4IS9A

Crystal structure of the escherichia coli lpxc/l-161,240 complex
Total Genus 83
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
83
sequence length
300
structure length
300
Chain Sequence
MIKQRTLKRIVQATGVGLHTGKKVTLTLRPAPANTGVIYRRTDLNPPVDFPADAKSVRDTMLCTCLVNEHDVRISTVEHLNAALAGLGIDNIVIEVNAPEIPIMDGSAAPFVYLLLDAGIDELNCAKKFVRIKETVRVEDGDKWAEFKPYNGFSLDFTIDFNHPAIDSSNQRYAMNFSADAFMRQISRARTFGFMRDIEYLQSRGLCLGGSFDCAIVVDDYRVLNEDGLRFEDEFVRHKMLDAIGDLFMCGHNIIGAFTAYKSGHALNNKLLQAVLAKQEAWEYVTFQDDAELPLAFKAP
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase
publication title Structural Basis of the Promiscuous Inhibitor Susceptibility of Escherichia coli LpxC.
pubmed doi rcsb
source organism Escherichia coli
molecule tags Hydrolase/hydrolase inhibitor
total genus 83
structure length 300
sequence length 300
chains with identical sequence B
ec nomenclature ec 3.5.1.-:
pdb deposition date 2013-01-16
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.230.20 Alpha Beta 2-Layer Sandwich Ribosomal Protein S5; domain 2 lpxc deacetylase, domain 1 4is9A01
3.30.1700.10 Alpha Beta 2-Layer Sandwich lpxc deacetylase, domain 1 lpxc deacetylase, domain 2 4is9A02
5DROA 3NZKA 4LCGA 3U1YA 4OKGA 2IESA 5DRQA 4J3DA 1YH8A 4LCHA 4MDTA 4MQYA 3P3GA 4IS9A 2GO4A 3UHMA 4FW3A 2O3ZA 1YHCA 3PS2A 4FW6A 2J65A 1XXEA 3PS3A 3PS1A 3P76A 2GO3A 4LCFA 4OZEA 4FW7A 2VESA 4FW5A 2JT2A 4U3DA 3P3CA 1P42A 2IERA 3P3EA 5DRRA 5DRPA 4FW4A 4U3BA 4ISAA
chains in the Genus database with same CATH superfamily
4LCHA 1E3PA 4JI4I 4IFDA 2X7IA 4B3ME 2PO1B 4DUYE 1MX0A 4B3TI 4IFDF 5JEAA 2DEJA 4NXNE 2C39B 3HULA 4JI5I 1U2RA 3P76A 5C0XA 4DV7I 5JEAF 4M1KA 4B3TE 5C0XF 5L3JA 4OO1D 4DR5I 4GKKI 1H72C 1H74A 1FNMA 2HFSA 2HKJA 1FKAE 4Z7CA 2VQEE 2WW4A 2JEAA 2NN6D 4XTJA 3PYGA 2UXBI 4DR1I 4OX9I 3J80C 4DV6I 4JI7I 2JEBA 4HXZA 4K0KI 5FLXQ 2PO2A 4GKJE 5A2QC 4FW3A 4JI0I 4B3SE 1FWLA 4DPYA 1XMOE 5EL9A 3LNUA 4MU0A 2R3VA 2UUBE 1HNWE 4AIMA 5IWAE 4JI0E 1KKHA 2BA0D 2Z5CB 3GONA 1N36I 4LF8E 2V2QA 