4IXVA

Crystal structure of human arginase-2 complexed with inhibitor 2d: {(5r)-5-amino-5-carboxy-5-[1-(4-chlorobenzyl)piperidin-4-yl]pentyl}(trihydroxy)borate(1-)
Total Genus 116
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
116
sequence length
306
structure length
306
Chain Sequence
HSVAVIGAPFSQGQKRKGVEHGPAAIREAGLMKRLSSLGCHLKDFGDLSFTPVPKDDLYNNLIVNPRSVGLANQELAEVVSRAVSDGYSCVTLGGDHSLAIGTISGHARHCPDLCVVWVDAHADINTPLTTSSGNLHGQPVSFLLRELQDKVPQLPGFSWIKPCISSASIVYIGLRDVDPPEHFILKNYDIQYFSMRDIDRLGIQKVMERTFDLLIGKRQRPIHLSFDIDAFDPTLAPATGTPVVGGLTYREGMYIAEEIHNTGLLSALDLVEVNPQLATSEEEAKTTANLAVDVIASSFGQTREG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase/hydrolase inhibitor
molecule keywords Arginase-2, mitochondrial
publication title Synthesis of quaternary alpha-amino acid-based arginase inhibitors via the Ugi reaction.
pubmed doi rcsb
source organism Homo sapiens
total genus 116
structure length 306
sequence length 306
chains with identical sequence B, C
ec nomenclature ec 3.5.3.1: Arginase.
pdb deposition date 2013-01-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00491 Arginase Arginase family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.10 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Ureohydrolase domain 4ixvA00
4FCIA 2PLLA 1GQ7A 3E8QA 3RLAA 3E8ZA 3LP4A 2ZAVA 1WOIA 4MYKA 3E6KA 3LHLA 1T4PA 1P8MA 2AEBA 1P8QA 3DJ8A 3GN0A 4IU1A 1T4SA 1WVBA 4GSMA 4GWCA 5CEVA 4FCKA 2EIVA 1RLAA 1TA1A 4MYLA 4GWDA 3NIOA 1P8RA 4DZ4A 1TBJA 1T5GA 5RLAA 2RLAA 3PZLA 4RHQA 4RHJA 4CEVA 3MFVA 1T4TA 4IE1A 4Q41A 2EF5A 1HQHA 4HWWA 3M1RA 1ZPGA 3THHA 1CEVA 4IE2A 3F80A 4Q40A 1TBHA 4RHKA 2CEVA 1PQ3A 4RHLA 1HQGA 4MYFA 2EF4A 1T5FA 1P8SA 1HQ5A 3CEVA 4MYNA 4Q3PA 4ITYA 1GQ6A 3TH7A 4RHMA 1WOGA 4IXUA 3NIPA 1ZPEA 3SKKA 4GSVA 1WOHA 1P8NA 1R1OA 1TBLA 4Q42A 4IU5A 4HZEA 4IE3A 1P8OA 5HJAA 4Q3UA 1D3VA 4GSZA 2PHOA 3KV2A 3E6VA 3THJA 3NIQA 3SJTA 4IXVA 2PHAA 3MFWA 3E9BA 3LP7A 1P8PA 3MMRA 3THEA 4Q3QA 4RHIA 2A0MA 4Q3VA 4Q3RA 5HJ9A 4RLAA 1HQFA 1T4RA 4Q3SA 3TF3A 4Q3RC 4MXRA 1WVAA 4I06A 3GMZA 4IU0A 3MJLA 4G3HA 3SL0A 4HXQA 1HQXA 1XFKA 3SL1A 4Q3TA 4IU4A
