4I5NC

Structural mechanism of trimeric pp2a holoenzyme involving pr70: insight for cdc6 dephosphorylation
Total Genus 104
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
104
sequence length
293
structure length
293
Chain Sequence
DEKVFTKELDQWIEQLNECKQLSESQVKSLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAPR
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure of the Ca(2+)-dependent PP2A heterotrimer and insights into Cdc6 dephosphorylation.
pubmed doi rcsb
molecule keywords Serine/threonine-protein phosphatase 2A 65 kDa regulatory su
molecule tags Hydrolase/toxin
source organism Homo sapiens
total genus 104
structure length 293
sequence length 293
chains with identical sequence F
ec nomenclature ec 3.1.3.16: Protein-serine/threonine phosphatase.
pdb deposition date 2012-11-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
C PF00149 Metallophos Calcineurin-like phosphoesterase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.21.10 Alpha Beta 4-Layer Sandwich Purple Acid Phosphatase; chain A, domain 2 Purple Acid Phosphatase; chain A, domain 2 4i5nC00
2KKNA 2Q8UA 3LL8A 2HY1A 2DFJA 1HO5A 2BDXA 5F3WA 2O8AA 3QFOA 1M63A 4H2GA 3TGHA 2AHDA 3CK2A 1JK7A 1W24A 3T1IA 3QG5C 1WAO1 4MOVA 4ORAA 3KBPA 3RQZA 2NYMC 3H68A 5DNYA 3H61A 4ZVZA 5JPEA 1T71A 3H63A 4J6OA 4UT3B 1OI8A 3IB7A 4H2BA 1FJMA 2WDCA 3V4YA 3C9FA 3IVDA 2IE3C 2IAEC 2GJUA 3ICFA 1AUIA 4B2OA 4KKZA 3THOB 5C1VA 1HPUA 3EGGA 4IL1A 4I5LC 3HVQA 4UT2A 4O43A 1Z2XA 2WDEA 4O4KA 3PSNA 5IOHA 4FBKA 3K7WC 4LU9A 2CV9A 4H1YP 2BQ8X 1S3NA 3GVEA 3RL3A 4LTYA 2JOGA 4FBQA 2IE4C 4V0WA 3PSOA 5GTUA 1MF8A 4H1SA 4F0ZA 1NNWA 4OR9A 3RL4A 4DT2A 2QFPA 2XMOA 3FGAC 2QFRA 3H64A 3DSCA 4TUGA 2HYPA 3AUZA 3ZU0A 4LACC 2Z1AA 4V0VA 1S70A 2A22A 4IYPC 2QJCA 4H2FA 1IT6A 2Z06A 3K7VC 3JYFA 4UT3A 2YVTA 2WDFA 4JA7A 3RL5A 1S8EA 4NZVA 2O8GA 1USHA 3C5WC 1S3MA 1II7A 4DHLA 1Z2WA 4O5GA 1V73A 4H2IA 3QFKA 1S95A 3QFMA 4HD0A 4ORBA 5B8IA 4ZX2A 2P6BA 3IB8A 4JA9A 4KBPA 4YKEA 5JPFA 1SU1A 1QFCA 3H66A 3IVEA 4M0VA 5J28A 3DSDA 2WDDA 4WWLA 4XPNA 3E7AA 1QHWA 3N5UA 1OIEA 2ZBMA 1HP1A 4ORCA 4TUIA 3ZTVA 3H60A 1S3LA 2USHA 1U32A 1XM7A 1G5BA 3THNA 1XZWA 4O24A 1UF3A 2R17A 1OIDA 2NYLC 2HYOA 5JJTA 1TCOA 3E7BA 1KBPA 3DW8C 1UTEA 4UWQA 4V0XA 4MP0A 5EQVA 3H69A 3P71C 4FCXA 4Q7FA 2NXFA 1WARA 5INBA 2NPPC 1T70A 4DSYA 4G9JA 3AV0A 3H62B 4I5NC 3QFNA 5HPEA 2BCDA 3EGHA 4MOYA 3H67A 2Z72A 4FBWA