4LF4E 1Y60A 2BM0A 2Z5BB 4J3DA 1N32E 4BA2B 1N36E 4HYMA 4DUZI 2HKEA 3WU5A 1Y5YA 1I94E 5IT9Q 2JE6A 1OYPA 4DUZE 4OZEA 3QT8A 1FI4A 4JI6I 4LF7I 3T1HI 1EA6A 4HY1A 4PRXA 4RPFA 2BA1G 1J5EE 2PNLA 2BV3A 1N0UA 1RHYA 2HK3A 4JG4A 3WU4A 1B62A 4X64E 4AQYE 4MQYA 4DR7I 3HJCA 2LJPA 3KRNA 5BR8E 1KVKA 3ZKBA 5K36E 2DEIA 4DV1E 1PIEA 2WP8A 4IZJA 4LFBI 3PS3A 3CDJA 5JEAB 1KIJA 3CWVA 5C0XB 4DR3E 1MU5A 1Y4SA 1P42A 3P3CA 4MU1A 1HNZE 4JYAI 4LFBE 1B63A 4LFCE 3JAMC 4DPXA 1Z0EA 1Z0VA 4JI2I 2CGEA 3D4JA 3LTOA 4BA2A 4JYAE 3J7AG 1IBKI 2NPFA 2AJ4A 2JEAB 2E5LE 1N0VC 4LF5E 3P06A 1BKNA 4JI1E 4FW6A 4DR6E 5FLXC 1N34E 4X62E 3PYEA 1Y6ZA 1OJ4A 4YHHE 4NXME 4USKA 4JI3I 2VQFE 4GQUA 1KTVA 1Z0BA 3ZZTA 4X66E 1XMQE 3PRYA 2A2CA 2UU9E 3PYFA 4PU9A 4JI3E 3M7NG 4WUCA 2GS8A 1ZM9A 4MDTA 3ZKDA 4DV3I 1HNXE 2E1RA 2HHHI 3K1JA 1MG7A 3GLLA 4DR4I 3QT6A 2C38A 4FWGA 3L7ZB 4JI4E 2O1UA 5IT9C 2UUAI 2JE6B 3H4LA 4N3OA 1RREA 1VISA 1HR0I 4JI5E 4JI8I 4KHPI 1IBLI 1XNQI 4DV7E 4EMDA 2J7KA 1Z0CA 3ZM7A 4DR5E 1HR0E 4GKKE 4KHPE 1ZXMA 2VF3A 2GO4A 4DU8A 4DV5I 4IZKB 4OO1E 4USMA 2F1DA 2UXBE 4DR1E 1S16A 2GO3A 4BA1A 4OX9E 4JI7E 4DV6E 2WP8B 4IZJB 4FW5A 1USVA 4K0KE 4ZVIA 2NN6E 3F0NA 2V2ZA 3M85D 5DRPA 4NBQA 1EI1A 1UDNA 4AIDA 4DV4I 3OTOI 5DNLA 4I3HA 4Z7YA 2ZBKB 2PNZA 1ZXNA 4JV5I 1R6LA 2PO0B 4YY3I 1WUUA 3OTOE 3L7ZA 3PS1A 2HFUA 1N33I 5K36B 4YY3E 4QNJA 1NZ0A 1PKPA 3T1YI 2NN6A 3GMEA 2BM1A 1N33E 5DROA 4LCGA 4OKGA 4JI6E 3T1YE 1HK7A 4LF7E 5K36C 4B3RI 2UXCI 1YH8A 2ZM6I 3T1HE 2Z5EA 4FW9A 1K47A 4IS9A 4IZKA 4WUBA 1H7SA 4B3RE 2UXCE 3CDIA 4DV0I 4DR7E 4LCFA 4X65I 2C38B 2JT2A 1S4EA 2BR2A 2V2VA 1UDSA 3P3EA 1QZRA 2BA0G 2R42A 3B8HA 3Q1QA 4KQVA 1FJGI 4FN5A 4FWDA 2UXDI 2PO0A 1VI7A 5ELWA 2A2DA 1A6FA 3P3GA 4JI2E 3M6AA 3B4TA 2UXDE 5K36A 1XXEA 4DPWA 3J81Q 2X36A 1IBKE 4IFDD 2V34A 5K36F 1XNRI 4DXLA 5JEAD 4BA1B 2AE8A 2EFGA 5C0XD 2OI2A 1XNRE 3NZKA 4ED4A 5LMNI 2IESA 1NHIA 5GMEA 4IFDE 4MYUA 4LFAI 1H73A 4R1FA 2PNZB 2HK2A 3H1CA 3UHMA 2O1VA 4LF9I 4DR2I 1H7UA 4WUDA 4LFAE 1ZM2A 4DV3E 2WNRB 4OO1B 1USUA 2HHHE 4FW7A 4DR4E 4MU4A 3QT7A 