4ISAA

Crystal structure of the escherichia coli lpxc/bb-78485 complex
Total Genus 90
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
90
sequence length
300
structure length
300
Chain Sequence
MIKQRTLKRIVQATGVGLHTGKKVTLTLRPAPANTGVIYRRTDLNPPVDFPADAKSVRDTMLCTCLVNEHDVRISTVEHLNAALAGLGIDNIVIEVNAPEIPIMDGSAAPFVYLLLDAGIDELNCAKKFVRIKETVRVEDGDKWAEFKPYNGFSLDFTIDFNHPAIDSSNQRYAMNFSADAFMRQISRARTFGFMRDIEYLQSRGLCLGGSFDCAIVVDDYRVLNEDGLRFEDEFVRHKMLDAIGDLFMCGHNIIGAFTAYKSGHALNNKLLQAVLAKQEAWEYVTFQDDAELPLAFKAP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase
publication title Structural Basis of the Promiscuous Inhibitor Susceptibility of Escherichia coli LpxC.
pubmed doi rcsb
source organism Escherichia coli
molecule tags Hydrolase/hydrolase inhibitor
total genus 90
structure length 300
sequence length 300
ec nomenclature ec 3.5.1.-:
pdb deposition date 2013-01-16
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.230.20 Alpha Beta 2-Layer Sandwich Ribosomal Protein S5; domain 2 lpxc deacetylase, domain 1 4isaA01
3.30.1700.10 Alpha Beta 2-Layer Sandwich lpxc deacetylase, domain 1 lpxc deacetylase, domain 2 4isaA02
3P3GA 1P42A 4IS9A 2GO3A 4LCGA 1XXEA 4MQYA 3PS3A 4ISAA 4J3DA 1YH8A 4FW5A 3UHMA 2O3ZA 2J65A 5DROA 5DRQA 4LCHA 3U1YA 4FW3A 3P3EA 4FW7A 4U3DA 4OZEA 5DRPA 3PS1A 4FW4A 4MDTA 4OKGA 4LCFA 4U3BA 3P76A 2VESA 2GO4A 3NZKA 5DRRA 2JT2A 4FW6A 2IESA 3P3CA 1YHCA 2IERA 3PS2A
chains in the Genus database with same CATH superfamily
3ZM7A 2JEBB 5LMNI 4AQYI 3PS3A 3LPSA 3T1HE 1ZM4A 2J65A 1UDOA 4NXMI 4DXLA 4FN5A 2UUAE 4MU4A 4DR7I 4FWDA 1EA6A 2UUBI 2NN6A 5JEAE 1USUA 2Z5CA 1XNRE 3ZZUA 5K36F 1NHIA 4LF8I 5BR8I 1P42A 1IBME 4MYTA 5EL9A 4GKKE 2PNZA 4J3DA 3WU5A 2BR2B 4OO1C 4LF6I 4JV5E 4JI6E 1Z0BA 2WW4A 1OJ4A 5C0XE 4OO1D 4IFDB 3QT8A 4FW3A 2CZ9A 4B3RE 4DPXA 4OX9I 3H4LA 3PS1A 4X64E 4OKGA 3J7AM 2A2CA 4JI3I 4DR1E 1IBLI 3PYEA 4MU0A 4DV3I 4K0KI 2JE6A 1IBKE 2A2DA 3PYGA 2OI2A 2WNRA 2ZBKB 4GKJI 2V34A 4UTGA 4DV2E 2PNMA 1ZM2A 4AIMA 3CDJA 