4IS9A

Crystal structure of the escherichia coli lpxc/l-161,240 complex
Total Genus 83
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
83
sequence length
300
structure length
300
Chain Sequence
MIKQRTLKRIVQATGVGLHTGKKVTLTLRPAPANTGVIYRRTDLNPPVDFPADAKSVRDTMLCTCLVNEHDVRISTVEHLNAALAGLGIDNIVIEVNAPEIPIMDGSAAPFVYLLLDAGIDELNCAKKFVRIKETVRVEDGDKWAEFKPYNGFSLDFTIDFNHPAIDSSNQRYAMNFSADAFMRQISRARTFGFMRDIEYLQSRGLCLGGSFDCAIVVDDYRVLNEDGLRFEDEFVRHKMLDAIGDLFMCGHNIIGAFTAYKSGHALNNKLLQAVLAKQEAWEYVTFQDDAELPLAFKAP
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase
publication title Structural Basis of the Promiscuous Inhibitor Susceptibility of Escherichia coli LpxC.
pubmed doi rcsb
source organism Escherichia coli
molecule tags Hydrolase/hydrolase inhibitor
total genus 83
structure length 300
sequence length 300
chains with identical sequence B
ec nomenclature ec 3.5.1.-:
pdb deposition date 2013-01-16
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.230.20 Alpha Beta 2-Layer Sandwich Ribosomal Protein S5; domain 2 lpxc deacetylase, domain 1 4is9A01
3.30.1700.10 Alpha Beta 2-Layer Sandwich lpxc deacetylase, domain 1 lpxc deacetylase, domain 2 4is9A02
2GO4A 4FW4A 4FW5A 2IESA 3PS1A 3PS2A 4J3DA 4LCGA 1P42A 4LCFA 5DRQA 4U3BA 3P3CA 3P3GA 2J65A 3U1YA 4MQYA 5DRPA 4FW6A 5DRRA 1YH8A 4ISAA 3NZKA 3P76A 4IS9A 2JT2A 4LCHA 3P3EA 4U3DA 1XXEA 4OKGA 3PS3A 4FW3A 4OZEA 2VESA 4MDTA 2O3ZA 2GO3A 1YHCA 2IERA 5DROA 4FW7A 3UHMA
chains in the Genus database with same CATH superfamily
4LFAI 2UXCE 1IBLI 4GKJI 3T1HI 3PS1A 3J7AM 2DEIA 5ELWA 1MU5A 4BA1B 3CDJA 2WP8B 3WU4A 4X62E 4DV5I 4DR2I 2J7KA 1H74A 4ED4A 2V8PA 1OJ4A 4DR7E 4AM3A 1EA6A 4AQYE 4DUYE 2C39B 1UDSA 1Z0WA 3CWVA 1Y4UA 2O3ZA 1UDQA 4YY3E 4X65E 3K17A 2BV3A 1KKHA 2VQFE 4JI1E 2X7IA 2BA1D 4JI0E 3K1JA 4RPFA 1I94E 5LMNE 3V2UC 4JI8I 2BM0A 3T1YE 4JI4E 4LFAE 4DR4I 1IBLE 4LF5I 3T1HE 1KTVA 2OI2A 4ZVIA 4GKKI 3PYEA 1H7SA 1N36I 2O1UA 1XMOI 1A6FA 4DV5E 4P52A 4DR2E 5LMUI 5BR8I 4GQUA 4HYMA 1Z5AA 1KVKA 