4J3DA

Pseudomonas aeruginosa lpxc in complex with a hydroxamate inhibitor
Total Genus 84
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
84
sequence length
297
structure length
287
Chain Sequence
MIKQRTLKNIIRATGVGLHSGEKVYLTLKPAPVDTGIVFCRTDLDPVVEIPARAENVGETTMSTTLVKGDVKVDTVEHLLSAMAGLGIDNAYVELSASEVPIMDGSAGPFVFLIQSAGLQEQEAAKKFIRIKREVSVEEGDKRAVFVPFDGFKVSFEIDQQASVDFSSTSFVKEVSRARTFGFMRDIEYLRSQNLALGGSVENAIVVDENRVLNEDGLRYEDEFVKHKILDAIGDLYLLGNSLIGEFRGFKSGHALNNQLLRTLIADKDAWEVVTFEDARTAPISYM
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Exploring the UDP pocket of LpxC through amino acid analogs.
pubmed doi rcsb
source organism Pseudomonas aeruginosa
molecule tags Hydrolase/hydrolase inhibitor
molecule keywords UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase
total genus 84
structure length 287
sequence length 297
chains with identical sequence B
ec nomenclature ec 3.5.1.108: UDP-3-O-acyl-N-acetylglucosamine deacetylase.
pdb deposition date 2013-02-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF03331 LpxC UDP-3-O-acyl N-acetylglycosamine deacetylase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.230.20 Alpha Beta 2-Layer Sandwich Ribosomal Protein S5; domain 2 lpxc deacetylase, domain 1 4j3dA01
3.30.1700.10 Alpha Beta 2-Layer Sandwich lpxc deacetylase, domain 1 lpxc deacetylase, domain 2 4j3dA02
3P3GA 1P42A 4FW3A 1YHCA 3P3CA 4U3BA 4LCFA 4FW5A 5DRQA 2GO4A 4ISAA 4OZEA 4LCHA 3PS2A 4LCGA 4MDTA 3P3EA 2O3ZA 2GO3A 3UHMA 3PS3A 5DROA 4U3DA 2J65A 4IS9A 5DRPA 5DRRA 4FW4A 4MQYA 4OKGA 3NZKA 4FW7A 2VESA 4FW6A 3U1YA 2IERA 3P76A 3PS1A 1YH8A 4J3DA 1XXEA 2JT2A 2IESA
chains in the Genus database with same CATH superfamily
1H7SA 2OI2A 3PYDA 5K36D 4ISAA 4DPXA 2O3ZA 5BR8E 1R6MA 2J65A 3LPSA 1J5EI 1N33I 1N0VC 4IS9A 2XEXA 2PO1A 3PYGA 4GQUA 1H72C 2VQFE 4JI5I 1S16A 2HHHI 4BA1B 1R6LA 1FNMA 4JYAI 3J7AM 4B3SE 1OYSA 2AJ4A 2HFUA 1HR0I 3P3CA 4OZEA 4IZJA 4AQYI 3M7NG 2DEIA 2GQ0A 5DROA 3ZKBA 1XMOI 3DD6A 2CZ9A 1ZM3A 1ZM4A 4DR4E 3PRYA 4JI3I 4X65I 