4IXUA

Crystal structure of human arginase-2 complexed with inhibitor 11d: {(5r)-5-amino-5-carboxy-5-[(3-endo)-8-(3,4-dichlorobenzyl)-8-azabicyclo[3.2.1]oct-3-yl]pentyl}(trihydroxy)borate(1-)
Total Genus 120
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
120
sequence length
306
structure length
306
Chain Sequence
HSVAVIGAPFSQGQKRKGVEHGPAAIREAGLMKRLSSLGCHLKDFGDLSFTPVPKDDLYNNLIVNPRSVGLANQELAEVVSRAVSDGYSCVTLGGDHSLAIGTISGHARHCPDLCVVWVDAHADINTPLTTSSGNLHGQPVSFLLRELQDKVPQLPGFSWIKPCISSASIVYIGLRDVDPPEHFILKNYDIQYFSMRDIDRLGIQKVMERTFDLLIGKRQRPIHLSFDIDAFDPTLAPATGTPVVGGLTYREGMYIAEEIHNTGLLSALDLVEVNPQLATSEEEAKTTANLAVDVIASSFGQTREG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase/hydrolase inhibitor
molecule keywords Arginase-2, mitochondrial
publication title Synthesis of quaternary alpha-amino acid-based arginase inhibitors via the Ugi reaction.
pubmed doi rcsb
source organism Homo sapiens
total genus 120
structure length 306
sequence length 306
chains with identical sequence B, C
ec nomenclature ec 3.5.3.1: Arginase.
pdb deposition date 2013-01-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00491 Arginase Arginase family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.10 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Ureohydrolase domain 4ixuA00
2PHAA 4Q3UA 4Q3RA 4RLAA 1RLAA 5HJAA 4HWWA 1WOGA 3THHA 4MXRA 4DZ4A 3E6VA 3SJTA 3CEVA 4HZEA 4FCIA 3KV2A 4IE3A 3GMZA 1R1OA 3E8ZA 4HXQA 1PQ3A 2AEBA 3TH7A 2RLAA 3LP7A 3MJLA 1P8NA 4IE2A 1WOIA 3E8QA 1WOHA 3M1RA 3LHLA 2CEVA 3F80A 1TBLA 4Q3QA 4MYFA 3MMRA 4MYLA 3LP4A 1T4TA 3SL1A 4Q3RC 3SL0A 4IU1A 5HJ9A 1ZPGA 4MYKA 2PHOA 4Q41A 4Q42A 3PZLA 1HQFA 4RHQA 4RHIA 1P8RA 5CEVA 1HQHA 2A0MA 4I06A 1T5FA 4IXUA 3TF3A 4RHJA 4IE1A 1T4SA 1P8PA 4IU0A 4MYNA 3MFWA 4FCKA 3SKKA 4Q3VA 1HQXA 4CEVA 5RLAA 1XFKA 3E6KA 4G3HA 4GSMA 3MFVA 4GWCA 3RLAA 1GQ6A 4RHLA 4ITYA 1WVAA 1D3VA 4GWDA 2ZAVA 1TBJA 2EF4A 2PLLA 4IXVA 1P8OA 1ZPEA 1CEVA 1HQ5A 4RHMA 4IU5A 3DJ8A 1HQGA 3E9BA 4IU4A 3GN0A 4RHKA 1P8MA 4GSVA 1T5GA 4Q3SA 4Q3TA 1WVBA 1P8QA 4GSZA 4Q3PA 1P8SA 1GQ7A 3NIOA 1T4RA 3THEA 1T4PA 2EF5A 1TBHA 2EIVA 3NIQA 3NIPA 4Q40A 1TA1A 3THJA