4K0KI 4FW3A 2PO2A 4DU7A 4BA2A 4IZKA 4LF6I 1B62A 4DPTA 4LF7I 4DV2I 5K36A 4FW4A 5LL6R 4JI8E 4LF4I 4MQYA 2HHHI 1R6MA 4DR4E 4LF5E 4OO1F 4FWHA 1ZXNA 3V5RA 4GKKE 4MYTA 4IZJD 4MYUA 4PRVA 1N36E 1XMQI 2WNRA 4DU8A 1XMOE 2E5LE 5LMUE 2HK2A 1NHJA 2Z5CA 4K0KE 3PRYA 2HFUA 3QT8A 4BA1A 2O1VA 2UXDI 3ZKDA 4LF6E 2F1DA 2WP8A 4LF7E 4DV2E 1E3HA 5DRQA 3P3CA 2Z5EA 1H73A 3F0NA 1MG7A 1Z0TA 1EI1A 4LF4E 2HHHE 1BKNA 2C39A 4LF8E 2V2VA 3WU3A 3QT6A 4LOMA 2UXBI 1OYSA 1J5EI 1XXEA 3PS3A 1XMQE 5K36E 3PYDA 4B3TI 4FWGA 1R6LA 2NN6D 3GCMA 4DV3I 5FLXC 1N33E 5JEAC 1OYRA 1H7UA 2UXDE 2PO2B 2NPFA 4BA2B 2Q2EB 4IZKB 2R42A 2IOQA 5K36B 4DR1I 1HR0I 1Z0BA 2JEBB 4OO1D 1ZM4A 1FKAE 3J80C 4AQYI 4UT4A 4EMDA 4IFDC 1MX0A 2UXBE 2PNZA 1J5EE 3ZZ0A 1NHHA 1I94I 2NN6C 2WNRB 4B3TE 4KHPI 4HXZA 2Z5CB 4DV3E 1Z0EA 2C37B 2JE6B 1S16A 3LPSA 4DPYA 2Z5BB 4JI5I 4HY1A 4DR1E 3GMEA 4OO1C 1HR0E 4U3DA 1HNWI 4OZEA 4DR3I 2PO1B 2IOPA 3LTOA 4FW7A 1IBMI 5JEAF 5C0XD 2GO4A 5FLXQ 4KHPE 4DV7E 1D6TA 2ZBKB 2PO0B 1Z5CA 2UU9I 3M7NG 1UDOA 3D4JA 1QZRA 4IZJA 4LFCI 4JI5E 3M85G 4DV6I 4ISAA 3GLLA 3J80Q 2V2QA 4R1FA 2E5LI 4IFDF 4USMA 3CDIA 1HNWE 2NN6F 1S4EA 3HULA 1KIJA 4DR3E 1PVGA 1E3PA 2CVEA 5C0XC 4NXME 1IBME 2PNZB 2JEBA 2J65A 4DR6I 2HK3A 3QT5A 2BA0G 3H1CA 4LF8I 1USUA 3J81C 2UU9E 3J7AG 2CZ9A 4DV4I 4LFCE 4DV6E 4Z7CA 2HFSA 5FWKA 2JE6A 2C37A 2CG9A 1HNXI 1Y5YA 1N33I 2Z5BA 4FW5A 5JEAD 5DNXA 1USVA 1K47A 2AE8A 1Y6ZA 3WU6A 1FJGI 3PYGA 4PRXA 2JEAB 4OO1A 4AIDA 4DR6E 1FNMA 4B3ME 4FW6A 5A2QC 1YH8A 4B3RI 2C38B 2PO1A 3P76A 2HKJA 3Q6MA 4IFDD 4AIMA 4DV4E 2A2CA 4DPXA 4IZJB 2PNLA 5DNLA 4HACA 3M6AA 4X64I 3B8HA 3ZZUA 2PO0A 5C0XF 1HNXE 5GMEA 4J3DA 4LCFA 3P3GA 4DV1I 1IBKI 3U1KA 5L3JA 4DXLA 1RREA 1NZ0A 2GS8A 4FN5A 2R3VA 1FJGE 1VISA 4USKA 3J81Q 4MU0A 1XNRI 4JI3I 3K85A 5IWAI 4IS9A 2PNMA 2LJPA 4B3RE 3Q6NA 4OKGA 1Z0VA 3Q1QA 4MDTA 1DARA 3B82A 3JAMC 5GMDA 4OX9I 4DUZI 4B3SI 2IERA 5C0XA 1XNQI 4DV7I 4X64E 2UUCI 1Z5BA 1P42A 2NN6B 4OO1E 3H4LA 4JI6I 4DV1E 2O1WA 5DRPA 1IBKE 2UUAI 5A2QQ 1XNRE 4JI3E 4NXNI 2WW4A 5IWAE 4LFBI 3KRNA 4OO1B 1Z0GA 