chains in the Genus database with same CATH superfamily
2KKNA 2Q8UA 3LL8A 2HY1A 2DFJA 1HO5A 2BDXA 5F3WA 2O8AA 3QFOA 1M63A 4H2GA 3TGHA 2AHDA 3CK2A 1JK7A 1W24A 3T1IA 3QG5C 1WAO1 4MOVA 4ORAA 3KBPA 3RQZA 2NYMC 3H68A 5DNYA 3H61A 4ZVZA 5JPEA 1T71A 3H63A 4J6OA 2ZOAA 4UT3B 1OI8A 3IB7A 4H2BA 1FJMA 2WDCA 3V4YA 3C9FA 3IVDA 2IE3C 2IAEC 2GJUA 3ICFA 1AUIA 4B2OA 4KKZA 3THOB 5C1VA 1HPUA 3EGGA 4IL1A 4I5LC 3HVQA 4UT2A 4O43A 1Z2XA 2WDEA 4O4KA 3PSNA 5IOHA 4FBKA 3K7WC 4LU9A 2CV9A 4H1YP 2BQ8X 1S3NA 3GVEA 3RL3A 2ZO9B 2JOGA 4FBQA 4LTYA 2IE4C 4V0WA 3PSOA 5GTUA 1MF8A 4H1SA 4F0ZA 1NNWA 4OR9A 3RL4A 4DT2A 2QFPA 2XMOA 3FGAC 2QFRA 3H64A 3DSCA 4TUGA 2HYPA 3AUZA 3ZU0A 4LACC 2Z1AA 4V0VA 1S70A 2A22A 4IYPC 2QJCA 4H2FA 1IT6A 2Z06A 3K7VC 3JYFA 4UT3A 2YVTA 2WDFA 4JA7A 3RL5A 1S8EA 4NZVA 3E0JA 2O8GA 1USHA 3C5WC 1S3MA 1II7A 4DHLA 1Z2WA 4O5GA 1V73A 4H2IA 3QFKA 1S95A 3QFMA 4HD0A 4ORBA 5B8IA 4ZX2A 2P6BA 3FLOA 3IB8A 4JA9A 4KBPA 4YKEA 5JPFA 1SU1A 1QFCA 3H66A 3IVEA 4M0VA 5J28A 3DSDA 2WDDA 4WWLA 4XPNA 3E7AA 1QHWA 3N5UA 1OIEA 2ZBMA 1HP1A 4ORCA 4TUIA 2DXNA 3ZTVA 3H60A 1S3LA 2USHA 1U32A 1XM7A 1G5BA 3THNA 1XZWA 4O24A 1UF3A 2R17A 1OIDA 2NYLC 2HYOA 5JJTA 1TCOA 3E7BA 1KBPA 3DW8C 1UTEA 4UWQA 4V0XA 2DXLA 4MP0A 5EQVA 3H69A 3P71C 4FCXA 4Q7FA 2NXFA 1WARA 5INBA 2NPPC 1T70A 4DSYA 4G9JA 3AV0A 2YEQA 3H62B 4I5NC 3QFNA 5HPEA 2BCDA 3EGHA 4MOYA 3H67A 2Z72A 4FBWA 3D03A
chains in the Genus database with same CATH topology
2KKNA 2Q8UA 3LL8A 2HY1A 2DFJA 1HO5A 2BDXA 5F3WA 2O8AA 3QFOA 1M63A 4H2GA 3TGHA 2AHDA 3CK2A 1JK7A 1W24A 3T1IA 3QG5C 1WAO1 4MOVA 4ORAA 3KBPA 3RQZA 2NYMC 3H68A 5DNYA 3H61A 4ZVZA 5JPEA 1T71A 3H63A 4J6OA 2ZOAA 4UT3B 1OI8A 3IB7A 4H2BA 1FJMA 2WDCA 3V4YA 3C9FA 3IVDA 2IE3C 2IAEC 2GJUA 3ICFA 1AUIA 4B2OA 4KKZA 3THOB 5C1VA 1HPUA 3EGGA 4IL1A 4I5LC 3HVQA 4UT2A 4O43A 1Z2XA 2WDEA 4O4KA 3PSNA 5IOHA 4FBKA 3K7WC 4LU9A 2CV9A 4H1YP 2BQ8X 1S3NA 3GVEA 3RL3A 2ZO9B 2JOGA 4FBQA 4LTYA 2IE4C 4V0WA 3PSOA 5GTUA 1MF8A 4H1SA 4F0ZA 1NNWA 4OR9A 3RL4A 4DT2A 2QFPA 2XMOA 3FGAC 2QFRA 3H64A 3DSCA 4TUGA 2HYPA 3AUZA 3ZU0A 4LACC 2Z1AA 4V0VA 1S70A 2A22A 4IYPC 2QJCA 4H2FA 1IT6A 2Z06A 