4IJOA

Unraveling hidden allosteric regulatory sites in structurally homologues metalloproteases
Total Genus 44
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
44
sequence length
158
structure length
158
Chain Sequence
GPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Unraveling hidden regulatory sites in structurally homologous metalloproteases
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords Macrophage metalloelastase
total genus 44
structure length 158
sequence length 158
ec nomenclature ec 3.4.24.65: Macrophage elastase.
pdb deposition date 2012-12-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00413 Peptidase_M10 Matrixin
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.390.10 Alpha Beta 3-Layer(aba) Sandwich Collagenase (Catalytic Domain) Collagenase (Catalytic Domain) 4ijoA00
2Z2DA 4FXYP 2JNPA 1OM7A 3EHXA 2DDYA 1A85A 1AF0A 1QIBA 5D2BA 1GKDA 3AYKA 3LKAA 1QUAA 1MMBA 5D7WA 4DD8A 2E2DA 1CGEA 3KHIA 4CTHA 1WNIA 1XFUA 1G05A 1O0TA 3HBUP 5I3MA 3LUNA 1HFCA 2DDFA 2J83A 1UMSA 4ON1A 5D1UA 2MLSA 4G0DA 1XFZA 2DW0A 1BQQM 1O0QA 4Q1LA 1GE7A 2PJTA 2YB9A 1MMQA 2OVXA 4IN9A 3LQ0A 1Y0VA 1H71P 4HMAA 2JT6A 5I0LA 4JQGA 5H8XA 3G42A 4WZVA 1GE5A 2XS4A 2Y6DA 4JA1A 1QIAA 1KUKA 3EDGA 5LABA 3VTGA 1SLNA 1K7GA 1CK7A 5I4OA 1R1IA 2O3EA 1ZVXA 1UEAA 2W13A 4H76A 5I2ZA 2L0RA 3K7LA 4AXQA 4WF6A 3LJGA 3CKIA 4WKIA 3HBVP 3LK8A 4PKSA 1BUVM 5D1TA 2JT5A 1JIWP 1Q3AA 5CXAA 3TS4A 2MLRA 3KRYA 3LMCA 2W0DA 2FV9A 5D1SA 4QKZA 4A3WA 1D7XA 1ZTQA 1FBLA 2OW9A 3KWVC 1YOUA 3LE9A 4PKWA 4GUYA 2OVZA 3KEJA 4EFSA 1BUDA 1YP1A 1RMZA 2WOAA 3KEKA 2OY2A 1XFYA 3DPEA 5D3CA 2X3AA 1L6JA 3LJZA 3I7GA 3LILA 3TSKA 2KRJA 1YCMA 4H3XA 3LEAA 1XFVA 2W15A 1HOVA 3L0VA 4HX3A 4PKUA 3WV3A 1BKCI 2OW0A 4PKVA 1GE6A 1QJIA 1EB6A 3TT4A 1EUBA 3F16A 3OHOA 1JH1A 3HY7A 2X3BA 456CA 1KUIA 2RJQA 4PKTA 4XBHA 3TVCA 1QJJA 1OS9A 3E8RA 1FM1A 1ASTA 1GO8P 1Z3JA 1BIWA 1G4KA 1C3IA 2E3XA 4ILWD 1SRPA 1K7QA 4JP4A 4JPAA 3VI1A 4IJOA 1PWPA 1G49A 2RJPA 3ZXHA 1KUHA 1CGLA 1ATLA 1EAKA 3AYUA 3I7IA 3NX7A 4GR3A 1KBCA 2W12A 2ERQA 1JAPA 1HFSA 1I1IP 3GBOA 2N8RA 1CXVA 1AKLA 2AIGP 1SMPA 2X3CA 4I03A 1JAQA 2W14A 3LQBA 1R1JA 1BSWA 3DL1A 1PWVA 2XS3A 3N2VA 3P1VA 1IADA 4DPEA 2FV5A 1MNCA 1C7KA 2SRTA 2ERPA 1C8TA 5B5PA 3LUMA 1OM8A 2OXWA 4L19A 5CZMA 1CGFA 2WO8A 4GR8A 1D8MA 3RTSA 3EWJA 1ROSA 4GQLA 1JK3A 5BOTA 1R1HA 4FXQA 1DMTA 4H1QA 4GR0A 4GWNA 1CQRA 2JIHA 1USNA 2POJA 3B92A 1JJ9A 2OZRA 2AYKA 3UVCA 3DWBA 1B3DA 3LJTA 3F17A 1RM8A 3HB2P 1OS2A 1ZS0A 3N2UA 4DV8A 1JAOA 2V4BA 4XM6A 4IUWA 2D1NA 2MZIA 3EDZA 3OHLA 4AYKA 1D5JA 2OXUA 1ZXCA 5L7FA 4PKQA 1KUFA 3HDBA 3G5CA 966CA 1IAAA 1Y93A 3SHIA 1XUCA 2YIGA 1A86A 3L0TA 2EROA 1HV5A 1B8YA 2K9CA 1OM6A 2Y6CA 3LIRA 1BM6A 4R3VA 1XUDA 1PWUA 4WK7A 3F15A 1SU3A 1XFXA 5CUHA 1CAQA 1R54A 2MZEA 1G9KA 1IABA 4H84A 1J7NA 2WO9A 3B2ZA 4GWMA 