chains in the Genus database with same CATH superfamily
2PHAA 4Q3UA 5EFGA 4Q3RA 4RLAA 3RQDA 4RN0A 1RLAA 5HJAA 2VQJA 4HWWA 5DC5A 1WOGA 3ZNSA 3THHA 4MXRA 4DZ4A 3E6VA 5EFJD 5EFNA 5DC6A 3SJTA 5EF8A 3CEVA 5G1BA 5DC7A 4HZEA 5G0JA 4FCIA 3KV2A 4LY1A 4IE3A 3GMZA 1R1OA 3MZ7A 3E8ZA 3Q9BA 5EEMA 4HXQA 1PQ3A 2AEBA 3TH7A 5THSA 5THVA 2RLAA 3LP7A 3MJLA 1P8NA 4IE2A 2GH6A 3F06A 1WOIA 3E8QA 1WOHA 3M1RA 1T64A 3LHLA 5G0YA 4QA1A 4CBTA 4BZ8A 2CEVA 3F80A 1TBLA 4Q3QA 1ZZ1A 3EW8A 4MYFA 3MMRA 3F07A 2VQQA 4MYLA 3LP4A 3MAXA 1T4TA 1VKGA 5G1CA 5IWGA 5LI3A 4LXZA 3SL1A 3Q9CA 4Q3RC 3SL0A 3SFFA 5EFBD 1ZZ0A 4IU1A 5G0GA 5HJ9A 1C3RA 5IX0A 1ZPGA 5A2SA 4MYKA 4BZ6A 2PHOA 4Q41A 5D1DA 4Q42A 3PZLA 3Q9FA 4ZUOA 1HQFA 4RHQA 2VQMA 1P8RA 4RHIA 1HQHA 4ZUNA 4ZUPA 5CEVA 2A0MA 3C0YA 1T5FA 4I06A 4QA3A 5EEFA 3ZNRA 5D1CA 4IXUA 4CBYA 2VQVA 3TF3A 4RN1A 4RN2A 3EZPA 5BWZA 4RHJA 4IE1A 1T4SA 5G10A 1P8PA 3EZTA 4IU0A 4QA6A 4QA0A 2VQOA 4MYNA 5EFHA 3MFWA 3SFHA 4FCKA 3SKKA 4Q3VA 1HQXA 5G11A 4BKXB 4CEVA 5RLAA 5G0XA 1XFKA 3E6KA 1C3SA 4G3HA 4GSMA 5FCWA 3MFVA 4GWCA 5G12A 4CQFA 3MZ4A 3RLAA 5DC8A 1GQ6A 4RHLA 4ITYA 5G3WA 1WVAA 1D3VA 4GWDA 4QA2A 5G17A 3MZ6A 1T69A 5EFKB 2ZAVA 1TBJA 2EF4A 2PLLA 4IXVA 1P8OA 4QA5A 4ZURA 1ZPEA 3MENA 1CEVA 1HQ5A 3C0ZA 4RHMA 4IU5A 3DJ8A 5EENA 1HQGA 3E9BA 4IU4A 5G0HA 5JI5A 3GN0A 1C3PA 1P8MA 4RHKA 4ZUQA 4GSVA 5G0IA 1T5GA 4Q3SA 4Q3TA 4ZUMA 5EEIA 1WVBA 1P8QA 3F0RA 4GSZA 5D1BA 4A69A 5G1AA 3MZ3A 3Q9EA 5EF7A 4BZ7A 5ICNB 4Q3PA 5EEKA 1P8SA 1GQ7A 4BZ5A 3NIOA 1T67A 1T4RA 2VQWG 2VCGA 4QA4A 5FUEA 1ZZ3A 4QA7A 1T4PA 2EF5A 2V5WA 5G13A 3THEA 1TBHA 2EIVA 3NIQA 4BZ9A 3NIPA 4Q40A 5THTA 3EWFA 2V5XA 3C10A 1TA1A 1W22A 5THUA 3THJA
chains in the Genus database with same CATH topology
