4ISAA

Crystal structure of the escherichia coli lpxc/bb-78485 complex
Total Genus 90
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
90
sequence length
300
structure length
300
Chain Sequence
MIKQRTLKRIVQATGVGLHTGKKVTLTLRPAPANTGVIYRRTDLNPPVDFPADAKSVRDTMLCTCLVNEHDVRISTVEHLNAALAGLGIDNIVIEVNAPEIPIMDGSAAPFVYLLLDAGIDELNCAKKFVRIKETVRVEDGDKWAEFKPYNGFSLDFTIDFNHPAIDSSNQRYAMNFSADAFMRQISRARTFGFMRDIEYLQSRGLCLGGSFDCAIVVDDYRVLNEDGLRFEDEFVRHKMLDAIGDLFMCGHNIIGAFTAYKSGHALNNKLLQAVLAKQEAWEYVTFQDDAELPLAFKAP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural Basis of the Promiscuous Inhibitor Susceptibility of Escherichia coli LpxC.
pubmed doi rcsb
source organism Escherichia coli
molecule tags Hydrolase/hydrolase inhibitor
molecule keywords UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase
total genus 90
structure length 300
sequence length 300
ec nomenclature ec 3.5.1.-:
pdb deposition date 2013-01-16
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.230.20 Alpha Beta 2-Layer Sandwich Ribosomal Protein S5; domain 2 lpxc deacetylase, domain 1 4isaA01
3.30.1700.10 Alpha Beta 2-Layer Sandwich lpxc deacetylase, domain 1 lpxc deacetylase, domain 2 4isaA02
1P42A 3P3CA 4LCHA 2GO4A 4U3DA 4J3DA 4FW3A 3P3EA 1YH8A 3P76A 4MDTA 4FW6A 3PS3A 4OZEA 4IS9A 1YHCA 4FW5A 3PS1A 2VESA 2JT2A 3PS2A 4FW7A 4LCGA 4ISAA 2IESA 3P3GA 4OKGA 3UHMA 2J65A 5DRPA 4U3BA 4MQYA 4LCFA 1XXEA 2IERA 2GO3A 4FW4A 5DROA 3NZKA 3U1YA 5DRQA 2O3ZA 5DRRA
chains in the Genus database with same CATH superfamily
4X64I 4U3DA 3PRYA 4HYMA 4YHHI 1IBMI 2Q2EB 3PS3A 1XMQI 3K1JA 4X65I 4IS9A 2UXDE 4ISAA 2UUCI 4GKKI 4OO1B 2R3VA 4DV7I 3Q6MA 1H72C 3H1CA 3J7AM 4AM3A 3T1HE 1Z5CA 3ZZ0A 1XHKA 2Z5EA 4JI7I 2PO0A 1FKAE 3ZKBA 5FLXC 1FJGI 3H4LA 3GMEA 4LFCI 1RHYA 4DPYA 2VESA 5JEAA 1OYRA 4ED4A 5JEAE 2V34A 4DV0E 2PNZB 4WUDA 4HACA 5LMUE 2V8PA 2F4VE 4IFDF 1MG7A 3OTOI 2DEIA 1K47A 4K0KE 3ZM7A 1R6LA 4IFDC 4X66I 3QT8A 1MX0A 1ZM4A 2UUBI 2F4VI 5K36E 2X36A 2A2DA 3OTOE 4IFDD 4LFAI 1J5EI 