4ISAA

Crystal structure of the escherichia coli lpxc/bb-78485 complex
Total Genus 90
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
90
sequence length
300
structure length
300
Chain Sequence
b'MIKQRTLKRIVQATGVGLHTGKKVTLTLRPAPANTGVIYRRTDLNPPVDFPADAKSVRDTMLCTCLVNEHDVRISTVEHLNAALAGLGIDNIVIEVNAPEIPIMDGSAAPFVYLLLDAGIDELNCAKKFVRIKETVRVEDGDKWAEFKPYNGFSLDFTIDFNHPAIDSSNQRYAMNFSADAFMRQISRARTFGFMRDIEYLQSRGLCLGGSFDCAIVVDDYRVLNEDGLRFEDEFVRHKMLDAIGDLFMCGHNIIGAFTAYKSGHALNNKLLQAVLAKQEAWEYVTFQDDAELPLAFKAP'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase
publication title Structural Basis of the Promiscuous Inhibitor Susceptibility of Escherichia coli LpxC.
pubmed doi rcsb
source organism Escherichia coli
molecule tags Hydrolase/hydrolase inhibitor
total genus 90
structure length 300
sequence length 300
ec nomenclature ec 3.5.1.-:
pdb deposition date 2013-01-16
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.230.20 Alpha Beta 2-Layer Sandwich Ribosomal Protein S5; domain 2 lpxc deacetylase, domain 1 4isaA01
3.30.1700.10 Alpha Beta 2-Layer Sandwich lpxc deacetylase, domain 1 lpxc deacetylase, domain 2 4isaA02
4OKGA 2JT2A 2GO3A 3P76A 3P3GA 5DRRA 2J65A 2O3ZA 4MQYA 3PS2A 4IS9A 4ISAA 3UHMA 4FW7A 3P3CA 4OZEA 5DRPA 5DRQA 3PS1A 1XXEA 3P3EA 4MDTA 4FW4A 4LCHA 2IERA 5DROA 4J3DA 4U3BA 4FW3A 4FW5A 2IESA 1P42A 4FW6A 1YH8A 2VESA 3NZKA 4LCFA 4U3DA 1YHCA 3PS3A 4LCGA 2GO4A 3U1YA
chains in the Genus database with same CATH superfamily
2WP8A 1EI1A 1IBKI 4LFAI 3PS2A 2JE6B 1RREA 4JI2I 4YY3E 2V2QA 2UXBI 4LF9E 2C37A 1Z0TA 4B3RE 5IWAE 2CGEA 1XNQE 1NZ0A 3Q6MA 2JEBA 4DR4E 1ZXNA 3WU4A 2IOQA 3JAMQ 2CG9A 5LL6R 4JI1I 1E3PA 2O1WA 4DU8A 4X64I 1UEKA 4LF8E 3HKMA 3NZKA 1OYPA 1Y60A 4DV2E 3U1YA 4OKGA 1IBLE 4DR1E 3P3GA 2BA1D 4DV6E 4LF4E 4JV5E 2VF3A 2AE8A 1N33I 3PYGA 2ZITA 5FLXQ 2UU9I 1XNRE 4YHHI 2C38A 1VI7A 4X66I 1UDOA 4OO1B 3T1YI 4R1FA 5EL9A 1KTVA 2IERA 3J80C 4J3DA 1IBME 4NXNI 5BR8E 2Z5CB 5C0XE 4DR3I 1FKAE 4DR7I 2C39B 4DV7I 1HNXE 3M7NG 