2F4VI 2AJ4A 1PIEA 4NXMI 4OX9E 4DUZE 3L7ZA 4B3SE 2JEAA 1XNQE 2BA1G 2UUCE 4HACB 1N0UA 3U1YA 2VQEI 2C38A 5EKWA 3WU5A 4DV0I 1WUUA 2E1RA 4NBQA 2ZM6I 4JI6E 1HNZI 1ZM3A 2UUAE 2HKEA 4JI2I 1VI7A 1N0VC 4FW9A 5C0XE 4KQVA 2UUBI 4NXNE 3JAMQ 5IT9C 1YHCA 4LFBE 5DROA 3QT7A 1RHYA 2V34A 5K36F 5JEAA 1ZM9A 2BM1A 2F4VE 3M7ND 2IESA 4GKJE 1Z59A 2CGEA 4N3OA 2XEXA 4QNJA 2V2ZA 5C0XB 3M85D 4DR5I 4B3MI 1OYPA 5EL9A 2VQEE 4FWDA 4DV0E 2ZM6E 1HNZE 4IFDA 4JYAI 3P3EA 4X66I 4JI2E 1FWKA 1NHIA 4WUBA 3LNUA 2NN6A 4UTGA 3HJCA 2UUBE 4LPFA 1Y4SA 2BA0D 3OTOI 1ZXMA 1RR9A 3PYFA 3L7ZB 4JG4A 4DR5E 4I3HA 1UDNA 1N34I 2BR2A 1XHKA 4QNKA 4JI7I 3HKMA 4LCHA 4MU3A 1HK7A 5BR8E 4JYAE 5JEAE 4X66E 4YHHI 4PU9A 5IT9Q 3UHMA 4JV5I 5K36D 3PS2A 1ZM2A 3ZM7A 2GQ0A 4U3BA 4P7AA 1Z0CA 1FI4A 3OTOE 4URLA 3P06A 1N32I 5JEAB 2VF3A 3B78A 4IFDE 3GONA 4MU1A 4DPUA 5DRRA 2ZITA 1UEKA 4MU4A 4LF9I 3ZZTA 2JT2A 3B4TA 1N34E 2NN6E 2DEJA 4JI7E 2VESA 4DPWA 2UXCI 1Y60A 4YHHE 2X36A 4IFDB 5K36C 4LCGA 4JV5E 2EFGA 4X62I 1ELOA 1U2RA 2A2DA 4M1KA 1N32E 4DR7I 1H72C 1B63A 3ZKBA 3NZKA 4DUYI 1FWLA 4YY3I 4X65I 4Z7YA 4LF9E 2VQFI 4JI1I 1PKPA 2GO3A 4WUDA 4WUCA 4JI0I 3DD6A 2BR2B 5LMNI 4XTJA 2O1TA 3T1YI 4JI4I
chains in the Genus database with same CATH topology
2GO4A 4FW4A 4FW5A 2IESA 3PS1A 3PS2A 4J3DA 4LCGA 1P42A 4LCFA 5DRQA 4U3BA 3P3CA 3P3GA 2J65A 3U1YA 4MQYA 5DRPA 4FW6A 5DRRA 1YH8A 4ISAA 3NZKA 3P76A 4IS9A 2JT2A 4LCHA 3P3EA 4U3DA 1XXEA 4OKGA 3PS3A 4FW3A 4OZEA 2VESA 4MDTA 2O3ZA 2GO3A 1YHCA 2IERA 5DROA 4FW7A 3UHMA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2GO4 A;  4FW4 A;  4FW5 A;  2IES A;  3PS1 A;  3PS2 A;  4J3D A;  4LCG A;  1P42 A;  4LCF A;  5DRQ A;  4U3B A;  3P3C A;  3P3G A;  2J65 A;  3U1Y A;  4MQY A;  5DRP A;  4FW6 A;  5DRR A;  1YH8 A;  4ISA A;  3NZK A;  3P76 A;  4IS9 A;  2JT2 A;  4LCH A;  3P3E A;  4U3D A;  1XXE A;  4OKG A;  3PS3 A;  4FW3 A;  4OZE A;  2VES A;  4MDT A;  2O3Z A;  2GO3 A;  1YHC A;  2IER A;  5DRO A;  4FW7 A;  3UHM A; 
#chains in the Genus database with same CATH topology
