4IU5A

Crystal structure of leishmania mexicana arginase in complex with catalytic product l-ornithine
Total Genus 107
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
107
sequence length
310
structure length
310
Chain Sequence
KKMSIVLAPFSGGQPHSGVELGPDYLLKQGLQQDMEKLGWDTRLERVFDGKVVEARKASDNGDRIGRVKRPRLTAECTEKIYKCVRRVAEQGRFPLTIGGDHSIALGTVAGVLSVHPDAGVIWVDAHADINTMSGTVSGNLHGCPLSILLGLDRENIPECFSWVPQVLKPNKIAYIGLRAVDDEEKKILHDLNIAAFSMHHVDRYGIDKVVSMAIEAVSPKGTEPVMVSYDVDTIDPLYVPATGTPVRGGLSFREALFLCERIAECGRLVALDVVECNPLLAATESHVNDTISVGCAIARCMMGETLLYTA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Arginase
publication title Crystal structure of arginase from Leishmania mexicana and implications for the inhibition of polyamine biosynthesis in parasitic infections.
pubmed doi rcsb
source organism Leishmania mexicana
molecule tags Hydrolase
total genus 107
structure length 310
sequence length 310
ec nomenclature ec 3.5.3.1: Arginase.
pdb deposition date 2013-01-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00491 Arginase Arginase family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.10 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Ureohydrolase domain 4iu5A00
4IE1A 1P8RA 4RHLA 5HJAA 4FCKA 2EF5A 3F80A 1GQ6A 3M1RA 4HXQA 3SKKA 4IU4A 4IXUA 1WOGA 1P8PA 4Q41A 3GN0A 4MYLA 4MYKA 3MJLA 4RHKA 4Q42A 1PQ3A 3RLAA 3MMRA 2CEVA 1HQ5A 1WOHA 1WVAA 1P8QA 3MFWA 4Q3SA 4MYNA 3E6VA 1WOIA 3E6KA 3KV2A 4RHJA 1T4TA 1HQGA 3SL1A 1HQFA 4GSZA 2PHAA 2RLAA 4Q3VA 3TF3A 1T4SA 4RHMA 4RHQA 4IU0A 3MFVA 4MYFA 3THHA 3CEVA 4IXVA 1T5FA 3SL0A 4Q40A 4FCIA 2ZAVA 1GQ7A 1HQHA 1T4RA 4MXRA 3LP4A 4RLAA 3NIOA 3THJA 4IE2A 1P8NA 4DZ4A 1TBLA 4IU1A 4IE3A 4HWWA 4GWDA 1CEVA 3SJTA 1P8OA 1TBJA 1WVBA 3LHLA 1T5GA 4Q3RA 3LP7A 1D3VA 3E8QA 1ZPEA 4G3HA 3GMZA 3E9BA 3PZLA 4GWCA 2EF4A 2AEBA 3DJ8A 1RLAA 1R1OA 1ZPGA 4CEVA 1TA1A 1XFKA 5CEVA 3NIPA 1P8MA 5HJ9A 3E8ZA 4ITYA 4Q3RC 3THEA 1HQXA 4Q3PA 1TBHA 2A0MA 4GSVA 4HZEA 3TH7A 2EIVA 4RHIA 4GSMA 4I06A 1T4PA 3NIQA 2PLLA 2PHOA 5RLAA 4Q3QA 4Q3UA 1P8SA 4IU5A 4Q3TA
chains in the Genus database with same CATH superfamily
