4ISAA

Crystal structure of the escherichia coli lpxc/bb-78485 complex
Total Genus 90
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
90
sequence length
300
structure length
300
Chain Sequence
MIKQRTLKRIVQATGVGLHTGKKVTLTLRPAPANTGVIYRRTDLNPPVDFPADAKSVRDTMLCTCLVNEHDVRISTVEHLNAALAGLGIDNIVIEVNAPEIPIMDGSAAPFVYLLLDAGIDELNCAKKFVRIKETVRVEDGDKWAEFKPYNGFSLDFTIDFNHPAIDSSNQRYAMNFSADAFMRQISRARTFGFMRDIEYLQSRGLCLGGSFDCAIVVDDYRVLNEDGLRFEDEFVRHKMLDAIGDLFMCGHNIIGAFTAYKSGHALNNKLLQAVLAKQEAWEYVTFQDDAELPLAFKAP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural Basis of the Promiscuous Inhibitor Susceptibility of Escherichia coli LpxC.
pubmed doi rcsb
source organism Escherichia coli
molecule tags Hydrolase/hydrolase inhibitor
molecule keywords UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase
total genus 90
structure length 300
sequence length 300
ec nomenclature ec 3.5.1.-:
pdb deposition date 2013-01-16
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.230.20 Alpha Beta 2-Layer Sandwich Ribosomal Protein S5; domain 2 lpxc deacetylase, domain 1 4isaA01
3.30.1700.10 Alpha Beta 2-Layer Sandwich lpxc deacetylase, domain 1 lpxc deacetylase, domain 2 4isaA02
3NZKA 4FW5A 5DROA 3P76A 1P42A 4J3DA 2GO3A 2J65A 3PS2A 4ISAA 4MQYA 4IS9A 5DRPA 4FW3A 3P3EA 3PS1A 4LCGA 4OKGA 3U1YA 4LCFA 2IESA 2O3ZA 4OZEA 2JT2A 1YH8A 2GO4A 3P3CA 3UHMA 4FW6A 1YHCA 4MDTA 2VESA 4LCHA 4U3DA 1XXEA 2IERA 4U3BA 5DRRA 4FW4A 3PS3A 5DRQA 4FW7A 3P3GA
chains in the Genus database with same CATH superfamily
4UT4A 4DV5I 2E5LI 2C37B 3L7ZA 4DPUA 4FW5A 3QT8A 4DV3E 2CGEA 4OO1E 3T1YI 3PYGA 1RREA 4GQUA 4ISAA 4IFDB 3B8HA 5DRPA 2HK3A 4JI5I 3ZKBA 1MG7A 4PU9A 2UXCI 2JT2A 2GO4A 3P3CA 2JEAA 3CWVA 1E3HA 2BM0A 4K0KE 2GS8A 2R3VA 4B3TI 2GQ0A 1Y60A 4WUCA 2UXCE 3Q1QA 5EL9A 3V5RA 4LF8E 4LFCI 4DPYA 4JI7I 4IZKA 1J5EI 4LF6I 4DV7I 4NXNE 2NN6C 2HKJA 4DR5I 4LPFA 3B78A 4DU8A 1N32I 5A2QC 2ZM6E 4IFDA 4JI6I 4LF5E 1A6FA 1H73A 2JE6A 2E1RA 1YHCA 2VESA 4XTJA 5LL6R 4DV2I 4DR7I 5K36B 