4DR3E 1Y6ZA 4FN5A 1XNRE 1RREA 3PYFA 4DV5I 4KQVA 4JI0E 2NN6E 2NN6A 1Z0CA 1ELOA 2BM0A 4JG4A 3GCMA 4NXNI 4LF5E 4DU8A 4B3SI 4JI2I 1QZRA 4DV6E 4DUYE 1EA6A 4B3TE 2GO4A 4FW3A 3Q6NA 1ZM2A 4X64E 3QT7A 5IT9Q 2Z5BB 5C0XB 4YHHE 1N34I 4UTGA 2V2QA 2C37B 5C0XC 4I3HA 1ZXMA 4AQYI 1Y4UA 2VQEE 1XNQI 2PO1A 2LJPA 2JE6B 5DNLA 1Z0VA 1WUUA 5C0XF 5DNXA 1FWLA 5A2QC 1IBKE 3J7AG 4OO1E 1N34E 5IWAE 2DEJA 4DXLA 4P52A 4FW4A 2HHHI 1HNWI 5K36A 4MU4A 4DV7E 4OO1A 4DPUA 4DUZI 3HKMA 2J7KA 4DPWA 4DV2I 4EMDA 3K17A 3T1HI 2HFUA 5LMNE 4FW6A 4FWDA 1H74A 3ZZUA 1KKHA 2VQFE 1Z0EA 2EFGA 3ZZTA 5GMEA 2HHHE 1HNWE 1YHCA 2WNRA 4FW5A 4OO1C 1Z59A 2GS8A 4FW7A 4IFDB 3B82A 1E3HA 4IZJD 1PIEA 4WUCA 2VQFI 3P06A 4DR4E 2NN6D 2IERA 1S16A 3LNUA 3PYGA 1ZXNA 3KRNA 4IZJB 2IOQA 5K36D 2BA1G 3LPSA 2PO0B 4K0KI 5C0XA 4JI6I 2BR2A 2ZM6E 4GKJE 3B4TA 3WU4A 2IOPA 1U2RA 1I94E 4JI8E 2O1UA 2UXCI 1N32I 2C38B 2CGEA 4IZKA 4DR6E 4AIMA 1Y4SA 2JT2A 1ZM3A 5GMDA 1NHJA 4DR3I 3ZKDA 4N3OA 4WUBA 4FW9A 4MQYA 1I94I 2V2ZA 4FWGA 3QT6A 5ELWA 4BA1A 4NXNE 5LL6R 4DR5E 4DPXA 2XEXA 1HNZI 5IT9C 3M7ND 4DR1I 4JI4I 4MU1A 4LF9I 4GQUA 2X7IA 5C0XE 4OZEA 2OI2A 4NXME 3D4JA 4USMA 3B78A 4MYUA 2NN6B 4DR1E 4AQYE 1OYSA 4MYTA 1Z0WA 2PO1B 3J80C 5IWAI 4DV4I 4PU9A 4JI5I 3HJCA 4LCHA 4LPFA 2UXDI 4DV0I 5K36B 2C37A 4X62E 1HK7A 4DV2E 5K36C 3M6AA 5LMUI 4DV4E 5LMNI 4LF7I 1Z0GA 2UUCE 2JE6A 4IFDE 4GKKE 2WW4A 4X66E 2WNRB 2HFSA 2UUBE 5JEAF 2UU9I 4LF7E 2UUAI 1DARA 1Z5BA 4JI7E 4DR4I 5JEAC 2PNLA 3L7ZA 4LF4I 1Y5YA 2UU9E 4B3RI 4LFBI 4JI3E 2JEAB 2E1RA 2PO2B 2CVEA 4JI6E 4LF8E 2ZM6I 1IBLI 4B3TI 2PNZA 2VF3A 3P3GA 4KHPE 2Z5CA 1MU5A 4B3RE 2PO2A 2BV3A 4LFBE 2C38A 4IZKB 1N33E 2C39B 5DROA 1H7SA 2Z5CB 4DR2E 5C0XD 2NN6C 3F0NA 4MU0A 1B63A 4LFAE 4PRXA 4BA1B 4R1FA 4OX9I 2NN6F 2JEBB 4JI4E 1UDOA 4LF9E 4DPTA 4X65E 2PNMA 1USVA 2JEBA 2HKJA 1KIJA 1KVKA 1UDNA 4DV6I 4LCFA 4DUYI 2O3ZA 3CWVA 1FWKA 1P42A 2O1VA 1VI7A 1UDQA 4UT4A 5EKWA 4HXZA 3P3EA 1H73A 2Z5BA 1XNQE 4DV3E 2F1DA 1Z5AA 4YY3I 1XMOE 4OO1F 4HY1A 1USUA 4X62I 1PVGA 5JEAB 3Q1QA 4PRVA 5BR8E 1OJ4A 3UHMA 1XMQE 2J65A 