4OO1B 3J81Q 1NZ0A 1PKPA 3CDIA 4NXNI 5IT9Q 4FW7A 4M1KA 2V2VA 3QT6A 4JI2E 2UU9E 4U3BA 2UXDE 2JEAA 2C37A 5EKWA 1Y4UA 2Z5BA 3HULA 3P3GA 4BA2B 2C39B 1XHKA 1OYPA 5K36E 2IOQA 4IFDF 1KIJA 3PRYA 4FWGA 4X66E 4FW9A 4DR3E 3B4TA 4IZKA 1I94E 5A2QQ 4DPYA 1D6TA 4ZVIA 3OTOE 3M7NG 4QNJA 4DV4E 2PO1B 2UUAI 3J80Q 2C39A 3K17A 3KRNA 4PRXA 3T1YE 4BA1A 4JI1I 1Z5BA 4JG4A 4B3TE 1KKHA 1XNRI 4LFBI 1H72C 1EI1A 4DU7A 1IBMI 2DEIA 5C0XA 2F4VE 1PIEA 3B78A 2V2ZA 3ZZ0A 4LF7I 1BKNA 1RREA 4JV5I 2X36A 2PO1A 4HXZA 4JI0E 4LCHA 4DV5E 1XMOI 1H74A 1E3PA 4UT4A 5DRPA 1ZXNA 4FW4A 4MDTA 4MYUA 4LCFA 4JYAE 1HR0I 4PU9A 2IERA 1HNXE 1K47A 5FLXQ 4B3SE 1FJGE 1N0VC 2WP8B 4DUZE 1IBKI 2NN6B 4YY3E 2X7IA 4LOMA 3M7ND 1OYSA 2Z5CB 4DUYE 3QT7A 1H7UA 4DV2I 2UXBE 1J5EE 2HHHI 4DR5E 2PNZB 4DR6E 4DPWA 4HY1A 1B62A 5IWAI 3WU3A 4DV6E 2IESA 2WP8A 3CWVA 2UU9I 4JI2I 2BA0D 5K36A 1Y6ZA 1N32E 3D4JA 3GCMA 4DV7E 4JI4I 2VQFI 3F0NA 4LCGA 2JE6B 1H73A 1Z5AA 3GLLA 2WNRB 4ED4A 3ZKDA 4X66I 4R1FA 4X65E 1R6LA 4DV1E 4DR3I 5GMDA 4LF9E 5JEAC 2F1DA 4N3OA 3Q6MA 1R6MA 3OTOI 5LMUE 1Y4SA 2NN6F 1UDNA 1XNQE 3B8HA 4NBQA 5JEAD 3T1YI 1ZXMA 2BM1A 4LF4I 2JEAB 3V5RA 2C37B 4FWHA 4B3TI 1Z59A 1XMQE 2Z5BB 2Z5EA 2DEJA 4JI7E 1Z5CA 5C0XC 1N34E 2PNLA 2UUCI 4JI8E 1S4EA 3LTOA 1A6FA 1S16A 2VQEE 5C0XD 3PYFA 3M6AA 4IZKB 5IT9C 2GO4A 5DRRA 3JAMC 4DU8A 5JEAB 2ZM6E 5LMNE 4JYAI 4AQYE 2E5LE 1VI7A 4DPUA 1FJGI 1NHJA 4BA1B 2R42A 2NPFA 4GQUA 2ZITA 4WUBA 1Z0VA 2O1WA 4NXME 3H1CA 4LFCE 5DROA 5C0XB 4HACB 4DR7E 2HKJA 3LNUA 2R3VA 3T1HI 1VISA 1H7SA 2AE8A 5JEAA 1DARA 4WUCA 5FWKA 3QT5A 1ZM9A 5A2QC 4LF8E 4YHHE 5BR8E 4X62E 3M85D 2XEXA 4HYMA 4DV6I 3J7AG 3Q1QA 2NN6E 3ZKBA 5K36C 1B63A 2E1RA 1N32I 1Z0TA 4DV7I 4ISAA 4OO1F 5K36D 4HACA 2EFGA 2UXCE 4GKKI 4OX9E 1N0UA 3HKMA 2BA0G 4JI6I 2J7KA 4X65I 1UDQA 5GMEA 1IBLE 4DV3E 4K0KE 4LF9I 1ELOA 1HK7A 4B3RI 2VF3A 4X64I 4GKJE 4IZJA 4DR1I 1Z0GA 4LFAE 1XNQI 2BM0A 5K36B 2V8PA 2BV3A 2O1TA 1YH8A 1XMQI 4NXNE 1HNWE 1ZM3A 4IFDE 5DRQA 3GONA 1N34I 4JI8I 4KQVA 4U3DA 1N36E 4DPTA 3GMEA 4MU1A 3B82A 2VESA 4B3ME 2CVEA 