4J3DA

Pseudomonas aeruginosa lpxc in complex with a hydroxamate inhibitor
Total Genus 84
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
84
sequence length
297
structure length
287
Chain Sequence
MIKQRTLKNIIRATGVGLHSGEKVYLTLKPAPVDTGIVFCRTDLDPVVEIPARAENVGETTMSTTLVKGDVKVDTVEHLLSAMAGLGIDNAYVELSASEVPIMDGSAGPFVFLIQSAGLQEQEAAKKFIRIKREVSVEEGDKRAVFVPFDGFKVSFEIDQQASVDFSSTSFVKEVSRARTFGFMRDIEYLRSQNLALGGSVENAIVVDENRVLNEDGLRYEDEFVKHKILDAIGDLYLLGNSLIGEFRGFKSGHALNNQLLRTLIADKDAWEVVTFEDARTAPISYM
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Exploring the UDP pocket of LpxC through amino acid analogs.
pubmed doi rcsb
source organism Pseudomonas aeruginosa
molecule tags Hydrolase/hydrolase inhibitor
molecule keywords UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase
total genus 84
structure length 287
sequence length 297
chains with identical sequence B
ec nomenclature ec 3.5.1.108: UDP-3-O-acyl-N-acetylglucosamine deacetylase.
pdb deposition date 2013-02-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF03331 LpxC UDP-3-O-acyl N-acetylglycosamine deacetylase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.230.20 Alpha Beta 2-Layer Sandwich Ribosomal Protein S5; domain 2 lpxc deacetylase, domain 1 4j3dA01
3.30.1700.10 Alpha Beta 2-Layer Sandwich lpxc deacetylase, domain 1 lpxc deacetylase, domain 2 4j3dA02
3PS1A 4ISAA 1P42A 1YH8A 4U3DA 2GO3A 3UHMA 4FW3A 5DROA 1YHCA 4FW5A 4OZEA 2J65A 3PS3A 5DRQA 4MQYA 3NZKA 3P3CA 4J3DA 4LCFA 4FW4A 4MDTA 2IERA 2JT2A 3P3EA 3PS2A 4LCHA 1XXEA 4FW6A 4FW7A 2VESA 3P3GA 2IESA 2GO4A 4OKGA 5DRRA 4LCGA 4IS9A 3P76A 5DRPA 3U1YA 2O3ZA 4U3BA
chains in the Genus database with same CATH superfamily
1IBMI 2UXCI 1OJ4A 4JI7I 3P06A 4AQYI 4DV0I 5LMNE 1H73A 2O1TA 4JYAE 1HK7A 2HHHI 1RHYA 1Z0CA 4DUZE 1XNQI 2C38B 1VISA 1XMOE 5C0XD 2JT2A 4JI3E 1XXEA 5JEAB 2VQEE 4BA1B 2BR2B 3ZKDA 2BM0A 4AIDA 4DV6E 2NN6E 4YHHE 1P42A 1VI7A 4IZJD 2PO2B 4JI1E 4LF9I 4LF4I 5EL9A 3H4LA 1N0VC 4FW5A 3ZKBA 4DV5I 3T1HI 1U2RA 4PRXA 4DV3E 1J5EE 