4H2EA 4H30A 3WV2A 1GO7P 4L63A 3HYGA 3P24A 3KMEA 2J0TA 3HDAP 2MZHA 1BKCE 3USNA 1XFWA 3V96B 2JSDA 1MMPA 3AIGA 3O2XA 1JIZA 1KUGA 3WV1A 1FLSA 1I73A 3O64A 3MA2A 1ND1A 1R55A 4ZR5A 3K7NA 1IAGA 3LGPA 1UMTA 3EDIA 3LIKA 4I35A 1YQYA 3ZVSA 1UTTA 1JKYA 2O36A 3KECA 1BZSA 4AIGA 4GF1A 1HY7A 2CLTA 2K2GA 3F1AA 830CA 1D8FA 2QPJA 3BA0A 1Y8JA 2D1OA 2HU6A 3EHYA 1GXDA 4H49A 2DW2A 4L6TA 3Q2HA 4FU4A 2USNA 3HY9A 3RTTA 2TCLA 5I43A 1PWWA 5I12A 3F19A 1IACA 5BOYA 1MMRA 1SATA 1I76A 1XURA 1ZXVA 4H82A 2OY4A 3EDHA 4AUOA 4XM7A 3F18A 3DNGA 4J4MA 3DSLA 2CKIA 1DTHA 1S4BP 4DF9A 4A7BA 1BKCA 5L79A 2OXZA 1GKCA 4PKRA 5JMYA 4XCTA 2I47A 1OO9A 2A8HA 3U1RA 3KMCA 2OW1A 1BQOA 3ELMA 1UTZA 3Q2GA 2OI0A 2X7MA 1CIZA 2OW2A 4XM8A 4G9LA 3DPFA 1IAEA 5B5OA 3ZUKA 2DW1A 5BPAA 1G12A 1HTDA 1JANA 1K7IA 1KAPP 4FVLA 1AYKA 1SLMA 4WKEA 4JIJA 1QICA 3B8ZA 1PWQA 1OMJA 1ZP5A
chains in the Genus database with same CATH superfamily
2Z2DA 4FXYP 2JNPA 1OM7A 3EHXA 2DDYA 1A85A 1AF0A 1QIBA 5D2BA 1GKDA 3AYKA 3LKAA 1QUAA 1MMBA 5D7WA 4DD8A 2E2DA 1CGEA 3KHIA 4CTHA 1WNIA 1XFUA 1G05A 1O0TA 3HBUP 5I3MA 3LUNA 1HFCA 2DDFA 2J83A 1UMSA 3DTKA 4ON1A 2MLSA 5D1UA 4G0DA 1XFZA 2DW0A 1BQQM 1O0QA 4Q1LA 1GE7A 2PJTA 2YB9A 1MMQA 2OVXA 4IN9A 3LQ0A 1Y0VA 1H71P 4HMAA 2JT6A 5I0LA 4JQGA 5H8XA 3G42A 4WZVA 1GE5A 2XS4A 2Y6DA 4JA1A 1QIAA 1KUKA 3EDGA 5LABA 3VTGA 1SLNA 1K7GA 1CK7A 5I4OA 1R1IA 2O3EA 1ZVXA 1UEAA 2W13A 4H76A 5I2ZA 2L0RA 3K7LA 4AXQA 4WF6A 3LJGA 3CKIA 4WKIA 3HBVP 3LK8A 4PKSA 1BUVM 5D1TA 2JT5A 1JIWP 1Q3AA 5CXAA 3TS4A 2MLRA 3KRYA 3LMCA 2W0DA 2FV9A 5D1SA 4QKZA 4A3WA 1D7XA 1ZTQA 1FBLA 2OW9A 3KWVC 1YOUA 3LE9A 4PKWA 4GUYA 2OVZA 3KEJA 4EFSA 1BUDA 1YP1A 1RMZA 2WOAA 3KEKA 2OY2A 1XFYA 3DPEA 5D3CA 2X3AA 1L6JA 3LJZA 3I7GA 3LILA 3TSKA 2KRJA 1YCMA 4H3XA 3LEAA 1XFVA 2W15A 1HOVA 3L0VA 4HX3A 4PKUA 3WV3A 1BKCI 1XAXA 2OW0A 4PKVA 1GE6A 1QJIA 1EB6A 3TT4A 1EUBA 3F16A 3OHOA 1JH1A 3HY7A 2X3BA 456CA 1KUIA 2RJQA 4PKTA 4XBHA 3TVCA 1QJJA 1OS9A 3E8RA 1FM1A 1ASTA 1GO8P 1Z3JA 1BIWA 1G4KA 1C3IA 2E3XA 4ILWD 1SRPA 1K7QA 4JP4A 4JPAA 3VI1A 4IJOA 1PWPA 1G49A 2RJPA 3ZXHA 1KUHA 1CGLA 1ATLA 1EAKA 3AYUA 3I7IA 3NX7A 4GR3A 1KBCA 2W12A 2ERQA 1JAPA 1HFSA 1I1IP 3GBOA 2N8RA 1CXVA 1AKLA 2AIGP 1SMPA 2X3CA 4I03A 1JAQA 2W14A 3LQBA 1R1JA 1BSWA 3DL1A 1PWVA 2XS3A 3N2VA 3P1VA 1IADA 4DPEA 2FV5A 1MNCA 1C7KA 2SRTA 2ERPA 1C8TA 5B5PA 3LUMA 1OM8A 2OXWA 4L19A 5CZMA 1CGFA 2WO8A 4GR8A 1D8MA 1TVIA 3DTEA 3RTSA 3EWJA 1ROSA 4GQLA 1JK3A 5BOTA 1R1HA 4FXQA 1DMTA 4H1QA 4GR0A 4GWNA 1CQRA 2JIHA 1USNA 2POJA 3B92A 1JJ9A 2OZRA 2AYKA 3UVCA 3DWBA 1OZ9A 1B3DA 3LJTA 3F17A 1RM8A 3HB2P 1OS2A 1ZS0A 3N2UA 4DV8A 1JAOA 2V4BA 4XM6A 4IUWA 4L7AA 2D1NA 2MZIA 3EDZA 3OHLA 4AYKA 1D5JA 2OXUA 1ZXCA 5L7FA 4PKQA 1KUFA 3HDBA 3G5CA 966CA 3DTIA 1IAAA 1Y93A 3SHIA 1XUCA 2YIGA 1A86A 3L0TA 2EROA 1HV5A 1B8YA 2K9CA 1OM6A 2Y6CA 3LIRA 1BM6A 4R3VA 1XUDA 1PWUA 