1IBLI 1OYRA 1S16A 2O1UA 5FLXC 3WU5A 1PIEA 3CDJA 1Z0CA 4URLA 3D4JA 1HK7A 1FJGE 1IBKE 1FKAE 2DEJA 2UUCE 1XNQE 1B62A 4JI0E 4DUYI 4ED4A 5C0XB 4NXNI 4OZEA 4IFDC 4OO1B 4NXMI 4DR2I 4JYAI 4LFAE 4JI1E 1Z0GA 1XNQI 1N0UA 3PYEA 5DNXA 4IFDF 4KHPI 4AM3A 2A2DA 3M6AA 4DR4E 2V2VA 2PO1B 2O1VA 1OYSA 2X7IA 4J3DA 2PNZA 2Z5BB 3J80Q 2PO1A 1FWKA 4DV0E 4JV5E 2UXBI 4FW3A 4HACB 3OTOE 1I94I 2HKEA 3ZZUA 3QT6A 1HNXI 2BA1D 4BA2B 4DPWA 4NBQA 4MU4A 1NHHA 1HR0E 4U3DA 2JEBA 5EKWA 2HFUA 2C39B 2VQEI 5IT9Q 4Z7YA 4JI4I 4LF9E 2BA0D 3DD6A 3P76A 2UUCI 4B3MI 4WUBA 2GO3A 3GLLA 3P3EA 2Z5BA 2PNZB 4X64I 2UXDE 3ZM7A 1UEKA 4KHPE 4DV2E 1ELOA 5JEAC 3WU6A 5LMUI 4LCHA 4B3SI 1N33E 5L3JA 4U3BA 4DPTA 3K1JA 4MU3A 4KQVA 2VF3A 2NN6E 3H1CA 2Q2EB 3NZKA 4MYUA 1XNRI 5DROA 4DR5E 1N33I 1IBKI 4B3RE 4IFDE 4DU7A 4MU1A 1Z59A 3OTOI 2JE6B 4LOMA 2ZBKB 3P06A 4FWGA 3GONA 4DV6I 4IFDD 2AE8A 1USUA 4FWHA 1UDSA 2NN6D 4MDTA 3T1HE 2IERA 4DR3E 2VQFI 4DR1I 1N32E 3WU3A 3J80C 4X66I 3T1YE 1KKHA 3QT7A 4DR2E 2XEXA 4X66E 3Q6MA 4HY1A 1RR9A 2HHHE 2IESA 5BR8I 5ELWA 2CZ9A 2Z5EA 1DARA 5C0XC 4FWDA 1KIJA 3B82A 1FJGI 2UUBE 2BR2B 2V8PA 5A2QQ 3HJCA 4OKGA 3CDIA 5K36D 4X65E 4DR7E 1PKPA 2O1WA 4DR6E 5BR8E 1XNRE 1S4EA 4PRXA 3PRYA 5JEAD 5GMEA 1EI1A 3PS2A 4Z7CA 4GKJE 2C39A 4JI6E 3PS1A 5C0XA 2BM1A 4LCFA 1N36E 5C0XD 3WU4A 4LF4I 3L7ZB 1ZM3A 4JV5I 1IBME 1Z0EA 1Z5AA 1Y5YA 2PO2A 5GMDA 2X36A 2PO2B 4MU0A 4IZJA 2ZITA 4USKA 1ZM9A 4OO1D 5K36A 1D6TA 4DV0I 1NHJA 1ZM2A 3LPSA 4HXZA 2PO0B 4YHHE 3GCMA 1PVGA 5FLXQ 4MQYA 3J7AG 2WW4A 4PRVA 4X62E 2A2CA 4FW6A 5C0XF 1HNXE 4LFCE 2C38A 4LFAI 2Z5CA 4DV3I 3K85A 4DV4I 5JEAE 4X62I 1Y4UA 1OYPA 3PS3A 4LF7I 1FNMA 1E3PA 4UTGA 4K0KI 3JAMC 2UU9I 4X65I 2VQFE 4DR1E 4I3HA 2UXDI 2F1DA 2UXBE 4QNKA 5K36F 2R42A 3ZZ0A 4AIMA 4JI2E 1KVKA 4DV1E 1HNWI 4DPXA 2O3ZA 1UDNA 4AQYI 1IBMI 4P7AA 2VQEE 4B3RI 2JEBB 4OO1F 2E5LE 1MU5A 2ZM6I 4DV7E 5LMNI 2C37A 4OX9E 2C38B 1Y6ZA 2V2ZA 2IOQA 1QZRA 2AJ4A 4DV5E 4RPFA 1R6LA 1H7SA 1I94E 2BA1G 1H72C 4YHHI 1BKNA 2PNLA 3LNUA 1EA6A 4BA1A 3J81Q 1WUUA 2OI2A 4DV1I 2F4VE 2WP8B 3GMEA 4ZVIA 