5D1BA 3F07A 4IE1A 1P8RA 4RHLA 5HJAA 4ZUNA 4FCKA 2EF5A 3F80A 3ZNRA 5EFJD 1GQ6A 3M1RA 4HXQA 4RN1A 5THUA 3SKKA 2VCGA 4IU4A 5EF7A 1VKGA 4IXUA 1WOGA 2GH6A 5EEKA 3C0ZA 1P8PA 4Q41A 3GN0A 4MYLA 4MYKA 3MJLA 5EFBD 3C0YA 4QA4A 4RHKA 4BZ5A 4Q42A 1PQ3A 1T69A 3RLAA 3MAXA 3MMRA 2CEVA 3EZPA 4QA2A 1HQ5A 1WOHA 1WVAA 4QA5A 5G0YA 5EENA 3RQDA 4BKXB 5DC7A 1P8QA 3MFWA 4Q3SA 5G11A 5G1CA 4MYNA 3E6VA 3MZ3A 5BWZA 1WOIA 3E6KA 3KV2A 4RHJA 4CBTA 1T4TA 1HQGA 3SL1A 3Q9CA 1HQFA 4GSZA 5G10A 4A69A 2PHAA 3C10A 2RLAA 3EW8A 3MZ6A 5G17A 4Q3VA 3SFFA 2VQOA 5IWGA 5DC8A 2VQMA 3TF3A 1T64A 2VQVA 1T4SA 4RHMA 1ZZ0A 4BZ7A 4RHQA 1ZZ1A 4IU0A 3F0RA 3MFVA 5A2SA 1C3PA 4MYFA 3THHA 3CEVA 5EFGA 4IXVA 5FCWA 1T5FA 3SL0A 5JI5A 4Q40A 4FCIA 2ZAVA 1GQ7A 5G1AA 1HQHA 1T4RA 4MXRA 3LP4A 3EWFA 4RLAA 1C3RA 3NIOA 4CBYA 5G0GA 5THSA 3THJA 4IE2A 1P8NA 4ZUMA 4DZ4A 1TBLA 5EF8A 4IU1A 4IE3A 5G1BA 5D1CA 4BZ6A 4HWWA 4GWDA 5DC6A 1CEVA 3SFHA 3SJTA 1P8OA 1TBJA 1WVBA 3LHLA 5G12A 5IX0A 1T5GA 4Q3RA 3LP7A 4QA1A 1D3VA 4CQFA 3E8QA 1ZPEA 3MENA 4G3HA 4ZUPA 5LI3A 3GMZA 2V5XA 3E9BA 2VQQA 3PZLA 5THTA 4GWCA 2EF4A 5G0JA 4QA3A 3ZNSA 2V5WA 5EEMA 2AEBA 3DJ8A 4ZUOA 1R1OA 1RLAA 4RN0A 1ZPGA 4LXZA 2VQWG 4CEVA 1TA1A 1XFKA 4RN2A 1W22A 3NIPA 5CEVA 5EEFA 1P8MA 5HJ9A 4QA0A 3E8ZA 5THVA 4ITYA 3Q9EA 3Q9FA 2VQJA 4Q3RC 3F06A 1ZZ3A 5G0IA 3THEA 4BZ8A 5DC5A 3Q9BA 5G0HA 1HQXA 4Q3PA 1TBHA 2A0MA 4GSVA 3MZ7A 4HZEA 5EFNA 2EIVA 5EEIA 4RHIA 3TH7A 4GSMA 3EZTA 4LY1A 4ZURA 4I06A 4QA6A 1T4PA 3NIQA 4QA7A 2PLLA 2PHOA 5RLAA 4BZ9A 5EFKB 5D1DA 5EFHA 5G13A 1T67A 4ZUQA 4Q3QA 4Q3UA 5ICNB 5G3WA 1P8SA 5FUEA 5G0XA 3MZ4A 1C3SA 4IU5A 4Q3TA
chains in the Genus database with same CATH topology
4IE1A 1P8RA 4RHLA 5HJAA 4FCKA 2EF5A 3F80A 1GQ6A 3M1RA 4HXQA 3SKKA 4IU4A 4IXUA 1WOGA 1P8PA 4Q41A 3GN0A 4MYLA 4MYKA 3MJLA 4RHKA 4Q42A 1PQ3A 3RLAA 3MMRA 2CEVA 1HQ5A 1WOHA 1WVAA 1P8QA 3MFWA 4Q3SA 4MYNA 3E6VA 1WOIA 3E6KA 3KV2A 4RHJA 1T4TA 1HQGA 3SL1A 1HQFA 4GSZA 2PHAA 2RLAA 4Q3VA 3TF3A 1T4SA 4RHMA 4RHQA 4IU0A 3MFVA 4MYFA 3THHA 3CEVA 4IXVA 1T5FA 3SL0A 4Q40A 4FCIA 2ZAVA 1GQ7A 1HQHA 1T4RA 4MXRA 3LP4A 4RLAA 3NIOA 3THJA 4IE2A 1P8NA 4DZ4A 1TBLA 4IU1A 4IE3A 4HWWA 4GWDA 1CEVA 3SJTA 1P8OA 1TBJA 1WVBA 3LHLA 1T5GA 4Q3RA 3LP7A 1D3VA 3E8QA 1ZPEA 4G3HA 3GMZA 3E9BA 3PZLA 4GWCA 2EF4A 2AEBA 3DJ8A 1RLAA 1R1OA 1ZPGA 4CEVA 1TA1A 1XFKA 5CEVA 3NIPA 1P8MA 5HJ9A 3E8ZA 4ITYA 4Q3RC 3THEA 1HQXA 4Q3PA 1TBHA 2A0MA 4GSVA 4HZEA 3TH7A 2EIVA 4RHIA 4GSMA 4I06A 1T4PA 3NIQA 2PLLA 2PHOA 5RLAA 4Q3QA 4Q3UA 1P8SA 4IU5A 4Q3TA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4IE1 A;  1P8R A;  4RHL A;  5HJA A;  4FCK A;  2EF5 A;  3F80 A;  1GQ6 A;  3M1R A;  4HXQ A;  3SKK A;  4IU4 A;  4IXU A;  1WOG A;  1P8P A;  4Q41 A;  3GN0 A;  4MYL A;  4MYK A;  3MJL A;  4RHK A;  4Q42 A;  1PQ3 A;  3RLA