4WK7A 3F15A 1SU3A 1XFXA 5CUHA 2YUFA 1CAQA 1R54A 2MZEA 1G9KA 1IABA 4H84A 1J7NA 2WO9A 3B2ZA 4GWMA 4H2EA 4H30A 3WV2A 1GO7P 4L63A 3HYGA 3P24A 3KMEA 2J0TA 3HDAP 2MZHA 1BKCE 3USNA 1XFWA 3V96B 2JSDA 1MMPA 3AIGA 3O2XA 1JIZA 1KUGA 3WV1A 1FLSA 1I73A 3O64A 3MA2A 1ND1A 1R55A 4ZR5A 3K7NA 1IAGA 3LGPA 1UMTA 3EDIA 3LIKA 4I35A 1YQYA 3ZVSA 1UTTA 1JKYA 2O36A 3KECA 1BZSA 4AIGA 4GF1A 1HY7A 2CLTA 2K2GA 3F1AA 830CA 1D8FA 2QPJA 3BA0A 1Y8JA 2D1OA 2HU6A 3EHYA 1GXDA 4H49A 2DW2A 4L6TA 3Q2HA 4FU4A 2USNA 3HY9A 1XM5A 3RTTA 2TCLA 5I43A 1PWWA 5I12A 3F19A 1IACA 5BOYA 1MMRA 1SATA 1I76A 1XURA 1ZXVA 4H82A 2OY4A 3EDHA 4AUOA 4XM7A 3F18A 3DNGA 4J4MA 3DSLA 2CKIA 1DTHA 1S4BP 4DF9A 4A7BA 1BKCA 5L79A 2OXZA 1GKCA 4PKRA 5JMYA 4XCTA 2I47A 1OO9A 2A8HA 3U1RA 3KMCA 2OW1A 1BQOA 3ELMA 1UTZA 3Q2GA 2OI0A 2X7MA 1CIZA 2OW2A 4XM8A 4G9LA 3DPFA 1IAEA 5B5OA 3ZUKA 2DW1A 5BPAA 1G12A 1HTDA 1JANA 1K7IA 1KAPP 4FVLA 1AYKA 1SLMA 4WKEA 4JIJA 1QICA 3B8ZA 1PWQA 1OMJA 1ZP5A
chains in the Genus database with same CATH topology
2Z2DA 4FXYP 2JNPA 1OM7A 3EHXA 2DDYA 1A85A 1AF0A 1QIBA 5D2BA 1GKDA 3AYKA 3LKAA 1QUAA 1MMBA 5D7WA 4DD8A 2E2DA 1CGEA 3KHIA 4CTHA 1WNIA 1XFUA 1G05A 1O0TA 3HBUP 5I3MA 3LUNA 1HFCA 2DDFA 2J83A 1UMSA 3DTKA 4ON1A 2MLSA 5D1UA 4G0DA 1XFZA 2DW0A 1BQQM 1O0QA 4Q1LA 1GE7A 2PJTA 2YB9A 1MMQA 2OVXA 4IN9A 3LQ0A 1Y0VA 1H71P 4HMAA 2JT6A 5I0LA 4JQGA 5H8XA 3G42A 4WZVA 1GE5A 2XS4A 2Y6DA 4JA1A 1QIAA 1KUKA 3EDGA 5LABA 3VTGA 1SLNA 1K7GA 1CK7A 5I4OA 1R1IA 2O3EA 1ZVXA 1UEAA 2W13A 4H76A 5I2ZA 2L0RA 3K7LA 4AXQA 4WF6A 3LJGA 3CKIA 4WKIA 3HBVP 3LK8A 4PKSA 1BUVM 5D1TA 2JT5A 1JIWP 1Q3AA 5CXAA 3TS4A 2MLRA 3KRYA 3LMCA 2W0DA 2FV9A 5D1SA 4QKZA 4A3WA 1D7XA 1ZTQA 1FBLA 2OW9A 3KWVC 1YOUA 3LE9A 4PKWA 4GUYA 2OVZA 3KEJA 4EFSA 1BUDA 1YP1A 1RMZA 2WOAA 3KEKA 2OY2A 1XFYA 3DPEA 5D3CA 2X3AA 1L6JA 3LJZA 3I7GA 3LILA 3TSKA 2KRJA 1YCMA 4H3XA 3LEAA 1XFVA 2W15A 1HOVA 3L0VA 4HX3A 4PKUA 3WV3A 1BKCI 2OW0A 4PKVA 1GE6A 1QJIA 1EB6A 3TT4A 1EUBA 3F16A 3OHOA 1JH1A 3HY7A 2X3BA 456CA 1KUIA 2RJQA 4PKTA 4XBHA 3TVCA 1QJJA 1OS9A 3E8RA 1FM1A 1ASTA 1GO8P 1Z3JA 1BIWA 1G4KA 1C3IA 2E3XA 4ILWD 1SRPA 1K7QA 4JP4A 4JPAA 3VI1A 4IJOA 1PWPA 1G49A 2RJPA 3ZXHA 1KUHA 1CGLA 1ATLA 1EAKA 3AYUA 3I7IA 3NX7A 4GR3A 1KBCA 2W12A 2ERQA 1JAPA 1HFSA 1I1IP 3GBOA 2N8RA 1CXVA 1AKLA 2AIGP 1SMPA 2X3CA 4I03A 1JAQA 2W14A 3LQBA 1R1JA 1BSWA 3DL1A 1PWVA 2XS3A 3N2VA 3P1VA 1IADA 4DPEA 2FV5A 1MNCA 1C7KA 2SRTA 2ERPA 1C8TA 5B5PA 3LUMA 1OM8A 2OXWA 4L19A 5CZMA 1CGFA 2WO8A 4GR8A 1D8MA 3DTEA 3RTSA 3EWJA 1ROSA 4GQLA 1JK3A 5BOTA 1R1HA 4FXQA 1DMTA 4H1QA 4GR0A 4GWNA 1CQRA 2JIHA 1USNA 2POJA 3B92A 1JJ9A 2OZRA 2AYKA 3UVCA 3DWBA 1B3DA 3LJTA 3F17A 1RM8A 3HB2P 1OS2A 1ZS0A 3N2UA 4DV8A 1JAOA 2V4BA 4XM6A 4IUWA 4L7AA 2D1NA 2MZIA 3EDZA 3OHLA 4AYKA 1D5JA 2OXUA 1ZXCA 5L7FA 4PKQA 1KUFA 3HDBA 3G5CA 966CA 3DTIA 1IAAA 1Y93A 3SHIA 1XUCA 