4X64E 4HYMA 3J81C 2JEAB 2DEIA 3ZZTA 4LF5I 3B4TA 2NN6B 3JAMQ 2CG9A 4HACA 1MX0A 4FW7A 3M85D 4DV4E 3H4LA 4OO1A 3ZKDA 5C0XE 4WUDA 1VI7A 5JEAF 1XMOI 1HR0I 2J65A 1J5EE 4LF6E 4YY3I 2V34A 4DXLA 1Z0VA 4DR6I 3PYFA 4FN5A 1VISA 3K17A 2UUAE 1YH8A 3T1HI 5K36E 1U2RA 4DR3I 1K47A 4B3TE 2BR2A 2F4VI 2WP8A 3M7NG 1USVA 4BA1B 1N34I 2UU9E 1OJ4A 1Z0TA 4JI8E 1XMQI 4LFBI 5K36C 4JI5E 1H7UA 3PYDA 1N36I 2BV3A 4FW9A 4DUYE 1HNZE 4JYAE 3U1YA 5IWAE 5JEAA 4GKJI 3Q6NA 1RHYA 4MYTA 1XXEA 1IBLE 3F0NA 1ZXNA 3LTOA 4AQYE 1Z0WA 3J7AM 4JI2I 2UUBI 3M7ND 2HFSA 1N34E 4IZKB 4DV6E 1FI4A 1N0VC 1P42A 4YY3E 2PNMA 2HHHI 2O1TA 1Y4SA 4DUZE 2UUAI 3HKMA 4QNJA 1FWLA 3HULA 4LCGA 2IOPA 4AIDA 4LF4E 4JI1I 1HNZI 4OX9I 2J7KA 1NHIA 1Z5BA 4LF8I 2NPFA 4JI7E 4JI8I 5LMUE 4B3SE 3P3GA 1HNWE 4DUZI 2PO0A 1UDQA 4IS9A 4IZJB 1B63A 3KRNA 2NN6F 2CVEA 2EFGA 1ZM4A 4N3OA 4USMA 1KTVA 3M85G 1ZXMA 3U1KA 5JEAB 1UDOA 2Z5CB 4FW4A 1XMOE 3UHMA 4NXME 2HK2A 2LJPA 1H74A 5LMNE 4JI0I 1NZ0A 4OO1C 4M1KA 3V2UC 4JI3I 4GKKE 2WNRB 5FWKA 1XMQE 4LFBE 3QT5A 4P52A 5DNLA 1XHKA 4JI3E 4B3ME 4GKKI 4DR4I 2WNRA 4JG4A 4R1FA 4JI4E 4LF9I 4BA2A 2V2QA 2NN6A 4LF7E 5IWAI 2BA0G 5DRRA 5IT9C 4IZJD 1R6MA 1Z0BA 5DRQA 4EMDA 1Z5CA
chains in the Genus database with same CATH topology
3NZKA 4FW5A 5DROA 3P76A 1P42A 4J3DA 2GO3A 2J65A 3PS2A 4ISAA 4MQYA 4IS9A 5DRPA 4FW3A 3P3EA 3PS1A 4LCGA 4OKGA 3U1YA 4LCFA 2IESA 2O3ZA 4OZEA 2JT2A 1YH8A 2GO4A 3P3CA 3UHMA 4FW6A 1YHCA 4MDTA 2VESA 4LCHA 4U3DA 1XXEA 2IERA 4U3BA 5DRRA 4FW4A 3PS3A 5DRQA 4FW7A 3P3GA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3NZK A;  4FW5 A;  5DRO A;  3P76 A;  1P42 A;  4J3D A;  2GO3 A;  2J65 A;  3PS2 A;  4ISA A;  4MQY A;  4IS9 A;  5DRP A;  4FW3 A;  3P3E A;  3PS1 A;  4LCG A;  4OKG A;  3U1Y A;  4LCF A;  2IES A;  2O3Z A;  4OZE A;  2JT2 A;  1YH8 A;  2GO4 A;  3P3C A;  3UHM A;  4FW6 A;  1YHC A;  4MDT A;  2VES A;  4LCH A;  4U3D A;  1XXE A;  2IER A;  4U3B A;  5DRR A;  4FW4 A;  3PS3 A;  5DRQ A;  4FW7 A;  3P3G A; 
#chains in the Genus database with same CATH topology