A;  3MMR A;  2CEV A;  1HQ5 A;  1WOH A;  1WVA A;  1P8Q A;  3MFW A;  4Q3S A;  4MYN A;  3E6V A;  1WOI A;  3E6K A;  3KV2 A;  4RHJ A;  1T4T A;  1HQG A;  3SL1 A;  1HQF A;  4GSZ A;  2PHA A;  2RLA A;  4Q3V A;  3TF3 A;  1T4S A;  4RHM A;  4RHQ A;  4IU0 A;  3MFV A;  4MYF A;  3THH A;  3CEV A;  4IXV A;  1T5F A;  3SL0 A;  4Q40 A;  4FCI A;  2ZAV A;  1GQ7 A;  1HQH A;  1T4R A;  4MXR A;  3LP4 A;  4RLA A;  3NIO A;  3THJ A;  4IE2 A;  1P8N A;  4DZ4 A;  1TBL A;  4IU1 A;  4IE3 A;  4HWW A;  4GWD A;  1CEV A;  3SJT A;  1P8O A;  1TBJ A;  1WVB A;  3LHL A;  1T5G A;  4Q3R A;  3LP7 A;  1D3V A;  3E8Q A;  1ZPE A;  4G3H A;  3GMZ A;  3E9B A;  3PZL A;  4GWC A;  2EF4 A;  2AEB A;  3DJ8 A;  1RLA A;  1R1O A;  1ZPG A;  4CEV A;  1TA1 A;  1XFK A;  5CEV A;  3NIP A;  1P8M A;  5HJ9 A;  3E8Z A;  4ITY A;  4Q3R C;  3THE A;  1HQX A;  4Q3P A;  1TBH A;  2A0M A;  4GSV A;  4HZE A;  3TH7 A;  2EIV A;  4RHI A;  4GSM A;  4I06 A;  1T4P A;  3NIQ A;  2PLL A;  2PHO A;  5RLA A;  4Q3Q A;  4Q3U A;  1P8S A;  4IU5 A;  4Q3T A; 
#chains in the Genus database with same CATH topology
 5D1B A;  3F07 A;  4IE1 A;  1P8R A;  4RHL A;  5HJA A;  4ZUN A;  4FCK A;  2EF5 A;  3F80 A;  3ZNR A;  5EFJ D;  1GQ6 A;  3M1R A;  4HXQ A;  4RN1 A;  5THU A;  3SKK A;  2VCG A;  4IU4 A;  5EF7 A;  1VKG A;  4IXU A;  1WOG A;  2GH6 A;  5EEK A;  3C0Z A;  1P8P A;  4Q41 A;  3GN0 A;  4MYL A;  4MYK A;  3MJL A;  5EFB D;  3C0Y A;  4QA4 A;  4RHK A;  4BZ5 A;  4Q42 A;  1PQ3 A;  1T69 A;  3RLA A;  3MAX A;  3MMR A;  2CEV A;  3EZP A;  4QA2 A;  1HQ5 A;  1WOH A;  1WVA A;  4QA5 A;  5G0Y A;  5EEN A;  3RQD A;  4BKX B;  5DC7 A;  1P8Q A;  3MFW A;  4Q3S A;  5G11 A;  5G1C A;  4MYN A;  3E6V A;  3MZ3 A;  5BWZ A;  1WOI A;  3E6K A;  3KV2 A;  4RHJ A;  4CBT A;  1T4T A;  1HQG A;  3SL1 A;  3Q9C A;  1HQF A;  4GSZ A;  5G10 A;  4A69 A;  2PHA A;  3C10 A;  2RLA A;  3EW8 A;  3MZ6 A;  5G17 A;  4Q3V A;  3SFF A;  2VQO A;  5IWG A;  5DC8 A;  2VQM A;  3TF3 A;  1T64 A;  2VQV A;  1T4S A;  4RHM A;  1ZZ0 A;  4BZ7 A;  4RHQ A;  1ZZ1 A;  4IU0 A;  3F0R A;  3MFV A;  5A2S A;  1C3P A;  4MYF A;  3THH A;  3CEV A;  5EFG A;  4IXV A;  5FCW A;  1T5F A;  3SL0 A;  5JI5 A;  4Q40 A;  4FCI A;  2ZAV A;  1GQ7 A;  5G1A A;  1HQH A;  1T4R A;  4MXR A;  3LP4 A;  3EWF A;  4RLA A;  1C3R A;  3NIO A;  4CBY A;  5G0G A;  5THS A;  3THJ A;  4IE2 A;  1P8N A;  4ZUM A;  4DZ4 A;  1TBL A;  5EF8 A;  4IU1 A;  4IE3 A;  5G1B A;  5D1C A;  4BZ6 A;  4HWW A;  4GWD A;  5DC6 A;  1CEV A;  