2PHAA 4Q3UA 4Q3RA 4RLAA 1RLAA 5HJAA 4HWWA 1WOGA 3THHA 4MXRA 4DZ4A 3E6VA 3SJTA 3CEVA 4HZEA 4FCIA 3KV2A 4IE3A 3GMZA 1R1OA 3E8ZA 4HXQA 1PQ3A 2AEBA 3TH7A 2RLAA 3LP7A 3MJLA 1P8NA 4IE2A 1WOIA 3E8QA 1WOHA 3M1RA 3LHLA 2CEVA 3F80A 1TBLA 4Q3QA 4MYFA 3MMRA 4MYLA 3LP4A 1T4TA 3SL1A 4Q3RC 3SL0A 4IU1A 5HJ9A 1ZPGA 4MYKA 2PHOA 4Q41A 4Q42A 3PZLA 1HQFA 4RHQA 4RHIA 1P8RA 5CEVA 1HQHA 2A0MA 4I06A 1T5FA 4IXUA 3TF3A 4RHJA 4IE1A 1T4SA 1P8PA 4IU0A 4MYNA 3MFWA 4FCKA 3SKKA 4Q3VA 1HQXA 4CEVA 5RLAA 1XFKA 3E6KA 4G3HA 4GSMA 3MFVA 4GWCA 3RLAA 1GQ6A 4RHLA 4ITYA 1WVAA 1D3VA 4GWDA 2ZAVA 1TBJA 2EF4A 2PLLA 4IXVA 1P8OA 1ZPEA 1CEVA 1HQ5A 4RHMA 4IU5A 3DJ8A 1HQGA 3E9BA 4IU4A 3GN0A 4RHKA 1P8MA 4GSVA 1T5GA 4Q3SA 4Q3TA 1WVBA 1P8QA 4GSZA 4Q3PA 1P8SA 1GQ7A 3NIOA 1T4RA 3THEA 1T4PA 2EF5A 1TBHA 2EIVA 3NIQA 3NIPA 4Q40A 1TA1A 3THJA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2PHA A;  4Q3U A;  4Q3R A;  4RLA A;  1RLA A;  5HJA A;  4HWW A;  1WOG A;  3THH A;  4MXR A;  4DZ4 A;  3E6V A;  3SJT A;  3CEV A;  4HZE A;  4FCI A;  3KV2 A;  4IE3 A;  3GMZ A;  1R1O A;  3E8Z A;  4HXQ A;  1PQ3 A;  2AEB A;  3TH7 A;  2RLA A;  3LP7 A;  3MJL A;  1P8N A;  4IE2 A;  1WOI A;  3E8Q A;  1WOH A;  3M1R A;  3LHL A;  2CEV A;  3F80 A;  1TBL A;  4Q3Q A;  4MYF A;  3MMR A;  4MYL A;  3LP4 A;  1T4T A;  3SL1 A;  4Q3R C;  3SL0 A;  4IU1 A;  5HJ9 A;  1ZPG A;  4MYK A;  2PHO A;  4Q41 A;  4Q42 A;  3PZL A;  1HQF A;  4RHQ A;  4RHI A;  1P8R A;  5CEV A;  1HQH A;  2A0M A;  4I06 A;  1T5F A;  4IXU A;  3TF3 A;  4RHJ A;  4IE1 A;  1T4S A;  1P8P A;  4IU0 A;  4MYN A;  3MFW A;  4FCK A;  3SKK A;  4Q3V A;  1HQX A;  4CEV A;  5RLA A;  1XFK A;  3E6K A;  4G3H A;  4GSM A;  3MFV A;  4GWC A;  3RLA A;  1GQ6 A;  4RHL A;  4ITY A;  1WVA A;  1D3V A;  4GWD A;  2ZAV A;  1TBJ A;  2EF4 A;  2PLL A;  4IXV A;  1P8O A;  1ZPE A;  1CEV A;  1HQ5 A;  4RHM A;  4IU5 A;  3DJ8 A;  1HQG A;  3E9B A;  4IU4 A;  3GN0 A;  4RHK A;  1P8M A;  4GSV A;  1T5G A;  4Q3S A;  4Q3T A;  1WVB A;  1P8Q A;  4GSZ A;  4Q3P A;  1P8S A;  1GQ7 A;  3NIO A;  1T4R A;  3THE A;  1T4P A;  2EF5 A;  1TBH A;  2EIV A;  3NIQ A;  3NIP A;  4Q40 A;  1TA1 A;  3THJ A; 
