4IOAS

Crystal structure of compound 4e bound to large ribosomal subunit (50s) from deinococcus radiodurans
Total Genus 25
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
25
sequence length
175
structure length
175
Chain Sequence
MELTAKPRTPKQKLDESMIAAVAYNKENNVSFALDRKAFDRAFRQQSTTGLFDITVEGGETFPALVKAVQMDKRKRAPIHVDFYMVTYGEPVEVSVPVHTTGRSQGEVQGGLVDIVVHNLQIVAPGPRRIPQELVVDVTKMNIGDHITAGDIKLPEGCTLAADPELTVVSVLPPR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Novel 3-O-carbamoyl erythromycin A derivatives (carbamolides) with activity against resistant staphylococcal and streptococcal isolates.
pubmed doi rcsb
molecule tags Ribosome/ribosome inhibitor
molecule keywords 23S ribosomal RNA
total genus 25
structure length 175
sequence length 175
ec nomenclature
pdb deposition date 2013-01-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
S PF01386 Ribosomal_L25p Ribosomal L25p family
S PF14693 Ribosomal_TL5_C Ribosomal protein TL5, C-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.40.240.10 Mainly Beta Beta Barrel Ribosomal Protein L25; Chain P Ribosomal Protein L25; Chain P 4ioaS01
2.170.120.20 Mainly Beta Beta Complex RNA Polymerase Alpha Subunit; Chain A, domain 2 Ribosomal protein L25, beta domain 4ioaS02
1QRTA 5DM7S 1ZJWA 5IZNA 3DLLS 1QTQA 5GAHW 4IOCS 4JXZA 4IO9S 4WF9S 2RE8A 3J7ZV 5DM6S 2ZJRS 5GAEW 5BNZA 1QRSA 5GAGW 5JVGS 1EXDA 4WCES 5GADW 4U67S 4WFBS 1B75A 5HL7S 1EUYA 4WFAS 3CF5S 3PIPS 5JVHS 4JYZA 1EUQA 4P2BA 1GTSA 1GTRA 1QRUA 1D6KA 4H3SA 2ZJQS 1FEUA 1O0CA 1NYLA 3AIIA 2HZ7A 2ZJPS 2RD2A 1O0BA 4IOAS 4UY88 3PIOS 1DFUP 4JXXA 4WFNS
chains in the Genus database with same CATH superfamily
1I6VA 5FLMC 3K7AC 1QRTA 3S1NC 5IP9C 2GAEA 5DM7S 2L5NA 4YFNA 1ZJWA 5IZNA 4OIOA 4C3IC 4BY7C 4WF9S 2JA8C 3J7ZV 2ZJRS 1Y1VC 1HQMA 5D4DA 3GTOC 5GAGW 3GTGC 2PA8D 4NOIA 1I50C 1TWAC 1ZYRA 4WCES 2E2HC 4C2MC 4U67S 4A3FC 4G7HA 5HL7S 1EUYA 4XSZA 2EGVA 4WFAS 4G7ZA 3W2VB 4MEXA 2JA6C 3GTJC 2PNWA 4OIPA 2PI8A 2A69A 4H3SA 3GTLC 3HOVC 3LYWA 4LK1A 3S2DC 2ZJPS 2A68A 1TWCC 2EGWA 1Y1WC 4GZYA 4JXXA 4H4KA 4WFNS 4G7OA 3PO3C 2R93C 2WB1D 3S1MC 4KN7A 4IOCS 5IP7C 2L3UA 4BBSC 2JA7C 2R7ZC 4LK0A 1VHYA 5TMCA 1TWGC 4BY1C 4A3GC 4YG2A 3GTQC 2JA5C 5GADW 1K83C 4WFBS 1B75A 4A3MC 4BXXC 3W2WB 5HQHA 4MEYA 1Z85A 3S16C 4JYZA 2G5DA 1D6KA 3S2HC 2ZJQS 3PO2C 1FEUA 1SMYA 1O0CA 3X1LB 3AIIA 2RD2A 2CX8A 1O0BA 4BBRC 2PMZD 4YFKA 4MQ9A 4XLPA 1YNJA 3HOUC 3PIOS 2YU9C 4A3DC 2KPUA 2E2IC 5IYCC 2PJJA 4C3JC 2AE0X 3S15C 2Z0YA 1QTQA 