2AE8A 1Z5CA 1RREA 4YHHE 4MYTA 4LF4I 3P76A 4FWHA 1E3HA 1N0UA 3U1KA 2UUCE 2JEAA 2WP8B 4LF6E 1OYRA 4U3BA 2O1UA 2PO1B 3HKMA 2NN6E 4DR3I 1BKNA 4X65E 2IOPA 4JG4A 2LJPA 4WUDA 4GKKI 5LMUE 2NN6A 2UXCE 3ZKDA 2JEBB 2O1WA 2HFSA 1Y4SA 1N32I 4U3DA 4HXZA 4DV3E 2R42A 3M85G 5DRPA 5JEAA 1USUA 5C0XE 3V2UC 4JI6I 4DPUA 3F0NA 3OTOI 4HACB 4DPYA 1OYPA 2ZM6I 4LFAE 2VQEE 2UUBI 4DV4E 1HNWI 5GMEA 2HKJA 1XNQE 4QNKA 3T1HI 4AIDA 4B3TE 1Z5BA 4LCFA 4JI6E 4HACA 1E3PA 4DV7I 4P7AA 1Y5YA 4DR6I 5LL6R 3Q6MA 4DV4I 2VQEI 4M1KA 2BA0D 2NN6B 3T1HE 4MYUA 4JI2E 4NXME 2UXDI 2BR2A 5EKWA 3OTOE 5DRRA 2V2ZA 3B4TA 2UU9E 2ZM6E 4DR6E 1FWKA 1Z0VA 1RR9A 5C0XD 3PYEA 1FI4A 2PNLA 3M85D 4X66E 1ELOA 3ZZ0A 1UDSA 4DV7E 2Z5BA 4GKJI 4BA2B 4DUZI 1K47A 4LF8I 3GLLA 4PRVA 1ZM2A 2NN6C 4OO1D 4DV6E 4OO1B 1XNRE 4UT4A 5JEAC 1NHIA 1PKPA 1MX0A 1UEKA 4DUZE 3H4LA 4IZJD 1IBMI 4JI4I 4LF5I 4DR2E 3H1CA 4LFAI 1Z5AA 4WUBA 2C38A 4B3ME 4Z7YA 1XNQI 5K36B 5C0XF 1IBLI 4AQYE 3P3EA 1N32E 1HK7A 2JEBA 4B3SI 3UHMA 2GO3A 2IOQA 4MU0A 5FLXC 2NN6F 3J81C 3GMEA 4IFDE 1VI7A 4DV3I 3J7AG 3K1JA 5K36A 2VESA 4FW6A 5JEAD 3CDJA 4DUYI 4DV2E 2F1DA 5ELWA 5LMNE 1J5EE 3P3GA 2Z5CB 2CG9A 4LFCE 4GKJE 4LF9I 4MU1A 2C37B 1FWLA 2VQFI 4WUCA 1H74A 2F4VE 4DPWA 4DR2I 4JYAE 4EMDA 1D6TA 4IFDA 4PRXA 4USKA 4LFCI 1H73A 4DR3E 4FW4A 4FW7A 1N36I 4USMA 2V2VA 1Z0WA 2VF3A 4LFBE 4J3DA 2NPFA 5IT9Q 3J81Q 1WUUA 4AM3A 2BA0G 4URLA 1KKHA 1Y6ZA 4KQVA 4IFDB 4PU9A 4I3HA 2UUBE 1Z0EA 1N34I 4JI0E 1A6FA 3ZM7A 2PO2A 3QT7A 3NZKA 5A2QQ 3V5RA 5K36C 2Q2EB 3WU4A 4HY1A 2PNZB 4Z7CA 2F4VI 3PS1A 5LMUI 2UXCI 1UDOA 3WU3A 2O1TA 1UDNA 1ZXNA 4B3MI 4FW3A 3D4JA 1IBKI 2ZITA 3K17A 4OO1F 2DEJA 4LF7I 4OO1E 4X62I 1I94I 4YY3I 2O1VA 3B82A 2CGEA 4IZKB 2X7IA 4IFDC 1FJGE 5A2QC 4DV1I 1Z59A 4LF7E 3CWVA 2V34A 4DU8A 1OJ4A 2WP8A 3ZZTA 2GS8A 4R1FA 2BA1G 2JEAB 5C0XB 5FWKA 2A2DA 2UXBE 2C38B 4DV1E 2IESA 4LF9E 1YHCA 1IBME 4FW5A 4K0KE 2WNRB 4MDTA 2PNMA 2C37A 4DR7E 1B63A 2Z5CA 4IFDF 3M7ND 4BA2A 2IERA 5C0XC 2Z5BB 1N36E 2BM1A 5BR8I 4AIMA 2JT2A 1B62A 4BA1A 2EFGA 1XNRI 2X36A 2Z5EA 1HR0E 4DUYE 4XTJA 3CDIA 5DNLA 4GKKE 4JI8E 