2YIGA 1A86A 3L0TA 2EROA 1HV5A 1B8YA 2K9CA 1OM6A 2Y6CA 3LIRA 1BM6A 4R3VA 1XUDA 1PWUA 4WK7A 3F15A 1SU3A 1XFXA 5CUHA 2YUFA 1CAQA 1R54A 2MZEA 1G9KA 1IABA 4H84A 1J7NA 2WO9A 3B2ZA 4GWMA 4H2EA 4H30A 3WV2A 1GO7P 4L63A 3HYGA 3P24A 3KMEA 2J0TA 3HDAP 2MZHA 1BKCE 3USNA 1XFWA 3V96B 2JSDA 1MMPA 3AIGA 3O2XA 1JIZA 1KUGA 3WV1A 1FLSA 1I73A 3O64A 3MA2A 1ND1A 1R55A 4ZR5A 3K7NA 1IAGA 3LGPA 1UMTA 3EDIA 3LIKA 4I35A 1YQYA 3ZVSA 1UTTA 1JKYA 2O36A 3KECA 1BZSA 4AIGA 4GF1A 1HY7A 2CLTA 2K2GA 3F1AA 830CA 1D8FA 2QPJA 3BA0A 1Y8JA 2D1OA 2HU6A 3EHYA 1GXDA 4H49A 2DW2A 4L6TA 3Q2HA 4FU4A 2USNA 3HY9A 3RTTA 2TCLA 5I43A 1PWWA 5I12A 3F19A 1IACA 5BOYA 1MMRA 1SATA 1I76A 1XURA 1ZXVA 4H82A 2OY4A 3EDHA 4AUOA 4XM7A 3F18A 3DNGA 4J4MA 3DSLA 2CKIA 1DTHA 1S4BP 4DF9A 4A7BA 1BKCA 5L79A 2OXZA 1GKCA 4PKRA 5JMYA 4XCTA 2I47A 1OO9A 2A8HA 3U1RA 3KMCA 2OW1A 1BQOA 3ELMA 1UTZA 3Q2GA 2OI0A 2X7MA 1CIZA 2OW2A 4XM8A 4G9LA 3DPFA 1IAEA 5B5OA 3ZUKA 2DW1A 5BPAA 1G12A 1HTDA 1JANA 1K7IA 1KAPP 4FVLA 1AYKA 1SLMA 4WKEA 4JIJA 1QICA 3B8ZA 1PWQA 1OMJA 1ZP5A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2Z2D A;  4FXY P;  2JNP A;  1OM7 A;  3EHX A;  2DDY A;  1A85 A;  1AF0 A;  1QIB A;  5D2B A;  1GKD A;  3AYK A;  3LKA A;  1QUA A;  1MMB A;  5D7W A;  4DD8 A;  2E2D A;  1CGE A;  3KHI A;  4CTH A;  1WNI A;  1XFU A;  1G05 A;  1O0T A;  3HBU P;  5I3M A;  3LUN A;  1HFC A;  2DDF A;  2J83 A;  1UMS A;  4ON1 A;  5D1U A;  2MLS A;  4G0D A;  1XFZ A;  2DW0 A;  1BQQ M;  1O0Q A;  4Q1L A;  1GE7 A;  2PJT A;  2YB9 A;  1MMQ A;  2OVX A;  4IN9 A;  3LQ0 A;  1Y0V A;  1H71 P;  4HMA A;  2JT6 A;  5I0L A;  4JQG A;  5H8X A;  3G42 A;  4WZV A;  1GE5 A;  2XS4 A;  2Y6D A;  4JA1 A;  1QIA A;  1KUK A;  3EDG A;  5LAB A;  3VTG A;  1SLN A;  1K7G A;  1CK7 A;  5I4O A;  1R1I A;  2O3E A;  1ZVX A;  1UEA A;  2W13 A;  4H76 A;  5I2Z A;  2L0R A;  3K7L A;  4AXQ A;  4WF6 A;  3LJG A;  3CKI A;  4WKI A;  3HBV P;  3LK8 A;  4PKS A;  1BUV M;  5D1T A;  2JT5 A;  1JIW P;  1Q3A A;  5CXA A;  3TS4 A;  2MLR A;  3KRY A;  3LMC A;  2W0D A;  2FV9 A;  5D1S A;  4QKZ A;  4A3W A;  1D7X A;  1ZTQ A;  1FBL A;  2OW9 A;  3KWV C;  1YOU A;  3LE9 A;  4PKW A;  4GUY A;  2OVZ A;  3KEJ A;  4EFS A;  1BUD A;  1YP1 A;  1RMZ A;  2WOA A;  3KEK A;  2OY2 A;  1XFY A;  3DPE A;  5D3C A;  2X3A A;  1L6J A;  3LJZ A;  3I7G A;  3LIL A;  3TSK A;  2KRJ A;  1YCM A;  4H3X A;  3LEA A;  1XFV A;  2W15 A;  1HOV A;  3L0V A;  4HX3 A;  4PKU A;  3WV3 A;  1BKC I;  2OW0 A;  4PKV A;  1GE6 A;  1QJI A;  1EB6 A;  3TT4 A;  1EUB A;  3F16 A;  3OHO A;  1JH1 A;  3HY7 A;  2X3B A;  456C A;  1KUI A;  2RJQ A;  4PKT A;  4XBH A;  3TVC A;  1QJJ A;  1OS9 A;  3E8R A;  1FM1 A;  1AST A;  1GO8 P;  1Z3J A;  1BIW A;  1G4K A;  1C3I A;  2E3X A;  4ILW D;  1SRP A;  1K7Q A;  4JP4 A;  4JPA A;  3VI1 A;  4IJO A;  1PWP A;  1G49 A;  2RJP A;  3ZXH A;  1KUH A;  1CGL A;  1ATL A;  