4J51A

Cyrstal structure of protein tyrosine phosphatase lyp catalytic domain complex with small molecular inhibitor l75n04
Total Genus 108
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
108
sequence length
303
structure length
302
Chain Sequence
MDQREILQKFLDEAQSKKITKEEFANEFLKLKRQSTKYKADKTYPTTVAEKPKNIKKNRYKDILPYDYSRVELSLITDEDSSYINANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACMEYEMGKKKCERYWAEPGEMQLEFGPFSVSCEAEKRKSDYIIRTLKVKFNSETRTIYQFHYKNWPDHDVPSSIDPILELIWDVRCYQEDDSVPICIHCSAGCGRTGVICAIDYTWMLLKDGIIPENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLELFKRQMDVIRDKHSG
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title A Potent and Selective Small-Molecule Inhibitor for the Lymphoid-Specific Tyrosine Phosphatase (LYP), a Target Associated with Autoimmune Diseases.
pubmed doi rcsb
molecule keywords Tyrosine-protein phosphatase non-receptor type 22
molecule tags Hydrolase/hydrolase inhibitor
source organism Homo sapiens
total genus 108
structure length 302
sequence length 303
chains with identical sequence B
ec nomenclature ec 3.1.3.48: Protein-tyrosine-phosphatase.
pdb deposition date 2013-02-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00102 Y_phosphatase Protein-tyrosine phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.190.10 Alpha Beta Alpha-Beta Complex Protein-Tyrosine Phosphatase; Chain A Protein tyrosine phosphatase superfamily 4j51A00
2I5XA 1LYVA 3S3FA 1FQ1A 3D1OA 4D3RA 1ONZA 3CWEA 2HNPA 4WOHA 2E0TA 2Q05A 2QBQA 1SUGA 4RHGA 3GXHA 2OC3A 3S3KA 3AWEA 1I9TA 2CMCA 2C7SA 2HXPA 1ONYA 3BLTA 1NWLA 2PQ5A 3I80A 3QCNA 2CNEA 2QDMA 5M43A 1YN9A 1GWZA 1FPRA 3V0HA 2CJZA 5KA9A 3EB1A 2F6ZA 2HC2A 3QCCA 5KAAA 5KA3A 3QCKA 4BJOA 1Q1MA 1KAKA 2HCMA 4WU2A 4ZRTA 4RH5A 3ZM3A 2VEXA 2CMAA 4JNBA 1G1FA 4KYQA 1MKPA 1EENA 1Q6MA 2R0BA 3ZM2A 2B3OA 3D42A 2ZN7A 3S4EA 4PYHA 3RGQA 1KAVA 2GWOA 1ZZWA 4B04A 3O4TA 2I3RA 5KA8A 4GS0A 5K24A 5IBMA 2QDCA 1NZ7A 2A8BA 1NWEA 3MOZA 1A5YA 1OEMX 5KA0A 1AAXA 1I57A 1OHCA 2VEYA 2CNIA 3GXGA 1Q6NA 4OHIA 1G7GA 3BM8A 3O5XA 2CNFA 1JF7A 4IKCA 4YR8B 3RZ2A 3QCDA 5MMZB 1R6HA 5K25A 4KYRA 1Q6JA 2PSZA 4WU3A 1J4XA 2H4GA 4I8NA 2NLKA 3S3HA 4H34A 1X24A 3QCFA 3ZM0A 4ZI4A 