4ZH4A 4IO9S 1NXZA 2RE8A 2NVYC 1I3QC 2Y0SD 4YFXA 1SFOC 1QRSA 2A6EA 5JVGS 3CQZC 4LLGA 4XSXA 3M4OC 4A93C 5C44C 4C3HC 2E2JC 2O5IA 1VHKA 3S14C 2NVXC 4Y52C 1UDXA 2BE5A 3HKZD 4OIQA 5C4JC 3FKIC 1EUQA 2KXYA 4P2BA 1GTRA 2NWAA 2WAQD 2NVTC 3WODA 3H0GC 3M3YC 4OIRA 4Q4ZA 1TWHC 4A3LC 3HOZC 4X6AC 3HOXC 2A6HA 1I6HC 3S1RC 5C4XC 4JK1A 1DFUP 1EXDA 4AYBD 4KN4A 1IW7A 2B63C 4A3KC 3GTKC 4Q5SA 3DLLS 3S1QC 5GAHW 2PPBA 4Y7NC 4JXZA 3RZOC 2NVQC 2O5JA 4A3JC 3H3VD 5DM6S 4V194 4QIWD 5GAEW 5BNZA 3I4MC 3KW2A 4A3EC 4QJVA 5TMFA 2VUMC 2PICA 1V6ZA 3DXJA 4J3CA 5IYBC 2CW0A 3HOWC 3I4NC 5IYDC 3CF5S 4A3BC 3PIPS 3GTMC 4OINA 5JVHS 3CZBA 1GTSA 1QRUA 1TWFC 4XLNA 3RZDC 4A3CC 1BDFA 4LJZA 1WCMC 3EQLA 5C3EC 1R9TC 4A3IC 1NYLA 1YNNA 2KQ1A 2HZ7A 4E8BA 3GTPC 2G6GA 3HOYC 3S17C 4L69A 4IOAS 4UY88 4KMUA 2R92C
chains in the Genus database with same CATH topology
1QRTA 5DM7S 1ZJWA 5IZNA 3DLLS 1QTQA 5GAHW 4IOCS 4JXZA 4IO9S 4WF9S 2RE8A 3J7ZV 5DM6S 2ZJRS 4V194 5GAEW 5BNZA 1QRSA 5GAGW 5JVGS 1EXDA 4WCES 5GADW 4U67S 4WFBS 1B75A 5HL7S 1EUYA 4WFAS 3CF5S 3W2VB 1UDXA 3W2WB 3PIPS 5JVHS 4JYZA 1EUQA 4P2BA 1GTSA 1GTRA 1QRUA 1D6KA 4H3SA 2ZJQS 1FEUA 4JXXA 1O0CA 3X1LB 1NYLA 3AIIA 2HZ7A 2ZJPS 2RD2A 1O0BA 4IOAS 4UY88 3PIOS 1DFUP 4H4KA 4WFNS
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1QRT A;  5DM7 S;  1ZJW A;  5IZN A;  3DLL S;  1QTQ A;  5GAH W;  4IOC S;  4JXZ A;  4IO9 S;  4WF9 S;  2RE8 A;  3J7Z V;  5DM6 S;  2ZJR S;  5GAE W;  5BNZ A;  1QRS A;  5GAG W;  5JVG S;  1EXD A;  4WCE S;  5GAD W;  4U67 S;  4WFB S;  1B75 A;  5HL7 S;  1EUY A;  4WFA S;  3CF5 S;  3PIP S;  5JVH S;  4JYZ A;  1EUQ A;  4P2B A;  1GTS A;  1GTR A;  1QRU A;  1D6K A;  4H3S A;  2ZJQ S;  1FEU A;  1O0C A;  1NYL A;  3AII A;  2HZ7 A;  2ZJP S;  2RD2 A;  1O0B A;  4IOA S;  4UY8 8;  3PIO S;  1DFU P;  4JXX A;  4WFN S; 
#chains in the Genus database with same CATH topology
 1I6V A;  5FLM C;  3K7A C;  1QRT A;  3S1N C;  5IP9 C;  2GAE A;  5DM7 S;  2L5N A;  4YFN A;  1ZJW A;  5IZN A;  4OIO A;  4C3I C;  4BY7 C;  4WF9 S;  2JA8 C;  3J7Z V;  2ZJR S;  1Y1V C;  1HQM A;  5D4D A;  3GTO C;  5GAG W;  3GTG C;  2PA8 D;  4NOI A;  1I50 C;  1TWA C;  1ZYR A;  4WCE S;  2E2H C;  4C2M C;  4U67 S;  4A3F C;  4G7H A;  5HL7 S;  1EUY A;  4XSZ A;  2EGV A;  4WFA S;  4G7Z A;  3W2V B;  4MEX A;  2JA6 C;  3GTJ C;  2PNW A;  4OIP A;  2PI8 A;  2A69 A;  4H3S A;  3GTL C;  3HOV C;  3LYW A;  4LK1 A;  3S2D C;  2ZJP S;  2A68 A;  1TWC C;  2EGW A;  1Y1W C;  4GZY A;  4JXX A;  4H4K A;  4WFN S;  4G7O A;  3PO3 C;  2R93 C;  2WB1 D;  