 4LFA I;  2UXC E;  1IBL I;  4GKJ I;  3T1H I;  3PS1 A;  3J7A M;  2DEI A;  5ELW A;  1MU5 A;  4BA1 B;  3CDJ A;  2WP8 B;  3WU4 A;  4X62 E;  4DV5 I;  4DR2 I;  2J7K A;  1H74 A;  4ED4 A;  2V8P A;  1OJ4 A;  4DR7 E;  4AM3 A;  1EA6 A;  4AQY E;  4DUY E;  2C39 B;  1UDS A;  1Z0W A;  3CWV A;  1Y4U A;  2O3Z A;  1UDQ A;  4YY3 E;  4X65 E;  3K17 A;  2BV3 A;  1KKH A;  2VQF E;  4JI1 E;  2X7I A;  2BA1 D;  4JI0 E;  3K1J A;  4RPF A;  1I94 E;  5LMN E;  3V2U C;  4JI8 I;  2BM0 A;  3T1Y E;  4JI4 E;  4LFA E;  4DR4 I;  1IBL E;  4LF5 I;  3T1H E;  1KTV A;  2OI2 A;  4ZVI A;  4GKK I;  3PYE A;  1H7S A;  1N36 I;  2O1U A;  1XMO I;  1A6F A;  4DV5 E;  4P52 A;  4DR2 E;  5LMU I;  5BR8 I;  4GQU A;  4HYM A;  1Z5A A;  1KVK A;  4K0K I;  4FW3 A;  2PO2 A;  4DU7 A;  4BA2 A;  4IZK A;  4LF6 I;  1B62 A;  4DPT A;  4LF7 I;  4DV2 I;  5K36 A;  4FW4 A;  5LL6 R;  4JI8 E;  4LF4 I;  4MQY A;  2HHH I;  1R6M A;  4DR4 E;  4LF5 E;  4OO1 F;  4FWH A;  1ZXN A;  3V5R A;  4GKK E;  4MYT A;  4IZJ D;  4MYU A;  4PRV A;  1N36 E;  1XMQ I;  2WNR A;  4DU8 A;  1XMO E;  2E5L E;  5LMU E;  2HK2 A;  1NHJ A;  2Z5C A;  4K0K E;  3PRY A;  2HFU A;  3QT8 A;  4BA1 A;  2O1V A;  2UXD I;  3ZKD A;  4LF6 E;  2F1D A;  2WP8 A;  4LF7 E;  4DV2 E;  1E3H A;  5DRQ A;  3P3C A;  2Z5E A;  1H73 A;  3F0N A;  1MG7 A;  1Z0T A;  1EI1 A;  4LF4 E;  2HHH E;  1BKN A;  2C39 A;  4LF8 E;  2V2V A;  3WU3 A;  3QT6 A;  4LOM A;  2UXB I;  1OYS A;  1J5E I;  1XXE A;  3PS3 A;  1XMQ E;  5K36 E;  3PYD A;  4B3T I;  4FWG A;  1R6L A;  2NN6 D;  3GCM A;  4DV3 I;  5FLX C;  1N33 E;  5JEA C;  1OYR A;  1H7U A;  2UXD E;  2PO2 B;  2NPF A;  4BA2 B;  2Q2E B;  4IZK B;  2R42 A;  2IOQ A;  5K36 B;  4DR1 I;  1HR0 I;  1Z0B A;  2JEB B;  4OO1 D;  1ZM4 A;  1FKA E;  3J80 C;  4AQY I;  4UT4 A;  4EMD A;  4IFD C;  1MX0 A;  2UXB E;  2PNZ A;  1J5E E;  3ZZ0 A;  1NHH A;  1I94 I;  2NN6 C;  2WNR B;  4B3T E;  4KHP I;  4HXZ A;  2Z5C B;  4DV3 E;  1Z0E A;  2C37 B;  2JE6 B;  1S16 A;  3LPS A;  4DPY A;  2Z5B B;  4JI5 I;  4HY1 A;  4DR1 E;  3GME A;  4OO1 C;  1HR0 E;  4U3D A;  1HNW