2BGDA 3ZM1A 2RF6A 2HY3A 1M3GA 2Q47A 4QBEA 2ZMMA 3V0IA 4GE2A 5J8RA 1JLNA 2WGPA 4H1OA 4WTYA 5IBSA 3RO1A 3OLRA 1C87A 1GFYA 4RKKA 2QCJA 3QCEA 4NYHA 2Y96A 1YGUA 3EMUA 2B4UA 2JJDA 1OEOX 3ZMPA 1QZ0A 2F46A 2I75A 4RDDA 4AZ1A 2FJNA 2OUDA 2ESBA 2H4KA 1PH0A 3V0EA 3OMHA 1C88A 4Z6BA 2F6YA 3QCGA 3QCBA 5EHPA 5I6VA 3F9BA 4GE6A 2BGEA 4R0SA 1BZCA 1BZJA 4GRYA 2PA5A 1Q6SA 2QBPA 1U26A 3A5JA 1WRMA 4BPCA 4KI9A 3O3LA 1G4WR 2H03A 2QEPA 1ZCKA 3LJ8A 4JBCA 4Y14A 1XXVA 1ZCLA 2F6WA 3O4SA 1NO6A 1QXKA 3BRHA 3V0GA 2F71A 1LQFA 4D3PA 1T4JA 4D3QA 2B4PA 3U96A 1PTTA 1YZ4A 1V3AA 2QBRA 1C85A 2HB1A 1RPMA 1LARA 2NT2A 3MMJA 5K22A 2J16A 5K9WA 1EEOA 2H4VA 3B7OA 2M3VA 4QAPA 4MBBA 2NV5A 3EU0A 5KA4A 1WCHA 4OHEA 3QKPA 2CMBA 1XBOA 2OZ5A 5EHRA 2J17A 2FJMA 1C86A 4HJPA 2P6XA 2G6ZA 2HC1A 2OOQA 5KABA 4QUNA 2FH7A 2B07A 1T48A 1U24A 1PA1A 2I4EA 4NNDA 2AHSA 1PTUA 4NWGA 2NTAA 4GRZA 2I6OA 4JMJA 1PA9A 4OHLA 4YAAA 4J51A 3D44A 5BZXA 5KADA 3AWGA 3EZZA 4TVVA 2B49A 3O4UA 1PXHA 3ZV2A 3QCJA 1PYNA 2F6TA 3CM3A 3BLUA 2CM8A 3ZMQA 2I6PA 4ZN5A 4QBWA 5GTJA 1FPZA 1OHEA 4RI5A 1C83A 5LXQB 3MOWA 2B4SA 3D9CA 1L8KA 3N0AA 4OHHA 5KA7A 2SHPA 4GE5A 2I1YA 3QCLA 1G7FA 3D1QA 2AZRA 4S0GA 3D1HA 3I36A 3QCMA 1OEVA 1WAXA 1BZHA 2BV5A 2I4GA 2YDUA 4JMKA 1C84A 1OEUA 2F6VA 3F81A 3A5KA 3QCHA 4OHDA 1I9SA 3QKQA 2F6FA 3V0FA 5K23A 4ERCA 2QCTA 3I7ZA 1XXPA 2CM3A 1YFOA 1ZC0A 2I4HA 2C46A 2I6IA 4R30A 2CM2A 2I3UA 3H2XA 5AWXA 5KA1A 2H04A 3S4OA 5KA2A 3QCIA 1YTWA 2NT7A 2PI7A 2CFVA 2PT0A 2B4OA 2BIJA 4QAHA 1OHDA 3F9AA 2G59A 2PBNA 2CNGA 3M4UA 1XM2A 3AWFA 2I6MA 3F41A 1YTNA 4NWFA 1XRIA 1PTVA 2QBSA 2HNQA 4DGPA 2DXPA 1NL9A 1ECVA 1U25A 2HVLA 4GFVA 4RH9A 1NNYA 2GJTA 1G1GA 3S3EA 4ICZA 2IMGA 5BUGA 2Y2FA 2F70A 2CNHA 4PVGA 2GP0A 2QDPA 4NX8A 2H02A 3F99A 2VEVA 3EAXA 4GFUA 5BX1A 5K9VA 1Q6TA 1OETA 2VEUA 5BZZA 3PS5A 2P4DA 4HJQA 4GWFA 2I6JA 2MBCA 1P15A 1PTYA 1YPTA 2BZLA 3SR9A 2I42A 2NZ6A 1T49A 2J16B 1OESA 2VEWA 4HRFA 1VHRA 2A3KA 1G1HA 3V0JA 3NMEA 1Q6PA 4R0TA 1YTSA 5KACA 1RXDA 4Y2EA 1YWFA 1D5RA 1L8GA 4QUMA 3SMEA 1YGRA 4DGXA 1G4US 4RI4A 2CM7A 3RGOA 3V0DA 5HDEA
chains in the Genus database with same CATH superfamily