1YHCA 2UXDI 4AIDA 5LL6R 2ZM6I 2HFUA 4JI5E 2E5LI 4USKA 1HNZE 4MU3A 2PO0A 3L7ZA 4IFDC 4OO1E 3P06A 3UHMA 3K1JA 4IFDD 1USVA 4P7AA 4LFCI 2GS8A 1NHHA 4OZEA 1KVKA 1I94I 4JI1E 3P76A 4QNKA 2JEBA 1Y5YA 4DR2E 2IOPA 4DV4I 2O1UA 4XTJA 4LFBE 1E3HA 4LF5E 3PYDA 4YHHI 4X62I 1Z0EA 4IS9A 2BA1D 4LF7E 1XXEA 4DV0E 2GQ0A 1FKAE 3ZZTA 1FNMA 1XMOE 3DD6A 2HK3A 3WU4A 2F4VI 1UEKA 4KHPE 1U2RA 3M85G 2UXCI 2O1VA 4DR4E 1RHYA 3P3EA 1HR0E 2CGEA 3J81C 3WU6A 1WUUA 4EMDA 1N33E 4JI0I 4DV5I 1KTVA 4FW6A 3PS2A 2BR2A 1HNXI 3Q6NA 4B3SI 4LFAI 2HKEA 4IFDA 4DUZI 2HHHE 4YY3I 2PO2B 4IZJD 5L3JA 4RPFA 4URLA 2O3ZA 3HJCA 4DUYI 4LPFA 1HNWI 1RR9A 2UXBI 5IWAE 3JAMQ 1J5EI 2UUBE 4DR5I 1FWLA 2C38B 1N36I 4DR6I 4JI4E 3NZKA 2JT2A 2VQFE 4PRVA 1PVGA 3U1KA 4B3MI 1FI4A 3J80C 2GO3A 2PO2A 4OO1A 4LF6E 1Y60A 4IZJB 4JI5I 1HNZI 2AJ4A 2Q2EB 2C38A 3U1YA 1Z0CA 4USMA 4JI3E 5JEAF 1MG7A 2V2QA 4DV1I 4BA2A 1FWKA 4LF4E 3P3CA 2NN6C 4MQYA 4DR2I 1OYRA 5LMUI 1Z0WA 4WUDA 1QZRA 4LF5I 2NN6D 5ELWA 4Z7CA 2HFSA 3V2UC 2UUCE 5FLXC 5C0XF 4AM3A 2LJPA 4FW5A 4DV0I 1MX0A 1MU5A 4JI7I 5DNXA 2PO0B 4KHPI 4P52A 3L7ZB 2CG9A 4DR4I 1UDSA 2BA1G 5DNLA 4I3HA 4Z7YA 3K85A 2VQEI 1N33I 2HK2A
chains in the Genus database with same CATH topology
3P3GA 1P42A 4IS9A 2GO3A 4LCGA 1XXEA 4MQYA 3PS3A 4ISAA 4J3DA 1YH8A 4FW5A 3UHMA 2O3ZA 2J65A 5DROA 5DRQA 4LCHA 3U1YA 4FW3A 3P3EA 4FW7A 4U3DA 4OZEA 5DRPA 3PS1A 4FW4A 4MDTA 4OKGA 4LCFA 4U3BA 3P76A 2VESA 2GO4A 3NZKA 5DRRA 2JT2A 4FW6A 2IESA 3P3CA 1YHCA 2IERA 3PS2A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3P3G A;  1P42 A;  4IS9 A;  2GO3 A;  4LCG A;  1XXE A;  4MQY A;  3PS3 A;  4ISA A;  4J3D A;  1YH8 A;  4FW5 A;  3UHM A;  2O3Z A;  2J65 A;  5DRO A;  5DRQ A;  4LCH A;  3U1Y A;  4FW3 A;  3P3E A;  4FW7 A;  4U3D A;  4OZE A;  5DRP A;  3PS1 A;  4FW4 A;  4MDT A;  4OKG A;  4LCF A;  4U3B A;  3P76 A;  2VES A;  2GO4 A;  3NZK A;  5DRR A;  2JT2 A;  4FW6 A;  2IES A;  3P3C A;  1YHC A;  2IER A;  3PS2 A; 
#chains in the Genus database with same CATH topology
