03A 4WWLA 1NNWA 1Z2XA 1W24A 3FGAC 4H2IA 5B8IA 1HO5A 2IE4C 3H64A 4FBKA 4H1SA 5EQVA 3THNA 2YEQA 3E0JA 4NZVA 3H60A 2Z1AA 2NYLC 2HY1A 2JOGA 5INBA 3ZU0A 1HPUA 3IVEA 1SU1A 2NYMC 2KKNA 1QFCA 1T71A 2DXNA 3QG5C 3DSCA 5IOHA 3EGGA 5DNYA 3T1IA 4B2OA 5JJTA 2WDFA 3IVDA 2Z06A 4ZVZA 1JK7A 3E7AA 1USHA 4LACC 3V4YA 4LTYA 5J28A 2O8AA 1QHWA 1XM7A 3ICFA 1TCOA 2YVTA 4H1YP 4H2GA 4HD0A 4UT3B 2BCDA 3QFNA 1KBPA 3QFKA 4UWQA 1S3MA 4MOYA 4V0WA 4FCXA 5JPFA 3ZTVA 2DFJA 1XZWA 4IL1A 2ZBMA 4M0VA 4H2BA 3TGHA 4IYPC 4TUIA 1OIDA 3P71C 5C1VA 1UTEA 1OIEA 4MOVA 3H67A 3THOB 2WDCA 3E7BA 1MF8A 1U32A 2HYPA 1AUIA 2ZOAA 4I5NC 4J6OA 1WAO1 1IT6A 4MP0A 4UT3A 3H63A 4I5LC 3H66A 3CK2A 3FLOA 4O43A 3H61A 4DSYA 3IB7A 2BQ8X 3HVQA 3JYFA 4FBQA 3C5WC 4ORCA 3AUZA 2IE3C 2AHDA 3H62B 4V0VA 3QFMA 1FJMA 4YKEA 3DW8C 2WDEA 2WDDA 4G9JA 4FBWA 4DT2A 1Z2WA 1S3NA 1M63A 4ORAA 2QFRA 1UF3A 3C9FA 3K7VC 3LL8A 5JPEA 4XPNA 2P6BA 5GTUA 4O24A 1S8EA 3DSDA 1V73A 4DHLA 3AV0A 1S3LA 1HP1A
chains in the Genus database with same CATH topology
4KBPA 2Q8UA 3RL4A 2GJUA 2NPPC 3EGHA 1G5BA 2BDXA 4OR9A 3IB8A 4JA9A 2O8GA 1T70A 2XMOA 4Q7FA 3N5UA 2NXFA 3KBPA 1S95A 1S70A 4KKZA 3PSNA 4LU9A 4O4KA 3RL3A 3RQZA 4JA7A 2Z72A 3K7WC 3H68A 1OI8A 2IAEC 2DXLA 1WARA 2QFPA 2ZO9B 4UT2A 2QJCA 2R17A 5F3WA 4H2FA 2HYOA 4O5GA 5HPEA 4TUGA 2A22A 2USHA 4ORBA 3RL5A 4V0XA 3PSOA 4ZX2A 4F0ZA 3GVEA 3H69A 1II7A 3QFOA 2CV9A 3D03A 4WWLA 1NNWA 1Z2XA 1W24A 3FGAC 4H2IA 5B8IA 1HO5A 2IE4C 3H64A 4FBKA 4H1SA 5EQVA 3THNA 2YEQA 3E0JA 4NZVA 3H60A 2Z1AA 2NYLC 2HY1A 2JOGA 5INBA 3ZU0A 1HPUA 3IVEA 1SU1A 2NYMC 2KKNA 1QFCA 1T71A 2DXNA 3QG5C 3DSCA 5IOHA 3EGGA 5DNYA 3T1IA 4B2OA 5JJTA 2WDFA 3IVDA 2Z06A 4ZVZA 1JK7A 3E7AA 1USHA 4LACC 3V4YA 4LTYA 5J28A 2O8AA 1QHWA 1XM7A 3ICFA 1TCOA 2YVTA 4H1YP 4H2GA 4HD0A 4UT3B 2BCDA 3QFNA 1KBPA 3QFKA 4UWQA 1S3MA 4MOYA 4V0WA 4FCXA 5JPFA 3ZTVA 2DFJA 1XZWA 4IL1A 2ZBMA 4M0VA 4H2BA 3TGHA 4IYPC 4TUIA 1OIDA 3P71C 5C1VA 1UTEA 1OIEA 4MOVA 3H67A 3THOB 2WDCA 3E7BA 1MF8A 1U32A 2HYPA 1AUIA 2ZOAA 4I5NC 4J6OA 1WAO1 1IT6A 4MP0A 4UT3A 3H63A 4I5LC 3H66A 3CK2A 3FLOA 4O43A 3H61A 4DSYA 3IB7A 2BQ8X 3HVQA 3JYFA 4FBQA 3C5WC 