4IKRA

Crystal structure of type 1 human methionine aminopeptidase in complex with 2-(4-(5-chloro-6-methyl-2-(pyridin-2-yl)pyrimidin-4-yl)piperazin-1-yl)ethanol
Total Genus 101
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
101
sequence length
304
structure length
304
Chain Sequence
YRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLFHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSARPHFMS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Identification, Biochemical and Structural Evaluation of Species-Specific Inhibitors against Type I Methionine Aminopeptidases
pubmed doi rcsb
molecule keywords Methionine aminopeptidase 1
source organism Homo sapiens
molecule tags Hydrolase
total genus 101
structure length 304
sequence length 304
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2012-12-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4ikrA00
1YJ3A 1R5HA 2BWVA 2BHBA 2GU7A 3BIQA 4FLLA 2BHDA 2EA4A 4U6WA 4ZWPA 1C24A 2Q96A 2ADUA 4S00A 1B6AA 3CB5A 1WLRA 3CB6A 4B28A 2BWUA 2EVMA 2HOWA 3TAVA 2GG8A 4Z7MA 2V3YA 3L7GA 1YW9A 1W2MA 2BWYA 4R60A 4PNCA 4U69A 5CE6A 1QZYA 4IDYA 1B59A 4IKSA 2GG0A 3BIPA 2EVOA 1QXYA 2BWWA 1YVMA 4S01A 2BB7A 2B3LA 1XGNA 1A16A 4IKUA 2BWXA 1BOAA 4A6WA 5FCHA 3TB5A 4FKCA 3PKCA 2V6CA 1BN5A 1C22A 4IKTA 2BWTA 1QXZA 1Y1NA 2OAZA 2B3KA 1O0XA 4KM3A 2GG7A 1C27A 2V3ZA 5E5BA 4U6CA 2GU5A 2NQ6A 1CHMA 4RZYA 2IW2A 3FM3A 3MR1A 4ZNGA 2B3HA 1KQ9A 4U76A 5JI6A 4IF7A 3S6BA 2GGBA 3IG4A 3PKAA 2GA2A 2GZ5A 5CDLA 1M35A 2GG5A 2P9AA 3IU9A 4MATA 3PKDA 2ZSGA 4IECA 4U6EA 2EA2A 3IU7A 1PV9A 4ZWUA 5D6FA 3RORA 1XGMA 4S2RP 4FLKA 4ZWOA 1R5GA 2BN7A 2BH3A 2Q95A 2Q94A 2EVCA 4IKRA 2OKNA 1XGSA 2NQ7A 2V3XA 3IU8A 4FLIA 2DFIA 5CLSA 4JUQA 3RVAA 2P98A 1WL6A 3BITA 2BWSA 2MATA 4PV4A 4QR8A 3PKBA 4RZZA 4U1BA 5CNXA 1QXWA 2BHCA 3MATA 3CTZA 4U70A 5FCFA 4U75A 5D6EA 3L24A 2Q8KA 2GU6A 1WKMA 2BHAA 4FO7A 2GTXA 2Q92A 1C21A 4OOKA 2P99A 4S2TP 1YW8A 2GU4A 4U6JA 4FO8A 4U71A 1N51A 3Q6DA 1C23A 5CIKA 4A6VA 1KP0A 1WN1A 1XGOA 4U73A 4HXXA 5JFRA 5JHUA 2GGCA 1JAWA 4EGEA 2G6PA 3MX6A 1XNZA 2GG2A 1R58A 3PKEA 2Q93A 1W7VA 1WBQA 4IPAA 5CDVA 4FLJA 1KQ0A 4IU6A 1MATA 4RGZ1 1YW7A 1WL9A 4FUKA 3FMQA 3FMRA 1WY2A 2GG9A 3D27A 2GG3A 4U6ZA 5CDEA