4DV3I 3M85D 4U3BA 4YY3E 3T1YE 1XXEA 2R42A 5EL9A 4GKJI 2WP8B 3P3CA 2A2CA 1N0UA 5BR8I 2UUAE 4P7AA 1YH8A 4MDTA 1VISA 2UXBE 2CG9A 1A6FA 5FLXQ 1BKNA 4RPFA 1NZ0A 3PS1A 3U1KA 1NHIA 4QNKA 2O1TA 3V5RA 4IFDA 4M1KA 2BM1A 1FJGE 1J5EE 4DR5I 4LF8I 3DD6A 3GLLA 1EI1A 1IBLE 2JEAA 5DRPA 1XNRI 1FNMA 4KHPI 1N36I 4DV1E 2BA1D 5DRQA 3K85A 2V2VA 3L7ZB 1D6TA 2AE8A 5L3JA 3J81Q 2AJ4A 3P76A 1HR0E 3V2UC 4JI8I 2UXCE 1HNXE 3J81C 1N36E 4DV1I 2CZ9A 5JEAD 4QNJA 3PYDA 4DR7I 1H7UA 5A2QQ 3HULA 4JYAE 2GQ0A 2VQEI 4LF6I 3M7NG 1Z0BA 3CDJA 1HNXI 4JV5E 2BA0G 1HNZE 3NZKA 1IBME 4DV5E 4B3ME 4DU7A 2ZITA 4JV5I 1B62A 4LF5I 4B3SE 4B3MI 2O1WA 2BA0D 4LCGA 1OYPA 2IESA 4JI5E 2GO3A 4HACB 4Z7YA 3LTOA 3WU6A 4JI3I 5DRRA 3J80Q 3T1YI 4IZJA 2HK2A 1IBKI 3GONA 4JI1I 4LFCE 2WP8A 3CDIA 4NBQA 2BR2B 4MU3A 2HK3A 1N33I 1S4EA 2UXBI 2NPFA 4OO1D 2HKEA 4DUZE 1FI4A 4JI1E 4LOMA 4AIDA 1KTVA 1N32E 4USKA 2E5LE 4DR6I 1R6MA 1Y60A 4OX9E 4FWHA 4ZVIA 1N0VC 1ZM9A 3PYEA 1Z0TA 4LF4E 4J3DA 3WU3A 2E5LI 1UEKA 1NHHA 3QT5A 1RR9A 4BA2B 3JAMC 1PKPA 1HR0I 3JAMQ 4XTJA 1UDSA 4JI0I 3B8HA 4BA2A 3PS2A 4NXMI 5K36F 4DR7E 4OKGA 3M85G 4URLA 4JI2E 2ZBKB 4DR2I 2C39A 4JYAI 4Z7CA 4LF6E 1E3PA 3WU5A 3U1YA 1XMOI 5FWKA
chains in the Genus database with same CATH topology
1P42A 3P3CA 4LCHA 2GO4A 4U3DA 4J3DA 4FW3A 3P3EA 1YH8A 3P76A 4MDTA 4FW6A 3PS3A 4OZEA 4IS9A 1YHCA 4FW5A 3PS1A 2VESA 2JT2A 3PS2A 4FW7A 4LCGA 4ISAA 2IESA 3P3GA 4OKGA 3UHMA 2J65A 5DRPA 4U3BA 4MQYA 4LCFA 1XXEA 2IERA 2GO3A 4FW4A 5DROA 3NZKA 3U1YA 5DRQA 2O3ZA 5DRRA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1P42 A;  3P3C A;  4LCH A;  2GO4 A;  4U3D A;  4J3D A;  4FW3 A;  3P3E A;  1YH8 A;  3P76 A;  4MDT A;  4FW6 A;  3PS3 A;  4OZE A;  4IS9 A;  1YHC A;  4FW5 A;  3PS1 A;  2VES A;  2JT2 A;  3PS2 A;  4FW7 A;  4LCG A;  4ISA A;  2IES A;  3P3G A;  4OKG A;  3UHM A;  2J65 A;  5DRP A;  4U3B A;  4MQY A;  4LCF A;  1XXE A;  2IER A;  2GO3 A;  4FW4 A;  5DRO A;  3NZK A;  3U1Y A;  5DRQ A;  2O3Z A;  5DRR A; 
#chains in the Genus database with same CATH topology