1R6MA 4MU1A 1I94E 3Q6NA 4DV4E 2O1VA 2X36A 1OYRA 3M85D 4DR5I 4MQYA 3WU6A 4IS9A 5JEAA 4Z7CA 2BR2B 4DPTA 5JEAC 1Y6ZA 2NN6D 2GS8A 4YY3I 1USUA 4B3TI 4B3RI 1PVGA 5IWAI 2NN6F 4LPFA 5GMDA 2J7KA 5C0XB 1H7SA 4IFDD 4LFBE 4LF7E 3ZM7A 4JYAE 2ZM6E 4IFDF 3HJCA 4HXZA 1Z59A 3OTOI 2HK3A 2PNLA 4DV2I 4HACA 3M7ND 3GONA 2UUCI 5DNXA 2O3ZA 4ZVIA 1IBLI 4BA1A 4DV6I 1N36E 1HK7A 3P3CA 4LF4I 3J7AM 2NN6E 4JV5I 2O1UA 1XNRI 4MU4A 5DROA 2JEAA 2PO2A 2HFUA 5FWKA 4DV3E 1ZM4A 1IBMI 5BR8I 4U3DA 5K36A 1N34E 2V2ZA 1PIEA 4MU3A 1HNXI 1I94I 4JI5E 2DEJA 1A6FA 2PNZA 4ED4A 5EKWA 5ELWA 2WNRA 3DD6A 4OO1D 1FI4A 1Y5YA 1Z0GA 1Y4UA 5A2QC 1YH8A 2Z5BB 4X65E 4OO1F 4LCFA 2DEIA 4NXME 4LFBI 1PKPA 5DNLA 2WW4A 4JYAI 1UDQA 4GKKE 3J7AG 4JI8I 4JI3E 4KHPE 5DRPA 1S16A 3LTOA 1HNZI 3KRNA 3ZZTA 1N36I 4OO1E 1N32I 2BA0D 1Z5AA 4K0KE 4DPYA 1D6TA 2WP8B 1N0VC 4DR2E 1XMQI 5C0XD 4P7AA 4IZJA 2PNMA 1HR0E 4DV3I 5C0XF 1HNWE 2C37B 4DPUA 4LFCE 2J65A 1EA6A 3ZZ0A 4B3MI 3QT7A 2JEBB 1N34I 2BM1A 2F4VI 2E1RA 4FW7A 1NHJA 2UXCI 1Z0VA 2HK2A 4JI5I 1RR9A 4DU7A 4MDTA 4FW4A 4LCHA 4OX9E 2PO0A 4AIDA 4FW5A 4X62E 3T1HE 4FW6A 4BA2A 4FW9A 3QT8A 5JEAE 1E3HA 1ZM9A 4KQVA 1XHKA 4X65I 5GMEA 4QNJA 2C38B 3PYDA 4ISAA 1H7UA 5IT9Q 2HKJA 4GKKI 1RHYA 3PS1A 4JI3I 3PRYA 3K85A 4LF9I 2OI2A 4MU0A 3B82A 1XNQI 4FW3A 4JI7E 4JI6E 2V2VA 4DR4I 1J5EE 1B62A 2BV3A 2VESA 2HKEA 3D4JA 4EMDA 3JAMC 5JEAB 4DR2I 4LF8I 4B3SE 1HR0I 4DUZE 1HNWI 1MG7A 3J81Q 4GQUA 1Z0WA 4DR1I 1Z0EA 4URLA 2A2CA 2NPFA 1U2RA 1MU5A 4DPXA 5LMNE 4IZKA 5FLXC 4HACB 2XEXA 4P52A 4X62I 3T1HI 1YHCA 4BA1B 2PO1A 1B63A 1XMOE 5K36C 1OYSA 1Z5CA 3ZZUA 4HYMA 4DXLA 4DV4I 2UXDE 2JEAB 3ZKBA 4USMA 2PO2B 4HY1A 5DRQA 1UDSA 2Z5EA 1XXEA 1VISA 1FJGE 2NN6A 1Z0CA 3L7ZA 5K36B 1ZM3A 3V2UC 4JI7I 4JI6I 4IFDA 4LF7I 4IFDC 2GO3A 3B8HA 4M1KA 2EFGA 2ZM6I 2F1DA 2UUBE 4B3SI 3GCMA 3T1YE 2WNRB 4AQYE 4FWGA 2LJPA 3ZKDA 3LNUA 2JE6A 4NBQA 4DR7E 3J81C 4U3BA 4UT4A 3WU5A 2HHHE 4DR5E 1DARA 4DUYE 1USVA 2BA1G 5LMNI 4LOMA 2V34A 3PYEA 2JT2A 3LPSA 5JEAD 3HULA 2R42A 4B3TE 5JEAF 1XMOI 4MYUA 4DV1E 2CVEA 1H73A 