chains in the Genus database with same CATH superfamily
1YJ3A 1R5HA 2BWVA 2BHBA 2GU7A 3BIQA 4FLLA 2BHDA 2EA4A 4U6WA 4ZWPA 1C24A 2Q96A 2ADUA 4S00A 1B6AA 3CB5A 1WLRA 3CB6A 4B28A 2BWUA 2EVMA 2HOWA 3TAVA 2GG8A 4Z7MA 2V3YA 3L7GA 1YW9A 1W2MA 2BWYA 4R60A 4PNCA 4U69A 5CE6A 1QZYA 4IDYA 1B59A 4IKSA 2GG0A 3BIPA 2EVOA 1QXYA 2BWWA 1YVMA 4S01A 2BB7A 2B3LA 1XGNA 1A16A 4IKUA 2BWXA 1BOAA 4A6WA 5FCHA 3TB5A 4FKCA 3PKCA 2V6CA 1BN5A 1C22A 4IKTA 2BWTA 1QXZA 1Y1NA 2OAZA 2B3KA 1O0XA 4KM3A 2GG7A 1C27A 2V3ZA 5E5BA 4U6CA 2GU5A 2NQ6A 1CHMA 4RZYA 2IW2A 3FM3A 3MR1A 4ZNGA 2B3HA 1KQ9A 4U76A 5JI6A 4IF7A 3S6BA 2GGBA 3IG4A 3PKAA 2GA2A 2GZ5A 5CDLA 1M35A 2GG5A 2P9AA 3IU9A 4MATA 3PKDA 2ZSGA 4IECA 4U6EA 2EA2A 3IU7A 1PV9A 4ZWUA 5D6FA 3RORA 1XGMA 4S2RP 4FLKA 4ZWOA 1R5GA 2BN7A 2BH3A 2Q95A 2Q94A 2EVCA 4IKRA 2OKNA 1XGSA 2NQ7A 2V3XA 3IU8A 4FLIA 2DFIA 5CLSA 4JUQA 3RVAA 2P98A 1WL6A 3BITA 2BWSA 2MATA 4PV4A 4QR8A 3PKBA 4RZZA 4U1BA 5CNXA 1QXWA 2BHCA 3MATA 3CTZA 4U70A 5FCFA 4U75A 5D6EA 3L24A 2Q8KA 2GU6A 1WKMA 2BHAA 4FO7A 2GTXA 2Q92A 1C21A 4OOKA 2P99A 4S2TP 1YW8A 2GU4A 4U6JA 4FO8A 4U71A 1N51A 3Q6DA 1C23A 5CIKA 4A6VA 1KP0A 1WN1A 1XGOA 4U73A 4HXXA 5JFRA 5JHUA 2GGCA 1JAWA 4EGEA 2G6PA 3MX6A 1XNZA 2GG2A 1R58A 3PKEA 2Q93A 1W7VA 1WBQA 4IPAA 5CDVA 4FLJA 1KQ0A 4IU6A 1MATA 4RGZ1 1YW7A 1WL9A 4FUKA 3FMQA 3FMRA 1WY2A 2GG9A 3D27A 2GG3A 4U6ZA 5CDEA
chains in the Genus database with same CATH topology
1YJ3A 1R5HA 2BWVA 2BHBA 2GU7A 3BIQA 4FLLA 2BHDA 2EA4A 4U6WA 4ZWPA 1C24A 2Q96A 2ADUA 4S00A 1B6AA 3CB5A 1WLRA 3CB6A 4B28A 2BWUA 2EVMA 2HOWA 3TAVA 2GG8A 4Z7MA 2V3YA 3L7GA 1YW9A 1W2MA 2BWYA 4R60A 4PNCA 4U69A 5CE6A 1QZYA 4IDYA 1B59A 4IKSA 2GG0A 3BIPA 2EVOA 1QXYA 2BWWA 1YVMA 4S01A 2BB7A 2B3LA 1XGNA 1A16A 4IKUA 2BWXA 1BOAA 4A6WA 5FCHA 3TB5A 4FKCA 3PKCA 2V6CA 1BN5A 1C22A 4IKTA 2BWTA 1QXZA 1Y1NA 2OAZA 2B3KA 1O0XA 4KM3A 2GG7A 1C27A 2V3ZA 5E5BA 4U6CA 2GU5A 2NQ6A 1CHMA 4RZYA 2IW2A 3FM3A 3MR1A 4ZNGA 2B3HA 1KQ9A 4U76A 5JI6A 4IF7A 3S6BA 2GGBA 3IG4A 3PKAA 2GA2A 2GZ5A 5CDLA 1M35A 2GG5A 2P9AA 3IU9A 4MATA 3PKDA 2ZSGA 4IECA 4U6EA 2EA2A 3IU7A 1PV9A 4ZWUA 5D6FA 3RORA 1XGMA 4S2RP 4FLKA 4ZWOA 1R5GA 2BN7A 2BH3A 2Q95A 2Q94A 2EVCA 4IKRA 2OKNA 1XGSA 2NQ7A 2V3XA 3IU8A 4FLIA 