4ORCA 3AUZA 2IE3C 2AHDA 3H62B 4V0VA 3QFMA 1FJMA 4YKEA 3DW8C 2WDEA 2WDDA 4G9JA 4FBWA 4DT2A 1Z2WA 1S3NA 1M63A 4ORAA 2QFRA 1UF3A 3C9FA 3K7VC 3LL8A 5JPEA 4XPNA 2P6BA 5GTUA 4O24A 1S8EA 3DSDA 1V73A 4DHLA 3AV0A 1S3LA 1HP1A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4KBP A;  2Q8U A;  3RL4 A;  2GJU A;  2NPP C;  3EGH A;  1G5B A;  2BDX A;  4OR9 A;  3IB8 A;  4JA9 A;  2O8G A;  1T70 A;  2XMO A;  4Q7F A;  3N5U A;  2NXF A;  3KBP A;  1S95 A;  1S70 A;  4KKZ A;  3PSN A;  4LU9 A;  4O4K A;  3RL3 A;  3RQZ A;  4JA7 A;  2Z72 A;  3K7W C;  3H68 A;  1OI8 A;  2IAE C;  2QFP A;  1WAR A;  4UT2 A;  2QJC A;  2R17 A;  5F3W A;  4H2F A;  2HYO A;  4O5G A;  5HPE A;  4TUG A;  2A22 A;  2USH A;  4ORB A;  3RL5 A;  4V0X A;  3PSO A;  4ZX2 A;  4F0Z A;  3GVE A;  3H69 A;  1II7 A;  3QFO A;  2CV9 A;  4WWL A;  1NNW A;  1Z2X A;  1W24 A;  3FGA C;  4H2I A;  5B8I A;  1HO5 A;  2IE4 C;  3H64 A;  4FBK A;  4H1S A;  5EQV A;  3THN A;  4NZV A;  3H60 A;  2Z1A A;  2NYL C;  2HY1 A;  2JOG A;  5INB A;  3ZU0 A;  1HPU A;  3IVE A;  1SU1 A;  2NYM C;  2KKN A;  1QFC A;  1T71 A;  3QG5 C;  3DSC A;  5IOH A;  3EGG A;  5DNY A;  3T1I A;  4B2O A;  5JJT A;  2WDF A;  3IVD A;  2Z06 A;  4ZVZ A;  1JK7 A;  3E7A A;  1USH A;  4LAC C;  3V4Y A;  4LTY A;  5J28 A;  2O8A A;  1QHW A;  1XM7 A;  3ICF A;  1TCO A;  2YVT A;  4H1Y P;  4H2G A;  4HD0 A;  4UT3 B;  2BCD A;  3QFN A;  1KBP A;  3QFK A;  4UWQ A;  1S3M A;  4MOY A;  4V0W A;  4FCX A;  5JPF A;  3ZTV A;  2DFJ A;  1XZW A;  4IL1 A;  2ZBM A;  4M0V A;  4H2B A;  3TGH A;  4IYP C;  4TUI A;  1OID A;  3P71 C;  5C1V A;  1UTE A;  1OIE A;  4MOV A;  3H67 A;  3THO B;  2WDC A;  3E7B A;  1MF8 A;  1U32 A;  2HYP A;  1AUI A;  4I5N C;  4J6O A;  1WAO 1;  1IT6 A;  4MP0 A;  4UT3 A;  3H63 A;  4I5L C;  3H66 A;  3CK2 A;  4O43 A;  4DSY A;  3H61 A;  3IB7 A;  2BQ8 X;  3HVQ A;  3JYF A;  4FBQ A;  3C5W C;  4ORC A;  3AUZ A;  2IE3 C;  2AHD A;  3H62 B;  4V0V A;  3QFM A;  1FJM A;  4YKE A;  3DW8 C;  2WDE A;  2WDD A;  4G9J A;  4FBW A;  4DT2 A;  1Z2W A;  1S3N A;  1M63 A;  4ORA A;  2QFR A;  1UF3 A;  3C9F A;  3K7V C;  3LL8 A;  5JPE A;  4XPN A;  2P6B A;  5GTU A;  4O24 A;  1S8E A;  3DSD A;  1V73 A;  4DHL A;  3AV0 A;  1S3L A;  1HP1 A; 