3P3EA 2UXDI 4IZJB 4PU9A 5LMUE 1P42A 3OTOE 1FJGI 4LF6E 4OO1A 4JG4A 3B4TA 3M85G 4FWDA 4OO1C 2UUCE 2BM0A 2Z5CA 2VQFE 4DV5E 4DV0E 1N0UA 2C39A 5DRRA 3H1CA 4NXMI 2AJ4A 3V5RA 3U1KA 2PO0B 1R6LA 3QT6A 4WUCA 2UUBI 2E5LE 2X7IA 4AQYI 1UDNA 4KHPI 4BA2B 2BR2A 2ZBKB 3K17A 3WU3A 1FWKA 2HFSA 1Y4SA 3P06A 1Z5BA 3GLLA 5K36D 2HHHI 4LF5E 4JI0E 4K0KI 5C0XA 4DUYI 5K36F 1KKHA 4JI4E 2UUAE 4DR6E 4GKJE 3P76A 2Q2EB 5C0XC 3CWVA 4AM3A 1KVKA 1NHIA 4DPWA 4LFCI 4OZEA 4FWHA 5A2QQ 2VQEE 3Q1QA 3M6AA 4DV1I 2GQ0A 5L3JA 5K36E 4OX9I 2R3VA 4FN5A 4UTGA 5LMUI 1WUUA 1IBKE 3B78A 2O1TA 4JI8E 4LFAE 4LF6I 4JI2E 4PRVA 3K1JA 2UXBE 3H4LA 2VQFI 3UHMA 4DV5I 1HNZE 1NHHA 4DV0I 4Z7YA 4RPFA 3GMEA 4IZKB 1N32E 4WUDA 4I3HA 4JI1E 1XMQE 4X64E 4IFDE 2E5LI 4IZJD 2IESA 5IT9C 3F0NA 1FNMA 2NN6C 2PO1B 4QNKA 1BKNA 1KIJA 2V8PA 1H74A 2A2DA 4AIMA 4B3ME 3PS3A 4LCGA 3PYFA 4XTJA 2PNZB 1J5EI 2F4VE 1K47A 4WUBA 1S4EA 4LF5I 4JI0I 1N33E 2UXCE 2Z5BA 2UU9E 1H72C 4YHHE 1OJ4A 1ELOA 4JI4I 3QT5A 3J80Q 2UUAI 4X66E 4DR6I 4GKJI 4MYTA 2NN6B 1MX0A 3L7ZB 1Z0BA 2BA0G 4DUZI 1ZM2A 4NXNE 3CDJA 2IOPA 4N3OA 4DR3E 4IFDB 2VQEI 4DV7E 4USKA 1QZRA 1FWLA 3CDIA 4PRXA 1ZXMA 2GO4A 2CZ9A
chains in the Genus database with same CATH topology
4OKGA 2JT2A 2GO3A 3P76A 3P3GA 5DRRA 2J65A 2O3ZA 4MQYA 3PS2A 4IS9A 4ISAA 3UHMA 4FW7A 3P3CA 4OZEA 5DRPA 5DRQA 3PS1A 1XXEA 3P3EA 4MDTA 4FW4A 4LCHA 2IERA 5DROA 4J3DA 4U3BA 4FW3A 4FW5A 2IESA 1P42A 4FW6A 1YH8A 2VESA 3NZKA 4LCFA 4U3DA 1YHCA 3PS3A 4LCGA 2GO4A 3U1YA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4OKG A;  2JT2 A;  2GO3 A;  3P76 A;  3P3G A;  5DRR A;  2J65 A;  2O3Z A;  4MQY A;  3PS2 A;  4IS9 A;  4ISA A;  3UHM A;  4FW7 A;  3P3C A;  4OZE A;  5DRP A;  5DRQ A;  3PS1 A;  1XXE A;  3P3E A;  4MDT A;  4FW4 A;  4LCH A;  2IER A;  5DRO A;  4J3D A;  4U3B A;  4FW3 A;  4FW5 A;  2IES A;  1P42 A;  4FW6 A;  1YH8 A;  2VES A;  3NZK A;  4LCF A;  4U3D A;  1YHC A;  3PS3 A;  4LCG A;  2GO4 A;  3U1Y A; 
#chains in the Genus database with same CATH topology