3K7VC 3JYFA 4UT3A 2YVTA 2WDFA 4JA7A 3RL5A 1S8EA 4NZVA 3E0JA 2O8GA 1USHA 3C5WC 1S3MA 1II7A 4DHLA 1Z2WA 4O5GA 1V73A 4H2IA 3QFKA 1S95A 3QFMA 4HD0A 4ORBA 5B8IA 4ZX2A 2P6BA 3FLOA 3IB8A 4JA9A 4KBPA 4YKEA 5JPFA 1SU1A 1QFCA 3H66A 3IVEA 4M0VA 5J28A 3DSDA 2WDDA 4WWLA 4XPNA 3E7AA 1QHWA 3N5UA 1OIEA 2ZBMA 1HP1A 4ORCA 4TUIA 2DXNA 3ZTVA 3H60A 1S3LA 2USHA 1U32A 1XM7A 1G5BA 3THNA 1XZWA 4O24A 1UF3A 2R17A 1OIDA 2NYLC 2HYOA 5JJTA 1TCOA 3E7BA 1KBPA 3DW8C 1UTEA 4UWQA 4V0XA 2DXLA 4MP0A 5EQVA 3H69A 3P71C 4FCXA 4Q7FA 2NXFA 1WARA 5INBA 2NPPC 1T70A 4DSYA 4G9JA 3AV0A 2YEQA 3H62B 4I5NC 3QFNA 5HPEA 2BCDA 3EGHA 4MOYA 3H67A 2Z72A 4FBWA 3D03A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2KKN A;  2Q8U A;  3LL8 A;  2HY1 A;  2DFJ A;  1HO5 A;  2BDX A;  5F3W A;  2O8A A;  3QFO A;  1M63 A;  4H2G A;  3TGH A;  2AHD A;  3CK2 A;  1JK7 A;  1W24 A;  3T1I A;  3QG5 C;  1WAO 1;  4MOV A;  4ORA A;  3KBP A;  3RQZ A;  2NYM C;  3H68 A;  5DNY A;  3H61 A;  4ZVZ A;  5JPE A;  1T71 A;  3H63 A;  4J6O A;  4UT3 B;  1OI8 A;  3IB7 A;  4H2B A;  1FJM A;  2WDC A;  3V4Y A;  3C9F A;  3IVD A;  2IE3 C;  2IAE C;  2GJU A;  3ICF A;  1AUI A;  4B2O A;  4KKZ A;  3THO B;  5C1V A;  1HPU A;  3EGG A;  4IL1 A;  4I5L C;  3HVQ A;  4UT2 A;  4O43 A;  1Z2X A;  2WDE A;  4O4K A;  3PSN A;  5IOH A;  4FBK A;  3K7W C;  4LU9 A;  2CV9 A;  4H1Y P;  2BQ8 X;  1S3N A;  3GVE A;  3RL3 A;  4LTY A;  2JOG A;  4FBQ A;  2IE4 C;  4V0W A;  3PSO A;  5GTU A;  1MF8 A;  4H1S A;  4F0Z A;  1NNW A;  4OR9 A;  3RL4 A;  4DT2 A;  2QFP A;  2XMO A;  3FGA C;  2QFR A;  3H64 A;  3DSC A;  4TUG A;  2HYP A;  3AUZ A;  3ZU0 A;  4LAC C;  2Z1A A;  4V0V A;  1S70 A;  2A22 A;  4IYP C;  2QJC A;  4H2F A;  1IT6 A;  2Z06 A;  3K7V C;  3JYF A;  4UT3 A;  2YVT A;  2WDF A;  4JA7 A;  3RL5 A;  1S8E A;  4NZV A;  2O8G A;  1USH A;  3C5W C;  1S3M A;  1II7 A;  4DHL A;  1Z2W A;  4O5G A;  1V73 A;  4H2I A;  3QFK A;  1S95 A;  3QFM A;  4HD0 A;  4ORB A;  5B8I A;  4ZX2 A;  2P6B A;  3IB8 A;  4JA9 A;  4KBP A;  4YKE A;  5JPF A;  1SU1 A;  1QFC A;  3H66 A;  3IVE A;  4M0V A;  5J28 A;  3DSD A;  2WDD A;  4WWL A;  4XPN A;  3E7A A;  1QHW A;  3N5U A;  1OIE A;  2ZBM A;  1HP1 A;  4ORC A;  4TUI A;  3ZTV A;  3H60 A;  1S3L A;  2USH A;  1U32 A;  1XM7 A;  1G5B A;  3THN A;  1XZW A;  4O24 A;  1UF3 