1EAK A;  3AYU A;  3I7I A;  3NX7 A;  4GR3 A;  1KBC A;  2W12 A;  2ERQ A;  1JAP A;  1HFS A;  1I1I P;  3GBO A;  2N8R A;  1CXV A;  1AKL A;  2AIG P;  1SMP A;  2X3C A;  4I03 A;  1JAQ A;  2W14 A;  3LQB A;  1R1J A;  1BSW A;  3DL1 A;  1PWV A;  2XS3 A;  3N2V A;  3P1V A;  1IAD A;  4DPE A;  2FV5 A;  1MNC A;  1C7K A;  2SRT A;  2ERP A;  1C8T A;  5B5P A;  3LUM A;  1OM8 A;  2OXW A;  4L19 A;  5CZM A;  1CGF A;  2WO8 A;  4GR8 A;  1D8M A;  3RTS A;  3EWJ A;  1ROS A;  4GQL A;  1JK3 A;  5BOT A;  1R1H A;  4FXQ A;  1DMT A;  4H1Q A;  4GR0 A;  4GWN A;  1CQR A;  2JIH A;  1USN A;  2POJ A;  3B92 A;  1JJ9 A;  2OZR A;  2AYK A;  3UVC A;  3DWB A;  1B3D A;  3LJT A;  3F17 A;  1RM8 A;  3HB2 P;  1OS2 A;  1ZS0 A;  3N2U A;  4DV8 A;  1JAO A;  2V4B A;  4XM6 A;  4IUW A;  2D1N A;  2MZI A;  3EDZ A;  3OHL A;  4AYK A;  1D5J A;  2OXU A;  1ZXC A;  5L7F A;  4PKQ A;  1KUF A;  3HDB A;  3G5C A;  966C A;  1IAA A;  1Y93 A;  3SHI A;  1XUC A;  2YIG A;  1A86 A;  3L0T A;  2ERO A;  1HV5 A;  1B8Y A;  2K9C A;  1OM6 A;  2Y6C A;  3LIR A;  1BM6 A;  4R3V A;  1XUD A;  1PWU A;  4WK7 A;  3F15 A;  1SU3 A;  1XFX A;  5CUH A;  1CAQ A;  1R54 A;  2MZE A;  1G9K A;  1IAB A;  4H84 A;  1J7N A;  2WO9 A;  3B2Z A;  4GWM A;  4H2E A;  4H30 A;  3WV2 A;  1GO7 P;  4L63 A;  3HYG A;  3P24 A;  3KME A;  2J0T A;  3HDA P;  2MZH A;  1BKC E;  3USN A;  1XFW A;  3V96 B;  2JSD A;  1MMP A;  3AIG A;  3O2X A;  1JIZ A;  1KUG A;  3WV1 A;  1FLS A;  1I73 A;  3O64 A;  3MA2 A;  1ND1 A;  1R55 A;  4ZR5 A;  3K7N A;  1IAG A;  3LGP A;  1UMT A;  3EDI A;  3LIK A;  4I35 A;  1YQY A;  3ZVS A;  1UTT A;  1JKY A;  2O36 A;  3KEC A;  1BZS A;  4AIG A;  4GF1 A;  1HY7 A;  2CLT A;  2K2G A;  3F1A A;  830C A;  1D8F A;  2QPJ A;  3BA0 A;  1Y8J A;  2D1O A;  2HU6 A;  3EHY A;  1GXD A;  4H49 A;  2DW2 A;  4L6T A;  3Q2H A;  4FU4 A;  2USN A;  3HY9 A;  3RTT A;  2TCL A;  5I43 A;  1PWW A;  5I12 A;  3F19 A;  1IAC A;  5BOY A;  1MMR A;  1SAT A;  1I76 A;  1XUR A;  1ZXV A;  4H82 A;  2OY4 A;  3EDH A;  4AUO A;  4XM7 A;  3F18 A;  3DNG A;  4J4M A;  3DSL A;  2CKI A;  1DTH A;  1S4B P;  4DF9 A;  4A7B A;  1BKC A;  5L79 A;  2OXZ A;  1GKC A;  4PKR A;  5JMY A;  4XCT A;  2I47 A;  1OO9 A;  2A8H A;  3U1R A;  3KMC A;  2OW1 A;  1BQO A;  3ELM A;  1UTZ A;  3Q2G A;  2OI0 A;  2X7M A;  1CIZ A;  2OW2 A;  4XM8 A;  4G9L A;  3DPF A;  1IAE A;  5B5O A;  3ZUK A;  2DW1 A;  5BPA A;  1G12 A;  1HTD A;  1JAN A;  1K7I A;  1KAP P;  4FVL A;  1AYK A;  1SLM A;  4WKE A;  4JIJ A;  1QIC A;  3B8Z A;  1PWQ A;  1OMJ A;  1ZP5 A; 
#chains in the Genus database with same CATH topology