 2WP8 A;  1EI1 A;  1IBK I;  4LFA I;  3PS2 A;  2JE6 B;  1RRE A;  4JI2 I;  4YY3 E;  2V2Q A;  2UXB I;  4LF9 E;  2C37 A;  1Z0T A;  4B3R E;  5IWA E;  2CGE A;  1XNQ E;  1NZ0 A;  3Q6M A;  2JEB A;  4DR4 E;  1ZXN A;  3WU4 A;  2IOQ A;  3JAM Q;  2CG9 A;  5LL6 R;  4JI1 I;  1E3P A;  2O1W A;  4DU8 A;  4X64 I;  1UEK A;  4LF8 E;  3HKM A;  3NZK A;  1OYP A;  1Y60 A;  4DV2 E;  3U1Y A;  4OKG A;  1IBL E;  4DR1 E;  3P3G A;  2BA1 D;  4DV6 E;  4LF4 E;  4JV5 E;  2VF3 A;  2AE8 A;  1N33 I;  3PYG A;  2ZIT A;  5FLX Q;  2UU9 I;  1XNR E;  4YHH I;  2C38 A;  1VI7 A;  4X66 I;  1UDO A;  4OO1 B;  3T1Y I;  4R1F A;  5EL9 A;  1KTV A;  2IER A;  3J80 C;  4J3D A;  1IBM E;  4NXN I;  5BR8 E;  2Z5C B;  5C0X E;  4DR3 I;  1FKA E;  4DR7 I;  2C39 B;  4DV7 I;  1HNX E;  3M7N G;  1R6M A;  4MU1 A;  1I94 E;  3Q6N A;  4DV4 E;  2O1V A;  2X36 A;  1OYR A;  3M85 D;  4DR5 I;  4MQY A;  3WU6 A;  4IS9 A;  5JEA A;  4Z7C A;  2BR2 B;  4DPT A;  5JEA C;  1Y6Z A;  2NN6 D;  2GS8 A;  4YY3 I;  1USU A;  4B3T I;  4B3R I;  1PVG A;  5IWA I;  2NN6 F;  4LPF A;  5GMD A;  2J7K A;  5C0X B;  1H7S A;  4IFD D;  4LFB E;  4LF7 E;  3ZM7 A;  4JYA E;  2ZM6 E;  4IFD F;  3HJC A;  4HXZ A;  1Z59 A;  3OTO I;  2HK3 A;  2PNL A;  4DV2 I;  4HAC A;  3M7N D;  3GON A;  2UUC I;  5DNX A;  2O3Z A;  4ZVI A;  1IBL I;  4BA1 A;  4DV6 I;  1N36 E;  1HK7 A;  3P3C A;  4LF4 I;  3J7A M;  2NN6 E;  4JV5 I;  2O1U A;  1XNR I;  4MU4 A;  5DRO A;  2JEA A;  2PO2 A;  2HFU A;  5FWK A;  4DV3 E;  1ZM4 A;  1IBM I;  5BR8 I;  4U3D A;  5K36 A;  1N34 E;  2V2Z A;  1PIE A;  4MU3 A;  1HNX I;  1I94 I;  4JI5 E;  2DEJ A;  1A6F A;  2PNZ A;  4ED4 A;  5EKW A;  5ELW A;  2WNR A;  3DD6 A;  4OO1 D;  1FI4 A;  1Y5Y A;  1Z0G A;  1Y4U A;  5A2Q C;  1YH8 A;  2Z5B B;  4X65 E;  4OO1 F;  4LCF A;  2DEI A;  4NXM E;  4LFB I;  1PKP A;  5DNL A;  2WW4 A;  4JYA I;  1UDQ A;  4GKK E;  3J7A G;  4JI8 I;  4JI3 E;  4KHP E;  5DRP A;  1S16 A;  3LTO A;  1HNZ I;  3KRN A;  3ZZT A;  1N36 I;  4OO1 E;  1N32 I;  2BA0 D;  1Z5A A;  4K0K E;  4DPY A;  1D6T A;  2WP8 B;  1N0V C;  4DR2 E;  1XMQ I;  5C0X D;  