 4UT4 A;  4DV5 I;  2E5L I;  2C37 B;  3L7Z A;  4DPU A;  4FW5 A;  3QT8 A;  4DV3 E;  2CGE A;  4OO1 E;  3T1Y I;  3PYG A;  1RRE A;  4GQU A;  4ISA A;  4IFD B;  3B8H A;  5DRP A;  2HK3 A;  4JI5 I;  3ZKB A;  1MG7 A;  4PU9 A;  2UXC I;  2JT2 A;  2GO4 A;  3P3C A;  2JEA A;  3CWV A;  1E3H A;  2BM0 A;  4K0K E;  2GS8 A;  2R3V A;  4B3T I;  2GQ0 A;  1Y60 A;  4WUC A;  2UXC E;  3Q1Q A;  5EL9 A;  3V5R A;  4LF8 E;  4LFC I;  4DPY A;  4JI7 I;  4IZK A;  1J5E I;  4LF6 I;  4DV7 I;  4NXN E;  2NN6 C;  2HKJ A;  4DR5 I;  4LPF A;  3B78 A;  4DU8 A;  1N32 I;  5A2Q C;  2ZM6 E;  4IFD A;  4JI6 I;  4LF5 E;  1A6F A;  1H73 A;  2JE6 A;  2E1R A;  1YHC A;  2VES A;  4XTJ A;  5LL6 R;  4DV2 I;  4DR7 I;  5K36 B;  1IBL I;  1OYR A;  1S16 A;  2O1U A;  5FLX C;  3WU5 A;  1PIE A;  3CDJ A;  1Z0C A;  4URL A;  3D4J A;  1HK7 A;  1FJG E;  1IBK E;  1FKA E;  2DEJ A;  2UUC E;  1XNQ E;  1B62 A;  4JI0 E;  4DUY I;  4ED4 A;  5C0X B;  4NXN I;  4OZE A;  4IFD C;  4OO1 B;  4NXM I;  4DR2 I;  4JYA I;  4LFA E;  4JI1 E;  1Z0G A;  1XNQ I;  1N0U A;  3PYE A;  5DNX A;  4IFD F;  4KHP I;  4AM3 A;  2A2D A;  3M6A A;  4DR4 E;  2V2V A;  2PO1 B;  2O1V A;  1OYS A;  2X7I A;  4J3D A;  2PNZ A;  2Z5B B;  3J80 Q;  2PO1 A;  1FWK A;  4DV0 E;  4JV5 E;  2UXB I;  4FW3 A;  4HAC B;  3OTO E;  1I94 I;  2HKE A;  3ZZU A;  3QT6 A;  1HNX I;  2BA1 D;  4BA2 B;  4DPW A;  4NBQ A;  4MU4 A;  1NHH A;  1HR0 E;  4U3D A;  2JEB A;  5EKW A;  2HFU A;  2C39 B;  2VQE I;  5IT9 Q;  4Z7Y A;  4JI4 I;  4LF9 E;  2BA0 D;  3DD6 A;  3P76 A;  2UUC I;  4B3M I;  4WUB A;  2GO3 A;  3GLL A;  3P3E A;  2Z5B A;  2PNZ B;  4X64 I;  2UXD E;  3ZM7 A;  1UEK A;  4KHP E;  4DV2 E;  1ELO A;  5JEA C;  3WU6 A;  5LMU I;  4LCH A;  4B3S I;  1N33 E;  5L3J A;  4U3B A;  4DPT A;  3K1J A;  4MU3 A;  4KQV A;  2VF3 A;  2NN6 E;  3H1C A;  2Q2E B;  3NZK A;  4MYU A;  1XNR I;  5DRO A;  4DR5 E;  1N33 I;  1IBK I;  4B3R E;  4IFD E;  4DU7 A;  4MU1 A;  1Z59 A;  3OTO I;  2JE6 B;  4LOM A;  2ZBK B;  3P06 A;  4FWG A;  3GON A;  4DV6 I;  4IFD D;  2AE8 A;  1USU A;  4FWH A;  1UDS A;  2NN6 