4ED4A 3PS2A 4B3RE 1N36I 1ELOA 4LFAE 1IBME 1FNMA 3PYFA 1ZXNA 4WUCA 2WP8A 4FN5A 2PNZB 4JV5E 4JYAI 5K36A 4AIMA 4IFDF 5IT9C 4XTJA 4Z7YA 4USKA 4DU7A 4P7AA 4JI3I 1XNRI 4GKKI 2A2CA 2WP8B 4MU3A 2ZM6I 2NPFA 4OO1D 1UEKA 5DNLA 2NN6A 4FW4A 1R6MA 4R1FA 1MX0A 4LFBE 2V2QA 5BR8I 4JI4E 2PNMA 2C39B 5GMEA 1D6TA 1KIJA 4MU4A 2V34A 4N3OA 4JI1I 1XHKA 4JI6E 2BV3A 4IZKA 4JI2E 4IFDC 4IFDB 1H74A 3WU4A 3QT6A 2NN6B 4FW3A 3L7ZB 4DR5E 1R6LA 4HYMA 2Z5CA 1Y4SA 4OX9E 1S4EA 2BR2A 2NN6F 1KVKA 1Z5AA 4USMA 4DR1E 4DR6I 2ZBKB 4LCHA 4IZJB 1WUUA 1Z5BA 2R3VA 4GQUA 1XMOI 2Z5CB 2LJPA 4LOMA 4DV7E 2WNRB 1H7SA 1UDSA 4DV2E 4P52A 3GONA 1IBKI 3B82A 2R42A 1HNXE 5IT9Q 4U3DA 1Y6ZA 4QNKA 2BA1G 1Z5CA 2J7KA 2J65A 4LF8E 1HNWI 2HFSA 4LF6E 4IFDE 5A2QQ 4MYTA 1PIEA 3Q6MA 3GMEA 4JI6I 1N32E 2CGEA 3T1YE 4JI7E 3CDJA 1Y60A 2HK2A 2UUAI 3K17A 1ZM9A 5LMUE 5L3JA 4DPXA 2Z5BA 4DPWA 4B3TI 2HHHE 4WUDA 4B3ME 2PO1B 2IOQA 3CWVA 2C39A 1B63A 4OZEA 4UT4A 5JEAC 1E3HA 3QT5A 4HACA 3ZZ0A 1OYRA 3QT7A 2HKEA 4FWGA 5K36F 3J81C 3P76A 2VQFE 4PU9A 4HACB 3JAMC 3PYEA 2BA0D 4DV4I 5DROA 5EKWA 1FWKA 2E5LI 4DV1I 1MG7A 4YY3E 2HKJA 4AQYE 1FJGI 1HR0E 4DV0E 4IFDD 4J3DA 3PRYA 1N32I 2DEJA 2BA1D 4FW6A 2C37A 2JEAA 2IESA 4DR1I 4DUYE 5K36C 4DR6E 2CZ9A 1EA6A 1KTVA 1PKPA 4OO1C 4JG4A 1PVGA 1ZM2A 4LFCE 5JEAA 5LL6R 5C0XB 1NHIA 1ZM3A 1HNZE 2OI2A 1FI4A 1HNXI 4LF9E 3J80C 1RR9A 1N34E 2VQFI 2VESA 4GKJI 3JAMQ 3M7NG 4OO1A 4LF5I 3Q1QA 3T1YI 2BA0G 2X7IA 5JEAD 3LTOA 4OX9I 2E1RA 2UUCI 3H1CA 2BM1A 2UUBI 5FLXC 4DPTA 4FWDA 1H72C 2HFUA 4JI8E 2UXDE 1Z0VA 4X64I 4Z7CA 2PNZA 1E3PA 1K47A 2XEXA 2V2ZA 2X36A 3V5RA 1IBLE 4DV2I 1IBKE 4X62E 4FW9A 2V2VA 4JI5I 1XMQE 2O3ZA 5A2QC 1S16A 1Z0TA 4LF6I 1BKNA 2HK3A 4X65E 5DRQA 3K1JA 4IFDA 1UDNA 2WNRA 3WU5A 3B8HA 5IWAE 4NXNE 3P3EA 3J7AG 1N33I 4IZKB 3L7ZA 3J7AM 1FJGE 1USUA 5C0XA 1HR0I 4LF5E 4DXLA 5LMUI 4RPFA 2UXCE 3ZM7A 5FLXQ 2JEBA 3B4TA 5LMNI 1Z0WA 4MU0A 3PS1A 4DR3E 2C38A 4DR4I 1YH8A 4DV7I 2JEAB 4X64E 3GCMA 1FKAE 1Z0GA 3UHMA 4BA1A 2PO0B 5K36D 4HY1A 2AE8A 4AM3A 1HNZI 2JEBB 4MDTA 5FWKA 3M6AA 3LPSA 3M85D 2PO0A 1NHJA 5DNXA 1HNWE 2GO4A 