4IU0A

Crystal structure of leishmania mexicana arginase in complex with inhibitor abh
Total Genus 120
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
120
sequence length
310
structure length
310
Chain Sequence
b'KKMSIVLAPFSGGQPHSGVELGPDYLLKQGLQQDMEKLGWDTRLERVFDGKVVEARKASDNGDRIGRVKRPRLTAECTEKIYKCVRRVAEQGRFPLTIGGDHSIALGTVAGVLSVHPDAGVIWVDAHADINTMSGTVSGNLHGCPLSILLGLDRENIPECFSWVPQVLKPNKIAYIGLRAVDDEEKKILHDLNIAAFSMHHVDRYGIDKVVSMAIEAVSPKGTEPVMVSYDVDTIDPLYVPATGTPVRGGLSFREALFLCERIAECGRLVALDVVECNPLLAATESHVNDTISVGCAIARCMMGETLLYT'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Arginase
publication title Crystal structure of arginase from Leishmania mexicana and implications for the inhibition of polyamine biosynthesis in parasitic infections.
pubmed doi rcsb
source organism Leishmania mexicana
molecule tags Hydrolase/hydrolase inhibitor
total genus 120
structure length 310
sequence length 310
ec nomenclature ec 3.5.3.1: Arginase.
pdb deposition date 2013-01-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00491 Arginase Arginase family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.10 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Ureohydrolase domain 4iu0A00
4GWDA 4Q3TA 4RHQA 2PLLA 4Q42A 4DZ4A 4G3HA 3NIPA 1HQFA 4Q3PA 1TBLA 3MFVA 4Q40A 3THHA 5HJ9A 4GWCA 4IXVA 1ZPGA 1CEVA 1R1OA 4IE1A 2RLAA 1TA1A 1T4PA 1P8PA 5HJAA 4MYFA 3E9BA 3E6VA 1HQ5A 3SKKA 1P8QA 1WVAA 4IU1A 4MXRA 3DJ8A 3CEVA 4RHIA 3LP4A 2ZAVA 3RLAA 2A0MA 2EF5A 3MFWA 4MYLA 1XFKA 1P8SA 4IE3A 1P8OA 3LP7A 3THJA 5RLAA 4GSZA 2PHAA 4RHJA 1GQ7A 1WOGA 3NIOA 4HXQA 3GMZA 4FCIA 3GN0A 1T5FA 4IU5A 4MYKA 1WVBA 3NIQA 4GSMA 4HZEA 1TBHA 1P8MA 3SJTA 1T4TA 4Q3SA 1P8NA 3M1RA 1T5GA 4RHKA 3PZLA 4GSVA 1HQGA 2EIVA 3E6KA 4ITYA 1PQ3A 3TH7A 4Q41A 1ZPEA 4IU4A 1HQXA 1T4SA 2EF4A 2PHOA 3E8ZA 1RLAA 4Q3UA 4CEVA 4IU0A 3THEA 1P8RA 4Q3VA 4HWWA 4FCKA 5CEVA 3F80A 3E8QA 1WOHA 3TF3A 1TBJA 1WOIA 1D3VA 4IE2A 1HQHA 4Q3RA 1T4RA 3KV2A 4MYNA 3LHLA 2CEVA 3SL0A 3SL1A 3MJLA 4RHMA 4RLAA 3MMRA 4I06A 1GQ6A 4RHLA 4Q3RC 4IXUA 2AEBA 4Q3QA
chains in the Genus database with same CATH superfamily