 3ZM7 A;  2JEB B;  5LMN I;  4AQY I;  3PS3 A;  3LPS A;  3T1H E;  1ZM4 A;  2J65 A;  1UDO A;  4NXM I;  4DXL A;  4FN5 A;  2UUA E;  4MU4 A;  4DR7 I;  4FWD A;  1EA6 A;  2UUB I;  2NN6 A;  5JEA E;  1USU A;  2Z5C A;  1XNR E;  3ZZU A;  5K36 F;  1NHI A;  4LF8 I;  5BR8 I;  1P42 A;  1IBM E;  4MYT A;  5EL9 A;  4GKK E;  2PNZ A;  4J3D A;  3WU5 A;  2BR2 B;  4OO1 C;  4LF6 I;  4JV5 E;  4JI6 E;  1Z0B A;  2WW4 A;  1OJ4 A;  5C0X E;  4OO1 D;  4IFD B;  3QT8 A;  4FW3 A;  2CZ9 A;  4B3R E;  4DPX A;  4OX9 I;  3H4L A;  3PS1 A;  4X64 E;  4OKG A;  3J7A M;  2A2C A;  4JI3 I;  4DR1 E;  1IBL I;  3PYE A;  4MU0 A;  4DV3 I;  4K0K I;  2JE6 A;  1IBK E;  2A2D A;  3PYG A;  2OI2 A;  2WNR A;  2ZBK B;  4GKJ I;  2V34 A;  4UTG A;  4DV2 E;  2PNM A;  1ZM2 A;  4AIM A;  3CDJ A;  4OO1 B;  3J81 Q;  1NZ0 A;  1PKP A;  3CDI A;  4NXN I;  5IT9 Q;  4FW7 A;  4M1K A;  2V2V A;  3QT6 A;  4JI2 E;  2UU9 E;  4U3B A;  2UXD E;  2JEA A;  2C37 A;  5EKW A;  1Y4U A;  2Z5B A;  3HUL A;  3P3G A;  4BA2 B;  2C39 B;  1XHK A;  1OYP A;  5K36 E;  2IOQ A;  4IFD F;  1KIJ A;  3PRY A;  4FWG A;  4X66 E;  4FW9 A;  4DR3 E;  3B4T A;  4IZK A;  1I94 E;  5A2Q Q;  4DPY A;  1D6T A;  4ZVI A;  3OTO E;  3M7N G;  4QNJ A;  4DV4 E;  2PO1 B;  2UUA I;  3J80 Q;  2C39 A;  3K17 A;  3KRN A;  4PRX A;  3T1Y E;  4BA1 A;  4JI1 I;  1Z5B A;  4JG4 A;  4B3T E;  1KKH A;  1XNR I;  4LFB I;  1H72 C;  1EI1 A;  4DU7 A;  1IBM I;  2DEI A;  5C0X A;  2F4V E;  1PIE A;  3B78 A;  2V2Z A;  3ZZ0 A;  4LF7 I;  1BKN A;  1RRE A;  4JV5 I;  2X36 A;  2PO1 A;  4HXZ A;  4JI0 E;  4LCH A;  4DV5 E;  1XMO I;  1H74 A;  1E3P A;  4UT4 A;  5DRP A;  1ZXN A;  4FW4 A;  4MDT A;  4MYU A;  4LCF A;  4JYA E;  1HR0 I;  4PU9 A;  2IER A;  1HNX E;  1K47 A;  5FLX Q;  4B3S E;  1FJG E;  1N0V C;  2WP8 B;  4DUZ E;  1IBK I;  2NN6 B;  4YY3 E;  2X7I A;  4LOM A;  3M7N D;  1OYS A;  2Z5C B;  4DUY E;  3QT7 A;  1H7U A;  4DV2 I;  2UXB E;  1J5E E;  2HHH I;  4DR5 E;  2PNZ B;  4DR6 E;  4DPW A;  4HY1 A;  1B62 A;  5IWA I;  3WU3 A;  4DV6 E;  2IES A;  2WP8 A;  3CWV A;  2UU9 I;  4JI2 I;  2BA0 D;  5K36 A;  