2CG9A 4B3SI 4DR2E 3WU3A 5DRRA 2UXBE 1I94E 4I3HA 4EMDA 4NBQA 4DR7I 1KKHA 4GKJE 4HXZA 2IOPA 1UDOA 4DV1E 4LF7I 1FWLA 4NXNI 5C0XC 4DV3I 3V2UC 1J5EI 3K85A 4B3TE 3PS3A 4WUBA 4OO1B 4JI0I 3D4JA 3P3CA 4X66I 4LCFA 2ZITA 4QNJA 2PO1A 5K36B 4OO1E 3P3GA 2Q2EB 4JV5I 4LFCI 4IS9A 5K36E 2EFGA 4U3BA 2VQEI 2V8PA 2GQ0A 4KHPE 1UDQA 2GO3A 5C0XF 3OTOE 5C0XE 1OYSA 1RREA 1N34I 2NN6C 5BR8E 1NHHA 4JI4I 4BA2B 5JEAE 5JEAF 1B62A 4K0KE 2E5LE 4DV5E 1Z0EA 4YY3I 1OYPA 4DPUA 3T1HE 5IWAI 2O1VA 2PNLA 4LCGA 4M1KA 2F1DA 4FWHA 3U1KA 4DUYI 3PYGA 4JI8I 4DR5I 1Y4UA 2C37B 4ISAA 2UXDI 3CDIA 3KRNA 3F0NA 3HULA 4IZJA 4JI0E 4DPYA 4X66E 1QZRA 4MYUA 1USVA 4MQYA 4NXME 1Y5YA 3NZKA 5ELWA 4X62I 4JI5E 1XMQI 2ZM6E 3HJCA 2WW4A 3DD6A 4KHPI 4YHHI 2UU9I 4LFBI 5DRPA 2JE6A 4ZVIA 3B78A 2GS8A 4FW7A 4B3SE 4LF4E 3OTOI 4KQVA 1EI1A 2F4VE 2O1UA 2UXBI 4OO1F 1DARA 2Z5EA 2DEIA 4X65I 4DR7E 4LF8I 4URLA 3Q6NA 3ZZUA 1Z0BA 4JI2I 5GMDA 1MU5A 1N33E 2O1WA 2UUCE 2Z5BB 3M85G 1N36E 4B3RI 2UUBE 4LFAI 2JE6B 3QT8A 2PO2A 3GLLA 2IERA 3LNUA 1XNQE 4DUZI 1A6FA 2UUAE 4OKGA 3WU6A 4DR3I 4DR4E 1IBLI 1NZ0A 4LPFA 3U1YA 4DU8A 1N0UA 4B3MI 2CVEA 2NN6D 3J81Q 1XNRE 4GKKE 4NXMI 4PRVA 3ZZTA 4DV6I 1YHCA 3HKMA 3M7ND 3J80Q 4DR2I 2A2DA 3PYDA 1H7UA 1I94I 4MU1A 2UU9E 1ZXMA 1Z59A 2AJ4A 2F4VI 4K0KI 4BA2A 1ZM4A 4LF7E 4UTGA 2VF3A 4DV4E
chains in the Genus database with same CATH topology
3PS1A 4ISAA 1P42A 1YH8A 4U3DA 2GO3A 3UHMA 4FW3A 5DROA 1YHCA 4FW5A 4OZEA 2J65A 3PS3A 5DRQA 4MQYA 3NZKA 3P3CA 4J3DA 4LCFA 4FW4A 4MDTA 2IERA 2JT2A 3P3EA 3PS2A 4LCHA 1XXEA 4FW6A 4FW7A 2VESA 3P3GA 2IESA 2GO4A 4OKGA 5DRRA 4LCGA 4IS9A 3P76A 5DRPA 3U1YA 2O3ZA 4U3BA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3PS1 A;  4ISA A;  1P42 A;  1YH8 A;  4U3D A;  2GO3 A;  3UHM A;  4FW3 A;  5DRO A;  1YHC A;  4FW5 A;  4OZE A;  2J65 A;  3PS3 A;  5DRQ A;  4MQY A;  3NZK A;  3P3C A;  4J3D A;  4LCF A;  4FW4 A;  4MDT A;  2IER A;  2JT2 A;  3P3E A;  3PS2 A;  4LCH A;  1XXE A;  4FW6 A;  4FW7 A;  2VES A;  3P3G A;  2IES A;  2GO4 A;  4OKG A;  5DRR A;  4LCG A;  4IS9 A;  3P76 A;  5DRP A;  3U1Y A;  2O3Z A;  4U3B A; 