5D1DA 5G1AA 5THTA 4GWDA 4Q3TA 4RHQA 4CQFA 2PLLA 4ZUOA 5G0YA 4Q42A 4DZ4A 5G17A 4G3HA 2VQOA 5EEIA 5FCWA 4RN1A 3NIPA 1HQFA 4Q3PA 5EFJD 1TBLA 3MFVA 4Q40A 3C0ZA 4QA0A 5EF7A 5HJ9A 4GWCA 5EENA 3THHA 4IXVA 4BKXB 1ZPGA 4ZUMA 5EFHA 1C3PA 1CEVA 5LI3A 1R1OA 4QA5A 4IE1A 2RLAA 1TA1A 1T4PA 5DC7A 1P8PA 3EW8A 5HJAA 4MYFA 5THUA 3E9BA 5G12A 3E6VA 1HQ5A 3SKKA 3MAXA 3Q9FA 1ZZ1A 4CBTA 1C3SA 3SFFA 1P8QA 1WVAA 1ZZ0A 3Q9CA 4QA6A 4QA4A 5G0IA 4IU1A 4MXRA 3DJ8A 3CEVA 3EZTA 4RHIA 3LP4A 2ZAVA 3RLAA 2A0MA 2EF5A 1VKGA 3MFWA 3RQDA 4MYLA 1XFKA 4CBYA 1T69A 1P8SA 1T67A 5IWGA 4IE3A 1P8OA 3LP7A 3THJA 3ZNRA 4BZ5A 5THSA 4QA1A 5RLAA 4ZUNA 4GSZA 2PHAA 4RN0A 4RHJA 1GQ7A 3Q9EA 1W22A 1C3RA 1WOGA 3MZ4A 3SFHA 3NIOA 4HXQA 3GMZA 3MZ3A 4FCIA 4LXZA 5DC8A 5EFKB 5G0GA 3GN0A 2VQJA 1T5FA 5FUEA 4IU5A 4MYKA 5G11A 1WVBA 3NIQA 4GSMA 4HZEA 1ZZ3A 1TBHA 3Q9BA 5JI5A 1P8MA 5G0JA 5EEFA 3SJTA 1T4TA 4Q3SA 1P8NA 3M1RA 1T5GA 2VCGA 4RHKA 3PZLA 4GSVA 5G0HA 5BWZA 3F07A 1HQGA 2EIVA 3E6KA 3F06A 1PQ3A 4ITYA 4ZURA 3TH7A 4Q41A 5A2SA 1ZPEA 4BZ8A 5G13A 4BZ6A 3EWFA 4IU4A 3C10A 4LY1A 1HQXA 1T4SA 2EF4A 2PHOA 2VQQA 1RLAA 3E8ZA 3MENA 4Q3UA 4QA2A 4ZUPA 5G1CA 4BZ7A 5ICNB 5D1CA 4IU0A 4CEVA 2VQMA 3THEA 1P8RA 4Q3VA 4HWWA 4FCKA 4QA3A 5DC6A 3F80A 3E8QA 5CEVA 4RN2A 5D1BA 1WOHA 3F0RA 5G3WA 4A69A 5EEMA 3TF3A 1TBJA 1WOIA 1D3VA 3EZPA 1T64A 5G1BA 5G0XA 2V5WA 5EF8A 4IE2A 4ZUQA 1HQHA 4Q3RA 2V5XA 3ZNSA 1T4RA 3KV2A 3MZ6A 4MYNA 3LHLA 2CEVA 5EEKA 3SL0A 5THVA 2GH6A 3MJLA 4RHMA 4RLAA 3SL1A 3MMRA 3C0YA 5EFNA 3MZ7A 5G10A 4QA7A 5EFBD 4BZ9A 2VQWG 4I06A 1GQ6A 4RHLA 5EFGA 5DC5A 4Q3RC 2VQVA 4IXUA 2AEBA 4Q3QA 5IX0A
chains in the Genus database with same CATH topology
4GWDA 4Q3TA 4RHQA 2PLLA 4Q42A 4DZ4A 4G3HA 3NIPA 1HQFA 4Q3PA 1TBLA 3MFVA 4Q40A 3THHA 5HJ9A 4GWCA 4IXVA 1ZPGA 1CEVA 1R1OA 4IE1A 2RLAA 1TA1A 1T4PA 1P8PA 5HJAA 4MYFA 3E9BA 3E6VA 1HQ5A 3SKKA 1P8QA 1WVAA 4IU1A 4MXRA 3DJ8A 3CEVA 4RHIA 3LP4A 2ZAVA 3RLAA 2A0MA 2EF5A 3MFWA 4MYLA 1XFKA 1P8SA 4IE3A 1P8OA 3LP7A 3THJA 5RLAA 4GSZA 2PHAA 4RHJA 1GQ7A 1WOGA 3NIOA 4HXQA 3GMZA 4FCIA 3GN0A 1T5FA 4IU5A 4MYKA 1WVBA 3NIQA 4GSMA 4HZEA 1TBHA 1P8MA 3SJTA 1T4TA 4Q3SA 1P8NA 3M1RA 1T5GA 4RHKA 3PZLA 4GSVA 1HQGA 2EIVA 3E6KA 4ITYA 1PQ3A 3TH7A 4Q41A 1ZPEA 4IU4A 1HQXA 1T4SA 2EF4A 2PHOA 3E8ZA 1RLAA 4Q3UA 4CEVA 4IU0A 3THEA 1P8RA 4Q3VA 4HWWA 4FCKA 5CEVA 3F80A 3E8QA 1WOHA 3TF3A 1TBJA 1WOIA 1D3VA 4IE2A 1HQHA 4Q3RA 1T4RA 3KV2A 4MYNA 3LHLA 2CEVA 3SL0A 3SL1A 3MJLA 4RHMA 4RLAA 3MMRA 4I06A 1GQ6A 4RHLA 4Q3RC 4IXUA 2AEBA 4Q3QA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4GWD A;  4Q3T A;  4RHQ A;  2PLL A;  4Q42 A;  4DZ4 A;  4G3H A;  3NIP A;  1HQF A;  4Q3P A;  1TBL A;  3MFV A;  4Q40 A;  3THH A;  5HJ9 A;  4GWC A;  4IXV A;  1ZPG A;  1CEV A;  1R1O A;  4IE1 A;  2RLA A;  1TA1 A;  