A;  2R17 A;  1OID A;  2NYL C;  2HYO A;  5JJT A;  1TCO A;  3E7B A;  1KBP A;  3DW8 C;  1UTE A;  4UWQ A;  4V0X A;  4MP0 A;  5EQV A;  3H69 A;  3P71 C;  4FCX A;  4Q7F A;  2NXF A;  1WAR A;  5INB A;  2NPP C;  1T70 A;  4DSY A;  4G9J A;  3AV0 A;  3H62 B;  4I5N C;  3QFN A;  5HPE A;  2BCD A;  3EGH A;  4MOY A;  3H67 A;  2Z72 A;  4FBW A; 
#chains in the Genus database with same CATH topology
 2KKN A;  2Q8U A;  3LL8 A;  2HY1 A;  2DFJ A;  1HO5 A;  2BDX A;  5F3W A;  2O8A A;  3QFO A;  1M63 A;  4H2G A;  3TGH A;  2AHD A;  3CK2 A;  1JK7 A;  1W24 A;  3T1I A;  3QG5 C;  1WAO 1;  4MOV A;  4ORA A;  3KBP A;  3RQZ A;  2NYM C;  3H68 A;  5DNY A;  3H61 A;  4ZVZ A;  5JPE A;  1T71 A;  3H63 A;  4J6O A;  2ZOA A;  4UT3 B;  1OI8 A;  3IB7 A;  4H2B A;  1FJM A;  2WDC A;  3V4Y A;  3C9F A;  3IVD A;  2IE3 C;  2IAE C;  2GJU A;  3ICF A;  1AUI A;  4B2O A;  4KKZ A;  3THO B;  5C1V A;  1HPU A;  3EGG A;  4IL1 A;  4I5L C;  3HVQ A;  4UT2 A;  4O43 A;  1Z2X A;  2WDE A;  4O4K A;  3PSN A;  5IOH A;  4FBK A;  3K7W C;  4LU9 A;  2CV9 A;  4H1Y P;  2BQ8 X;  1S3N A;  3GVE A;  3RL3 A;  2ZO9 B;  2JOG A;  4FBQ A;  4LTY A;  2IE4 C;  4V0W A;  3PSO A;  5GTU A;  1MF8 A;  4H1S A;  4F0Z A;  1NNW A;  4OR9 A;  3RL4 A;  4DT2 A;  2QFP A;  2XMO A;  3FGA C;  2QFR A;  3H64 A;  3DSC A;  4TUG A;  2HYP A;  3AUZ A;  3ZU0 A;  4LAC C;  2Z1A A;  4V0V A;  1S70 A;  2A22 A;  4IYP C;  2QJC A;  4H2F A;  1IT6 A;  2Z06 A;  3K7V C;  3JYF A;  4UT3 A;  2YVT A;  2WDF A;  4JA7 A;  3RL5 A;  1S8E A;  4NZV A;  3E0J A;  2O8G A;  1USH A;  3C5W C;  1S3M A;  1II7 A;  4DHL A;  1Z2W A;  4O5G A;  1V73 A;  4H2I A;  3QFK A;  1S95 A;  3QFM A;  4HD0 A;  4ORB A;  5B8I A;  4ZX2 A;  2P6B A;  3FLO A;  3IB8 A;  4JA9 A;  4KBP A;  4YKE A;  5JPF A;  1SU1 A;  1QFC A;  3H66 A;  3IVE A;  4M0V A;  5J28 A;  3DSD A;  2WDD A;  4WWL A;  4XPN A;  3E7A A;  1QHW A;  3N5U A;  1OIE A;  2ZBM A;  1HP1 A;  4ORC A;  4TUI A;  2DXN A;  3ZTV A;  3H60 A;  1S3L A;  2USH A;  1U32 A;  1XM7 A;  1G5B A;  3THN A;  1XZW A;  4O24 A;  1UF3 A;  2R17 A;  1OID A;  2NYL C;  2HYO A;  5JJT A;  1TCO A;  3E7B A;  1KBP A;  3DW8 C;  1UTE A;  4UWQ A;  4V0X A;  2DXL A;  4MP0 A;  5EQV A;  3H69 A;  3P71 C;  4FCX A;  4Q7F A;  2NXF A;  1WAR A;  5INB A;  2NPP C;  1T70 A;  4DSY A;  4G9J A;  3AV0 A;  2YEQ A;  3H62 B;  4I5N C;  3QFN A;  5HPE A;  2BCD A;  3EGH A;  4MOY A;  3H67 A;  2Z72 A;  4FBW A;  3D03 A; 