#chains in the Genus database with same CATH topology
 1IBM I;  2UXC I;  1OJ4 A;  4JI7 I;  3P06 A;  4AQY I;  4DV0 I;  5LMN E;  1H73 A;  2O1T A;  4JYA E;  1HK7 A;  2HHH I;  1RHY A;  1Z0C A;  4DUZ E;  1XNQ I;  2C38 B;  1VIS A;  1XMO E;  5C0X D;  2JT2 A;  4JI3 E;  1XXE A;  5JEA B;  2VQE E;  4BA1 B;  2BR2 B;  3ZKD A;  2BM0 A;  4AID A;  4DV6 E;  2NN6 E;  4YHH E;  1P42 A;  1VI7 A;  4IZJ D;  2PO2 B;  4JI1 E;  4LF9 I;  4LF4 I;  5EL9 A;  3H4L A;  1N0V C;  4FW5 A;  3ZKB A;  4DV5 I;  3T1H I;  1U2R A;  4PRX A;  4DV3 E;  1J5E E;  4ED4 A;  3PS2 A;  4B3R E;  1N36 I;  1ELO A;  4LFA E;  1IBM E;  1FNM A;  3PYF A;  1ZXN A;  4WUC A;  2WP8 A;  4FN5 A;  2PNZ B;  4JV5 E;  4JYA I;  5K36 A;  4AIM A;  4IFD F;  5IT9 C;  4XTJ A;  4Z7Y A;  4USK A;  4DU7 A;  4P7A A;  4JI3 I;  1XNR I;  4GKK I;  2A2C A;  2WP8 B;  4MU3 A;  2ZM6 I;  2NPF A;  4OO1 D;  1UEK A;  5DNL A;  2NN6 A;  4FW4 A;  1R6M A;  4R1F A;  1MX0 A;  4LFB E;  2V2Q A;  5BR8 I;  4JI4 E;  2PNM A;  2C39 B;  5GME A;  1D6T A;  1KIJ A;  4MU4 A;  2V34 A;  4N3O A;  4JI1 I;  1XHK A;  4JI6 E;  2BV3 A;  4IZK A;  4JI2 E;  4IFD C;  4IFD B;  1H74 A;  3WU4 A;  3QT6 A;  2NN6 B;  4FW3 A;  3L7Z B;  4DR5 E;  1R6L A;  4HYM A;  2Z5C A;  1Y4S A;  4OX9 E;  1S4E A;  2BR2 A;  2NN6 F;  1KVK A;  1Z5A A;  4USM A;  4DR1 E;  4DR6 I;  2ZBK B;  4LCH A;  4IZJ B;  1WUU A;  1Z5B A;  2R3V A;  4GQU A;  1XMO I;  2Z5C B;  2LJP A;  4LOM A;  4DV7 E;  2WNR B;  1H7S A;  1UDS A;  4DV2 E;  4P52 A;  3GON A;  1IBK I;  3B82 A;  2R42 A;  1HNX E;  5IT9 Q;  4U3D A;  1Y6Z A;  4QNK A;  2BA1 G;  1Z5C A;  2J7K A;  2J65 A;  4LF8 E;  1HNW I;  2HFS A;  4LF6 E;  4IFD E;  5A2Q Q;  4MYT A;  1PIE A;  3Q6M A;  3GME A;  4JI6 I;  1N32 E;  2CGE A;  3T1Y E;  4JI7 E;  3CDJ A;  1Y60 A;  2HK2 A;  2UUA I;  3K17 A;  1ZM9 A;  5LMU E;  5L3J A;  4DPX A;  2Z5B A;  4DPW A;  4B3T I;  2HHH E;  4WUD A;  4B3M E;  2PO1 B;  2IOQ A;  3CWV A;  2C39 A;  1B63 A;  4OZE A;  4UT4 A;  5JEA C;  1E3H A;  3QT5 A;  4HAC A;  3ZZ0 A;  1OYR A;  3QT7 A;  2HKE A;  4FWG A;  5K36 F;  