1T4P A;  1P8P A;  5HJA A;  4MYF A;  3E9B A;  3E6V A;  1HQ5 A;  3SKK A;  1P8Q A;  1WVA A;  4IU1 A;  4MXR A;  3DJ8 A;  3CEV A;  4RHI A;  3LP4 A;  2ZAV A;  3RLA A;  2A0M A;  2EF5 A;  3MFW A;  4MYL A;  1XFK A;  1P8S A;  4IE3 A;  1P8O A;  3LP7 A;  3THJ A;  5RLA A;  4GSZ A;  2PHA A;  4RHJ A;  1GQ7 A;  1WOG A;  3NIO A;  4HXQ A;  3GMZ A;  4FCI A;  3GN0 A;  1T5F A;  4IU5 A;  4MYK A;  1WVB A;  3NIQ A;  4GSM A;  4HZE A;  1TBH A;  1P8M A;  3SJT A;  1T4T A;  4Q3S A;  1P8N A;  3M1R A;  1T5G A;  4RHK A;  3PZL A;  4GSV A;  1HQG A;  2EIV A;  3E6K A;  4ITY A;  1PQ3 A;  3TH7 A;  4Q41 A;  1ZPE A;  4IU4 A;  1HQX A;  1T4S A;  2EF4 A;  2PHO A;  3E8Z A;  1RLA A;  4Q3U A;  4CEV A;  4IU0 A;  3THE A;  1P8R A;  4Q3V A;  4HWW A;  4FCK A;  5CEV A;  3F80 A;  3E8Q A;  1WOH A;  3TF3 A;  1TBJ A;  1WOI A;  1D3V A;  4IE2 A;  1HQH A;  4Q3R A;  1T4R A;  3KV2 A;  4MYN A;  3LHL A;  2CEV A;  3SL0 A;  3SL1 A;  3MJL A;  4RHM A;  4RLA A;  3MMR A;  4I06 A;  1GQ6 A;  4RHL A;  4Q3R C;  4IXU A;  2AEB A;  4Q3Q A; 
#chains in the Genus database with same CATH topology
 5D1D A;  5G1A A;  5THT A;  4GWD A;  4Q3T A;  4RHQ A;  4CQF A;  2PLL A;  4ZUO A;  5G0Y A;  4Q42 A;  4DZ4 A;  5G17 A;  4G3H A;  2VQO A;  5EEI A;  5FCW A;  4RN1 A;  3NIP A;  1HQF A;  4Q3P A;  5EFJ D;  1TBL A;  3MFV A;  4Q40 A;  3C0Z A;  4QA0 A;  5EF7 A;  5HJ9 A;  4GWC A;  5EEN A;  3THH A;  4IXV A;  4BKX B;  1ZPG A;  4ZUM A;  5EFH A;  1C3P A;  1CEV A;  5LI3 A;  1R1O A;  4QA5 A;  4IE1 A;  2RLA A;  1TA1 A;  1T4P A;  5DC7 A;  1P8P A;  3EW8 A;  5HJA A;  4MYF A;  5THU A;  3E9B A;  5G12 A;  3E6V A;  1HQ5 A;  3SKK A;  3MAX A;  3Q9F A;  1ZZ1 A;  4CBT A;  1C3S A;  3SFF A;  1P8Q A;  1WVA A;  1ZZ0 A;  3Q9C A;  4QA6 A;  4QA4 A;  5G0I A;  4IU1 A;  4MXR A;  3DJ8 A;  3CEV A;  3EZT A;  4RHI A;  3LP4 A;  2ZAV A;  3RLA A;  2A0M A;  2EF5 A;  1VKG A;  3MFW A;  3RQD A;  4MYL A;  1XFK A;  4CBY A;  1T69 A;  1P8S A;  1T67 A;  5IWG A;  4IE3 A;  1P8O A;  3LP7 A;  3THJ A;  3ZNR A;  4BZ5 A;  5THS A;  4QA1 A;  5RLA A;  4ZUN A;  4GSZ A;  2PHA A;  4RN0 A;  4RHJ A;  1GQ7 A;  3Q9E A;  1W22 A;  1C3R A;  1WOG A;  3MZ4 A;  3SFH A;  3NIO A;  4HXQ A;  3GMZ A;  3MZ3 A;  4FCI A;  4LXZ A;  5DC8 A;  5EFK B;  5G0G A;  3GN0 A;  2VQJ A;  1T5F A;  5FUE A;  4IU5 A;  4MYK A;  5G11 A;  1WVB A;  3NIQ A;  4GSM A;  4HZE A;  1ZZ3 A;  1TBH A;  3Q9B A;  5JI5 A;  1P8M A;  5G0J A;  5EEF A;  3SJT A;  1T4T A;  4Q3S A;  1P8N A;  3M1R A;  1T5G