 2Z2D A;  4FXY P;  2JNP A;  1OM7 A;  3EHX A;  2DDY A;  1A85 A;  1AF0 A;  1QIB A;  5D2B A;  1GKD A;  3AYK A;  3LKA A;  1QUA A;  1MMB A;  5D7W A;  4DD8 A;  2E2D A;  1CGE A;  3KHI A;  4CTH A;  1WNI A;  1XFU A;  1G05 A;  1O0T A;  3HBU P;  5I3M A;  3LUN A;  1HFC A;  2DDF A;  2J83 A;  1UMS A;  3DTK A;  4ON1 A;  2MLS A;  5D1U A;  4G0D A;  1XFZ A;  2DW0 A;  1BQQ M;  1O0Q A;  4Q1L A;  1GE7 A;  2PJT A;  2YB9 A;  1MMQ A;  2OVX A;  4IN9 A;  3LQ0 A;  1Y0V A;  1H71 P;  4HMA A;  2JT6 A;  5I0L A;  4JQG A;  5H8X A;  3G42 A;  4WZV A;  1GE5 A;  2XS4 A;  2Y6D A;  4JA1 A;  1QIA A;  1KUK A;  3EDG A;  5LAB A;  3VTG A;  1SLN A;  1K7G A;  1CK7 A;  5I4O A;  1R1I A;  2O3E A;  1ZVX A;  1UEA A;  2W13 A;  4H76 A;  5I2Z A;  2L0R A;  3K7L A;  4AXQ A;  4WF6 A;  3LJG A;  3CKI A;  4WKI A;  3HBV P;  3LK8 A;  4PKS A;  1BUV M;  5D1T A;  2JT5 A;  1JIW P;  1Q3A A;  5CXA A;  3TS4 A;  2MLR A;  3KRY A;  3LMC A;  2W0D A;  2FV9 A;  5D1S A;  4QKZ A;  4A3W A;  1D7X A;  1ZTQ A;  1FBL A;  2OW9 A;  3KWV C;  1YOU A;  3LE9 A;  4PKW A;  4GUY A;  2OVZ A;  3KEJ A;  4EFS A;  1BUD A;  1YP1 A;  1RMZ A;  2WOA A;  3KEK A;  2OY2 A;  1XFY A;  3DPE A;  5D3C A;  2X3A A;  1L6J A;  3LJZ A;  3I7G A;  3LIL A;  3TSK A;  2KRJ A;  1YCM A;  4H3X A;  3LEA A;  1XFV A;  2W15 A;  1HOV A;  3L0V A;  4HX3 A;  4PKU A;  3WV3 A;  1BKC I;  1XAX A;  2OW0 A;  4PKV A;  1GE6 A;  1QJI A;  1EB6 A;  3TT4 A;  1EUB A;  3F16 A;  3OHO A;  1JH1 A;  3HY7 A;  2X3B A;  456C A;  1KUI A;  2RJQ A;  4PKT A;  4XBH A;  3TVC A;  1QJJ A;  1OS9 A;  3E8R A;  1FM1 A;  1AST A;  1GO8 P;  1Z3J A;  1BIW A;  1G4K A;  1C3I A;  2E3X A;  4ILW D;  1SRP A;  1K7Q A;  4JP4 A;  4JPA A;  3VI1 A;  4IJO A;  1PWP A;  1G49 A;  2RJP A;  3ZXH A;  1KUH A;  1CGL A;  1ATL A;  1EAK A;  3AYU A;  3I7I A;  3NX7 A;  4GR3 A;  1KBC A;  2W12 A;  2ERQ A;  1JAP A;  1HFS A;  1I1I P;  3GBO A;  2N8R A;  1CXV A;  1AKL A;  2AIG P;  1SMP A;  2X3C A;  4I03 A;  1JAQ A;  2W14 A;  3LQB A;  1R1J A;  1BSW A;  3DL1 A;  1PWV A;  2XS3 A;  3N2V A;  3P1V A;  1IAD A;  4DPE A;  2FV5 A;  1MNC A;  1C7K A;  2SRT A;  2ERP A;  1C8T A;  5B5P A;  3LUM A;  1OM8 A;  2OXW A;  4L19 A;  5CZM A;  1CGF A;  2WO8 A;  4GR8 A;  1D8M A;  1TVI A;  3DTE A;  3RTS A;  3EWJ A;  1ROS A;  4GQL A;  1JK3 A;  5BOT A;  1R1H A;  4FXQ A;  1DMT A;  4H1Q A;  4GR0 A;  4GWN A;  1CQR A;  2JIH A;  1USN A;  2POJ A;  3B92 A;  1JJ9 A;  2OZR A;  2AYK A;  3UVC A;  3DWB A;  1OZ9 A;  1B3D A;  3LJT A;  3F17 A;  1RM8 A;  3HB2 P;  1OS2 A;  1ZS0 A;  3N2U A;  4DV8 A;  1JAO A;  2V4B A;  4XM6 A;  4IUW A;  4L7A A;  2D1N A;  2MZI A;  3EDZ A;  3OHL A;  4AYK A;  1D5J A;  2OXU A;  1ZXC A;  5L7F A;  4PKQ A;  1KUF A;  3HDB A;  3G5C A;  966C A;  3DTI A;  1IAA A;  1Y93 A;  3SHI A;  1XUC A;  2YIG A;  1A86 A;  3L0T A;  2ERO A;  1HV5 A;  1B8Y A;  2K9C A;  1OM6 A;  2Y6C A;  3LIR A;  1BM6 A;  4R3V A;  1XUD A;  1PWU A;  4WK7 A;  3F15 A;  1SU3 A;  1XFX A;  5CUH A;  2YUF A;  1CAQ A;  1R54 A;  2MZE A;  1G9K A;  1IAB A;  4H84 A;  1J7N A;  2WO9 A;  3B2Z A;  4GWM A;  4H2E A;  4H30 A;  3WV2 A;  1GO7 P;  4L63 A;  3HYG A;  3P24 A;  3KME A;  