 4X64 I;  4U3D A;  3PRY A;  4HYM A;  4YHH I;  1IBM I;  2Q2E B;  3PS3 A;  1XMQ I;  3K1J A;  4X65 I;  4IS9 A;  2UXD E;  4ISA A;  2UUC I;  4GKK I;  4OO1 B;  2R3V A;  4DV7 I;  3Q6M A;  1H72 C;  3H1C A;  3J7A M;  4AM3 A;  3T1H E;  1Z5C A;  3ZZ0 A;  1XHK A;  2Z5E A;  4JI7 I;  2PO0 A;  1FKA E;  3ZKB A;  5FLX C;  1FJG I;  3H4L A;  3GME A;  4LFC I;  1RHY A;  4DPY A;  2VES A;  5JEA A;  1OYR A;  4ED4 A;  5JEA E;  2V34 A;  4DV0 E;  2PNZ B;  4WUD A;  4HAC A;  5LMU E;  2V8P A;  2F4V E;  4IFD F;  1MG7 A;  3OTO I;  2DEI A;  1K47 A;  4K0K E;  3ZM7 A;  1R6L A;  4IFD C;  4X66 I;  3QT8 A;  1MX0 A;  1ZM4 A;  2UUB I;  2F4V I;  5K36 E;  2X36 A;  2A2D A;  3OTO E;  4IFD D;  4LFA I;  1J5E I;  4DR3 E;  1Y6Z A;  4FN5 A;  1XNR E;  1RRE A;  3PYF A;  4DV5 I;  4KQV A;  4JI0 E;  2NN6 E;  2NN6 A;  1Z0C A;  1ELO A;  2BM0 A;  4JG4 A;  3GCM A;  4NXN I;  4LF5 E;  4DU8 A;  4B3S I;  4JI2 I;  1QZR A;  4DV6 E;  4DUY E;  1EA6 A;  4B3T E;  2GO4 A;  4FW3 A;  3Q6N A;  1ZM2 A;  4X64 E;  3QT7 A;  5IT9 Q;  2Z5B B;  5C0X B;  4YHH E;  1N34 I;  4UTG A;  2V2Q A;  2C37 B;  5C0X C;  4I3H A;  1ZXM A;  4AQY I;  1Y4U A;  2VQE E;  1XNQ I;  2PO1 A;  2LJP A;  2JE6 B;  5DNL A;  1Z0V A;  1WUU A;  5C0X F;  5DNX A;  1FWL A;  5A2Q C;  1IBK E;  3J7A G;  4OO1 E;  1N34 E;  5IWA E;  2DEJ A;  4DXL A;  4P52 A;  4FW4 A;  2HHH I;  1HNW I;  5K36 A;  4MU4 A;  4DV7 E;  4OO1 A;  4DPU A;  4DUZ I;  3HKM A;  2J7K A;  4DPW A;  4DV2 I;  4EMD A;  3K17 A;  3T1H I;  2HFU A;  5LMN E;  4FW6 A;  4FWD A;  1H74 A;  3ZZU A;  1KKH A;  2VQF E;  1Z0E A;  2EFG A;  3ZZT A;  5GME A;  2HHH E;  1HNW E;  1YHC A;  2WNR A;  4FW5 A;  4OO1 C;  1Z59 A;  2GS8 A;  4FW7 A;  4IFD B;  3B82 A;  1E3H A;  4IZJ D;  1PIE A;  4WUC A;  2VQF I;  3P06 A;  4DR4 E;  2NN6 D;  2IER A;  1S16 A;  3LNU A;  3PYG A;  1ZXN A;  3KRN A;  4IZJ B;  2IOQ A;  5K36 D;  2BA1 G;  3LPS A;  2PO0 B;  4K0K I;  5C0X A;  4JI6 I;  2BR2 A;  2ZM6 E;  4GKJ E;  3B4T A;  3WU4 A;  2IOP A;  1U2R A;  1I94 E;  4JI8 E;  2O1U A;  2UXC I;  1N32 I;  2C38 B;  2CGE A;  4IZK