A;  2VCG A;  4RHK A;  3PZL A;  4GSV A;  5G0H A;  5BWZ A;  3F07 A;  1HQG A;  2EIV A;  3E6K A;  3F06 A;  1PQ3 A;  4ITY A;  4ZUR A;  3TH7 A;  4Q41 A;  5A2S A;  1ZPE A;  4BZ8 A;  5G13 A;  4BZ6 A;  3EWF A;  4IU4 A;  3C10 A;  4LY1 A;  1HQX A;  1T4S A;  2EF4 A;  2PHO A;  2VQQ A;  1RLA A;  3E8Z A;  3MEN A;  4Q3U A;  4QA2 A;  4ZUP A;  5G1C A;  4BZ7 A;  5ICN B;  5D1C A;  4IU0 A;  4CEV A;  2VQM A;  3THE A;  1P8R A;  4Q3V A;  4HWW A;  4FCK A;  4QA3 A;  5DC6 A;  3F80 A;  3E8Q A;  5CEV A;  4RN2 A;  5D1B A;  1WOH A;  3F0R A;  5G3W A;  4A69 A;  5EEM A;  3TF3 A;  1TBJ A;  1WOI A;  1D3V A;  3EZP A;  1T64 A;  5G1B A;  5G0X A;  2V5W A;  5EF8 A;  4IE2 A;  4ZUQ A;  1HQH A;  4Q3R A;  2V5X A;  3ZNS A;  1T4R A;  3KV2 A;  3MZ6 A;  4MYN A;  3LHL A;  2CEV A;  5EEK A;  3SL0 A;  5THV A;  2GH6 A;  3MJL A;  4RHM A;  4RLA A;  3SL1 A;  3MMR A;  3C0Y A;  5EFN A;  3MZ7 A;  5G10 A;  4QA7 A;  5EFB D;  4BZ9 A;  2VQW G;  4I06 A;  1GQ6 A;  4RHL A;  5EFG A;  5DC5 A;  4Q3R C;  2VQV A;  4IXU A;  2AEB A;  4Q3Q A;  5IX0 A; 
#chains in the Genus database with same CATH homology
 4GWD A;  4Q3T A;  4RHQ A;  2PLL A;  4Q42 A;  4DZ4 A;  4G3H A;  3NIP A;  1HQF A;  4Q3P A;  1TBL A;  3MFV A;  4Q40 A;  3THH A;  5HJ9 A;  4GWC A;  4IXV A;  1ZPG A;  1CEV A;  1R1O A;  4IE1 A;  2RLA A;  1TA1 A;  1T4P A;  1P8P A;  5HJA A;  4MYF A;  3E9B A;  3E6V A;  1HQ5 A;  3SKK A;  1P8Q A;  1WVA A;  4IU1 A;  4MXR A;  3DJ8 A;  3CEV A;  4RHI A;  3LP4 A;  2ZAV A;  3RLA A;  2A0M A;  2EF5 A;  3MFW A;  4MYL A;  1XFK A;  1P8S A;  4IE3 A;  1P8O A;  3LP7 A;  3THJ A;  5RLA A;  4GSZ A;  2PHA A;  4RHJ A;  1GQ7 A;  1WOG A;  3NIO A;  4HXQ A;  3GMZ A;  4FCI A;  3GN0 A;  1T5F A;  4IU5 A;  4MYK A;  1WVB A;  3NIQ A;  4GSM A;  4HZE A;  1TBH A;  1P8M A;  3SJT A;  1T4T A;  4Q3S A;  1P8N A;  3M1R A;  1T5G A;  4RHK A;  3PZL A;  4GSV A;  1HQG A;  2EIV A;  3E6K A;  4ITY A;  1PQ3 A;  3TH7 A;  4Q41 A;  1ZPE A;  4IU4 A;  1HQX A;  1T4S A;  2EF4 A;  2PHO A;  3E8Z A;  1RLA A;  4Q3U A;  4CEV A;  4IU0 A;  3THE A;  1P8R A;  4Q3V A;  4HWW A;  4FCK A;  5CEV A;  3F80 A;  3E8Q A;  1WOH A;  3TF3 A;  1TBJ A;  1WOI A;  1D3V A;  4IE2 A;  1HQH A;  4Q3R A;  1T4R A;  3KV2 A;  4MYN A;  3LHL A;  2CEV A;  3SL0 A;  3SL1 A;  3MJL A;  4RHM A;  4RLA A;  3MMR A;  4I06 A;  1GQ6 A;  4RHL A;  4Q3R C;  4IXU A;  2AEB A;  4Q3Q A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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