4LF9E 2IOPA 5EKWA 4B3MI 4U3BA 2PNMA 2NN6B 4DUYI 2UUAE 3U1KA 4NXNI 2XEXA 4OO1C 5FWKA 1XHKA 4JI8E 1IBLE 5GMDA 4URLA 3V5RA 1XNQE 1DARA 4AM3A 2NN6C 1D6TA 2F4VI 4HACA 2GQ0A 2VQEI 3JAMQ 2Q2EB 1ELOA 4DPUA 4DV5E 4MU3A 2F4VE 2BA1D 2BR2B 2O1WA 4GKJI 4B3SI 3Q6NA 1XMOI 3B82A 2C37B 2V8PA 4LPFA 2UUBI 1HNWI 5IWAI 4DV4E 5LMUI 2WNRA 3K85A 4OO1A 1Z0TA 4LF8I 4JV5E 1UDQA 1Z0GA 4P52A 3ZZUA 4LF4I 3ZZ0A 4OO1F 3J81C 1Z5AA 1R6MA 5LMUE 3GCMA 2UUCI 1N32I 4IZJD 3WU3A 2NN6F 3PYDA 3B78A 3V2UC 3U1YA 1I94I 5LL6R 5DRQA 2ZITA 2PO1A 2UUCE 1E3HA 2C39A 2CVEA 3LPSA 1NHHA 1OYRA 1YHCA 4UTGA 2ZM6E 1J5EI 2CG9A 4P7AA 1Z0WA 1Y4UA 1Z5BA 5K36D 4DPTA 3M85G 1PVGA 5DRRA 4X64I 4AQYI 1Z5CA 3HKMA 4DV0E 5BR8I 4X65E 4DV1I 2C37A 1UEKA 2CZ9A 3J80Q 3M7ND 4FWHA 5A2QQ 4QNKA 3DD6A 2O1TA 1FJGE 4IFDB 4DR3I 1HNZI 3PS2A 4PRVA 4LFCI 2IOQA 4LOMA 1FWKA 2Z5CA 5DNXA 4LF6I 4U3DA 4HACB 1Z59A 4FW4A 4IFDC 3QT5A 2Z5BA 2E5LI 4LF5I 4JI1I 5JEAC 1RR9A 4LF6E 4DR6I 3J7AM 4DV2I 1ZM3A 1N34I 1IBMI 4X62I 4UT4A 5C0XC 3Q6MA 4YHHI 4NXMI 1OYSA 4MYTA 1UDOA 2O3ZA 2JEBB 5JEAE 1NHJA 2VQFI 2J65A 5LMNE 4DV2E 1IBME 3K17A 3WU6A 2PO2B 4DU7A 5C0XE 4X66I 1XMQI 2VESA 2UU9I 2IERA 1ZM4A 1HNXI 4DR2E 4ISAA
chains in the Genus database with same CATH topology
5DROA 3NZKA 4LCGA 3U1YA 4OKGA 2IESA 5DRQA 4J3DA 1YH8A 4LCHA 4MDTA 4MQYA 3P3GA 4IS9A 2GO4A 3UHMA 4FW3A 2O3ZA 1YHCA 3PS2A 4FW6A 2J65A 1XXEA 3PS3A 3PS1A 3P76A 2GO3A 4LCFA 4OZEA 4FW7A 2VESA 4FW5A 2JT2A 4U3DA 3P3CA 1P42A 2IERA 3P3EA 5DRRA 5DRPA 4FW4A 4U3BA 4ISAA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5DRO A;  3NZK A;  4LCG A;  3U1Y A;  4OKG A;  2IES A;  5DRQ A;  4J3D A;  1YH8 A;  4LCH A;  4MDT A;  4MQY A;  3P3G A;  4IS9 A;  2GO4 A;  3UHM A;  4FW3 A;  2O3Z A;  1YHC A;  3PS2 A;  4FW6 A;  2J65 A;  1XXE A;  3PS3 A;  3PS1 A;  3P76 A;  2GO3 A;  4LCF A;  4OZE A;  4FW7 A;  2VES A;  4FW5 A;  2JT2 A;  4U3D A;  3P3C A;  1P42 A;  2IER A;  3P3E A;  5DRR A;  5DRP A;  4FW4 A;  4U3B A;  4ISA A; 
#chains in the Genus database with same CATH topology