2I5XA 1LYVA 3S3FA 1FQ1A 3D1OA 3ZL8A 4D3RA 1ONZA 3CWEA 2HNPA 4WOHA 2GC6A 4CVMA 2E0TA 1P31A 2Q05A 2QBQA 1SUGA 4RHGA 3GXHA 2OC3A 3S3KA 3AWEA 1I9TA 2CMCA 2C7SA 2HXPA 1ONYA 3BLTA 1NWLA 2PQ5A 3I80A 3QCNA 2CNEA 2QDMA 5M43A 1YN9A 1GWZA 1FPRA 4QDIA 3V0HA 2CJZA 5KA9A 3EB1A 2F6ZA 3LK7A 2HC2A 3QCCA 5KAAA 5KA3A 3QCKA 4BJOA 1Q1MA 1KAKA 2HCMA 4WU2A 4ZRTA 4RH5A 2JFHA 3ZM3A 2VEXA 2XJAA 2CMAA 4JNBA 1G1FA 4KYQA 5A5EA 1MKPA 1EENA 1Q6MA 1O5ZA 2R0BA 3PYZA 3ZM2A 2B3OA 3D42A 2ZN7A 3S4EA 4PYHA 3RGQA 1KAVA 2GWOA 1ZZWA 4B04A 3O4TA 2I3RA 5KA8A 4GS0A 5K24A 5IBMA 2JFFA 2QDCA 1NZ7A 2A8BA 1NWEA 3MOZA 1A5YA 2Y68A 1OEMX 5KA0A 1AAXA 1I57A 1OHCA 2VEYA 2CNIA 3GXGA 1Q6NA 4OHIA 1G7GA 1FGSA 3BM8A 3O5XA 2CNFA 2VORA 1EEHA 1JF7A 4IKCA 4YR8B 3RZ2A 3QCDA 4C13A 5MMZB 1R6HA 5K25A 4KYRA 1Q6JA 2PSZA 4WU3A 1J4XA 2H4GA 4I8NA 2NLKA 3S3HA 1JBWA 4H34A 2VTEA 1X24A 1J6UA 4UAGA 3QCFA 1GQQA 3ZM0A 4ZI4A 2BGDA 3ZM1A 2RF6A 2HY3A 1M3GA 4CVKA 2Q47A 4QBEA 2ZMMA 3V0IA 4GE2A 5J8RA 1JLNA 2WGPA 4H1OA 4WTYA 5IBSA 3RO1A 3OLRA 1C87A 1GFYA 4RKKA 2QCJA 3QCEA 4NYHA 2Y96A 1YGUA 3EMUA 2B4UA 2JJDA 1OEOX 3ZMPA 1QZ0A 2F46A 2I75A 4RDDA 4AZ1A 2FJNA 3UAGA 2OUDA 2ESBA 2H4KA 1PH0A 3V0EA 3OMHA 1C88A 4Z6BA 2F6YA 3QCGA 3QCBA 5EHPA 5I6VA 3F9BA 4GE6A 2BGEA 4R0SA 1BZCA 1BZJA 4GRYA 2PA5A 1Q6SA 2QBPA 1U26A 3A5JA 2VTDA 1WRMA 4BPCA 4KI9A 3O3LA 1G4WR 2H03A 2QEPA 1ZCKA 2XPCA 3LJ8A 4JBCA 4Y14A 1XXVA 3HN7A 1ZCLA 2F6WA 3O4SA 1NO6A 2VOSA 1QXKA 3BRHA 3V0GA 1GG4A 2F71A 1LQFA 4D3PA 1T4JA 4D3QA 2B4PA 3U96A 1PTTA 4ZIYA 1YZ4A 1V3AA 2QBRA 1C85A 3ZM6A 2HB1A 1RPMA 1LARA 4C12A 2NT2A 3MMJA 5K22A 2J16A 5K9WA 1EEOA 2H4VA 3B7OA 2M3VA 4QAPA 4MBBA 2NV5A 3EU0A 5KA4A 1WCHA 4OHEA 3QKPA 4QF5A 2CMBA 1XBOA 2OZ5A 5EHRA 2J17A 2FJMA 1C86A 4HJPA 4BUCA 2P6XA 2G6ZA 2HC1A 2OOQA 5KABA 4QUNA 1P3DA 2B07A 2FH7A 1T48A 1U24A 2F00A 1PA1A 4HV4A 2I4EA 4NNDA 4BUBA 2AHSA 5A5FA 2Y67A 1E8CA 1PTUA 4NWGA 2NTAA 3N2AA 2I6OA 4GRZA 4JMJA 1PA9A 2UUOA 2GCAA 4OHLA 4YAAA 4J51A 3D44A 5BZXA 5KADA 3AWGA 3EZZA 4TVVA 1UAGA 2B49A 3O4UA 1PXHA 3ZV2A 2Y66A 3NRSA 3QCJA 1PYNA 2F6TA 3CM3A 3BLUA 1W78A 2CM8A 3ZMQA 2I6PA 4ZN5A 4QBWA 5GTJA 1FPZA 1E0DA 1OHEA 4RI5A 1C83A 5LXQB 3MOWA 2B4SA 3D9CA 1L8KA 2WJPA 3N0AA 2X5OA 4OHHA 5KA7A 2SHPA 4GE5A 2I1YA 2UUPA 3QCLA 1G7FA 3D1QA 2AZRA 4S0GA 3D1HA 3ZM5A 3I36A 3QCMA 1OEVA 1WAXA 1BZHA 2BV5A 2I4GA 2YDUA 4JMKA 3QCZA 1C84A 1JBVA 1OEUA 