3J81 C;  3P76 A;  2VQF E;  4PU9 A;  4HAC B;  3JAM C;  3PYE A;  2BA0 D;  4DV4 I;  5DRO A;  5EKW A;  1FWK A;  2E5L I;  4DV1 I;  1MG7 A;  4YY3 E;  2HKJ A;  4AQY E;  1FJG I;  1HR0 E;  4DV0 E;  4IFD D;  4J3D A;  3PRY A;  1N32 I;  2DEJ A;  2BA1 D;  4FW6 A;  2C37 A;  2JEA A;  2IES A;  4DR1 I;  4DUY E;  5K36 C;  4DR6 E;  2CZ9 A;  1EA6 A;  1KTV A;  1PKP A;  4OO1 C;  4JG4 A;  1PVG A;  1ZM2 A;  4LFC E;  5JEA A;  5LL6 R;  5C0X B;  1NHI A;  1ZM3 A;  1HNZ E;  2OI2 A;  1FI4 A;  1HNX I;  4LF9 E;  3J80 C;  1RR9 A;  1N34 E;  2VQF I;  2VES A;  4GKJ I;  3JAM Q;  3M7N G;  4OO1 A;  4LF5 I;  3Q1Q A;  3T1Y I;  2BA0 G;  2X7I A;  5JEA D;  3LTO A;  4OX9 I;  2E1R A;  2UUC I;  3H1C A;  2BM1 A;  2UUB I;  5FLX C;  4DPT A;  4FWD A;  1H72 C;  2HFU A;  4JI8 E;  2UXD E;  1Z0V A;  4X64 I;  4Z7C A;  2PNZ A;  1E3P A;  1K47 A;  2XEX A;  2V2Z A;  2X36 A;  3V5R A;  1IBL E;  4DV2 I;  1IBK E;  4X62 E;  4FW9 A;  2V2V A;  4JI5 I;  1XMQ E;  2O3Z A;  5A2Q C;  1S16 A;  1Z0T A;  4LF6 I;  1BKN A;  2HK3 A;  4X65 E;  5DRQ A;  3K1J A;  4IFD A;  1UDN A;  2WNR A;  3WU5 A;  3B8H A;  5IWA E;  4NXN E;  3P3E A;  3J7A G;  1N33 I;  4IZK B;  3L7Z A;  3J7A M;  1FJG E;  1USU A;  5C0X A;  1HR0 I;  4LF5 E;  4DXL A;  5LMU I;  4RPF A;  2UXC E;  3ZM7 A;  5FLX Q;  2JEB A;  3B4T A;  5LMN I;  1Z0W A;  4MU0 A;  3PS1 A;  4DR3 E;  2C38 A;  4DR4 I;  1YH8 A;  4DV7 I;  2JEA B;  4X64 E;  3GCM A;  1FKA E;  1Z0G A;  3UHM A;  4BA1 A;  2PO0 B;  5K36 D;  4HY1 A;  2AE8 A;  4AM3 A;  1HNZ I;  2JEB B;  4MDT A;  5FWK A;  3M6A A;  3LPS A;  3M85 D;  2PO0 A;  1NHJ A;  5DNX A;  1HNW E;  2GO4 A;  2CG9 A;  4B3S I;  4DR2 E;  3WU3 A;  5DRR A;  2UXB E;  1I94 E;  4I3H A;  4EMD A;  4NBQ A;  4DR7 I;  1KKH A;  4GKJ E;  4HXZ A;  2IOP A;  1UDO A;  4DV1 E;  4LF7 I;  1FWL A;  4NXN I;  5C0X C;  4DV3 I;  3V2U C;  1J5E I;  3K85 A;  4B3T E;  3PS3 A;  4WUB A;  4OO1 B;  4JI0 I;  3D4J A;  3P3C A;  4X66 I;  4LCF A;  2ZIT A;  4QNJ A;  2PO1 A;  5K36 B;  4OO1 E;  3P3G A;  2Q2E B;  4JV5 I;  4LFC I;  4IS9 A;  5K36 E;  2EFG A;  4U3B A;  2VQE I;  2V8P A;  