2DFIA 5CLSA 4JUQA 3RVAA 2P98A 1WL6A 3BITA 2BWSA 2MATA 4PV4A 4QR8A 3PKBA 4RZZA 4U1BA 5CNXA 1QXWA 2BHCA 3MATA 3CTZA 4U70A 5FCFA 4U75A 5D6EA 3L24A 2Q8KA 2GU6A 1WKMA 2BHAA 4FO7A 2GTXA 2Q92A 1C21A 4OOKA 2P99A 4S2TP 1YW8A 2GU4A 4U6JA 4FO8A 4U71A 1N51A 3Q6DA 1C23A 5CIKA 4A6VA 1KP0A 1WN1A 1XGOA 4U73A 4HXXA 5JFRA 5JHUA 2GGCA 1JAWA 4EGEA 2G6PA 3MX6A 1XNZA 2GG2A 1R58A 3PKEA 2Q93A 1W7VA 1WBQA 4IPAA 5CDVA 4FLJA 1KQ0A 4IU6A 1MATA 4RGZ1 1YW7A 1WL9A 4FUKA 3FMQA 3FMRA 1WY2A 2GG9A 3D27A 2GG3A 4U6ZA 5CDEA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1YJ3 A;  1R5H A;  2BWV A;  2BHB A;  2GU7 A;  3BIQ A;  4FLL A;  2BHD A;  2EA4 A;  4U6W A;  4ZWP A;  1C24 A;  2Q96 A;  2ADU A;  4S00 A;  1B6A A;  3CB5 A;  1WLR A;  3CB6 A;  4B28 A;  2BWU A;  2EVM A;  2HOW A;  3TAV A;  2GG8 A;  4Z7M A;  2V3Y A;  3L7G A;  1YW9 A;  1W2M A;  2BWY A;  4R60 A;  4PNC A;  4U69 A;  5CE6 A;  1QZY A;  4IDY A;  1B59 A;  4IKS A;  2GG0 A;  3BIP A;  2EVO A;  1QXY A;  2BWW A;  1YVM A;  4S01 A;  2BB7 A;  2B3L A;  1XGN A;  1A16 A;  4IKU A;  2BWX A;  1BOA A;  4A6W A;  5FCH A;  3TB5 A;  4FKC A;  3PKC A;  2V6C A;  1BN5 A;  1C22 A;  4IKT A;  2BWT A;  1QXZ A;  1Y1N A;  2OAZ A;  2B3K A;  1O0X A;  4KM3 A;  2GG7 A;  1C27 A;  2V3Z A;  5E5B A;  4U6C A;  2GU5 A;  2NQ6 A;  1CHM A;  4RZY A;  2IW2 A;  3FM3 A;  3MR1 A;  4ZNG A;  2B3H A;  1KQ9 A;  4U76 A;  5JI6 A;  4IF7 A;  3S6B A;  2GGB A;  3IG4 A;  3PKA A;  2GA2 A;  2GZ5 A;  5CDL A;  1M35 A;  2GG5 A;  2P9A A;  3IU9 A;  4MAT A;  3PKD A;  2ZSG A;  4IEC A;  4U6E A;  2EA2 A;  3IU7 A;  1PV9 A;  4ZWU A;  5D6F A;  3ROR A;  1XGM A;  4S2R P;  4FLK A;  4ZWO A;  1R5G A;  2BN7 A;  2BH3 A;  2Q95 A;  2Q94 A;  2EVC A;  4IKR A;  2OKN A;  1XGS A;  2NQ7 A;  2V3X A;  3IU8 A;  4FLI A;  2DFI A;  5CLS A;  4JUQ A;  3RVA A;  2P98 A;  1WL6 A;  3BIT A;  2BWS A;  2MAT A;  4PV4 A;  4QR8 A;  3PKB A;  4RZZ A;  4U1B A;  5CNX A;  1QXW A;  2BHC A;  3MAT A;  3CTZ A;  4U70 A;  5FCF A;  4U75 A;  5D6E A;  3L24 A;  2Q8K A;  2GU6 A;  1WKM A;  2BHA A;  4FO7 A;  2GTX A;  2Q92 A;  1C21 A;  4OOK A;  2P99 A;  4S2T P;  1YW8 A;  2GU4 A;  4U6J A;  4FO8 A;  4U71 A;  1N51 A;  3Q6D A;  1C23 A;  5CIK A;  4A6V A;  1KP0 A;  1WN1 A;  1XGO A;  4U73 A;  4HXX A;  5JFR A;  5JHU A;  2GGC A;  1JAW A;  4EGE A;  2G6P A;  3MX6 A;  1XNZ A;  2GG2 A;  1R58 A;  3PKE A;  2Q93 A;  1W7V A;  1WBQ A;  4IPA A;  5CDV A;  4FLJ A;  1KQ0 A;  4IU6 A;  1MAT A;  4RGZ 1;  1YW7 A;  1WL9 A;  4FUK A;  3FMQ A;  3FMR A;  1WY2 A;  2GG9 A;  3D27 A;  2GG3 A;  4U6Z A;  5CDE A; 