4N3OA 3WU5A 3Q1QA 4X66I 1USVA 4FN5A 2E5LI 4RPFA 1KTVA 3QT6A 1NHJA 2HKEA 3L7ZA 4NXNI 1VISA 4FWDA 1MU5A 3U1YA 4DR1I 2CVEA 4JI1E 3HJCA 1KIJA 1UDQA 1HNWE 3JAMQ 1Z0GA 3ZZUA 4DU7A 4NXNE 4DR4I 2PO2B 2GO4A 4DR5I 4JI7I 4OO1A 4LCHA 1ZM9A 5K36E 1Z0BA 3KRNA 4LFBI 1MG7A 4DV0I 4NXMI 2UXDE 2UUCI 5LMNI 3JAMC 2WW4A 2UU9I 4LF5E 1DARA 5L3JA 5JEAE 5C0XA 2UXBI 4DV0E 2ZBKB 1PVGA 2E1RA 1XXEA 4JV5I 2C39B 1XHKA 4LOMA 4JI3E 2HK3A 3J80Q 4KHPE 4B3TI 4LPFA 3PYFA 2HHHE 4DV6I 3LTOA 4IZJB 2HK2A 3QT5A 2UUAE 4KHPI 2A2CA 4FW9A 1EA6A 3J80C 4DR5E 4JV5E 4ZVIA 1HNZI 4FWGA 4JI2I 3B8HA 1H7UA 5JEAB 2V8PA 4HYMA 2V2QA 1XMQI 4MU4A 2NN6D 4JI7E 4OO1C 4LCGA 3P06A 2PO0B 4LF8E 4B3RE 1KVKA 3PS3A 1HNZE 4LF4E 1ZXMA 1HNXE 4ED4A 4MQYA 1U2RA 4JI1I 4DR1E 1IBKE 1RHYA 4JI5E 4B3RI 4DR7I 3T1YI 1Y60A 4LF6I 4DV2I 1PIEA 1FJGI 1P42A 3K85A 3HULA 5IT9C 2BA1D 5DNXA 1IBLE 3L7ZB 3PS2A 4DV5E 1EI1A 1HNXI 2WNRA 1N33E 4OX9I 2JE6B 4P52A 2UUAI 4OKGA 2J7KA 4DV5I 4YY3E 4NBQA 3Q6NA 1XMQE 1FKAE 1S4EA 2C39A 4K0KI 4X64E 3B78A 1YH8A 4OX9E 4YHHI 5K36F 4UTGA 2E5LE 1QZRA 5IWAI 3QT8A 4X62E 1I94E 4DXLA 1NHHA 2BR2B 5DRQA 4MU3A 4JI4E 3M6AA 4IZKA 2PO0A 3GONA 2JE6A 1NZ0A 1Z0TA 5EL9A 3GCMA 4X64I 3WU6A 1XMOE 4IFDD 5IWAE 5JEAF 2BV3A 4JI0I 1N34E 4DPTA 4QNJA 3LNUA 2R3VA 5GMDA 1Y4UA 2BM0A 2PNZA 5FLXQ 3T1YE 4JI8I 1Z0CA
chains in the Genus database with same CATH topology
3P3GA 1P42A 4FW3A 1YHCA 3P3CA 4U3BA 4LCFA 4FW5A 5DRQA 2GO4A 4ISAA 4OZEA 4LCHA 3PS2A 4LCGA 4MDTA 3P3EA 2O3ZA 2GO3A 3UHMA 3PS3A 5DROA 4U3DA 2J65A 4IS9A 5DRPA 5DRRA 4FW4A 4MQYA 4OKGA 3NZKA 4FW7A 2VESA 4FW6A 3U1YA 2IERA 3P76A 3PS1A 1YH8A 4J3DA 1XXEA 2JT2A 2IESA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3P3G A;  1P42 A;  4FW3 A;  1YHC A;  3P3C A;  4U3B A;  4LCF A;  4FW5 A;  5DRQ A;  2GO4 A;  4ISA A;  4OZE A;  4LCH A;  3PS2 A;  4LCG A;  4MDT A;  3P3E A;  2O3Z A;  2GO3 A;  3UHM A;  3PS3 A;  5DRO A;  4U3D A;  2J65 A;  4IS9 A;  5DRP A;  5DRR A;  4FW4 A;  4MQY A;  4OKG A;  3NZK A;  4FW7 A;  2VES A;  4FW6 A;  3U1Y A;  2IER A;  3P76 A;  3PS1 A;  1YH8 A;  4J3D A;  1XXE A;  2JT2 A;  2IES A; 
