4IZVA

The e41q/c145a double mutant of the amidase from nesterenkonia sp. an1 in complex with acrylamide
Total Genus 78
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
78
sequence length
271
structure length
262
Chain Sequence
GLVPRGSHMRIALMQHTARPLDPQHNLDLIDDAAARASEQGAQLLLTPQLFGFGYVPSQICAQVSAEQVDAARSRLRGIARDRGIALVWSLPGPEGPEQRGITAELADEHGEVLASYQKVQLYGPEEKAAFVPGEQPPPVLSWGGRQLSLLVAYDVEFPEMVRAAAARGAQLVLVPTALAGDETSVPGILLPARAVENGITLAYANHCGPEGGLVFDGGSVVVGPAGQPLGELGVEPGLLVVDLPDADYLQDRRAELHRNWL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Covalent modifications of the active site cysteine occur as a result of mutating the glutamate of the catalytic triad in the amidase from Nesterenkonia sp.
rcsb
source organism Nesterenkonia sp. 10004
molecule tags Hydrolase/substrate
molecule keywords Amidase
total genus 78
structure length 262
sequence length 271
ec nomenclature ec 3.5.1.4: Amidase.
pdb deposition date 2013-01-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00795 CN_hydrolase Carbon-nitrogen hydrolase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.110.10 Alpha Beta 4-Layer Sandwich Nitrilase/N-carbamoyl-D-aminoacid amidohydrolase Carbon-nitrogen hydrolase 4izvA00
3KLCA 4IZUA 2DYVA 5JQNA 2E11A 5KHAA 4HG3A 2E2LA 2W1VA 1UF4A 3KI8A 4HG5A 4IZSA 5H8KA 5H8LA 4CYGA 4LF0A 4CYYA 3P8KA 2UXYA 5H8IA 2GGLA 3ILVA 3DLAA 1UF8A 1J31A 2VHIA 1F89A 3WUYA 3SYTA 4F4HA 4HGDA 2DYUA 3IW3A 4IZVA 3SEQA 2PLQA 3HKXA 4KZFA 5H8JA 3SZGA 2VHHA 4GYNA 1EMSA 2E2KA 3IVZA 4CYFA 3N05A 4IZWA 1UF7A 3SEZA 1ERZA 1UF5A 4GYLA 4IZTA 3SDBA 1FO6A 2GGKA 4H5UA
chains in the Genus database with same CATH superfamily
3KLCA 4IZUA 2DYVA 5JQNA 2E11A 5KHAA 4HG3A 2E2LA 2W1VA 1UF4A 3KI8A 4HG5A 4IZSA 5H8KA 5H8LA 4CYGA 4LF0A 4CYYA 3P8KA 2UXYA 5H8IA 2GGLA 3ILVA 3DLAA 1UF8A 1J31A 2VHIA 1F89A 3WUYA 3SYTA 4F4HA 4HGDA 2DYUA 3IW3A 4IZVA 3SEQA 2PLQA 3HKXA 4KZFA 5H8JA 3SZGA 2VHHA 4GYNA 1EMSA 2E2KA 3IVZA 4CYFA 3N05A 4IZWA 1UF7A 3SEZA 1ERZA 1UF5A 4GYLA 4IZTA 3SDBA 1FO6A 2GGKA 4H5UA
chains in the Genus database with same CATH topology
3KLCA 4IZUA 2DYVA 5JQNA 2E11A 5KHAA 4HG3A 2E2LA 2W1VA 1UF4A 3KI8A 4HG5A 4IZSA 5H8KA 5H8LA 4CYGA 4LF0A 4CYYA 3P8KA 2UXYA 5H8IA 2GGLA 3ILVA 3DLAA 1UF8A 1J31A 2VHIA 1F89A 3WUYA 3SYTA 4F4HA 4HGDA 2DYUA 3IW3A 4IZVA 3SEQA 2PLQA 3HKXA 4KZFA 5H8JA 3SZGA 2VHHA 4GYNA 1EMSA 2E2KA 3IVZA 4CYFA 3N05A 4IZWA 1UF7A 3SEZA 1ERZA 1UF5A 4GYLA 4IZTA 3SDBA 1FO6A 2GGKA 4H5UA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3KLC A;  4IZU A;  2DYV A;  5JQN A;  2E11 A;  5KHA A;  4HG3 A;  2E2L A;  2W1V A;  1UF4 A;  3KI8 A;  4HG5 A;  4IZS A;  5H8K A;  5H8L A;  4CYG A;  4LF0 A;  4CYY A;  3P8K A;  2UXY A;  5H8I A;  2GGL A;  3ILV A;  3DLA A;  1UF8 A;  1J31 A;  2VHI A;  1F89 A;  3WUY A;  3SYT A;  4F4H A;  4HGD A;  2DYU A;  3IW3 A;  4IZV A;  3SEQ A;  2PLQ A;  3HKX A;  4KZF A;  5H8J A;  3SZG A;  2VHH A;  4GYN A;  1EMS A;  2E2K A;  3IVZ A;  4CYF A;  3N05 A;  4IZW A;  1UF7 A;  3SEZ A;  1ERZ A;  1UF5 A;  4GYL A;  4IZT A;  3SDB A;  1FO6 A;  2GGK A;  4H5U A; 
#chains in the Genus database with same CATH topology
 3KLC A;  4IZU A;  2DYV A;  5JQN A;  2E11 A;  5KHA A;  4HG3 A;  2E2L A;  2W1V A;  1UF4 A;  3KI8 A;  4HG5 A;  4IZS A;  5H8K A;  5H8L A;  4CYG A;  4LF0 A;  4CYY A;  3P8K A;  2UXY A;  5H8I A;  2GGL A;  3ILV A;  3DLA A;  1UF8 A;  1J31 A;  2VHI A;  1F89 A;  3WUY A;  3SYT A;  4F4H A;  4HGD A;  2DYU A;  3IW3 A;  4IZV A;  3SEQ A;  2PLQ A;  3HKX A;  4KZF A;  5H8J A;  3SZG A;  2VHH A;  4GYN A;  1EMS A;  2E2K A;  3IVZ A;  4CYF A;  3N05 A;  4IZW A;  1UF7 A;  3SEZ A;  1ERZ A;  1UF5 A;  4GYL A;  4IZT A;  3SDB A;  1FO6 A;  2GGK A;  4H5U A; 
#chains in the Genus database with same CATH homology
 3KLC A;  4IZU A;  2DYV A;  5JQN A;  2E11 A;  5KHA A;  4HG3 A;  2E2L A;  2W1V A;  1UF4 A;  3KI8 A;  4HG5 A;  4IZS A;  5H8K A;  5H8L A;  4CYG A;  4LF0 A;  4CYY A;  3P8K A;  2UXY A;  5H8I A;  2GGL A;  3ILV A;  3DLA A;  1UF8 A;  1J31 A;  2VHI A;  1F89 A;  3WUY A;  3SYT A;  4F4H A;  4HGD A;  2DYU A;  3IW3 A;  4IZV A;  3SEQ A;  2PLQ A;  3HKX A;  4KZF A;  5H8J A;  3SZG A;  2VHH A;  4GYN A;  1EMS A;  2E2K A;  3IVZ A;  4CYF A;  3N05 A;  4IZW A;  1UF7 A;  3SEZ A;  1ERZ A;  1UF5 A;  4GYL A;  4IZT A;  3SDB A;  1FO6 A;  2GGK A;  4H5U A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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