 4LCH A;  1E3P A;  4JI4 I;  4IFD A;  2X7I A;  4B3M E;  2PO1 B;  4DUY E;  1MX0 A;  4B3T I;  4IFD F;  5JEA A;  2DEJ A;  4NXN E;  2C39 B;  3HUL A;  4JI5 I;  1U2R A;  3P76 A;  5C0X A;  4DV7 I;  5JEA F;  4M1K A;  4B3T E;  5C0X F;  5L3J A;  4OO1 D;  4DR5 I;  4GKK I;  1H72 C;  1H74 A;  1FNM A;  2HFS A;  2HKJ A;  1FKA E;  4Z7C A;  2VQE E;  2WW4 A;  2JEA A;  2NN6 D;  4XTJ A;  3PYG A;  2UXB I;  4DR1 I;  4OX9 I;  3J80 C;  4DV6 I;  4JI7 I;  2JEB A;  4HXZ A;  4K0K I;  5FLX Q;  2PO2 A;  4GKJ E;  5A2Q C;  4FW3 A;  4JI0 I;  4B3S E;  1FWL A;  4DPY A;  1XMO E;  5EL9 A;  3LNU A;  4MU0 A;  2R3V A;  2UUB E;  1HNW E;  4AIM A;  5IWA E;  4JI0 E;  1KKH A;  2BA0 D;  2Z5C B;  3GON A;  1N36 I;  4LF8 E;  2V2Q A;  4LF4 E;  1Y60 A;  2BM0 A;  2Z5B B;  4J3D A;  1N32 E;  4BA2 B;  1N36 E;  4HYM A;  4DUZ I;  2HKE A;  3WU5 A;  1Y5Y A;  1I94 E;  5IT9 Q;  2JE6 A;  1OYP A;  4DUZ E;  4OZE A;  3QT8 A;  1FI4 A;  4JI6 I;  4LF7 I;  3T1H I;  1EA6 A;  4HY1 A;  4PRX A;  4RPF A;  2BA1 G;  1J5E E;  2PNL A;  2BV3 A;  1N0U A;  1RHY A;  2HK3 A;  4JG4 A;  3WU4 A;  1B62 A;  4X64 E;  4AQY E;  4MQY A;  4DR7 I;  3HJC A;  2LJP A;  3KRN A;  5BR8 E;  1KVK A;  3ZKB A;  5K36 E;  2DEI A;  4DV1 E;  1PIE A;  2WP8 A;  4IZJ A;  4LFB I;  3PS3 A;  3CDJ A;  5JEA B;  1KIJ A;  3CWV A;  5C0X B;  4DR3 E;  1MU5 A;  1Y4S A;  1P42 A;  3P3C A;  4MU1 A;  1HNZ E;  4JYA I;  4LFB E;  1B63 A;  4LFC E;  3JAM C;  4DPX A;  1Z0E A;  1Z0V A;  4JI2 I;  2CGE A;  3D4J A;  3LTO A;  4BA2 A;  4JYA E;  3J7A G;  1IBK I;  2NPF A;  2AJ4 A;  2JEA B;  2E5L E;  1N0V C;  4LF5 E;  3P06 A;  1BKN A;  4JI1 E;  4FW6 A;  4DR6 E;  5FLX C;  1N34 E;  4X62 E;  3PYE A;  1Y6Z A;  1OJ4 A;  4YHH E;  4NXM E;  4USK A;  4JI3 I;  2VQF E;  4GQU A;  1KTV A;  1Z0B A;  3ZZT A;  4X66 E;  1XMQ E;  3PRY A;  2A2C A;  2UU9 E;  3PYF A;  4PU9 A;  4JI3 E;  3M7N G;  4WUC A;  2GS8 A;  1ZM9 A;  4MDT A;  3ZKD A;  4DV3 I;  1HNX E;  2E1R A;  2HHH I;  3K1J A;  1MG7 A;  3GLL A;  4DR4 I;  3QT6 A;  2C38 A;  4FWG A;  3L7Z B;  4JI4 E;  2O1U A;  5IT9 C;  2UUA