2GQ0 A;  4KHP E;  1UDQ A;  2GO3 A;  5C0X F;  3OTO E;  5C0X E;  1OYS A;  1RRE A;  1N34 I;  2NN6 C;  5BR8 E;  1NHH A;  4JI4 I;  4BA2 B;  5JEA E;  5JEA F;  1B62 A;  4K0K E;  2E5L E;  4DV5 E;  1Z0E A;  4YY3 I;  1OYP A;  4DPU A;  3T1H E;  5IWA I;  2O1V A;  2PNL A;  4LCG A;  4M1K A;  2F1D A;  4FWH A;  3U1K A;  4DUY I;  3PYG A;  4JI8 I;  4DR5 I;  1Y4U A;  2C37 B;  4ISA A;  2UXD I;  3CDI A;  3KRN A;  3F0N A;  3HUL A;  4IZJ A;  4JI0 E;  4DPY A;  4X66 E;  1QZR A;  4MYU A;  1USV A;  4MQY A;  4NXM E;  1Y5Y A;  3NZK A;  5ELW A;  4X62 I;  4JI5 E;  1XMQ I;  2ZM6 E;  3HJC A;  2WW4 A;  3DD6 A;  4KHP I;  4YHH I;  2UU9 I;  4LFB I;  5DRP A;  2JE6 A;  4ZVI A;  3B78 A;  2GS8 A;  4FW7 A;  4B3S E;  4LF4 E;  3OTO I;  4KQV A;  1EI1 A;  2F4V E;  2O1U A;  2UXB I;  4OO1 F;  1DAR A;  2Z5E A;  2DEI A;  4X65 I;  4DR7 E;  4LF8 I;  4URL A;  3Q6N A;  3ZZU A;  1Z0B A;  4JI2 I;  5GMD A;  1MU5 A;  1N33 E;  2O1W A;  2UUC E;  2Z5B B;  3M85 G;  1N36 E;  4B3R I;  2UUB E;  4LFA I;  2JE6 B;  3QT8 A;  2PO2 A;  3GLL A;  2IER A;  3LNU A;  1XNQ E;  4DUZ I;  1A6F A;  2UUA E;  4OKG A;  3WU6 A;  4DR3 I;  4DR4 E;  1IBL I;  1NZ0 A;  4LPF A;  3U1Y A;  4DU8 A;  1N0U A;  4B3M I;  2CVE A;  2NN6 D;  3J81 Q;  1XNR E;  4GKK E;  4NXM I;  4PRV A;  3ZZT A;  4DV6 I;  1YHC A;  3HKM A;  3M7N D;  3J80 Q;  4DR2 I;  2A2D A;  3PYD A;  1H7U A;  1I94 I;  4MU1 A;  2UU9 E;  1ZXM A;  1Z59 A;  2AJ4 A;  2F4V I;  4K0K I;  4BA2 A;  1ZM4 A;  4LF7 E;  4UTG A;  2VF3 A;  4DV4 E; 
#chains in the Genus database with same CATH homology
 3PS1 A;  4ISA A;  1P42 A;  1YH8 A;  4U3D A;  2GO3 A;  3UHM A;  4FW3 A;  5DRO A;  1YHC A;  4FW5 A;  4OZE A;  2J65 A;  3PS3 A;  5DRQ A;  4MQY A;  3NZK A;  3P3C A;  4J3D A;  4LCF A;  4FW4 A;  4MDT A;  2IER A;  2JT2 A;  3P3E A;  3PS2 A;  4LCH A;  1XXE A;  4FW6 A;  4FW7 A;  2VES A;  3P3G A;  2IES A;  2GO4 A;  4OKG A;  5DRR A;  4LCG A;  4IS9 A;  3P76 A;  5DRP A;  3U1Y A;  2O3Z A;  4U3B A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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