A;  4DR6 E;  4AIM A;  1Y4S A;  2JT2 A;  1ZM3 A;  5GMD A;  1NHJ A;  4DR3 I;  3ZKD A;  4N3O A;  4WUB A;  4FW9 A;  4MQY A;  1I94 I;  2V2Z A;  4FWG A;  3QT6 A;  5ELW A;  4BA1 A;  4NXN E;  5LL6 R;  4DR5 E;  4DPX A;  2XEX A;  1HNZ I;  5IT9 C;  3M7N D;  4DR1 I;  4JI4 I;  4MU1 A;  4LF9 I;  4GQU A;  2X7I A;  5C0X E;  4OZE A;  2OI2 A;  4NXM E;  3D4J A;  4USM A;  3B78 A;  4MYU A;  2NN6 B;  4DR1 E;  4AQY E;  1OYS A;  4MYT A;  1Z0W A;  2PO1 B;  3J80 C;  5IWA I;  4DV4 I;  4PU9 A;  4JI5 I;  3HJC A;  4LCH A;  4LPF A;  2UXD I;  4DV0 I;  5K36 B;  2C37 A;  4X62 E;  1HK7 A;  4DV2 E;  5K36 C;  3M6A A;  5LMU I;  4DV4 E;  5LMN I;  4LF7 I;  1Z0G A;  2UUC E;  2JE6 A;  4IFD E;  4GKK E;  2WW4 A;  4X66 E;  2WNR B;  2HFS A;  2UUB E;  5JEA F;  2UU9 I;  4LF7 E;  2UUA I;  1DAR A;  1Z5B A;  4JI7 E;  4DR4 I;  5JEA C;  2PNL A;  3L7Z A;  4LF4 I;  1Y5Y A;  2UU9 E;  4B3R I;  4LFB I;  4JI3 E;  2JEA B;  2E1R A;  2PO2 B;  2CVE A;  4JI6 E;  4LF8 E;  2ZM6 I;  1IBL I;  4B3T I;  2PNZ A;  2VF3 A;  3P3G A;  4KHP E;  2Z5C A;  1MU5 A;  4B3R E;  2PO2 A;  2BV3 A;  4LFB E;  2C38 A;  4IZK B;  1N33 E;  2C39 B;  5DRO A;  1H7S A;  2Z5C B;  4DR2 E;  5C0X D;  2NN6 C;  3F0N A;  4MU0 A;  1B63 A;  4LFA E;  4PRX A;  4BA1 B;  4R1F A;  4OX9 I;  2NN6 F;  2JEB B;  4JI4 E;  1UDO A;  4LF9 E;  4DPT A;  4X65 E;  2PNM A;  1USV A;  2JEB A;  2HKJ A;  1KIJ A;  1KVK A;  1UDN A;  4DV6 I;  4LCF A;  4DUY I;  2O3Z A;  3CWV A;  1FWK A;  1P42 A;  2O1V A;  1VI7 A;  1UDQ A;  4UT4 A;  5EKW A;  4HXZ A;  3P3E A;  1H73 A;  2Z5B A;  1XNQ E;  4DV3 E;  2F1D A;  1Z5A A;  4YY3 I;  1XMO E;  4OO1 F;  4HY1 A;  1USU A;  4X62 I;  1PVG A;  5JEA B;  3Q1Q A;  4PRV A;  5BR8 E;  1OJ4 A;  3UHM A;  1XMQ E;  2J65 A;  4DV3 I;  3M85 D;  4U3B A;  4YY3 E;  3T1Y E;  1XXE A;  2R42 A;  5EL9 A;  4GKJ I;  2WP8 B;  3P3C A;  2A2C A;  1N0U A;  5BR8 I;  2UUA E;  4P7A A;  1YH8 A;  4MDT A;  1VIS A;  2UXB E;  2CG9 A;  1A6F A;  5FLX Q;  1BKN A;  4RPF A;  1NZ0 A;  3PS1 A;  3U1K A;  1NHI A;  4QNK A;  2O1T A;  3V5R A;  4IFD A;  