D;  4MDT A;  3T1H E;  2IER A;  4DR3 E;  2VQF I;  4DR1 I;  1N32 E;  3WU3 A;  3J80 C;  4X66 I;  3T1Y E;  1KKH A;  3QT7 A;  4DR2 E;  2XEX A;  4X66 E;  3Q6M A;  4HY1 A;  1RR9 A;  2HHH E;  2IES A;  5BR8 I;  5ELW A;  2CZ9 A;  2Z5E A;  1DAR A;  5C0X C;  4FWD A;  1KIJ A;  3B82 A;  1FJG I;  2UUB E;  2BR2 B;  2V8P A;  5A2Q Q;  3HJC A;  4OKG A;  3CDI A;  5K36 D;  4X65 E;  4DR7 E;  1PKP A;  2O1W A;  4DR6 E;  5BR8 E;  1XNR E;  1S4E A;  4PRX A;  3PRY A;  5JEA D;  5GME A;  1EI1 A;  3PS2 A;  4Z7C A;  4GKJ E;  2C39 A;  4JI6 E;  3PS1 A;  5C0X A;  2BM1 A;  4LCF A;  1N36 E;  5C0X D;  3WU4 A;  4LF4 I;  3L7Z B;  1ZM3 A;  4JV5 I;  1IBM E;  1Z0E A;  1Z5A A;  1Y5Y A;  2PO2 A;  5GMD A;  2X36 A;  2PO2 B;  4MU0 A;  4IZJ A;  2ZIT A;  4USK A;  1ZM9 A;  4OO1 D;  5K36 A;  1D6T A;  4DV0 I;  1NHJ A;  1ZM2 A;  3LPS A;  4HXZ A;  2PO0 B;  4YHH E;  3GCM A;  1PVG A;  5FLX Q;  4MQY A;  3J7A G;  2WW4 A;  4PRV A;  4X62 E;  2A2C A;  4FW6 A;  5C0X F;  1HNX E;  4LFC E;  2C38 A;  4LFA I;  2Z5C A;  4DV3 I;  3K85 A;  4DV4 I;  5JEA E;  4X62 I;  1Y4U A;  1OYP A;  3PS3 A;  4LF7 I;  1FNM A;  1E3P A;  4UTG A;  4K0K I;  3JAM C;  2UU9 I;  4X65 I;  2VQF E;  4DR1 E;  4I3H A;  2UXD I;  2F1D A;  2UXB E;  4QNK A;  5K36 F;  2R42 A;  3ZZ0 A;  4AIM A;  4JI2 E;  1KVK A;  4DV1 E;  1HNW I;  4DPX A;  2O3Z A;  1UDN A;  4AQY I;  1IBM I;  4P7A A;  2VQE E;  4B3R I;  2JEB B;  4OO1 F;  2E5L E;  1MU5 A;  2ZM6 I;  4DV7 E;  5LMN I;  2C37 A;  4OX9 E;  2C38 B;  1Y6Z A;  2V2Z A;  2IOQ A;  1QZR A;  2AJ4 A;  4DV5 E;  4RPF A;  1R6L A;  1H7S A;  1I94 E;  2BA1 G;  1H72 C;  4YHH I;  1BKN A;  2PNL A;  3LNU A;  1EA6 A;  4BA1 A;  3J81 Q;  1WUU A;  2OI2 A;  4DV1 I;  2F4V E;  2WP8 B;  3GME A;  4ZVI A;  4X64 E;  4HYM A;  3J81 C;  2JEA B;  2DEI A;  3ZZT A;  4LF5 I;  3B4T A;  2NN6 B;  3JAM Q;  2CG9 A;  4HAC A;  1MX0 A;  4FW7 A;  3M85 D;  4DV4 E;  3H4L A;  4OO1 A;  3ZKD A;  5C0X E;  4WUD A;  1VI7 A;  5JEA F;  1XMO I;  1HR0 I;  2J65 A;  1J5E E;  4LF6 E;  4YY3 I;  2V34 A;  4DXL A;  1Z0V A;  4DR6 I;  