3MVNA 2F6VA 3F81A 3A5KA 3QCHA 4OHDA 1I9SA 3QKQA 2F6FA 3V0FA 5K23A 4ERCA 2QCTA 2JFGA 3I7ZA 1XXPA 2CM3A 1YFOA 1ZC0A 2WTZA 2I4HA 2C46A 2I6IA 4R30A 2CM2A 2I3UA 3H2XA 5AWXA 5KA1A 2H04A 3S4OA 5KA2A 3QCIA 1YTWA 2NT7A 2PI7A 2CFVA 2PT0A 2B4OA 2BIJA 4QAHA 1OHDA 3F9AA 2G59A 2PBNA 2CNGA 1XM2A 1W7KA 3AWFA 2I6MA 3M4UA 3F41A 1YTNA 4NWFA 1XRIA 1PTVA 2QBSA 2HNQA 4DGPA 2DXPA 1NL9A 1ECVA 1U25A 2HVLA 2GC5A 4GFVA 4RH9A 1NNYA 2GJTA 1G1GA 3S3EA 2AM2A 4ICZA 2IMGA 5BUGA 2Y2FA 2F70A 2CNHA 4PVGA 2GP0A 2QDPA 2UAGA 4NX8A 2H02A 3F99A 2VEVA 3EAXA 4GFUA 5BX1A 5K9VA 1Q6TA 1OETA 2VEUA 4CVLA 5BZZA 3PS5A 2P4DA 4HJQA 4GWFA 2I6JA 2MBCA 1GQYA 1P15A 1PTYA 1YPTA 2BZLA 3SR9A 2I42A 2AM1A 2NZ6A 1T49A 2J16B 1OESA 2Y1OA 2VEWA 4HRFA 1VHRA 2A3KA 1G1HA 3V0JA 3NMEA 1Q6PA 4R0TA 2GCBA 1YTSA 5KACA 1RXDA 4Y2EA 1YWFA 1D5RA 1L8GA 4QUMA 3SMEA 1YGRA 4DGXA 1G4US 4RI4A 2CM7A 3RGOA 3V0DA 5HDEA
chains in the Genus database with same CATH topology
2I5XA 1LYVA 3S3FA 1FQ1A 3D1OA 4D3RA 1ONZA 3CWEA 2HNPA 4WOHA 2E0TA 2Q05A 2QBQA 1SUGA 4RHGA 3GXHA 2OC3A 3S3KA 3AWEA 1I9TA 2CMCA 2C7SA 2HXPA 1ONYA 3BLTA 1NWLA 2PQ5A 3I80A 3QCNA 2CNEA 2QDMA 5M43A 1YN9A 1GWZA 1FPRA 3V0HA 2CJZA 5KA9A 3EB1A 2F6ZA 2HC2A 3QCCA 5KAAA 5KA3A 3QCKA 4BJOA 1Q1MA 1KAKA 2HCMA 4WU2A 4ZRTA 4RH5A 3ZM3A 2VEXA 2CMAA 4JNBA 1G1FA 4KYQA 1MKPA 1EENA 1Q6MA 2R0BA 3ZM2A 2B3OA 3D42A 2ZN7A 3S4EA 4PYHA 3RGQA 1KAVA 2GWOA 1ZZWA 4B04A 3O4TA 2I3RA 5KA8A 4GS0A 5K24A 5IBMA 2QDCA 1NZ7A 2A8BA 1NWEA 3MOZA 1A5YA 1OEMX 5KA0A 1AAXA 1I57A 1OHCA 2VEYA 2CNIA 3GXGA 1Q6NA 4OHIA 1G7GA 3BM8A 3O5XA 2CNFA 1JF7A 4IKCA 4YR8B 3RZ2A 3QCDA 5MMZB 1R6HA 5K25A 4KYRA 1Q6JA 2PSZA 4WU3A 1J4XA 2H4GA 4I8NA 2NLKA 3S3HA 4H34A 1X24A 3QCFA 3ZM0A 4ZI4A 2BGDA 3ZM1A 2RF6A 2HY3A 1M3GA 2Q47A 4QBEA 2ZMMA 3V0IA 4GE2A 5J8RA 1JLNA 2WGPA 4H1OA 4WTYA 5IBSA 3RO1A 3OLRA 1C87A 1GFYA 4RKKA 2QCJA 3QCEA 4NYHA 2Y96A 1YGUA 3EMUA 2B4UA 2JJDA 1OEOX 3ZMPA 1QZ0A 2F46A 2I75A 4RDDA 4AZ1A 2FJNA 2OUDA 2ESBA 2H4KA 1PH0A 3V0EA 3OMHA 1C88A 4Z6BA 2F6YA 3QCGA 3QCBA 5EHPA 5I6VA 3F9BA 4GE6A 2BGEA 4R0SA 1BZCA 1BZJA 4GRYA 2PA5A 1Q6SA 2QBPA 1U26A 3A5JA 1WRMA 4BPCA 4KI9A 3O3LA 1G4WR 2H03A 2QEPA 1ZCKA 3LJ8A 4JBCA 4Y14A 1XXVA 1ZCLA 2F6WA 3O4SA 1NO6A 1QXKA 3BRHA 3V0GA 2F71A 1LQFA 4D3PA 1T4JA 