#chains in the Genus database with same CATH topology
 4KBP A;  2Q8U A;  3RL4 A;  2GJU A;  2NPP C;  3EGH A;  1G5B A;  2BDX A;  4OR9 A;  3IB8 A;  4JA9 A;  2O8G A;  1T70 A;  2XMO A;  4Q7F A;  3N5U A;  2NXF A;  3KBP A;  1S95 A;  1S70 A;  4KKZ A;  3PSN A;  4LU9 A;  4O4K A;  3RL3 A;  3RQZ A;  4JA7 A;  2Z72 A;  3K7W C;  3H68 A;  1OI8 A;  2IAE C;  2DXL A;  1WAR A;  2QFP A;  2ZO9 B;  4UT2 A;  2QJC A;  2R17 A;  5F3W A;  4H2F A;  2HYO A;  4O5G A;  5HPE A;  4TUG A;  2A22 A;  2USH A;  4ORB A;  3RL5 A;  4V0X A;  3PSO A;  4ZX2 A;  4F0Z A;  3GVE A;  3H69 A;  1II7 A;  3QFO A;  2CV9 A;  3D03 A;  4WWL A;  1NNW A;  1Z2X A;  1W24 A;  3FGA C;  4H2I A;  5B8I A;  1HO5 A;  2IE4 C;  3H64 A;  4FBK A;  4H1S A;  5EQV A;  3THN A;  2YEQ A;  3E0J A;  4NZV A;  3H60 A;  2Z1A A;  2NYL C;  2HY1 A;  2JOG A;  5INB A;  3ZU0 A;  1HPU A;  3IVE A;  1SU1 A;  2NYM C;  2KKN A;  1QFC A;  1T71 A;  2DXN A;  3QG5 C;  3DSC A;  5IOH A;  3EGG A;  5DNY A;  3T1I A;  4B2O A;  5JJT A;  2WDF A;  3IVD A;  2Z06 A;  4ZVZ A;  1JK7 A;  3E7A A;  1USH A;  4LAC C;  3V4Y A;  4LTY A;  5J28 A;  2O8A A;  1QHW A;  1XM7 A;  3ICF A;  1TCO A;  2YVT A;  4H1Y P;  4H2G A;  4HD0 A;  4UT3 B;  2BCD A;  3QFN A;  1KBP A;  3QFK A;  4UWQ A;  1S3M A;  4MOY A;  4V0W A;  4FCX A;  5JPF A;  3ZTV A;  2DFJ A;  1XZW A;  4IL1 A;  2ZBM A;  4M0V A;  4H2B A;  3TGH A;  4IYP C;  4TUI A;  1OID A;  3P71 C;  5C1V A;  1UTE A;  1OIE A;  4MOV A;  3H67 A;  3THO B;  2WDC A;  3E7B A;  1MF8 A;  1U32 A;  2HYP A;  1AUI A;  2ZOA A;  4I5N C;  4J6O A;  1WAO 1;  1IT6 A;  4MP0 A;  4UT3 A;  3H63 A;  4I5L C;  3H66 A;  3CK2 A;  3FLO A;  4O43 A;  3H61 A;  4DSY A;  3IB7 A;  2BQ8 X;  3HVQ A;  3JYF A;  4FBQ A;  3C5W C;  4ORC A;  3AUZ A;  2IE3 C;  2AHD A;  3H62 B;  4V0V A;  3QFM A;  1FJM A;  4YKE A;  3DW8 C;  2WDE A;  2WDD A;  4G9J A;  4FBW A;  4DT2 A;  1Z2W A;  1S3N A;  1M63 A;  4ORA A;  2QFR A;  1UF3 A;  3C9F A;  3K7V C;  3LL8 A;  5JPE A;  4XPN A;  2P6B A;  5GTU A;  4O24 A;  1S8E A;  3DSD A;  1V73 A;  4DHL A;  3AV0 A;  1S3L A;  1HP1 A; 