#chains in the Genus database with same CATH topology
 1H7S A;  2OI2 A;  3PYD A;  5K36 D;  4ISA A;  4DPX A;  2O3Z A;  5BR8 E;  1R6M A;  2J65 A;  3LPS A;  1J5E I;  1N33 I;  1N0V C;  4IS9 A;  2XEX A;  2PO1 A;  3PYG A;  4GQU A;  1H72 C;  2VQF E;  4JI5 I;  1S16 A;  2HHH I;  4BA1 B;  1R6L A;  1FNM A;  4JYA I;  3J7A M;  4B3S E;  1OYS A;  2AJ4 A;  2HFU A;  1HR0 I;  3P3C A;  4OZE A;  4IZJ A;  4AQY I;  3M7N G;  2DEI A;  2GQ0 A;  5DRO A;  3ZKB A;  1XMO I;  3DD6 A;  2CZ9 A;  1ZM3 A;  1ZM4 A;  4DR4 E;  3PRY A;  4JI3 I;  4X65 I;  2AE8 A;  1Z5C A;  1RRE A;  4YHH E;  4MYT A;  4LF4 I;  3P76 A;  4FWH A;  1E3H A;  1N0U A;  3U1K A;  2UUC E;  2JEA A;  2WP8 B;  4LF6 E;  1OYR A;  4U3B A;  2O1U A;  2PO1 B;  3HKM A;  2NN6 E;  4DR3 I;  1BKN A;  4X65 E;  2IOP A;  4JG4 A;  2LJP A;  4WUD A;  4GKK I;  5LMU E;  2NN6 A;  2UXC E;  3ZKD A;  2JEB B;  2O1W A;  2HFS A;  1Y4S A;  1N32 I;  4U3D A;  4HXZ A;  4DV3 E;  2R42 A;  3M85 G;  5DRP A;  5JEA A;  1USU A;  5C0X E;  3V2U C;  4JI6 I;  4DPU A;  3F0N A;  3OTO I;  4HAC B;  4DPY A;  1OYP A;  2ZM6 I;  4LFA E;  2VQE E;  2UUB I;  4DV4 E;  1HNW I;  5GME A;  2HKJ A;  1XNQ E;  4QNK A;  3T1H I;  4AID A;  4B3T E;  1Z5B A;  4LCF A;  4JI6 E;  4HAC A;  1E3P A;  4DV7 I;  4P7A A;  1Y5Y A;  4DR6 I;  5LL6 R;  3Q6M A;  4DV4 I;  2VQE I;  4M1K A;  2BA0 D;  2NN6 B;  3T1H E;  4MYU A;  4JI2 E;  4NXM E;  2UXD I;  2BR2 A;  5EKW A;  3OTO E;  5DRR A;  2V2Z A;  3B4T A;  2UU9 E;  2ZM6 E;  4DR6 E;  1FWK A;  1Z0V A;  1RR9 A;  5C0X D;  3PYE A;  1FI4 A;  2PNL A;  3M85 D;  4X66 E;  1ELO A;  3ZZ0 A;  1UDS A;  4DV7 E;  2Z5B A;  4GKJ I;  4BA2 B;  4DUZ I;  1K47 A;  4LF8 I;  3GLL A;  4PRV A;  1ZM2 A;  2NN6 C;  4OO1 D;  4DV6 E;  4OO1 B;  1XNR E;  4UT4 A;  5JEA C;  1NHI A;  1PKP A;  1MX0 A;  1UEK A;  4DUZ E;  3H4L A;  4IZJ D;  1IBM I;  4JI4 I;  4LF5 I;  4DR2 E;  3H1C A;  4LFA I;  1Z5A A;  4WUB A;  2C38 A;  4B3M E;  4Z7Y A;  1XNQ I;  5K36 B;  5C0X F;  1IBL I;  4AQY E;  3P3E A;  1N32 E;  1HK7 A;  2JEB A;  4B3S I;  3UHM A;  2GO3 A;  2IOQ A;  