3S1M C;  4KN7 A;  4IOC S;  5IP7 C;  2L3U A;  4BBS C;  2JA7 C;  2R7Z C;  4LK0 A;  1VHY A;  5TMC A;  1TWG C;  4BY1 C;  4A3G C;  4YG2 A;  3GTQ C;  2JA5 C;  5GAD W;  1K83 C;  4WFB S;  1B75 A;  4A3M C;  4BXX C;  3W2W B;  5HQH A;  4MEY A;  1Z85 A;  3S16 C;  4JYZ A;  2G5D A;  1D6K A;  3S2H C;  2ZJQ S;  3PO2 C;  1FEU A;  1SMY A;  1O0C A;  3X1L B;  3AII A;  2RD2 A;  2CX8 A;  1O0B A;  4BBR C;  2PMZ D;  4YFK A;  4MQ9 A;  4XLP A;  1YNJ A;  3HOU C;  3PIO S;  2YU9 C;  4A3D C;  2KPU A;  2E2I C;  5IYC C;  2PJJ A;  4C3J C;  2AE0 X;  3S15 C;  2Z0Y A;  1QTQ A;  4ZH4 A;  4IO9 S;  1NXZ A;  2RE8 A;  2NVY C;  1I3Q C;  2Y0S D;  4YFX A;  1SFO C;  1QRS A;  2A6E A;  5JVG S;  3CQZ C;  4LLG A;  4XSX A;  3M4O C;  4A93 C;  5C44 C;  4C3H C;  2E2J C;  2O5I A;  1VHK A;  3S14 C;  2NVX C;  4Y52 C;  1UDX A;  2BE5 A;  3HKZ D;  4OIQ A;  5C4J C;  3FKI C;  1EUQ A;  2KXY A;  4P2B A;  1GTR A;  2NWA A;  2WAQ D;  2NVT C;  3WOD A;  3H0G C;  3M3Y C;  4OIR A;  4Q4Z A;  1TWH C;  4A3L C;  3HOZ C;  4X6A C;  3HOX C;  2A6H A;  1I6H C;  3S1R C;  5C4X C;  4JK1 A;  1DFU P;  1EXD A;  4AYB D;  4KN4 A;  1IW7 A;  2B63 C;  4A3K C;  3GTK C;  4Q5S A;  3DLL S;  3S1Q C;  5GAH W;  2PPB A;  4Y7N C;  4JXZ A;  3RZO C;  2NVQ C;  2O5J A;  4A3J C;  3H3V D;  5DM6 S;  4V19 4;  4QIW D;  5GAE W;  5BNZ A;  3I4M C;  3KW2 A;  4A3E C;  4QJV A;  5TMF A;  2VUM C;  2PIC A;  1V6Z A;  3DXJ A;  4J3C A;  5IYB C;  2CW0 A;  3HOW C;  3I4N C;  5IYD C;  3CF5 S;  4A3B C;  3PIP S;  3GTM C;  4OIN A;  5JVH S;  3CZB A;  1GTS A;  1QRU A;  1TWF C;  4XLN A;  3RZD C;  4A3C C;  1BDF A;  4LJZ A;  1WCM C;  3EQL A;  5C3E C;  1R9T C;  4A3I C;  1NYL A;  1YNN A;  2KQ1 A;  2HZ7 A;  4E8B A;  3GTP C;  2G6G A;  3HOY C;  3S17 C;  4L69 A;  4IOA S;  4UY8 8;  4KMU A;  2R92 C; 
#chains in the Genus database with same CATH homology
 1QRT A;  5DM7 S;  1ZJW A;  5IZN A;  3DLL S;  1QTQ A;  5GAH W;  4IOC S;  4JXZ A;  4IO9 S;  4WF9 S;  2RE8 A;  3J7Z V;  5DM6 S;  2ZJR S;  4V19 4;  5GAE W;  5BNZ A;  1QRS A;  5GAG W;  5JVG S;  1EXD A;  4WCE S;  5GAD W;  4U67 S;  4WFB S;  1B75 A;  5HL7 S;  1EUY A;  4WFA S;  3CF5 S;  3W2V B;  1UDX A;  3W2W B;  3PIP S;  5JVH S;  4JYZ A;  1EUQ A;  4P2B A;  1GTS A;  1GTR A;  1QRU A;  1D6K A;  4H3S A;  2ZJQ S;  1FEU A;  4JXX A;  1O0C A;  3X1L B;  1NYL A;  3AII A;  2HZ7 A;  2ZJP S;  2RD2 A;  1O0B A;  4IOA S;  4UY8 8;  3PIO S;  1DFU P;  4H4K A;  4WFN S; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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