4I70A

Crystal structure of the trypanosoma brucei inosine-adenosine-guanosine nucleoside hydrolase
Total Genus 123
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
123
sequence length
327
structure length
316
Chain Sequence
MAKTVILDHDGNKDDFVAMILLLSNPKKVNLIGCICTDADCFVENGFDVTGKIMCAMHRLIKTPLFPIGKSTATAVNAFPTEWRFSAKNLDDMPFLNIVEDVALWEKLKPENEAHNGQQLLADLVMKSKEKVTVCVTGPLSNMAWCIEKYGEAFTSKVEECVIMGGAVDVGGNVFLPTTDGSAEWNIYWDPPAAKKVLCCPNIRCVLFSLDATNTVPVRSVDVKGFGAQNQYLLSQMVGTMWAMAYYAWDALTAAYILEPTIATLEPVALDVDVSKGKSEGRTPRASGEGKPCVHVARNPSKQMFHDLVFASTRVC
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase
molecule keywords Inosine-adenosine-guanosine-nucleoside hydrolase
publication title Structures of purine nucleosidase from Trypanosoma brucei bound to isozyme-specific trypanocidals and a novel metalorganic inhibitor
pubmed doi rcsb
source organism Trypanosoma brucei brucei
total genus 123
structure length 316
sequence length 327
ec nomenclature ec 3.2.2.1: Purine nucleosidase.
pdb deposition date 2012-11-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01156 IU_nuc_hydro Inosine-uridine preferring nucleoside hydrolase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.245.10 Alpha Beta Alpha-Beta Complex Inosine-uridine Nucleoside N-ribohydrolase; Chain A Ribonucleoside hydrolase-like 4i70A00
1KICA 1HP0A 4I72A 4I71A 2FF1A 3B9XA 3FZ0A 3B9GA 2FF2A 1KIEA 3EPWA 3T8JA 4I75A 1HOZA 3EPXA 2C40A 4I73A 4KL0A 4KPNA 3MKNA 4WR2A 4KPOA 4P5FA 1EZRA 1Q8FA 1YOEA 3MKMA 3G5IA 1MASA 2YHGA 1R4FA 3T8IA 4I70A 5TSQA 2MASA 4I74A
chains in the Genus database with same CATH superfamily
1KICA 1HP0A 4I72A 4I71A 2FF1A 3B9XA 3FZ0A 3B9GA 2FF2A 1KIEA 3EPWA 3T8JA 4I75A 1HOZA 3EPXA 2C40A 4I73A 4KL0A 4KPNA 3MKNA 4WR2A 4KPOA 4P5FA 1EZRA 1Q8FA 1YOEA 3MKMA 3G5IA 1MASA 2YHGA 1R4FA 3T8IA 4I70A 5TSQA 2MASA 4I74A
chains in the Genus database with same CATH topology
1KICA 1HP0A 4I72A 4I71A 2FF1A 3B9XA 3FZ0A 3B9GA 2FF2A 1KIEA 3EPWA 3T8JA 4I75A 1HOZA 3EPXA 2C40A 4I73A 4KL0A 4KPNA 3MKNA 4WR2A 4KPOA 4P5FA 1EZRA 1Q8FA 1YOEA 3MKMA 3G5IA 1MASA 2YHGA 1R4FA 3T8IA 4I70A 5TSQA 2MASA 4I74A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1KIC A;  1HP0 A;  4I72 A;  4I71 A;  2FF1 A;  3B9X A;  3FZ0 A;  3B9G A;  2FF2 A;  1KIE A;  3EPW A;  3T8J A;  4I75 A;  1HOZ A;  3EPX A;  2C40 A;  4I73 A;  4KL0 A;  4KPN A;  3MKN A;  4WR2 A;  4KPO A;  4P5F A;  1EZR A;  1Q8F A;  1YOE A;  3MKM A;  3G5I A;  1MAS A;  2YHG A;  1R4F A;  3T8I A;  4I70 A;  5TSQ A;  2MAS A;  4I74 A; 
#chains in the Genus database with same CATH topology
 1KIC A;  1HP0 A;  4I72 A;  4I71 A;  2FF1 A;  3B9X A;  3FZ0 A;  3B9G A;  2FF2 A;  1KIE A;  3EPW A;  3T8J A;  4I75 A;  1HOZ A;  3EPX A;  2C40 A;  4I73 A;  4KL0 A;  4KPN A;  3MKN A;  4WR2 A;  4KPO A;  4P5F A;  1EZR A;  1Q8F A;  1YOE A;  3MKM A;  3G5I A;  1MAS A;  2YHG A;  1R4F A;  3T8I A;  4I70 A;  5TSQ A;  2MAS A;  4I74 A; 
#chains in the Genus database with same CATH homology
 1KIC A;  1HP0 A;  4I72 A;  4I71 A;  2FF1 A;  3B9X A;  3FZ0 A;  3B9G A;  2FF2 A;  1KIE A;  3EPW A;  3T8J A;  4I75 A;  1HOZ A;  3EPX A;  2C40 A;  4I73 A;  4KL0 A;  4KPN A;  3MKN A;  4WR2 A;  4KPO A;  4P5F A;  1EZR A;  1Q8F A;  1YOE A;  3MKM A;  3G5I A;  1MAS A;  2YHG A;  1R4F A;  3T8I A;  4I70 A;  5TSQ A;  2MAS A;  4I74 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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