4M1K A;  2BM1 A;  1FJG E;  1J5E E;  4DR5 I;  4LF8 I;  3DD6 A;  3GLL A;  1EI1 A;  1IBL E;  2JEA A;  5DRP A;  1XNR I;  1FNM A;  4KHP I;  1N36 I;  4DV1 E;  2BA1 D;  5DRQ A;  3K85 A;  2V2V A;  3L7Z B;  1D6T A;  2AE8 A;  5L3J A;  3J81 Q;  2AJ4 A;  3P76 A;  1HR0 E;  3V2U C;  4JI8 I;  2UXC E;  1HNX E;  3J81 C;  1N36 E;  4DV1 I;  2CZ9 A;  5JEA D;  4QNJ A;  3PYD A;  4DR7 I;  1H7U A;  5A2Q Q;  3HUL A;  4JYA E;  2GQ0 A;  2VQE I;  4LF6 I;  3M7N G;  1Z0B A;  3CDJ A;  1HNX I;  4JV5 E;  2BA0 G;  1HNZ E;  3NZK A;  1IBM E;  4DV5 E;  4B3M E;  4DU7 A;  2ZIT A;  4JV5 I;  1B62 A;  4LF5 I;  4B3S E;  4B3M I;  2O1W A;  2BA0 D;  4LCG A;  1OYP A;  2IES A;  4JI5 E;  2GO3 A;  4HAC B;  4Z7Y A;  3LTO A;  3WU6 A;  4JI3 I;  5DRR A;  3J80 Q;  3T1Y I;  4IZJ A;  2HK2 A;  1IBK I;  3GON A;  4JI1 I;  4LFC E;  2WP8 A;  3CDI A;  4NBQ A;  2BR2 B;  4MU3 A;  2HK3 A;  1N33 I;  1S4E A;  2UXB I;  2NPF A;  4OO1 D;  2HKE A;  4DUZ E;  1FI4 A;  4JI1 E;  4LOM A;  4AID A;  1KTV A;  1N32 E;  4USK A;  2E5L E;  4DR6 I;  1R6M A;  1Y60 A;  4OX9 E;  4FWH A;  4ZVI A;  1N0V C;  1ZM9 A;  3PYE A;  1Z0T A;  4LF4 E;  4J3D A;  3WU3 A;  2E5L I;  1UEK A;  1NHH A;  3QT5 A;  1RR9 A;  4BA2 B;  3JAM C;  1PKP A;  1HR0 I;  3JAM Q;  4XTJ A;  1UDS A;  4JI0 I;  3B8H A;  4BA2 A;  3PS2 A;  4NXM I;  5K36 F;  4DR7 E;  4OKG A;  3M85 G;  4URL A;  4JI2 E;  2ZBK B;  4DR2 I;  2C39 A;  4JYA I;  4Z7C A;  4LF6 E;  1E3P A;  3WU5 A;  3U1Y A;  1XMO I;  5FWK A; 
#chains in the Genus database with same CATH homology
 1P42 A;  3P3C A;  4LCH A;  2GO4 A;  4U3D A;  4J3D A;  4FW3 A;  3P3E A;  1YH8 A;  3P76 A;  4MDT A;  4FW6 A;  3PS3 A;  4OZE A;  4IS9 A;  1YHC A;  4FW5 A;  3PS1 A;  2VES A;  2JT2 A;  3PS2 A;  4FW7 A;  4LCG A;  4ISA A;  2IES A;  3P3G A;  4OKG A;  3UHM A;  2J65 A;  5DRP A;  4U3B A;  4MQY A;  4LCF A;  1XXE A;  2IER A;  2GO3 A;  4FW4 A;  5DRO A;  3NZK A;  3U1Y A;  5DRQ A;  2O3Z A;  5DRR A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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