chains in the Genus database with same CATH superfamily
4FCIA 5EFJD 2PLLA 5FCWA 3EWFA 1GQ7A 4QA0A 3E8QA 4CQFA 3RLAA 5G1CA 5DC5A 3E8ZA 3LP4A 3MENA 3SFHA 2ZAVA 3Q9EA 1WOIA 5G10A 2VCGA 4MYKA 3E6KA 3LHLA 1T4PA 4A69A 1C3RA 1P8MA 2AEBA 1P8QA 5DC7A 3DJ8A 3GN0A 4IU1A 5G0JA 1T4SA 1WVBA 4BZ8A 4GSMA 4GWCA 5CEVA 4FCKA 2EIVA 1RLAA 5G1AA 5EFHA 5D1CA 2VQWG 1TA1A 4ZUNA 4ZUMA 3C0YA 4MYLA 5G17A 1W22A 3NIOA 3MZ7A 4GWDA 5EFBD 4CBTA 1P8RA 4DZ4A 1TBJA 3F06A 1T5GA 5RLAA 2RLAA 5FUEA 3Q9CA 4QA3A 3PZLA 4LXZA 4RN2A 4RHQA 4RHJA 2V5WA 5G11A 4CEVA 5THUA 1VKGA 3MFVA 1ZZ0A 5EEMA 1T4TA 4IE1A 4RN1A 2EF5A 5D1DA 4Q41A 5A2SA 1HQHA 4HWWA 3M1RA 1ZPGA 3THHA 1CEVA 3MZ3A 4IE2A 4LY1A 5G0XA 5EFNA 4BZ6A 3F80A 4Q40A 1TBHA 5BWZA 4RHKA 2CEVA 1PQ3A 4RHLA 1HQGA 4MYFA 2EF4A 4QA6A 1T5FA 3THEA 1P8SA 3ZNSA 4CBYA 1HQ5A 4BZ9A 3CEVA 4MYNA 4Q3PA 4ITYA 1GQ6A 5THSA 5EEFA 3TH7A 3F07A 5G0YA 3EZPA 5DC6A 4BZ5A 4RHMA 4ZUQA 5THVA 5IX0A 5G1BA 2VQJA 1WOGA 4IXUA 3NIPA 1ZPEA 3SKKA 3EW8A 4GSVA 1WOHA 5G0IA 1P8NA 4QA7A 1R1OA 3ZNRA 5JI5A 1TBLA 4Q42A 1T64A 4QA4A 4QA2A 5D1BA 5LI3A 2GH6A 4IU5A 4HZEA 4QA5A 3C10A 4IE3A 5EF8A 1P8OA 5HJAA 3EZTA 4Q3UA 1D3VA 2PHOA 4GSZA 1C3SA 3KV2A 3E6VA 4ZURA 1T67A 5THTA 5G0GA 3THJA 5ICNB 2VQOA 5G3WA 3NIQA 5EENA 5G13A 3SJTA 1ZZ3A 4IXVA 2PHAA 1C3PA 3E9BA 3LP7A 1P8PA 3MFWA 3MMRA 4RN0A 4Q3QA 4RHIA 5EFGA 5EEKA 2A0MA 4Q3VA 4ZUOA 5G0HA 3Q9BA 4Q3RA 5G12A 3RQDA 3MAXA 4BZ7A 4QA1A 5HJ9A 3F0RA 3MZ6A 4RLAA 3MZ4A 1HQFA 1T4RA 5IWGA 4Q3SA 3SFFA 3TF3A 4Q3RC 4MXRA 1ZZ1A 1WVAA 5EEIA 4BKXB 5DC8A 4I06A 3GMZA 4IU0A 3Q9FA 3MJLA 4G3HA 3SL0A 4HXQA 4ZUPA 5EF7A 1HQXA 1XFKA 3SL1A 1T69A 2V5XA 2VQMA 2VQVA 4Q3TA 5EFKB 2VQQA 4IU4A 3C0ZA
chains in the Genus database with same CATH topology