4P7A A;  4IZJ A;  2PNM A;  1HR0 E;  4DV3 I;  5C0X F;  1HNW E;  2C37 B;  4DPU A;  4LFC E;  2J65 A;  1EA6 A;  3ZZ0 A;  4B3M I;  3QT7 A;  2JEB B;  1N34 I;  2BM1 A;  2F4V I;  2E1R A;  4FW7 A;  1NHJ A;  2UXC I;  1Z0V A;  2HK2 A;  4JI5 I;  1RR9 A;  4DU7 A;  4MDT A;  4FW4 A;  4LCH A;  4OX9 E;  2PO0 A;  4AID A;  4FW5 A;  4X62 E;  3T1H E;  4FW6 A;  4BA2 A;  4FW9 A;  3QT8 A;  5JEA E;  1E3H A;  1ZM9 A;  4KQV A;  1XHK A;  4X65 I;  5GME A;  4QNJ A;  2C38 B;  3PYD A;  4ISA A;  1H7U A;  5IT9 Q;  2HKJ A;  4GKK I;  1RHY A;  3PS1 A;  4JI3 I;  3PRY A;  3K85 A;  4LF9 I;  2OI2 A;  4MU0 A;  3B82 A;  1XNQ I;  4FW3 A;  4JI7 E;  4JI6 E;  2V2V A;  4DR4 I;  1J5E E;  1B62 A;  2BV3 A;  2VES A;  2HKE A;  3D4J A;  4EMD A;  3JAM C;  5JEA B;  4DR2 I;  4LF8 I;  4B3S E;  1HR0 I;  4DUZ E;  1HNW I;  1MG7 A;  3J81 Q;  4GQU A;  1Z0W A;  4DR1 I;  1Z0E A;  4URL A;  2A2C A;  2NPF A;  1U2R A;  1MU5 A;  4DPX A;  5LMN E;  4IZK A;  5FLX C;  4HAC B;  2XEX A;  4P52 A;  4X62 I;  3T1H I;  1YHC A;  4BA1 B;  2PO1 A;  1B63 A;  1XMO E;  5K36 C;  1OYS A;  1Z5C A;  3ZZU A;  4HYM A;  4DXL A;  4DV4 I;  2UXD E;  2JEA B;  3ZKB A;  4USM A;  2PO2 B;  4HY1 A;  5DRQ A;  1UDS A;  2Z5E A;  1XXE A;  1VIS A;  1FJG E;  2NN6 A;  1Z0C A;  3L7Z A;  5K36 B;  1ZM3 A;  3V2U C;  4JI7 I;  4JI6 I;  4IFD A;  4LF7 I;  4IFD C;  2GO3 A;  3B8H A;  4M1K A;  2EFG A;  2ZM6 I;  2F1D A;  2UUB E;  4B3S I;  3GCM A;  3T1Y E;  2WNR B;  4AQY E;  4FWG A;  2LJP A;  3ZKD A;  3LNU A;  2JE6 A;  4NBQ A;  4DR7 E;  3J81 C;  4U3B A;  4UT4 A;  3WU5 A;  2HHH E;  4DR5 E;  1DAR A;  4DUY E;  1USV A;  2BA1 G;  5LMN I;  4LOM A;  2V34 A;  3PYE A;  2JT2 A;  3LPS A;  5JEA D;  3HUL A;  2R42 A;  4B3T E;  5JEA F;  1XMO I;  4MYU A;  4DV1 E;  2CVE A;  1H73 A;  3P3E A;  2UXD I;  4IZJ B;  4PU9 A;  5LMU E;  1P42 A;  3OTO E;  1FJG I;  4LF6 E;  4OO1 A;  4JG4 A;  3B4T A;  3M85 G;  4FWD A;  4OO1 C;  2UUC E;  2BM0 A;  2Z5C A;  2VQF E;  4DV5 E;  4DV0 E;  1N0U A;  2C39 A;  5DRR A;  3H1C A;  4NXM I;  2AJ4 A;  3V5R A;  3U1K