1Y6Z A;  1N32 E;  3D4J A;  3GCM A;  4DV7 E;  4JI4 I;  2VQF I;  3F0N A;  4LCG A;  2JE6 B;  1H73 A;  1Z5A A;  3GLL A;  2WNR B;  4ED4 A;  3ZKD A;  4X66 I;  4R1F A;  4X65 E;  1R6L A;  4DV1 E;  4DR3 I;  5GMD A;  4LF9 E;  5JEA C;  2F1D A;  4N3O A;  3Q6M A;  1R6M A;  3OTO I;  5LMU E;  1Y4S A;  2NN6 F;  1UDN A;  1XNQ E;  3B8H A;  4NBQ A;  5JEA D;  3T1Y I;  1ZXM A;  2BM1 A;  4LF4 I;  2JEA B;  3V5R A;  2C37 B;  4FWH A;  4B3T I;  1Z59 A;  1XMQ E;  2Z5B B;  2Z5E A;  2DEJ A;  4JI7 E;  1Z5C A;  5C0X C;  1N34 E;  2PNL A;  2UUC I;  4JI8 E;  1S4E A;  3LTO A;  1A6F A;  1S16 A;  2VQE E;  5C0X D;  3PYF A;  3M6A A;  4IZK B;  5IT9 C;  2GO4 A;  5DRR A;  3JAM C;  4DU8 A;  5JEA B;  2ZM6 E;  5LMN E;  4JYA I;  4AQY E;  2E5L E;  1VI7 A;  4DPU A;  1FJG I;  1NHJ A;  4BA1 B;  2R42 A;  2NPF A;  4GQU A;  2ZIT A;  4WUB A;  1Z0V A;  2O1W A;  4NXM E;  3H1C A;  4LFC E;  5DRO A;  5C0X B;  4HAC B;  4DR7 E;  2HKJ A;  3LNU A;  2R3V A;  3T1H I;  1VIS A;  1H7S A;  2AE8 A;  5JEA A;  1DAR A;  4WUC A;  5FWK A;  3QT5 A;  1ZM9 A;  5A2Q C;  4LF8 E;  4YHH E;  5BR8 E;  4X62 E;  3M85 D;  2XEX A;  4HYM A;  4DV6 I;  3J7A G;  3Q1Q A;  2NN6 E;  3ZKB A;  5K36 C;  1B63 A;  2E1R A;  1N32 I;  1Z0T A;  4DV7 I;  4ISA A;  4OO1 F;  5K36 D;  4HAC A;  2EFG A;  2UXC E;  4GKK I;  4OX9 E;  1N0U A;  3HKM A;  2BA0 G;  4JI6 I;  2J7K A;  4X65 I;  1UDQ A;  5GME A;  1IBL E;  4DV3 E;  4K0K E;  4LF9 I;  1ELO A;  1HK7 A;  4B3R I;  2VF3 A;  4X64 I;  4GKJ E;  4IZJ A;  4DR1 I;  1Z0G A;  4LFA E;  1XNQ I;  2BM0 A;  5K36 B;  2V8P A;  2BV3 A;  2O1T A;  1YH8 A;  1XMQ I;  4NXN E;  1HNW E;  1ZM3 A;  4IFD E;  5DRQ A;  3GON A;  1N34 I;  4JI8 I;  4KQV A;  4U3D A;  1N36 E;  4DPT A;  3GME A;  4MU1 A;  3B82 A;  2VES A;  4B3M E;  2CVE A;  1YHC A;  2UXD I;  4AID A;  5LL6 R;  2ZM6 I;  2HFU A;  4JI5 E;  2E5L I;  4USK A;  1HNZ E;  4MU3 A;  2PO0 A;  3L7Z A;  4IFD C;  4OO1 E;  3P06 A;  3UHM A;  3K1J A;  4IFD D;  1USV A;  4P7A A;  4LFC I;  2GS8 A;  1NHH A;  4OZE A;  1KVK A;  1I94 I;  4JI1 E;  3P76 