3SFH A;  3SJT A;  1P8O A;  1TBJ A;  1WVB A;  3LHL A;  5G12 A;  5IX0 A;  1T5G A;  4Q3R A;  3LP7 A;  4QA1 A;  1D3V A;  4CQF A;  3E8Q A;  1ZPE A;  3MEN A;  4G3H A;  4ZUP A;  5LI3 A;  3GMZ A;  2V5X A;  3E9B A;  2VQQ A;  3PZL A;  5THT A;  4GWC A;  2EF4 A;  5G0J A;  4QA3 A;  3ZNS A;  2V5W A;  5EEM A;  2AEB A;  3DJ8 A;  4ZUO A;  1R1O A;  1RLA A;  4RN0 A;  1ZPG A;  4LXZ A;  2VQW G;  4CEV A;  1TA1 A;  1XFK A;  4RN2 A;  1W22 A;  3NIP A;  5CEV A;  5EEF A;  1P8M A;  5HJ9 A;  4QA0 A;  3E8Z A;  5THV A;  4ITY A;  3Q9E A;  3Q9F A;  2VQJ A;  4Q3R C;  3F06 A;  1ZZ3 A;  5G0I A;  3THE A;  4BZ8 A;  5DC5 A;  3Q9B A;  5G0H A;  1HQX A;  4Q3P A;  1TBH A;  2A0M A;  4GSV A;  3MZ7 A;  4HZE A;  5EFN A;  2EIV A;  5EEI A;  4RHI A;  3TH7 A;  4GSM A;  3EZT A;  4LY1 A;  4ZUR A;  4I06 A;  4QA6 A;  1T4P A;  3NIQ A;  4QA7 A;  2PLL A;  2PHO A;  5RLA A;  4BZ9 A;  5EFK B;  5D1D A;  5EFH A;  5G13 A;  1T67 A;  4ZUQ A;  4Q3Q A;  4Q3U A;  5ICN B;  5G3W A;  1P8S A;  5FUE A;  5G0X A;  3MZ4 A;  1C3S A;  4IU5 A;  4Q3T A; 
#chains in the Genus database with same CATH homology
 4IE1 A;  1P8R A;  4RHL A;  5HJA A;  4FCK A;  2EF5 A;  3F80 A;  1GQ6 A;  3M1R A;  4HXQ A;  3SKK A;  4IU4 A;  4IXU A;  1WOG A;  1P8P A;  4Q41 A;  3GN0 A;  4MYL A;  4MYK A;  3MJL A;  4RHK A;  4Q42 A;  1PQ3 A;  3RLA A;  3MMR A;  2CEV A;  1HQ5 A;  1WOH A;  1WVA A;  1P8Q A;  3MFW A;  4Q3S A;  4MYN A;  3E6V A;  1WOI A;  3E6K A;  3KV2 A;  4RHJ A;  1T4T A;  1HQG A;  3SL1 A;  1HQF A;  4GSZ A;  2PHA A;  2RLA A;  4Q3V A;  3TF3 A;  1T4S A;  4RHM A;  4RHQ A;  4IU0 A;  3MFV A;  4MYF A;  3THH A;  3CEV A;  4IXV A;  1T5F A;  3SL0 A;  4Q40 A;  4FCI A;  2ZAV A;  1GQ7 A;  1HQH A;  1T4R A;  4MXR A;  3LP4 A;  4RLA A;  3NIO A;  3THJ A;  4IE2 A;  1P8N A;  4DZ4 A;  1TBL A;  4IU1 A;  4IE3 A;  4HWW A;  4GWD A;  1CEV A;  3SJT A;  1P8O A;  1TBJ A;  1WVB A;  3LHL A;  1T5G A;  4Q3R A;  3LP7 A;  1D3V A;  3E8Q A;  1ZPE A;  4G3H A;  3GMZ A;  3E9B A;  3PZL A;  4GWC A;  2EF4 A;  2AEB A;  3DJ8 A;  1RLA A;  1R1O A;  1ZPG A;  4CEV A;  1TA1 A;  1XFK A;  5CEV A;  3NIP A;  1P8M A;  5HJ9 A;  3E8Z A;  4ITY A;  4Q3R C;  3THE A;  1HQX A;  4Q3P A;  1TBH A;  2A0M A;  4GSV A;  4HZE A;  3TH7 A;  2EIV A;  4RHI A;  4GSM A;  4I06 A;  1T4P A;  3NIQ A;  2PLL A;  2PHO A;  5RLA A;  4Q3Q A;  4Q3U A;  1P8S A;  4IU5 A;  4Q3T A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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