I;  2JE6 B;  3H4L A;  4N3O A;  1RRE A;  1VIS A;  1HR0 I;  4JI5 E;  4JI8 I;  4KHP I;  1IBL I;  1XNQ I;  4DV7 E;  4EMD A;  2J7K A;  1Z0C A;  3ZM7 A;  4DR5 E;  1HR0 E;  4GKK E;  4KHP E;  1ZXM A;  2VF3 A;  2GO4 A;  4DU8 A;  4DV5 I;  4IZK B;  4OO1 E;  4USM A;  2F1D A;  2UXB E;  4DR1 E;  1S16 A;  2GO3 A;  4BA1 A;  4OX9 E;  4JI7 E;  4DV6 E;  2WP8 B;  4IZJ B;  4FW5 A;  1USV A;  4K0K E;  4ZVI A;  2NN6 E;  3F0N A;  2V2Z A;  3M85 D;  5DRP A;  4NBQ A;  1EI1 A;  1UDN A;  4AID A;  4DV4 I;  3OTO I;  5DNL A;  4I3H A;  4Z7Y A;  2ZBK B;  2PNZ A;  1ZXN A;  4JV5 I;  1R6L A;  2PO0 B;  4YY3 I;  1WUU A;  3OTO E;  3L7Z A;  3PS1 A;  2HFU A;  1N33 I;  5K36 B;  4YY3 E;  4QNJ A;  1NZ0 A;  1PKP A;  3T1Y I;  2NN6 A;  3GME A;  2BM1 A;  1N33 E;  5DRO A;  4LCG A;  4OKG A;  4JI6 E;  3T1Y E;  1HK7 A;  4LF7 E;  5K36 C;  4B3R I;  2UXC I;  1YH8 A;  2ZM6 I;  3T1H E;  2Z5E A;  4FW9 A;  1K47 A;  4IS9 A;  4IZK A;  4WUB A;  1H7S A;  4B3R E;  2UXC E;  3CDI A;  4DV0 I;  4DR7 E;  4LCF A;  4X65 I;  2C38 B;  2JT2 A;  1S4E A;  2BR2 A;  2V2V A;  1UDS A;  3P3E A;  1QZR A;  2BA0 G;  2R42 A;  3B8H A;  3Q1Q A;  4KQV A;  1FJG I;  4FN5 A;  4FWD A;  2UXD I;  2PO0 A;  1VI7 A;  5ELW A;  2A2D A;  1A6F A;  3P3G A;  4JI2 E;  3M6A A;  3B4T A;  2UXD E;  5K36 A;  1XXE A;  4DPW A;  3J81 Q;  2X36 A;  1IBK E;  4IFD D;  2V34 A;  5K36 F;  1XNR I;  4DXL A;  5JEA D;  4BA1 B;  2AE8 A;  2EFG A;  5C0X D;  2OI2 A;  1XNR E;  3NZK A;  4ED4 A;  5LMN I;  2IES A;  1NHI A;  5GME A;  4IFD E;  4MYU A;  4LFA I;  1H73 A;  4R1F A;  2PNZ B;  2HK2 A;  3H1C A;  3UHM A;  2O1V A;  4LF9 I;  4DR2 I;  1H7U A;  4WUD A;  4LFA E;  1ZM2 A;  4DV3 E;  2WNR B;  4OO1 B;  1USU A;  2HHH E;  4FW7 A;  4DR4 E;  4MU4 A;  3QT7 A;  4LF9 E;  2IOP A;  5EKW A;  4B3M I;  4U3B A;  2PNM A;  2NN6 B;  4DUY I;  2UUA E;  3U1K A;  4NXN I;  2XEX A;  4OO1 C;  5FWK A;  1XHK A;  4JI8 E;  1IBL E;  5GMD A;  4URL A;  3V5R A;  1XNQ E;  1DAR A;  4AM3 A;  2NN6 C;  1D6T A;  2F4V I;  4HAC A;  2GQ0 A;  2VQE I;  3JAM Q;  2Q2E B;  1ELO A;  