4D3QA 2B4PA 3U96A 1PTTA 1YZ4A 1V3AA 2QBRA 1C85A 2HB1A 1RPMA 1LARA 2NT2A 3MMJA 5K22A 2J16A 5K9WA 1EEOA 2H4VA 3B7OA 2M3VA 4QAPA 4MBBA 2NV5A 3EU0A 5KA4A 1WCHA 4OHEA 3QKPA 2CMBA 1XBOA 2OZ5A 5EHRA 2J17A 2FJMA 1C86A 4HJPA 2P6XA 2G6ZA 2HC1A 2OOQA 5KABA 4QUNA 2FH7A 2B07A 1T48A 1U24A 1PA1A 2I4EA 4NNDA 2AHSA 1PTUA 4NWGA 2NTAA 4GRZA 2I6OA 4JMJA 1PA9A 4OHLA 4YAAA 4J51A 3D44A 5BZXA 5KADA 3AWGA 3EZZA 4TVVA 2B49A 3O4UA 1PXHA 3ZV2A 3QCJA 1PYNA 2F6TA 3CM3A 3BLUA 2CM8A 3ZMQA 2I6PA 4ZN5A 4QBWA 5GTJA 1FPZA 1OHEA 4RI5A 1C83A 5LXQB 3MOWA 2B4SA 3D9CA 1L8KA 3N0AA 4OHHA 5KA7A 2SHPA 4GE5A 2I1YA 3QCLA 1G7FA 3D1QA 2AZRA 4S0GA 3D1HA 3I36A 3QCMA 1OEVA 1WAXA 1BZHA 2BV5A 2I4GA 2YDUA 4JMKA 1C84A 1OEUA 2F6VA 3F81A 3A5KA 3QCHA 4OHDA 1I9SA 3QKQA 2F6FA 3V0FA 5K23A 4ERCA 2QCTA 3I7ZA 1XXPA 2CM3A 1YFOA 1ZC0A 2I4HA 2C46A 2I6IA 4R30A 2CM2A 2I3UA 3H2XA 5AWXA 5KA1A 2H04A 3S4OA 5KA2A 3QCIA 1YTWA 2NT7A 2PI7A 2CFVA 2PT0A 2B4OA 2BIJA 4QAHA 1OHDA 3F9AA 2G59A 2PBNA 2CNGA 3M4UA 1XM2A 3AWFA 2I6MA 3F41A 1YTNA 4NWFA 1XRIA 1PTVA 2QBSA 2HNQA 4DGPA 2DXPA 1NL9A 1ECVA 1U25A 2HVLA 4GFVA 4RH9A 1NNYA 2GJTA 1G1GA 3S3EA 4ICZA 2IMGA 5BUGA 2Y2FA 2F70A 2CNHA 4PVGA 2GP0A 2QDPA 4NX8A 2H02A 3F99A 2VEVA 3EAXA 4GFUA 5BX1A 5K9VA 1Q6TA 1OETA 2VEUA 5BZZA 3PS5A 2P4DA 4HJQA 4GWFA 2I6JA 2MBCA 1P15A 1PTYA 1YPTA 2BZLA 3SR9A 2I42A 2NZ6A 1T49A 2J16B 1OESA 2VEWA 4HRFA 1VHRA 2A3KA 1G1HA 3V0JA 3NMEA 1Q6PA 4R0TA 1YTSA 5KACA 1RXDA 4Y2EA 1YWFA 1D5RA 1L8GA 4QUMA 3SMEA 1YGRA 4DGXA 1G4US 4RI4A 2CM7A 3RGOA 3V0DA 5HDEA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2I5X A;  1LYV A;  3S3F A;  1FQ1 A;  3D1O A;  4D3R A;  1ONZ A;  3CWE A;  2HNP A;  4WOH A;  2E0T A;  2Q05 A;  2QBQ A;  1SUG A;  4RHG A;  3GXH A;  2OC3 A;  3S3K A;  3AWE A;  1I9T A;  2CMC A;  2C7S A;  2HXP A;  1ONY A;  3BLT A;  1NWL A;  2PQ5 A;  3I80 A;  3QCN A;  2CNE A;  2QDM A;  5M43 A;  1YN9 A;  1GWZ A;  1FPR A;  3V0H A;  2CJZ A;  5KA9 A;  3EB1 A;  2F6Z A;  2HC2 A;  3QCC A;  5KAA A;  5KA3 A;  3QCK A;  4BJO A;  1Q1M A;  1KAK A;  2HCM A;  4WU2 A;  4ZRT A;  4RH5 A;  3ZM3 A;  2VEX A;  2CMA A;  4JNB A;  1G1F A;  4KYQ A;  1MKP A;  1EEN A;  1Q6M A;  2R0B A;  3ZM2 A;  2B3O A;  3D42 A;  2ZN7 A;  3S4E A;  4PYH A;  3RGQ A;  1KAV