2J0T A;  3HDA P;  2MZH A;  1BKC E;  3USN A;  1XFW A;  3V96 B;  2JSD A;  1MMP A;  3AIG A;  3O2X A;  1JIZ A;  1KUG A;  3WV1 A;  1FLS A;  1I73 A;  3O64 A;  3MA2 A;  1ND1 A;  1R55 A;  4ZR5 A;  3K7N A;  1IAG A;  3LGP A;  1UMT A;  3EDI A;  3LIK A;  4I35 A;  1YQY A;  3ZVS A;  1UTT A;  1JKY A;  2O36 A;  3KEC A;  1BZS A;  4AIG A;  4GF1 A;  1HY7 A;  2CLT A;  2K2G A;  3F1A A;  830C A;  1D8F A;  2QPJ A;  3BA0 A;  1Y8J A;  2D1O A;  2HU6 A;  3EHY A;  1GXD A;  4H49 A;  2DW2 A;  4L6T A;  3Q2H A;  4FU4 A;  2USN A;  3HY9 A;  1XM5 A;  3RTT A;  2TCL A;  5I43 A;  1PWW A;  5I12 A;  3F19 A;  1IAC A;  5BOY A;  1MMR A;  1SAT A;  1I76 A;  1XUR A;  1ZXV A;  4H82 A;  2OY4 A;  3EDH A;  4AUO A;  4XM7 A;  3F18 A;  3DNG A;  4J4M A;  3DSL A;  2CKI A;  1DTH A;  1S4B P;  4DF9 A;  4A7B A;  1BKC A;  5L79 A;  2OXZ A;  1GKC A;  4PKR A;  5JMY A;  4XCT A;  2I47 A;  1OO9 A;  2A8H A;  3U1R A;  3KMC A;  2OW1 A;  1BQO A;  3ELM A;  1UTZ A;  3Q2G A;  2OI0 A;  2X7M A;  1CIZ A;  2OW2 A;  4XM8 A;  4G9L A;  3DPF A;  1IAE A;  5B5O A;  3ZUK A;  2DW1 A;  5BPA A;  1G12 A;  1HTD A;  1JAN A;  1K7I A;  1KAP P;  4FVL A;  1AYK A;  1SLM A;  4WKE A;  4JIJ A;  1QIC A;  3B8Z A;  1PWQ A;  1OMJ A;  1ZP5 A; 
#chains in the Genus database with same CATH homology
 2Z2D A;  4FXY P;  2JNP A;  1OM7 A;  3EHX A;  2DDY A;  1A85 A;  1AF0 A;  1QIB A;  5D2B A;  1GKD A;  3AYK A;  3LKA A;  1QUA A;  1MMB A;  5D7W A;  4DD8 A;  2E2D A;  1CGE A;  3KHI A;  4CTH A;  1WNI A;  1XFU A;  1G05 A;  1O0T A;  3HBU P;  5I3M A;  3LUN A;  1HFC A;  2DDF A;  2J83 A;  1UMS A;  3DTK A;  4ON1 A;  2MLS A;  5D1U A;  4G0D A;  1XFZ A;  2DW0 A;  1BQQ M;  1O0Q A;  4Q1L A;  1GE7 A;  2PJT A;  2YB9 A;  1MMQ A;  2OVX A;  4IN9 A;  3LQ0 A;  1Y0V A;  1H71 P;  4HMA A;  2JT6 A;  5I0L A;  4JQG A;  5H8X A;  3G42 A;  4WZV A;  1GE5 A;  2XS4 A;  2Y6D A;  4JA1 A;  1QIA A;  1KUK A;  3EDG A;  5LAB A;  3VTG A;  1SLN A;  1K7G A;  1CK7 A;  5I4O A;  1R1I A;  2O3E A;  1ZVX A;  1UEA A;  2W13 A;  4H76 A;  5I2Z A;  2L0R A;  3K7L A;  4AXQ A;  4WF6 A;  3LJG A;  3CKI A;  4WKI A;  3HBV P;  3LK8 A;  4PKS A;  1BUV M;  5D1T A;  2JT5 A;  1JIW P;  1Q3A A;  5CXA A;  3TS4 A;  2MLR A;  3KRY A;  3LMC A;  2W0D A;  2FV9 A;  5D1S A;  4QKZ A;  4A3W A;  1D7X A;  1ZTQ A;  1FBL A;  2OW9 A;  3KWV C;  1YOU A;  3LE9 A;  4PKW A;  4GUY A;  2OVZ A;  3KEJ A;  4EFS A;  1BUD A;  1YP1 A;  1RMZ A;  2WOA A;  3KEK A;  2OY2 A;  1XFY A;  3DPE A;  5D3C A;  2X3A A;  1L6J A;  3LJZ A;  3I7G A;  3LIL A;  3TSK A;  2KRJ A;  1YCM A;  4H3X A;  3LEA A;  1XFV A;  2W15 A;  1HOV A;  3L0V A;  4HX3 A;  4PKU A;  3WV3 A;  1BKC I;  2OW0 A;  4PKV A;  1GE6 A;  1QJI A;  1EB6 A;  3TT4 A;  1EUB A;  3F16 A;  3OHO A;  1JH1 A;  3HY7 A;  2X3B A;  456C A;  1KUI A;  2RJQ A;  4PKT A;  4XBH A;  3TVC A;  1QJJ A;  1OS9 A;  3E8R A;  1FM1 A;  1AST A;  