#chains in the Genus database with same CATH homology
 4KBP A;  2Q8U A;  3RL4 A;  2GJU A;  2NPP C;  3EGH A;  1G5B A;  2BDX A;  4OR9 A;  3IB8 A;  4JA9 A;  2O8G A;  1T70 A;  2XMO A;  4Q7F A;  3N5U A;  2NXF A;  3KBP A;  1S95 A;  1S70 A;  4KKZ A;  3PSN A;  4LU9 A;  4O4K A;  3RL3 A;  3RQZ A;  4JA7 A;  2Z72 A;  3K7W C;  3H68 A;  1OI8 A;  2IAE C;  2DXL A;  1WAR A;  2QFP A;  2ZO9 B;  4UT2 A;  2QJC A;  2R17 A;  5F3W A;  4H2F A;  2HYO A;  4O5G A;  5HPE A;  4TUG A;  2A22 A;  2USH A;  4ORB A;  3RL5 A;  4V0X A;  3PSO A;  4ZX2 A;  4F0Z A;  3GVE A;  3H69 A;  1II7 A;  3QFO A;  2CV9 A;  3D03 A;  4WWL A;  1NNW A;  1Z2X A;  1W24 A;  3FGA C;  4H2I A;  5B8I A;  1HO5 A;  2IE4 C;  3H64 A;  4FBK A;  4H1S A;  5EQV A;  3THN A;  2YEQ A;  3E0J A;  4NZV A;  3H60 A;  2Z1A A;  2NYL C;  2HY1 A;  2JOG A;  5INB A;  3ZU0 A;  1HPU A;  3IVE A;  1SU1 A;  2NYM C;  2KKN A;  1QFC A;  1T71 A;  2DXN A;  3QG5 C;  3DSC A;  5IOH A;  3EGG A;  5DNY A;  3T1I A;  4B2O A;  5JJT A;  2WDF A;  3IVD A;  2Z06 A;  4ZVZ A;  1JK7 A;  3E7A A;  1USH A;  4LAC C;  3V4Y A;  4LTY A;  5J28 A;  2O8A A;  1QHW A;  1XM7 A;  3ICF A;  1TCO A;  2YVT A;  4H1Y P;  4H2G A;  4HD0 A;  4UT3 B;  2BCD A;  3QFN A;  1KBP A;  3QFK A;  4UWQ A;  1S3M A;  4MOY A;  4V0W A;  4FCX A;  5JPF A;  3ZTV A;  2DFJ A;  1XZW A;  4IL1 A;  2ZBM A;  4M0V A;  4H2B A;  3TGH A;  4IYP C;  4TUI A;  1OID A;  3P71 C;  5C1V A;  1UTE A;  1OIE A;  4MOV A;  3H67 A;  3THO B;  2WDC A;  3E7B A;  1MF8 A;  1U32 A;  2HYP A;  1AUI A;  2ZOA A;  4I5N C;  4J6O A;  1WAO 1;  1IT6 A;  4MP0 A;  4UT3 A;  3H63 A;  4I5L C;  3H66 A;  3CK2 A;  3FLO A;  4O43 A;  3H61 A;  4DSY A;  3IB7 A;  2BQ8 X;  3HVQ A;  3JYF A;  4FBQ A;  3C5W C;  4ORC A;  3AUZ A;  2IE3 C;  2AHD A;  3H62 B;  4V0V A;  3QFM A;  1FJM A;  4YKE A;  3DW8 C;  2WDE A;  2WDD A;  4G9J A;  4FBW A;  4DT2 A;  1Z2W A;  1S3N A;  1M63 A;  4ORA A;  2QFR A;  1UF3 A;  3C9F A;  3K7V C;  3LL8 A;  5JPE A;  4XPN A;  2P6B A;  5GTU A;  4O24 A;  1S8E A;  3DSD A;  1V73 A;  4DHL A;  3AV0 A;  1S3L A;  1HP1 A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...