A;  2GWO A;  1ZZW A;  4B04 A;  3O4T A;  2I3R A;  5KA8 A;  4GS0 A;  5K24 A;  5IBM A;  2QDC A;  1NZ7 A;  2A8B A;  1NWE A;  3MOZ A;  1A5Y A;  1OEM X;  5KA0 A;  1AAX A;  1I57 A;  1OHC A;  2VEY A;  2CNI A;  3GXG A;  1Q6N A;  4OHI A;  1G7G A;  3BM8 A;  3O5X A;  2CNF A;  1JF7 A;  4IKC A;  4YR8 B;  3RZ2 A;  3QCD A;  5MMZ B;  1R6H A;  5K25 A;  4KYR A;  1Q6J A;  2PSZ A;  4WU3 A;  1J4X A;  2H4G A;  4I8N A;  2NLK A;  3S3H A;  4H34 A;  1X24 A;  3QCF A;  3ZM0 A;  4ZI4 A;  2BGD A;  3ZM1 A;  2RF6 A;  2HY3 A;  1M3G A;  2Q47 A;  4QBE A;  2ZMM A;  3V0I A;  4GE2 A;  5J8R A;  1JLN A;  2WGP A;  4H1O A;  4WTY A;  5IBS A;  3RO1 A;  3OLR A;  1C87 A;  1GFY A;  4RKK A;  2QCJ A;  3QCE A;  4NYH A;  2Y96 A;  1YGU A;  3EMU A;  2B4U A;  2JJD A;  1OEO X;  3ZMP A;  1QZ0 A;  2F46 A;  2I75 A;  4RDD A;  4AZ1 A;  2FJN A;  2OUD A;  2ESB A;  2H4K A;  1PH0 A;  3V0E A;  3OMH A;  1C88 A;  4Z6B A;  2F6Y A;  3QCG A;  3QCB A;  5EHP A;  5I6V A;  3F9B A;  4GE6 A;  2BGE A;  4R0S A;  1BZC A;  1BZJ A;  4GRY A;  2PA5 A;  1Q6S A;  2QBP A;  1U26 A;  3A5J A;  1WRM A;  4BPC A;  4KI9 A;  3O3L A;  1G4W R;  2H03 A;  2QEP A;  1ZCK A;  3LJ8 A;  4JBC A;  4Y14 A;  1XXV A;  1ZCL A;  2F6W A;  3O4S A;  1NO6 A;  1QXK A;  3BRH A;  3V0G A;  2F71 A;  1LQF A;  4D3P A;  1T4J A;  4D3Q A;  2B4P A;  3U96 A;  1PTT A;  1YZ4 A;  1V3A A;  2QBR A;  1C85 A;  2HB1 A;  1RPM A;  1LAR A;  2NT2 A;  3MMJ A;  5K22 A;  2J16 A;  5K9W A;  1EEO A;  2H4V A;  3B7O A;  2M3V A;  4QAP A;  4MBB A;  2NV5 A;  3EU0 A;  5KA4 A;  1WCH A;  4OHE A;  3QKP A;  2CMB A;  1XBO A;  2OZ5 A;  5EHR A;  2J17 A;  2FJM A;  1C86 A;  4HJP A;  2P6X A;  2G6Z A;  2HC1 A;  2OOQ A;  5KAB A;  4QUN A;  2FH7 A;  2B07 A;  1T48 A;  1U24 A;  1PA1 A;  2I4E A;  4NND A;  2AHS A;  1PTU A;  4NWG A;  2NTA A;  4GRZ A;  2I6O A;  4JMJ A;  1PA9 A;  4OHL A;  4YAA A;  4J51 A;  3D44 A;  5BZX A;  5KAD A;  3AWG A;  3EZZ A;  4TVV A;  2B49 A;  3O4U A;  1PXH A;  3ZV2 A;  3QCJ A;  1PYN A;  2F6T A;  3CM3 A;  3BLU A;  2CM8 A;  3ZMQ A;  2I6P A;  4ZN5 A;  4QBW A;  5GTJ A;  1FPZ A;  1OHE A;  4RI5 A;  1C83 A;  5LXQ B;  3MOW A;  2B4S A;  3D9C A;  1L8K A;  3N0A A;  4OHH A;  5KA7 A;  2SHP A;  4GE5 A;  2I1Y A;  3QCL A;  1G7F A;  3D1Q A;  2AZR A;  4S0G