I;  4OZE A;  4DR3 I;  2PO1 B;  2IOP A;  3LTO A;  4FW7 A;  1IBM I;  5JEA F;  5C0X D;  2GO4 A;  5FLX Q;  4KHP E;  4DV7 E;  1D6T A;  2ZBK B;  2PO0 B;  1Z5C A;  2UU9 I;  3M7N G;  1UDO A;  3D4J A;  1QZR A;  4IZJ A;  4LFC I;  4JI5 E;  3M85 G;  4DV6 I;  4ISA A;  3GLL A;  3J80 Q;  2V2Q A;  4R1F A;  2E5L I;  4IFD F;  4USM A;  3CDI A;  1HNW E;  2NN6 F;  1S4E A;  3HUL A;  1KIJ A;  4DR3 E;  1PVG A;  1E3P A;  2CVE A;  5C0X C;  4NXM E;  1IBM E;  2PNZ B;  2JEB A;  2J65 A;  4DR6 I;  2HK3 A;  3QT5 A;  2BA0 G;  3H1C A;  4LF8 I;  1USU A;  3J81 C;  2UU9 E;  3J7A G;  2CZ9 A;  4DV4 I;  4LFC E;  4DV6 E;  4Z7C A;  2HFS A;  5FWK A;  2JE6 A;  2C37 A;  2CG9 A;  1HNX I;  1Y5Y A;  1N33 I;  2Z5B A;  4FW5 A;  5JEA D;  5DNX A;  1USV A;  1K47 A;  2AE8 A;  1Y6Z A;  3WU6 A;  1FJG I;  3PYG A;  4PRX A;  2JEA B;  4OO1 A;  4AID A;  4DR6 E;  1FNM A;  4B3M E;  4FW6 A;  5A2Q C;  1YH8 A;  4B3R I;  2C38 B;  2PO1 A;  3P76 A;  2HKJ A;  3Q6M A;  4IFD D;  4AIM A;  4DV4 E;  2A2C A;  4DPX A;  4IZJ B;  2PNL A;  5DNL A;  4HAC A;  3M6A A;  4X64 I;  3B8H A;  3ZZU A;  2PO0 A;  5C0X F;  1HNX E;  5GME A;  4J3D A;  4LCF A;  3P3G A;  4DV1 I;  1IBK I;  3U1K A;  5L3J A;  4DXL A;  1RRE A;  1NZ0 A;  2GS8 A;  4FN5 A;  2R3V A;  1FJG E;  1VIS A;  4USK A;  3J81 Q;  4MU0 A;  1XNR I;  4JI3 I;  3K85 A;  5IWA I;  4IS9 A;  2PNM A;  2LJP A;  4B3R E;  3Q6N A;  4OKG A;  1Z0V A;  3Q1Q A;  4MDT A;  1DAR A;  3B82 A;  3JAM C;  5GMD A;  4OX9 I;  4DUZ I;  4B3S I;  2IER A;  5C0X A;  1XNQ I;  4DV7 I;  4X64 E;  2UUC I;  1Z5B A;  1P42 A;  2NN6 B;  4OO1 E;  3H4L A;  4JI6 I;  4DV1 E;  2O1W A;  5DRP A;  1IBK E;  2UUA I;  5A2Q Q;  1XNR E;  4JI3 E;  4NXN I;  2WW4 A;  5IWA E;  4LFB I;  3KRN A;  4OO1 B;  1Z0G A;  2F4V I;  2AJ4 A;  1PIE A;  4NXM I;  4OX9 E;  4DUZ E;  3L7Z A;  4B3S E;  2JEA A;  1XNQ E;  2BA1 G;  2UUC E;  4HAC B;  1N0U A;  3U1Y A;  2VQE I;  2C38 A;  5EKW A;  3WU5 A;  4DV0 I;  1WUU A;  2E1R A;  4NBQ A;  2ZM6 I;  4JI6 E;  1HNZ I;  1ZM3 A;  2UUA E;  2HKE A;  4JI2 I;  1VI7 A;  1N0V C;  