4FCIA 2PLLA 1GQ7A 3E8QA 3RLAA 3E8ZA 3LP4A 2ZAVA 1WOIA 4MYKA 3E6KA 3LHLA 1T4PA 1P8MA 2AEBA 1P8QA 3DJ8A 3GN0A 4IU1A 1T4SA 1WVBA 4GSMA 4GWCA 5CEVA 4FCKA 2EIVA 1RLAA 1TA1A 4MYLA 4GWDA 3NIOA 1P8RA 4DZ4A 1TBJA 1T5GA 5RLAA 2RLAA 3PZLA 4RHQA 4RHJA 4CEVA 3MFVA 1T4TA 4IE1A 4Q41A 2EF5A 1HQHA 4HWWA 3M1RA 1ZPGA 3THHA 1CEVA 4IE2A 3F80A 4Q40A 1TBHA 4RHKA 2CEVA 1PQ3A 4RHLA 1HQGA 4MYFA 2EF4A 1T5FA 1P8SA 1HQ5A 3CEVA 4MYNA 4Q3PA 4ITYA 1GQ6A 3TH7A 4RHMA 1WOGA 4IXUA 3NIPA 1ZPEA 3SKKA 4GSVA 1WOHA 1P8NA 1R1OA 1TBLA 4Q42A 4IU5A 4HZEA 4IE3A 1P8OA 5HJAA 4Q3UA 1D3VA 4GSZA 2PHOA 3KV2A 3E6VA 3THJA 3NIQA 3SJTA 4IXVA 2PHAA 3MFWA 3E9BA 3LP7A 1P8PA 3MMRA 3THEA 4Q3QA 4RHIA 2A0MA 4Q3VA 4Q3RA 5HJ9A 4RLAA 1HQFA 1T4RA 4Q3SA 3TF3A 4Q3RC 4MXRA 1WVAA 4I06A 3GMZA 4IU0A 3MJLA 4G3HA 3SL0A 4HXQA 1HQXA 1XFKA 3SL1A 4Q3TA 4IU4A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4FCI A;  2PLL A;  1GQ7 A;  3E8Q A;  3RLA A;  3E8Z A;  3LP4 A;  2ZAV A;  1WOI A;  4MYK A;  3E6K A;  3LHL A;  1T4P A;  1P8M A;  2AEB A;  1P8Q A;  3DJ8 A;  3GN0 A;  4IU1 A;  1T4S A;  1WVB A;  4GSM A;  4GWC A;  5CEV A;  4FCK A;  2EIV A;  1RLA A;  1TA1 A;  4MYL A;  4GWD A;  3NIO A;  1P8R A;  4DZ4 A;  1TBJ A;  1T5G A;  5RLA A;  2RLA A;  3PZL A;  4RHQ A;  4RHJ A;  4CEV A;  3MFV A;  1T4T A;  4IE1 A;  4Q41 A;  2EF5 A;  1HQH A;  4HWW A;  3M1R A;  1ZPG A;  3THH A;  1CEV A;  4IE2 A;  3F80 A;  4Q40 A;  1TBH A;  4RHK A;  2CEV A;  1PQ3 A;  4RHL A;  1HQG A;  4MYF A;  2EF4 A;  1T5F A;  1P8S A;  1HQ5 A;  3CEV A;  4MYN A;  4Q3P A;  4ITY A;  1GQ6 A;  3TH7 A;  4RHM A;  1WOG A;  4IXU A;  3NIP A;  1ZPE A;  3SKK A;  4GSV A;  1WOH A;  1P8N A;  1R1O A;  1TBL A;  4Q42 A;  4IU5 A;  4HZE A;  4IE3 A;  1P8O A;  5HJA A;  4Q3U A;  1D3V A;  4GSZ A;  2PHO A;  3KV2 A;  3E6V A;  3THJ A;  3NIQ A;  3SJT A;  4IXV A;  2PHA A;  3MFW A;  3E9B A;  3LP7 A;  1P8P A;  3MMR A;  3THE A;  4Q3Q A;  4RHI A;  2A0M A;  4Q3V A;  4Q3R A;  5HJ9 A;  4RLA A;  1HQF A;  1T4R A;  4Q3S A;  3TF3 A;  4Q3R C;  4MXR A;  1WVA A;  4I06 A;  3GMZ A;  4IU0 A;  3MJL A;  4G3H A;  3SL0 A;  4HXQ A;  1HQX A;  1XFK A;  3SL1 A;  4Q3T A;  4IU4 A; 