A;  3D1H A;  3I36 A;  3QCM A;  1OEV A;  1WAX A;  1BZH A;  2BV5 A;  2I4G A;  2YDU A;  4JMK A;  1C84 A;  1OEU A;  2F6V A;  3F81 A;  3A5K A;  3QCH A;  4OHD A;  1I9S A;  3QKQ A;  2F6F A;  3V0F A;  5K23 A;  4ERC A;  2QCT A;  3I7Z A;  1XXP A;  2CM3 A;  1YFO A;  1ZC0 A;  2I4H A;  2C46 A;  2I6I A;  4R30 A;  2CM2 A;  2I3U A;  3H2X A;  5AWX A;  5KA1 A;  2H04 A;  3S4O A;  5KA2 A;  3QCI A;  1YTW A;  2NT7 A;  2PI7 A;  2CFV A;  2PT0 A;  2B4O A;  2BIJ A;  4QAH A;  1OHD A;  3F9A A;  2G59 A;  2PBN A;  2CNG A;  3M4U A;  1XM2 A;  3AWF A;  2I6M A;  3F41 A;  1YTN A;  4NWF A;  1XRI A;  1PTV A;  2QBS A;  2HNQ A;  4DGP A;  2DXP A;  1NL9 A;  1ECV A;  1U25 A;  2HVL A;  4GFV A;  4RH9 A;  1NNY A;  2GJT A;  1G1G A;  3S3E A;  4ICZ A;  2IMG A;  5BUG A;  2Y2F A;  2F70 A;  2CNH A;  4PVG A;  2GP0 A;  2QDP A;  4NX8 A;  2H02 A;  3F99 A;  2VEV A;  3EAX A;  4GFU A;  5BX1 A;  5K9V A;  1Q6T A;  1OET A;  2VEU A;  5BZZ A;  3PS5 A;  2P4D A;  4HJQ A;  4GWF A;  2I6J A;  2MBC A;  1P15 A;  1PTY A;  1YPT A;  2BZL A;  3SR9 A;  2I42 A;  2NZ6 A;  1T49 A;  2J16 B;  1OES A;  2VEW A;  4HRF A;  1VHR A;  2A3K A;  1G1H A;  3V0J A;  3NME A;  1Q6P A;  4R0T A;  1YTS A;  5KAC A;  1RXD A;  4Y2E A;  1YWF A;  1D5R A;  1L8G A;  4QUM A;  3SME A;  1YGR A;  4DGX A;  1G4U S;  4RI4 A;  2CM7 A;  3RGO A;  3V0D A;  5HDE A; 
#chains in the Genus database with same CATH topology
 2I5X A;  1LYV A;  3S3F A;  1FQ1 A;  3D1O A;  3ZL8 A;  4D3R A;  1ONZ A;  3CWE A;  2HNP A;  4WOH A;  2GC6 A;  4CVM A;  2E0T A;  1P31 A;  2Q05 A;  2QBQ A;  1SUG A;  4RHG A;  3GXH A;  2OC3 A;  3S3K A;  3AWE A;  1I9T A;  2CMC A;  2C7S A;  2HXP A;  1ONY A;  3BLT A;  1NWL A;  2PQ5 A;  3I80 A;  3QCN A;  2CNE A;  2QDM A;  5M43 A;  1YN9 A;  1GWZ A;  1FPR A;  4QDI A;  3V0H A;  2CJZ A;  5KA9 A;  3EB1 A;  2F6Z A;  3LK7 A;  2HC2 A;  3QCC A;  5KAA A;  5KA3 A;  3QCK A;  4BJO A;  1Q1M A;  1KAK A;  2HCM A;  4WU2 A;  4ZRT A;  4RH5 A;  2JFH A;  3ZM3 A;  2VEX A;  2XJA A;  2CMA A;  4JNB A;  1G1F A;  4KYQ A;  5A5E A;  1MKP A;  1EEN A;  1Q6M A;  1O5Z A;  2R0B A;  3PYZ A;  3ZM2 A;  2B3O A;  3D42 A;  2ZN7 A;  3S4E A;  4PYH A;  3RGQ A;  1KAV A;  2GWO A;  1ZZW A;  4B04 A;  3O4T A;  2I3R A;  5KA8 A;  4GS0 A;  5K24 A;  