A;  2PO0 B;  1R6L A;  3QT6 A;  4WUC A;  2UUB I;  2E5L E;  2X7I A;  4AQY I;  1UDN A;  4KHP I;  4BA2 B;  2BR2 A;  2ZBK B;  3K17 A;  3WU3 A;  1FWK A;  2HFS A;  1Y4S A;  3P06 A;  1Z5B A;  3GLL A;  5K36 D;  2HHH I;  4LF5 E;  4JI0 E;  4K0K I;  5C0X A;  4DUY I;  5K36 F;  1KKH A;  4JI4 E;  2UUA E;  4DR6 E;  4GKJ E;  3P76 A;  2Q2E B;  5C0X C;  3CWV A;  4AM3 A;  1KVK A;  1NHI A;  4DPW A;  4LFC I;  4OZE A;  4FWH A;  5A2Q Q;  2VQE E;  3Q1Q A;  3M6A A;  4DV1 I;  2GQ0 A;  5L3J A;  5K36 E;  4OX9 I;  2R3V A;  4FN5 A;  4UTG A;  5LMU I;  1WUU A;  1IBK E;  3B78 A;  2O1T A;  4JI8 E;  4LFA E;  4LF6 I;  4JI2 E;  4PRV A;  3K1J A;  2UXB E;  3H4L A;  2VQF I;  3UHM A;  4DV5 I;  1HNZ E;  1NHH A;  4DV0 I;  4Z7Y A;  4RPF A;  3GME A;  4IZK B;  1N32 E;  4WUD A;  4I3H A;  4JI1 E;  1XMQ E;  4X64 E;  4IFD E;  2E5L I;  4IZJ D;  2IES A;  5IT9 C;  3F0N A;  1FNM A;  2NN6 C;  2PO1 B;  4QNK A;  1BKN A;  1KIJ A;  2V8P A;  1H74 A;  2A2D A;  4AIM A;  4B3M E;  3PS3 A;  4LCG A;  3PYF A;  4XTJ A;  2PNZ B;  1J5E I;  2F4V E;  1K47 A;  4WUB A;  1S4E A;  4LF5 I;  4JI0 I;  1N33 E;  2UXC E;  2Z5B A;  2UU9 E;  1H72 C;  4YHH E;  1OJ4 A;  1ELO A;  4JI4 I;  3QT5 A;  3J80 Q;  2UUA I;  4X66 E;  4DR6 I;  4GKJ I;  4MYT A;  2NN6 B;  1MX0 A;  3L7Z B;  1Z0B A;  2BA0 G;  4DUZ I;  1ZM2 A;  4NXN E;  3CDJ A;  2IOP A;  4N3O A;  4DR3 E;  4IFD B;  2VQE I;  4DV7 E;  4USK A;  1QZR A;  1FWL A;  3CDI A;  4PRX A;  1ZXM A;  2GO4 A;  2CZ9 A; 
#chains in the Genus database with same CATH homology
 4OKG A;  2JT2 A;  2GO3 A;  3P76 A;  3P3G A;  5DRR A;  2J65 A;  2O3Z A;  4MQY A;  3PS2 A;  4IS9 A;  4ISA A;  3UHM A;  4FW7 A;  3P3C A;  4OZE A;  5DRP A;  5DRQ A;  3PS1 A;  1XXE A;  3P3E A;  4MDT A;  4FW4 A;  4LCH A;  2IER A;  5DRO A;  4J3D A;  4U3B A;  4FW3 A;  4FW5 A;  2IES A;  1P42 A;  4FW6 A;  1YH8 A;  2VES A;  3NZK A;  4LCF A;  4U3D A;  1YHC A;  3PS3 A;  4LCG A;  2GO4 A;  3U1Y A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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