3PYF A;  4FN5 A;  1VIS A;  3K17 A;  2UUA E;  1YH8 A;  3T1H I;  5K36 E;  1U2R A;  4DR3 I;  1K47 A;  4B3T E;  2BR2 A;  2F4V I;  2WP8 A;  3M7N G;  1USV A;  4BA1 B;  1N34 I;  2UU9 E;  1OJ4 A;  1Z0T A;  4JI8 E;  1XMQ I;  4LFB I;  5K36 C;  4JI5 E;  1H7U A;  3PYD A;  1N36 I;  2BV3 A;  4FW9 A;  4DUY E;  1HNZ E;  4JYA E;  3U1Y A;  5IWA E;  5JEA A;  4GKJ I;  3Q6N A;  1RHY A;  4MYT A;  1XXE A;  1IBL E;  3F0N A;  1ZXN A;  3LTO A;  4AQY E;  1Z0W A;  3J7A M;  4JI2 I;  2UUB I;  3M7N D;  2HFS A;  1N34 E;  4IZK B;  4DV6 E;  1FI4 A;  1N0V C;  1P42 A;  4YY3 E;  2PNM A;  2HHH I;  2O1T A;  1Y4S A;  4DUZ E;  2UUA I;  3HKM A;  4QNJ A;  1FWL A;  3HUL A;  4LCG A;  2IOP A;  4AID A;  4LF4 E;  4JI1 I;  1HNZ I;  4OX9 I;  2J7K A;  1NHI A;  1Z5B A;  4LF8 I;  2NPF A;  4JI7 E;  4JI8 I;  5LMU E;  4B3S E;  3P3G A;  1HNW E;  4DUZ I;  2PO0 A;  1UDQ A;  4IS9 A;  4IZJ B;  1B63 A;  3KRN A;  2NN6 F;  2CVE A;  2EFG A;  1ZM4 A;  4N3O A;  4USM A;  1KTV A;  3M85 G;  1ZXM A;  3U1K A;  5JEA B;  1UDO A;  2Z5C B;  4FW4 A;  1XMO E;  3UHM A;  4NXM E;  2HK2 A;  2LJP A;  1H74 A;  5LMN E;  4JI0 I;  1NZ0 A;  4OO1 C;  4M1K A;  3V2U C;  4JI3 I;  4GKK E;  2WNR B;  5FWK A;  1XMQ E;  4LFB E;  3QT5 A;  4P52 A;  5DNL A;  1XHK A;  4JI3 E;  4B3M E;  4GKK I;  4DR4 I;  2WNR A;  4JG4 A;  4R1F A;  4JI4 E;  4LF9 I;  4BA2 A;  2V2Q A;  2NN6 A;  4LF7 E;  5IWA I;  2BA0 G;  5DRR A;  5IT9 C;  4IZJ D;  1R6M A;  1Z0B A;  5DRQ A;  4EMD A;  1Z5C A; 
#chains in the Genus database with same CATH homology
 3NZK A;  4FW5 A;  5DRO A;  3P76 A;  1P42 A;  4J3D A;  2GO3 A;  2J65 A;  3PS2 A;  4ISA A;  4MQY A;  4IS9 A;  5DRP A;  4FW3 A;  3P3E A;  3PS1 A;  4LCG A;  4OKG A;  3U1Y A;  4LCF A;  2IES A;  2O3Z A;  4OZE A;  2JT2 A;  1YH8 A;  2GO4 A;  3P3C A;  3UHM A;  4FW6 A;  1YHC A;  4MDT A;  2VES A;  4LCH A;  4U3D A;  1XXE A;  2IER A;  4U3B A;  5DRR A;  4FW4 A;  3PS3 A;  5DRQ A;  4FW7 A;  3P3G A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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