4DPU A;  4DV5 E;  4MU3 A;  2F4V E;  2BA1 D;  2BR2 B;  2O1W A;  4GKJ I;  4B3S I;  3Q6N A;  1XMO I;  3B82 A;  2C37 B;  2V8P A;  4LPF A;  2UUB I;  1HNW I;  5IWA I;  4DV4 E;  5LMU I;  2WNR A;  3K85 A;  4OO1 A;  1Z0T A;  4LF8 I;  4JV5 E;  1UDQ A;  1Z0G A;  4P52 A;  3ZZU A;  4LF4 I;  3ZZ0 A;  4OO1 F;  3J81 C;  1Z5A A;  1R6M A;  5LMU E;  3GCM A;  2UUC I;  1N32 I;  4IZJ D;  3WU3 A;  2NN6 F;  3PYD A;  3B78 A;  3V2U C;  3U1Y A;  1I94 I;  5LL6 R;  5DRQ A;  2ZIT A;  2PO1 A;  2UUC E;  1E3H A;  2C39 A;  2CVE A;  3LPS A;  1NHH A;  1OYR A;  1YHC A;  4UTG A;  2ZM6 E;  1J5E I;  2CG9 A;  4P7A A;  1Z0W A;  1Y4U A;  1Z5B A;  5K36 D;  4DPT A;  3M85 G;  1PVG A;  5DRR A;  4X64 I;  4AQY I;  1Z5C A;  3HKM A;  4DV0 E;  5BR8 I;  4X65 E;  4DV1 I;  2C37 A;  1UEK A;  2CZ9 A;  3J80 Q;  3M7N D;  4FWH A;  5A2Q Q;  4QNK A;  3DD6 A;  2O1T A;  1FJG E;  4IFD B;  4DR3 I;  1HNZ I;  3PS2 A;  4PRV A;  4LFC I;  2IOQ A;  4LOM A;  1FWK A;  2Z5C A;  5DNX A;  4LF6 I;  4U3D A;  4HAC B;  1Z59 A;  4FW4 A;  4IFD C;  3QT5 A;  2Z5B A;  2E5L I;  4LF5 I;  4JI1 I;  5JEA C;  1RR9 A;  4LF6 E;  4DR6 I;  3J7A M;  4DV2 I;  1ZM3 A;  1N34 I;  1IBM I;  4X62 I;  4UT4 A;  5C0X C;  3Q6M A;  4YHH I;  4NXM I;  1OYS A;  4MYT A;  1UDO A;  2O3Z A;  2JEB B;  5JEA E;  1NHJ A;  2VQF I;  2J65 A;  5LMN E;  4DV2 E;  1IBM E;  3K17 A;  3WU6 A;  2PO2 B;  4DU7 A;  5C0X E;  4X66 I;  1XMQ I;  2VES A;  2UU9 I;  2IER A;  1ZM4 A;  1HNX I;  4DR2 E;  4ISA A; 
#chains in the Genus database with same CATH homology
 5DRO A;  3NZK A;  4LCG A;  3U1Y A;  4OKG A;  2IES A;  5DRQ A;  4J3D A;  1YH8 A;  4LCH A;  4MDT A;  4MQY A;  3P3G A;  4IS9 A;  2GO4 A;  3UHM A;  4FW3 A;  2O3Z A;  1YHC A;  3PS2 A;  4FW6 A;  2J65 A;  1XXE A;  3PS3 A;  3PS1 A;  3P76 A;  2GO3 A;  4LCF A;  4OZE A;  4FW7 A;  2VES A;  4FW5 A;  2JT2 A;  4U3D A;  3P3C A;  1P42 A;  2IER A;  3P3E A;  5DRR A;  5DRP A;  4FW4 A;  4U3B A;  4ISA A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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