#chains in the Genus database with same CATH topology
 1YJ3 A;  1R5H A;  2BWV A;  2BHB A;  2GU7 A;  3BIQ A;  4FLL A;  2BHD A;  2EA4 A;  4U6W A;  4ZWP A;  1C24 A;  2Q96 A;  2ADU A;  4S00 A;  1B6A A;  3CB5 A;  1WLR A;  3CB6 A;  4B28 A;  2BWU A;  2EVM A;  2HOW A;  3TAV A;  2GG8 A;  4Z7M A;  2V3Y A;  3L7G A;  1YW9 A;  1W2M A;  2BWY A;  4R60 A;  4PNC A;  4U69 A;  5CE6 A;  1QZY A;  4IDY A;  1B59 A;  4IKS A;  2GG0 A;  3BIP A;  2EVO A;  1QXY A;  2BWW A;  1YVM A;  4S01 A;  2BB7 A;  2B3L A;  1XGN A;  1A16 A;  4IKU A;  2BWX A;  1BOA A;  4A6W A;  5FCH A;  3TB5 A;  4FKC A;  3PKC A;  2V6C A;  1BN5 A;  1C22 A;  4IKT A;  2BWT A;  1QXZ A;  1Y1N A;  2OAZ A;  2B3K A;  1O0X A;  4KM3 A;  2GG7 A;  1C27 A;  2V3Z A;  5E5B A;  4U6C A;  2GU5 A;  2NQ6 A;  1CHM A;  4RZY A;  2IW2 A;  3FM3 A;  3MR1 A;  4ZNG A;  2B3H A;  1KQ9 A;  4U76 A;  5JI6 A;  4IF7 A;  3S6B A;  2GGB A;  3IG4 A;  3PKA A;  2GA2 A;  2GZ5 A;  5CDL A;  1M35 A;  2GG5 A;  2P9A A;  3IU9 A;  4MAT A;  3PKD A;  2ZSG A;  4IEC A;  4U6E A;  2EA2 A;  3IU7 A;  1PV9 A;  4ZWU A;  5D6F A;  3ROR A;  1XGM A;  4S2R P;  4FLK A;  4ZWO A;  1R5G A;  2BN7 A;  2BH3 A;  2Q95 A;  2Q94 A;  2EVC A;  4IKR A;  2OKN A;  1XGS A;  2NQ7 A;  2V3X A;  3IU8 A;  4FLI A;  2DFI A;  5CLS A;  4JUQ A;  3RVA A;  2P98 A;  1WL6 A;  3BIT A;  2BWS A;  2MAT A;  4PV4 A;  4QR8 A;  3PKB A;  4RZZ A;  4U1B A;  5CNX A;  1QXW A;  2BHC A;  3MAT A;  3CTZ A;  4U70 A;  5FCF A;  4U75 A;  5D6E A;  3L24 A;  2Q8K A;  2GU6 A;  1WKM A;  2BHA A;  4FO7 A;  2GTX A;  2Q92 A;  1C21 A;  4OOK A;  2P99 A;  4S2T P;  1YW8 A;  2GU4 A;  4U6J A;  4FO8 A;  4U71 A;  1N51 A;  3Q6D A;  1C23 A;  5CIK A;  4A6V A;  1KP0 A;  1WN1 A;  1XGO A;  4U73 A;  4HXX A;  5JFR A;  5JHU A;  2GGC A;  1JAW A;  4EGE A;  2G6P A;  3MX6 A;  1XNZ A;  2GG2 A;  1R58 A;  3PKE A;  2Q93 A;  1W7V A;  1WBQ A;  4IPA A;  5CDV A;  4FLJ A;  1KQ0 A;  4IU6 A;  1MAT A;  4RGZ 1;  1YW7 A;  1WL9 A;  4FUK A;  3FMQ A;  3FMR A;  1WY2 A;  2GG9 A;  3D27 A;  2GG3 A;  4U6Z A;  5CDE A; 