1GO8 P;  1Z3J A;  1BIW A;  1G4K A;  1C3I A;  2E3X A;  4ILW D;  1SRP A;  1K7Q A;  4JP4 A;  4JPA A;  3VI1 A;  4IJO A;  1PWP A;  1G49 A;  2RJP A;  3ZXH A;  1KUH A;  1CGL A;  1ATL A;  1EAK A;  3AYU A;  3I7I A;  3NX7 A;  4GR3 A;  1KBC A;  2W12 A;  2ERQ A;  1JAP A;  1HFS A;  1I1I P;  3GBO A;  2N8R A;  1CXV A;  1AKL A;  2AIG P;  1SMP A;  2X3C A;  4I03 A;  1JAQ A;  2W14 A;  3LQB A;  1R1J A;  1BSW A;  3DL1 A;  1PWV A;  2XS3 A;  3N2V A;  3P1V A;  1IAD A;  4DPE A;  2FV5 A;  1MNC A;  1C7K A;  2SRT A;  2ERP A;  1C8T A;  5B5P A;  3LUM A;  1OM8 A;  2OXW A;  4L19 A;  5CZM A;  1CGF A;  2WO8 A;  4GR8 A;  1D8M A;  3DTE A;  3RTS A;  3EWJ A;  1ROS A;  4GQL A;  1JK3 A;  5BOT A;  1R1H A;  4FXQ A;  1DMT A;  4H1Q A;  4GR0 A;  4GWN A;  1CQR A;  2JIH A;  1USN A;  2POJ A;  3B92 A;  1JJ9 A;  2OZR A;  2AYK A;  3UVC A;  3DWB A;  1B3D A;  3LJT A;  3F17 A;  1RM8 A;  3HB2 P;  1OS2 A;  1ZS0 A;  3N2U A;  4DV8 A;  1JAO A;  2V4B A;  4XM6 A;  4IUW A;  4L7A A;  2D1N A;  2MZI A;  3EDZ A;  3OHL A;  4AYK A;  1D5J A;  2OXU A;  1ZXC A;  5L7F A;  4PKQ A;  1KUF A;  3HDB A;  3G5C A;  966C A;  3DTI A;  1IAA A;  1Y93 A;  3SHI A;  1XUC A;  2YIG A;  1A86 A;  3L0T A;  2ERO A;  1HV5 A;  1B8Y A;  2K9C A;  1OM6 A;  2Y6C A;  3LIR A;  1BM6 A;  4R3V A;  1XUD A;  1PWU A;  4WK7 A;  3F15 A;  1SU3 A;  1XFX A;  5CUH A;  2YUF A;  1CAQ A;  1R54 A;  2MZE A;  1G9K A;  1IAB A;  4H84 A;  1J7N A;  2WO9 A;  3B2Z A;  4GWM A;  4H2E A;  4H30 A;  3WV2 A;  1GO7 P;  4L63 A;  3HYG A;  3P24 A;  3KME A;  2J0T A;  3HDA P;  2MZH A;  1BKC E;  3USN A;  1XFW A;  3V96 B;  2JSD A;  1MMP A;  3AIG A;  3O2X A;  1JIZ A;  1KUG A;  3WV1 A;  1FLS A;  1I73 A;  3O64 A;  3MA2 A;  1ND1 A;  1R55 A;  4ZR5 A;  3K7N A;  1IAG A;  3LGP A;  1UMT A;  3EDI A;  3LIK A;  4I35 A;  1YQY A;  3ZVS A;  1UTT A;  1JKY A;  2O36 A;  3KEC A;  1BZS A;  4AIG A;  4GF1 A;  1HY7 A;  2CLT A;  2K2G A;  3F1A A;  830C A;  1D8F A;  2QPJ A;  3BA0 A;  1Y8J A;  2D1O A;  2HU6 A;  3EHY A;  1GXD A;  4H49 A;  2DW2 A;  4L6T A;  3Q2H A;  4FU4 A;  2USN A;  3HY9 A;  3RTT A;  2TCL A;  5I43 A;  1PWW A;  5I12 A;  3F19 A;  1IAC A;  5BOY A;  1MMR A;  1SAT A;  1I76 A;  1XUR A;  1ZXV A;  4H82 A;  2OY4 A;  3EDH A;  4AUO A;  4XM7 A;  3F18 A;  3DNG A;  4J4M A;  3DSL A;  2CKI A;  1DTH A;  1S4B P;  4DF9 A;  4A7B A;  1BKC A;  5L79 A;  2OXZ A;  1GKC A;  4PKR A;  5JMY A;  4XCT A;  2I47 A;  1OO9 A;  2A8H A;  3U1R A;  3KMC A;  2OW1 A;  1BQO A;  3ELM A;  1UTZ A;  3Q2G A;  2OI0 A;  2X7M A;  1CIZ A;  2OW2 A;  4XM8 A;  4G9L A;  3DPF A;  1IAE A;  5B5O A;  3ZUK A;  2DW1 A;  5BPA A;  1G12 A;  1HTD A;  1JAN A;  1K7I A;  1KAP P;  4FVL A;  1AYK A;  1SLM A;  4WKE A;  4JIJ A;  1QIC A;  3B8Z A;  1PWQ A;  1OMJ A;  1ZP5 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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