#chains in the Genus database with same CATH homology
 2KKN A;  2Q8U A;  3LL8 A;  2HY1 A;  2DFJ A;  1HO5 A;  2BDX A;  5F3W A;  2O8A A;  3QFO A;  1M63 A;  4H2G A;  3TGH A;  2AHD A;  3CK2 A;  1JK7 A;  1W24 A;  3T1I A;  3QG5 C;  1WAO 1;  4MOV A;  4ORA A;  3KBP A;  3RQZ A;  2NYM C;  3H68 A;  5DNY A;  3H61 A;  4ZVZ A;  5JPE A;  1T71 A;  3H63 A;  4J6O A;  2ZOA A;  4UT3 B;  1OI8 A;  3IB7 A;  4H2B A;  1FJM A;  2WDC A;  3V4Y A;  3C9F A;  3IVD A;  2IE3 C;  2IAE C;  2GJU A;  3ICF A;  1AUI A;  4B2O A;  4KKZ A;  3THO B;  5C1V A;  1HPU A;  3EGG A;  4IL1 A;  4I5L C;  3HVQ A;  4UT2 A;  4O43 A;  1Z2X A;  2WDE A;  4O4K A;  3PSN A;  5IOH A;  4FBK A;  3K7W C;  4LU9 A;  2CV9 A;  4H1Y P;  2BQ8 X;  1S3N A;  3GVE A;  3RL3 A;  2ZO9 B;  2JOG A;  4FBQ A;  4LTY A;  2IE4 C;  4V0W A;  3PSO A;  5GTU A;  1MF8 A;  4H1S A;  4F0Z A;  1NNW A;  4OR9 A;  3RL4 A;  4DT2 A;  2QFP A;  2XMO A;  3FGA C;  2QFR A;  3H64 A;  3DSC A;  4TUG A;  2HYP A;  3AUZ A;  3ZU0 A;  4LAC C;  2Z1A A;  4V0V A;  1S70 A;  2A22 A;  4IYP C;  2QJC A;  4H2F A;  1IT6 A;  2Z06 A;  3K7V C;  3JYF A;  4UT3 A;  2YVT A;  2WDF A;  4JA7 A;  3RL5 A;  1S8E A;  4NZV A;  3E0J A;  2O8G A;  1USH A;  3C5W C;  1S3M A;  1II7 A;  4DHL A;  1Z2W A;  4O5G A;  1V73 A;  4H2I A;  3QFK A;  1S95 A;  3QFM A;  4HD0 A;  4ORB A;  5B8I A;  4ZX2 A;  2P6B A;  3FLO A;  3IB8 A;  4JA9 A;  4KBP A;  4YKE A;  5JPF A;  1SU1 A;  1QFC A;  3H66 A;  3IVE A;  4M0V A;  5J28 A;  3DSD A;  2WDD A;  4WWL A;  4XPN A;  3E7A A;  1QHW A;  3N5U A;  1OIE A;  2ZBM A;  1HP1 A;  4ORC A;  4TUI A;  2DXN A;  3ZTV A;  3H60 A;  1S3L A;  2USH A;  1U32 A;  1XM7 A;  1G5B A;  3THN A;  1XZW A;  4O24 A;  1UF3 A;  2R17 A;  1OID A;  2NYL C;  2HYO A;  5JJT A;  1TCO A;  3E7B A;  1KBP A;  3DW8 C;  1UTE A;  4UWQ A;  4V0X A;  2DXL A;  4MP0 A;  5EQV A;  3H69 A;  3P71 C;  4FCX A;  4Q7F A;  2NXF A;  1WAR A;  5INB A;  2NPP C;  1T70 A;  4DSY A;  4G9J A;  3AV0 A;  2YEQ A;  3H62 B;  4I5N C;  3QFN A;  5HPE A;  2BCD A;  3EGH A;  4MOY A;  3H67 A;  2Z72 A;  4FBW A;  3D03 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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