#chains in the Genus database with same CATH homology
 1YJ3 A;  1R5H A;  2BWV A;  2BHB A;  2GU7 A;  3BIQ A;  4FLL A;  2BHD A;  2EA4 A;  4U6W A;  4ZWP A;  1C24 A;  2Q96 A;  2ADU A;  4S00 A;  1B6A A;  3CB5 A;  1WLR A;  3CB6 A;  4B28 A;  2BWU A;  2EVM A;  2HOW A;  3TAV A;  2GG8 A;  4Z7M A;  2V3Y A;  3L7G A;  1YW9 A;  1W2M A;  2BWY A;  4R60 A;  4PNC A;  4U69 A;  5CE6 A;  1QZY A;  4IDY A;  1B59 A;  4IKS A;  2GG0 A;  3BIP A;  2EVO A;  1QXY A;  2BWW A;  1YVM A;  4S01 A;  2BB7 A;  2B3L A;  1XGN A;  1A16 A;  4IKU A;  2BWX A;  1BOA A;  4A6W A;  5FCH A;  3TB5 A;  4FKC A;  3PKC A;  2V6C A;  1BN5 A;  1C22 A;  4IKT A;  2BWT A;  1QXZ A;  1Y1N A;  2OAZ A;  2B3K A;  1O0X A;  4KM3 A;  2GG7 A;  1C27 A;  2V3Z A;  5E5B A;  4U6C A;  2GU5 A;  2NQ6 A;  1CHM A;  4RZY A;  2IW2 A;  3FM3 A;  3MR1 A;  4ZNG A;  2B3H A;  1KQ9 A;  4U76 A;  5JI6 A;  4IF7 A;  3S6B A;  2GGB A;  3IG4 A;  3PKA A;  2GA2 A;  2GZ5 A;  5CDL A;  1M35 A;  2GG5 A;  2P9A A;  3IU9 A;  4MAT A;  3PKD A;  2ZSG A;  4IEC A;  4U6E A;  2EA2 A;  3IU7 A;  1PV9 A;  4ZWU A;  5D6F A;  3ROR A;  1XGM A;  4S2R P;  4FLK A;  4ZWO A;  1R5G A;  2BN7 A;  2BH3 A;  2Q95 A;  2Q94 A;  2EVC A;  4IKR A;  2OKN A;  1XGS A;  2NQ7 A;  2V3X A;  3IU8 A;  4FLI A;  2DFI A;  5CLS A;  4JUQ A;  3RVA A;  2P98 A;  1WL6 A;  3BIT A;  2BWS A;  2MAT A;  4PV4 A;  4QR8 A;  3PKB A;  4RZZ A;  4U1B A;  5CNX A;  1QXW A;  2BHC A;  3MAT A;  3CTZ A;  4U70 A;  5FCF A;  4U75 A;  5D6E A;  3L24 A;  2Q8K A;  2GU6 A;  1WKM A;  2BHA A;  4FO7 A;  2GTX A;  2Q92 A;  1C21 A;  4OOK A;  2P99 A;  4S2T P;  1YW8 A;  2GU4 A;  4U6J A;  4FO8 A;  4U71 A;  1N51 A;  3Q6D A;  1C23 A;  5CIK A;  4A6V A;  1KP0 A;  1WN1 A;  1XGO A;  4U73 A;  4HXX A;  5JFR A;  5JHU A;  2GGC A;  1JAW A;  4EGE A;  2G6P A;  3MX6 A;  1XNZ A;  2GG2 A;  1R58 A;  3PKE A;  2Q93 A;  1W7V A;  1WBQ A;  4IPA A;  5CDV A;  4FLJ A;  1KQ0 A;  4IU6 A;  1MAT A;  4RGZ 1;  1YW7 A;  1WL9 A;  4FUK A;  3FMQ A;  3FMR A;  1WY2 A;  2GG9 A;  3D27 A;  2GG3 A;  4U6Z A;  5CDE A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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