A;  4QNK A;  2JEB A;  1Y5Y A;  4DR2 E;  2IOP A;  4DV4 I;  2O1U A;  4XTJ A;  4LFB E;  1E3H A;  4LF5 E;  3PYD A;  4YHH I;  4X62 I;  1Z0E A;  4IS9 A;  2BA1 D;  4LF7 E;  1XXE A;  4DV0 E;  2GQ0 A;  1FKA E;  3ZZT A;  1FNM A;  1XMO E;  3DD6 A;  2HK3 A;  3WU4 A;  2F4V I;  1UEK A;  4KHP E;  1U2R A;  3M85 G;  2UXC I;  2O1V A;  4DR4 E;  1RHY A;  3P3E A;  1HR0 E;  2CGE A;  3J81 C;  3WU6 A;  1WUU A;  4EMD A;  1N33 E;  4JI0 I;  4DV5 I;  1KTV A;  4FW6 A;  3PS2 A;  2BR2 A;  1HNX I;  3Q6N A;  4B3S I;  4LFA I;  2HKE A;  4IFD A;  4DUZ I;  2HHH E;  4YY3 I;  2PO2 B;  4IZJ D;  5L3J A;  4RPF A;  4URL A;  2O3Z A;  3HJC A;  4DUY I;  4LPF A;  1HNW I;  1RR9 A;  2UXB I;  5IWA E;  3JAM Q;  1J5E I;  2UUB E;  4DR5 I;  1FWL A;  2C38 B;  1N36 I;  4DR6 I;  4JI4 E;  3NZK A;  2JT2 A;  2VQF E;  4PRV A;  1PVG A;  3U1K A;  4B3M I;  1FI4 A;  3J80 C;  2GO3 A;  2PO2 A;  4OO1 A;  4LF6 E;  1Y60 A;  4IZJ B;  4JI5 I;  1HNZ I;  2AJ4 A;  2Q2E B;  2C38 A;  3U1Y A;  1Z0C A;  4USM A;  4JI3 E;  5JEA F;  1MG7 A;  2V2Q A;  4DV1 I;  4BA2 A;  1FWK A;  4LF4 E;  3P3C A;  2NN6 C;  4MQY A;  4DR2 I;  1OYR A;  5LMU I;  1Z0W A;  4WUD A;  1QZR A;  4LF5 I;  2NN6 D;  5ELW A;  4Z7C A;  2HFS A;  3V2U C;  2UUC E;  5FLX C;  5C0X F;  4AM3 A;  2LJP A;  4FW5 A;  4DV0 I;  1MX0 A;  1MU5 A;  4JI7 I;  5DNX A;  2PO0 B;  4KHP I;  4P52 A;  3L7Z B;  2CG9 A;  4DR4 I;  1UDS A;  2BA1 G;  5DNL A;  4I3H A;  4Z7Y A;  3K85 A;  2VQE I;  1N33 I;  2HK2 A; 
#chains in the Genus database with same CATH homology
 3P3G A;  1P42 A;  4IS9 A;  2GO3 A;  4LCG A;  1XXE A;  4MQY A;  3PS3 A;  4ISA A;  4J3D A;  1YH8 A;  4FW5 A;  3UHM A;  2O3Z A;  2J65 A;  5DRO A;  5DRQ A;  4LCH A;  3U1Y A;  4FW3 A;  3P3E A;  4FW7 A;  4U3D A;  4OZE A;  5DRP A;  3PS1 A;  4FW4 A;  4MDT A;  4OKG A;  4LCF A;  4U3B A;  3P76 A;  2VES A;  2GO4 A;  3NZK A;  5DRR A;  2JT2 A;  4FW6 A;  2IES A;  3P3C A;  1YHC A;  2IER A;  3PS2 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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