4FW9 A;  5C0X E;  4KQV A;  2UUB I;  4NXN E;  3JAM Q;  5IT9 C;  1YHC A;  4LFB E;  5DRO A;  3QT7 A;  1RHY A;  2V34 A;  5K36 F;  5JEA A;  1ZM9 A;  2BM1 A;  2F4V E;  3M7N D;  2IES A;  4GKJ E;  1Z59 A;  2CGE A;  4N3O A;  2XEX A;  4QNJ A;  2V2Z A;  5C0X B;  3M85 D;  4DR5 I;  4B3M I;  1OYP A;  5EL9 A;  2VQE E;  4FWD A;  4DV0 E;  2ZM6 E;  1HNZ E;  4IFD A;  4JYA I;  3P3E A;  4X66 I;  4JI2 E;  1FWK A;  1NHI A;  4WUB A;  3LNU A;  2NN6 A;  4UTG A;  3HJC A;  2UUB E;  4LPF A;  1Y4S A;  2BA0 D;  3OTO I;  1ZXM A;  1RR9 A;  3PYF A;  3L7Z B;  4JG4 A;  4DR5 E;  4I3H A;  1UDN A;  1N34 I;  2BR2 A;  1XHK A;  4QNK A;  4JI7 I;  3HKM A;  4LCH A;  4MU3 A;  1HK7 A;  5BR8 E;  4JYA E;  5JEA E;  4X66 E;  4YHH I;  4PU9 A;  5IT9 Q;  3UHM A;  4JV5 I;  5K36 D;  3PS2 A;  1ZM2 A;  3ZM7 A;  2GQ0 A;  4U3B A;  4P7A A;  1Z0C A;  1FI4 A;  3OTO E;  4URL A;  3P06 A;  1N32 I;  5JEA B;  2VF3 A;  3B78 A;  4IFD E;  3GON A;  4MU1 A;  4DPU A;  5DRR A;  2ZIT A;  1UEK A;  4MU4 A;  4LF9 I;  3ZZT A;  2JT2 A;  3B4T A;  1N34 E;  2NN6 E;  2DEJ A;  4JI7 E;  2VES A;  4DPW A;  2UXC I;  1Y60 A;  4YHH E;  2X36 A;  4IFD B;  5K36 C;  4LCG A;  4JV5 E;  2EFG A;  4X62 I;  1ELO A;  1U2R A;  2A2D A;  4M1K A;  1N32 E;  4DR7 I;  1H72 C;  1B63 A;  3ZKB A;  3NZK A;  4DUY I;  1FWL A;  4YY3 I;  4X65 I;  4Z7Y A;  4LF9 E;  2VQF I;  4JI1 I;  1PKP A;  2GO3 A;  4WUD A;  4WUC A;  4JI0 I;  3DD6 A;  2BR2 B;  5LMN I;  4XTJ A;  2O1T A;  3T1Y I;  4JI4 I; 
#chains in the Genus database with same CATH homology
 2GO4 A;  4FW4 A;  4FW5 A;  2IES A;  3PS1 A;  3PS2 A;  4J3D A;  4LCG A;  1P42 A;  4LCF A;  5DRQ A;  4U3B A;  3P3C A;  3P3G A;  2J65 A;  3U1Y A;  4MQY A;  5DRP A;  4FW6 A;  5DRR A;  1YH8 A;  4ISA A;  3NZK A;  3P76 A;  4IS9 A;  2JT2 A;  4LCH A;  3P3E A;  4U3D A;  1XXE A;  4OKG A;  3PS3 A;  4FW3 A;  4OZE A;  2VES A;  4MDT A;  2O3Z A;  2GO3 A;  1YHC A;  2IER A;  5DRO A;  4FW7 A;  3UHM A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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