#chains in the Genus database with same CATH topology
 4FCI A;  5EFJ D;  2PLL A;  5FCW A;  3EWF A;  1GQ7 A;  4QA0 A;  3E8Q A;  4CQF A;  3RLA A;  5G1C A;  5DC5 A;  3E8Z A;  3LP4 A;  3MEN A;  3SFH A;  2ZAV A;  3Q9E A;  1WOI A;  5G10 A;  2VCG A;  4MYK A;  3E6K A;  3LHL A;  1T4P A;  4A69 A;  1C3R A;  1P8M A;  2AEB A;  1P8Q A;  5DC7 A;  3DJ8 A;  3GN0 A;  4IU1 A;  5G0J A;  1T4S A;  1WVB A;  4BZ8 A;  4GSM A;  4GWC A;  5CEV A;  4FCK A;  2EIV A;  1RLA A;  5G1A A;  5EFH A;  5D1C A;  2VQW G;  1TA1 A;  4ZUN A;  4ZUM A;  3C0Y A;  4MYL A;  5G17 A;  1W22 A;  3NIO A;  3MZ7 A;  4GWD A;  5EFB D;  4CBT A;  1P8R A;  4DZ4 A;  1TBJ A;  3F06 A;  1T5G A;  5RLA A;  2RLA A;  5FUE A;  3Q9C A;  4QA3 A;  3PZL A;  4LXZ A;  4RN2 A;  4RHQ A;  4RHJ A;  2V5W A;  5G11 A;  4CEV A;  5THU A;  1VKG A;  3MFV A;  1ZZ0 A;  5EEM A;  1T4T A;  4IE1 A;  4RN1 A;  2EF5 A;  5D1D A;  4Q41 A;  5A2S A;  1HQH A;  4HWW A;  3M1R A;  1ZPG A;  3THH A;  1CEV A;  3MZ3 A;  4IE2 A;  4LY1 A;  5G0X A;  5EFN A;  4BZ6 A;  3F80 A;  4Q40 A;  1TBH A;  5BWZ A;  4RHK A;  2CEV A;  1PQ3 A;  4RHL A;  1HQG A;  4MYF A;  2EF4 A;  4QA6 A;  1T5F A;  3THE A;  1P8S A;  3ZNS A;  4CBY A;  1HQ5 A;  4BZ9 A;  3CEV A;  4MYN A;  4Q3P A;  4ITY A;  1GQ6 A;  5THS A;  5EEF A;  3TH7 A;  3F07 A;  5G0Y A;  3EZP A;  5DC6 A;  4BZ5 A;  4RHM A;  4ZUQ A;  5THV A;  5IX0 A;  5G1B A;  2VQJ A;  1WOG A;  4IXU A;  3NIP A;  1ZPE A;  3SKK A;  3EW8 A;  4GSV A;  1WOH A;  5G0I A;  1P8N A;  4QA7 A;  1R1O A;  3ZNR A;  5JI5 A;  1TBL A;  4Q42 A;  1T64 A;  4QA4 A;  4QA2 A;  5D1B A;  5LI3 A;  2GH6 A;  4IU5 A;  4HZE A;  4QA5 A;  3C10 A;  4IE3 A;  5EF8 A;  1P8O A;  5HJA A;  3EZT A;  4Q3U A;  1D3V A;  2PHO A;  4GSZ A;  1C3S A;  3KV2 A;  3E6V A;  4ZUR A;  1T67 A;  5THT A;  5G0G A;  3THJ A;  5ICN B;  2VQO A;  5G3W A;  3NIQ A;  5EEN A;  5G13 A;  3SJT A;  1ZZ3 A;  4IXV A;  2PHA A;  1C3P A;  3E9B A;  3LP7 