#chains in the Genus database with same CATH topology
 2PHA A;  4Q3U A;  5EFG A;  4Q3R A;  4RLA A;  3RQD A;  4RN0 A;  1RLA A;  5HJA A;  2VQJ A;  4HWW A;  5DC5 A;  1WOG A;  3ZNS A;  3THH A;  4MXR A;  4DZ4 A;  3E6V A;  5EFJ D;  5EFN A;  5DC6 A;  3SJT A;  5EF8 A;  3CEV A;  5G1B A;  5DC7 A;  4HZE A;  5G0J A;  4FCI A;  3KV2 A;  4LY1 A;  4IE3 A;  3GMZ A;  1R1O A;  3MZ7 A;  3E8Z A;  3Q9B A;  5EEM A;  4HXQ A;  1PQ3 A;  2AEB A;  3TH7 A;  5THS A;  5THV A;  2RLA A;  3LP7 A;  3MJL A;  1P8N A;  4IE2 A;  2GH6 A;  3F06 A;  1WOI A;  3E8Q A;  1WOH A;  3M1R A;  1T64 A;  3LHL A;  5G0Y A;  4QA1 A;  4CBT A;  4BZ8 A;  2CEV A;  3F80 A;  1TBL A;  4Q3Q A;  1ZZ1 A;  3EW8 A;  4MYF A;  3MMR A;  3F07 A;  2VQQ A;  4MYL A;  3LP4 A;  3MAX A;  1T4T A;  1VKG A;  5G1C A;  5IWG A;  5LI3 A;  4LXZ A;  3SL1 A;  3Q9C A;  4Q3R C;  3SL0 A;  3SFF A;  5EFB D;  1ZZ0 A;  4IU1 A;  5G0G A;  5HJ9 A;  1C3R A;  5IX0 A;  1ZPG A;  5A2S A;  4MYK A;  4BZ6 A;  2PHO A;  4Q41 A;  5D1D A;  4Q42 A;  3PZL A;  3Q9F A;  4ZUO A;  1HQF A;  4RHQ A;  2VQM A;  1P8R A;  4RHI A;  1HQH A;  4ZUN A;  4ZUP A;  5CEV A;  2A0M A;  3C0Y A;  1T5F A;  4I06 A;  4QA3 A;  5EEF A;  3ZNR A;  5D1C A;  4IXU A;  4CBY A;  2VQV A;  3TF3 A;  4RN1 A;  4RN2 A;  3EZP A;  5BWZ A;  4RHJ A;  4IE1 A;  1T4S A;  5G10 A;  1P8P A;  3EZT A;  4IU0 A;  4QA6 A;  4QA0 A;  2VQO A;  4MYN A;  5EFH A;  3MFW A;  3SFH A;  4FCK A;  3SKK A;  4Q3V A;  1HQX A;  5G11 A;  4BKX B;  4CEV A;  5RLA A;  5G0X A;  1XFK A;  3E6K A;  1C3S A;  4G3H A;  4GSM A;  5FCW A;  3MFV A;  4GWC A;  5G12 A;  4CQF A;  3MZ4 A;  3RLA A;  5DC8 A;  1GQ6 A;  4RHL A;  4ITY A;  5G3W A;  1WVA A;  1D3V A;  4GWD A;  4QA2 A;  5G17 A;  3MZ6 A;  1T69 A;  5EFK B;  2ZAV A;  1TBJ A;  2EF4 A;  2PLL A;  4IXV A;  1P8O A;  4QA5 A;  4ZUR A;  1ZPE A;  3MEN A;  1CEV A;  1HQ5 A;  3C0Z A;  4RHM A;  4IU5 A;  3DJ8 A;  5EEN A;  1HQG A;  3E9B