4MU0 A;  5FLX C;  2NN6 F;  3J81 C;  3GME A;  4IFD E;  1VI7 A;  4DV3 I;  3J7A G;  3K1J A;  5K36 A;  2VES A;  4FW6 A;  5JEA D;  3CDJ A;  4DUY I;  4DV2 E;  2F1D A;  5ELW A;  5LMN E;  1J5E E;  3P3G A;  2Z5C B;  2CG9 A;  4LFC E;  4GKJ E;  4LF9 I;  4MU1 A;  2C37 B;  1FWL A;  2VQF I;  4WUC A;  1H74 A;  2F4V E;  4DPW A;  4DR2 I;  4JYA E;  4EMD A;  1D6T A;  4IFD A;  4PRX A;  4USK A;  4LFC I;  1H73 A;  4DR3 E;  4FW4 A;  4FW7 A;  1N36 I;  4USM A;  2V2V A;  1Z0W A;  2VF3 A;  4LFB E;  4J3D A;  2NPF A;  5IT9 Q;  3J81 Q;  1WUU A;  4AM3 A;  2BA0 G;  4URL A;  1KKH A;  1Y6Z A;  4KQV A;  4IFD B;  4PU9 A;  4I3H A;  2UUB E;  1Z0E A;  1N34 I;  4JI0 E;  1A6F A;  3ZM7 A;  2PO2 A;  3QT7 A;  3NZK A;  5A2Q Q;  3V5R A;  5K36 C;  2Q2E B;  3WU4 A;  4HY1 A;  2PNZ B;  4Z7C A;  2F4V I;  3PS1 A;  5LMU I;  2UXC I;  1UDO A;  3WU3 A;  2O1T A;  1UDN A;  1ZXN A;  4B3M I;  4FW3 A;  3D4J A;  1IBK I;  2ZIT A;  3K17 A;  4OO1 F;  2DEJ A;  4LF7 I;  4OO1 E;  4X62 I;  1I94 I;  4YY3 I;  2O1V A;  3B82 A;  2CGE A;  4IZK B;  2X7I A;  4IFD C;  1FJG E;  5A2Q C;  4DV1 I;  1Z59 A;  4LF7 E;  3CWV A;  2V34 A;  4DU8 A;  1OJ4 A;  2WP8 A;  3ZZT A;  2GS8 A;  4R1F A;  2BA1 G;  2JEA B;  5C0X B;  5FWK A;  2A2D A;  2UXB E;  2C38 B;  4DV1 E;  2IES A;  4LF9 E;  1YHC A;  1IBM E;  4FW5 A;  4K0K E;  2WNR B;  4MDT A;  2PNM A;  2C37 A;  4DR7 E;  1B63 A;  2Z5C A;  4IFD F;  3M7N D;  4BA2 A;  2IER A;  5C0X C;  2Z5B B;  1N36 E;  2BM1 A;  5BR8 I;  4AIM A;  2JT2 A;  1B62 A;  4BA1 A;  2EFG A;  1XNR I;  2X36 A;  2Z5E A;  1HR0 E;  4DUY E;  4XTJ A;  3CDI A;  5DNL A;  4GKK E;  4JI8 E;  4N3O A;  3WU5 A;  3Q1Q A;  4X66 I;  1USV A;  4FN5 A;  2E5L I;  4RPF A;  1KTV A;  3QT6 A;  1NHJ A;  2HKE A;  3L7Z A;  4NXN I;  1VIS A;  4FWD A;  1MU5 A;  3U1Y A;  4DR1 I;  2CVE A;  4JI1 E;  3HJC A;  1KIJ A;  1UDQ A;  1HNW E;  3JAM Q;  1Z0G A;  3ZZU A;  4DU7 A;  4NXN E;  4DR4 I;  2PO2 B;  2GO4 A;  4DR5 I;  4JI7 I;  4OO1 A;  4LCH A;  1ZM9 A;  5K36 E;  1Z0B A;  3KRN A;  4LFB I;  1MG7 A;  4DV0 I;  4NXM I;  2UXD E;  2UUC I;  5LMN I;  3JAM C;  