A;  1P8P A;  3MFW A;  3MMR A;  4RN0 A;  4Q3Q A;  4RHI A;  5EFG A;  5EEK A;  2A0M A;  4Q3V A;  4ZUO A;  5G0H A;  3Q9B A;  4Q3R A;  5G12 A;  3RQD A;  3MAX A;  4BZ7 A;  4QA1 A;  5HJ9 A;  3F0R A;  3MZ6 A;  4RLA A;  3MZ4 A;  1HQF A;  1T4R A;  5IWG A;  4Q3S A;  3SFF A;  3TF3 A;  4Q3R C;  4MXR A;  1ZZ1 A;  1WVA A;  5EEI A;  4BKX B;  5DC8 A;  4I06 A;  3GMZ A;  4IU0 A;  3Q9F A;  3MJL A;  4G3H A;  3SL0 A;  4HXQ A;  4ZUP A;  5EF7 A;  1HQX A;  1XFK A;  3SL1 A;  1T69 A;  2V5X A;  2VQM A;  2VQV A;  4Q3T A;  5EFK B;  2VQQ A;  4IU4 A;  3C0Z A; 
#chains in the Genus database with same CATH homology
 4FCI A;  2PLL A;  1GQ7 A;  3E8Q A;  3RLA A;  3E8Z A;  3LP4 A;  2ZAV A;  1WOI A;  4MYK A;  3E6K A;  3LHL A;  1T4P A;  1P8M A;  2AEB A;  1P8Q A;  3DJ8 A;  3GN0 A;  4IU1 A;  1T4S A;  1WVB A;  4GSM A;  4GWC A;  5CEV A;  4FCK A;  2EIV A;  1RLA A;  1TA1 A;  4MYL A;  4GWD A;  3NIO A;  1P8R A;  4DZ4 A;  1TBJ A;  1T5G A;  5RLA A;  2RLA A;  3PZL A;  4RHQ A;  4RHJ A;  4CEV A;  3MFV A;  1T4T A;  4IE1 A;  4Q41 A;  2EF5 A;  1HQH A;  4HWW A;  3M1R A;  1ZPG A;  3THH A;  1CEV A;  4IE2 A;  3F80 A;  4Q40 A;  1TBH A;  4RHK A;  2CEV A;  1PQ3 A;  4RHL A;  1HQG A;  4MYF A;  2EF4 A;  1T5F A;  1P8S A;  1HQ5 A;  3CEV A;  4MYN A;  4Q3P A;  4ITY A;  1GQ6 A;  3TH7 A;  4RHM A;  1WOG A;  4IXU A;  3NIP A;  1ZPE A;  3SKK A;  4GSV A;  1WOH A;  1P8N A;  1R1O A;  1TBL A;  4Q42 A;  4IU5 A;  4HZE A;  4IE3 A;  1P8O A;  5HJA A;  4Q3U A;  1D3V A;  4GSZ A;  2PHO A;  3KV2 A;  3E6V A;  3THJ A;  3NIQ A;  3SJT A;  4IXV A;  2PHA A;  3MFW A;  3E9B A;  3LP7 A;  1P8P A;  3MMR A;  3THE A;  4Q3Q A;  4RHI A;  2A0M A;  4Q3V A;  4Q3R A;  5HJ9 A;  4RLA A;  1HQF A;  1T4R A;  4Q3S A;  3TF3 A;  4Q3R C;  4MXR A;  1WVA A;  4I06 A;  3GMZ A;  4IU0 A;  3MJL A;  4G3H A;  3SL0 A;  4HXQ A;  1HQX A;  1XFK A;  3SL1 A;  4Q3T A;  4IU4 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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