A;  4IU4 A;  5G0H A;  5JI5 A;  3GN0 A;  1C3P A;  1P8M A;  4RHK A;  4ZUQ A;  4GSV A;  5G0I A;  1T5G A;  4Q3S A;  4Q3T A;  4ZUM A;  5EEI A;  1WVB A;  1P8Q A;  3F0R A;  4GSZ A;  5D1B A;  4A69 A;  5G1A A;  3MZ3 A;  3Q9E A;  5EF7 A;  4BZ7 A;  5ICN B;  4Q3P A;  5EEK A;  1P8S A;  1GQ7 A;  4BZ5 A;  3NIO A;  1T67 A;  1T4R A;  2VQW G;  2VCG A;  4QA4 A;  5FUE A;  1ZZ3 A;  4QA7 A;  1T4P A;  2EF5 A;  2V5W A;  5G13 A;  3THE A;  1TBH A;  2EIV A;  3NIQ A;  4BZ9 A;  3NIP A;  4Q40 A;  5THT A;  3EWF A;  2V5X A;  3C10 A;  1TA1 A;  1W22 A;  5THU A;  3THJ A; 
#chains in the Genus database with same CATH homology
 2PHA A;  4Q3U A;  4Q3R A;  4RLA A;  1RLA A;  5HJA A;  4HWW A;  1WOG A;  3THH A;  4MXR A;  4DZ4 A;  3E6V A;  3SJT A;  3CEV A;  4HZE A;  4FCI A;  3KV2 A;  4IE3 A;  3GMZ A;  1R1O A;  3E8Z A;  4HXQ A;  1PQ3 A;  2AEB A;  3TH7 A;  2RLA A;  3LP7 A;  3MJL A;  1P8N A;  4IE2 A;  1WOI A;  3E8Q A;  1WOH A;  3M1R A;  3LHL A;  2CEV A;  3F80 A;  1TBL A;  4Q3Q A;  4MYF A;  3MMR A;  4MYL A;  3LP4 A;  1T4T A;  3SL1 A;  4Q3R C;  3SL0 A;  4IU1 A;  5HJ9 A;  1ZPG A;  4MYK A;  2PHO A;  4Q41 A;  4Q42 A;  3PZL A;  1HQF A;  4RHQ A;  4RHI A;  1P8R A;  5CEV A;  1HQH A;  2A0M A;  4I06 A;  1T5F A;  4IXU A;  3TF3 A;  4RHJ A;  4IE1 A;  1T4S A;  1P8P A;  4IU0 A;  4MYN A;  3MFW A;  4FCK A;  3SKK A;  4Q3V A;  1HQX A;  4CEV A;  5RLA A;  1XFK A;  3E6K A;  4G3H A;  4GSM A;  3MFV A;  4GWC A;  3RLA A;  1GQ6 A;  4RHL A;  4ITY A;  1WVA A;  1D3V A;  4GWD A;  2ZAV A;  1TBJ A;  2EF4 A;  2PLL A;  4IXV A;  1P8O A;  1ZPE A;  1CEV A;  1HQ5 A;  4RHM A;  4IU5 A;  3DJ8 A;  1HQG A;  3E9B A;  4IU4 A;  3GN0 A;  4RHK A;  1P8M A;  4GSV A;  1T5G A;  4Q3S A;  4Q3T A;  1WVB A;  1P8Q A;  4GSZ A;  4Q3P A;  1P8S A;  1GQ7 A;  3NIO A;  1T4R A;  3THE A;  1T4P A;  2EF5 A;  1TBH A;  2EIV A;  3NIQ A;  3NIP A;  4Q40 A;  1TA1 A;  3THJ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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