2WW4 A;  2UU9 I;  4LF5 E;  1DAR A;  5L3J A;  5JEA E;  5C0X A;  2UXB I;  4DV0 E;  2ZBK B;  1PVG A;  2E1R A;  1XXE A;  4JV5 I;  2C39 B;  1XHK A;  4LOM A;  4JI3 E;  2HK3 A;  3J80 Q;  4KHP E;  4B3T I;  4LPF A;  3PYF A;  2HHH E;  4DV6 I;  3LTO A;  4IZJ B;  2HK2 A;  3QT5 A;  2UUA E;  4KHP I;  2A2C A;  4FW9 A;  1EA6 A;  3J80 C;  4DR5 E;  4JV5 E;  4ZVI A;  1HNZ I;  4FWG A;  4JI2 I;  3B8H A;  1H7U A;  5JEA B;  2V8P A;  4HYM A;  2V2Q A;  1XMQ I;  4MU4 A;  2NN6 D;  4JI7 E;  4OO1 C;  4LCG A;  3P06 A;  2PO0 B;  4LF8 E;  4B3R E;  1KVK A;  3PS3 A;  1HNZ E;  4LF4 E;  1ZXM A;  1HNX E;  4ED4 A;  4MQY A;  1U2R A;  4JI1 I;  4DR1 E;  1IBK E;  1RHY A;  4JI5 E;  4B3R I;  4DR7 I;  3T1Y I;  1Y60 A;  4LF6 I;  4DV2 I;  1PIE A;  1FJG I;  1P42 A;  3K85 A;  3HUL A;  5IT9 C;  2BA1 D;  5DNX A;  1IBL E;  3L7Z B;  3PS2 A;  4DV5 E;  1EI1 A;  1HNX I;  2WNR A;  1N33 E;  4OX9 I;  2JE6 B;  4P52 A;  2UUA I;  4OKG A;  2J7K A;  4DV5 I;  4YY3 E;  4NBQ A;  3Q6N A;  1XMQ E;  1FKA E;  1S4E A;  2C39 A;  4K0K I;  4X64 E;  3B78 A;  1YH8 A;  4OX9 E;  4YHH I;  5K36 F;  4UTG A;  2E5L E;  1QZR A;  5IWA I;  3QT8 A;  4X62 E;  1I94 E;  4DXL A;  1NHH A;  2BR2 B;  5DRQ A;  4MU3 A;  4JI4 E;  3M6A A;  4IZK A;  2PO0 A;  3GON A;  2JE6 A;  1NZ0 A;  1Z0T A;  5EL9 A;  3GCM A;  4X64 I;  3WU6 A;  1XMO E;  4IFD D;  5IWA E;  5JEA F;  2BV3 A;  4JI0 I;  1N34 E;  4DPT A;  4QNJ A;  3LNU A;  2R3V A;  5GMD A;  1Y4U A;  2BM0 A;  2PNZ A;  5FLX Q;  3T1Y E;  4JI8 I;  1Z0C A; 
#chains in the Genus database with same CATH homology
 3P3G A;  1P42 A;  4FW3 A;  1YHC A;  3P3C A;  4U3B A;  4LCF A;  4FW5 A;  5DRQ A;  2GO4 A;  4ISA A;  4OZE A;  4LCH A;  3PS2 A;  4LCG A;  4MDT A;  3P3E A;  2O3Z A;  2GO3 A;  3UHM A;  3PS3 A;  5DRO A;  4U3D A;  2J65 A;  4IS9 A;  5DRP A;  5DRR A;  4FW4 A;  4MQY A;  4OKG A;  3NZK A;  4FW7 A;  2VES A;  4FW6 A;  3U1Y A;  2IER A;  3P76 A;  3PS1 A;  1YH8 A;  4J3D A;  1XXE A;  2JT2 A;  2IES A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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