5IBM A;  2JFF A;  2QDC A;  1NZ7 A;  2A8B A;  1NWE A;  3MOZ A;  1A5Y A;  2Y68 A;  1OEM X;  5KA0 A;  1AAX A;  1I57 A;  1OHC A;  2VEY A;  2CNI A;  3GXG A;  1Q6N A;  4OHI A;  1G7G A;  1FGS A;  3BM8 A;  3O5X A;  2CNF A;  2VOR A;  1EEH A;  1JF7 A;  4IKC A;  4YR8 B;  3RZ2 A;  3QCD A;  4C13 A;  5MMZ B;  1R6H A;  5K25 A;  4KYR A;  1Q6J A;  2PSZ A;  4WU3 A;  1J4X A;  2H4G A;  4I8N A;  2NLK A;  3S3H A;  1JBW A;  4H34 A;  2VTE A;  1X24 A;  1J6U A;  4UAG A;  3QCF A;  1GQQ A;  3ZM0 A;  4ZI4 A;  2BGD A;  3ZM1 A;  2RF6 A;  2HY3 A;  1M3G A;  4CVK A;  2Q47 A;  4QBE A;  2ZMM A;  3V0I A;  4GE2 A;  5J8R A;  1JLN A;  2WGP A;  4H1O A;  4WTY A;  5IBS A;  3RO1 A;  3OLR A;  1C87 A;  1GFY A;  4RKK A;  2QCJ A;  3QCE A;  4NYH A;  2Y96 A;  1YGU A;  3EMU A;  2B4U A;  2JJD A;  1OEO X;  3ZMP A;  1QZ0 A;  2F46 A;  2I75 A;  4RDD A;  4AZ1 A;  2FJN A;  3UAG A;  2OUD A;  2ESB A;  2H4K A;  1PH0 A;  3V0E A;  3OMH A;  1C88 A;  4Z6B A;  2F6Y A;  3QCG A;  3QCB A;  5EHP A;  5I6V A;  3F9B A;  4GE6 A;  2BGE A;  4R0S A;  1BZC A;  1BZJ A;  4GRY A;  2PA5 A;  1Q6S A;  2QBP A;  1U26 A;  3A5J A;  2VTD A;  1WRM A;  4BPC A;  4KI9 A;  3O3L A;  1G4W R;  2H03 A;  2QEP A;  1ZCK A;  2XPC A;  3LJ8 A;  4JBC A;  4Y14 A;  1XXV A;  3HN7 A;  1ZCL A;  2F6W A;  3O4S A;  1NO6 A;  2VOS A;  1QXK A;  3BRH A;  3V0G A;  1GG4 A;  2F71 A;  1LQF A;  4D3P A;  1T4J A;  4D3Q A;  2B4P A;  3U96 A;  1PTT A;  4ZIY A;  1YZ4 A;  1V3A A;  2QBR A;  1C85 A;  3ZM6 A;  2HB1 A;  1RPM A;  1LAR A;  4C12 A;  2NT2 A;  3MMJ A;  5K22 A;  2J16 A;  5K9W A;  1EEO A;  2H4V A;  3B7O A;  2M3V A;  4QAP A;  4MBB A;  2NV5 A;  3EU0 A;  5KA4 A;  1WCH A;  4OHE A;  3QKP A;  4QF5 A;  2CMB A;  1XBO A;  2OZ5 A;  5EHR A;  2J17 A;  2FJM A;  1C86 A;  4HJP A;  4BUC A;  2P6X A;  2G6Z A;  2HC1 A;  2OOQ A;  5KAB A;  4QUN A;  1P3D A;  2B07 A;  2FH7 A;  1T48 A;  1U24 A;  2F00 A;  1PA1 A;  4HV4 A;  2I4E A;  4NND A;  4BUB A;  2AHS A;  5A5F A;  2Y67 A;  1E8C A;  1PTU A;  4NWG A;  2NTA A;  3N2A A;  2I6O A;  4GRZ A;  4JMJ A;  1PA9 A;  2UUO A;  2GCA A;  4OHL A;  4YAA A;  4J51 A;  3D44 A;  5BZX A;  5KAD A;  3AWG A;  3EZZ A;  4TVV A;  1UAG A;  2B49 A;  3O4U A;  1PXH A;  3ZV2 A;  2Y66 A;  3NRS A;  3QCJ A;  1PYN A;  2F6T A;  3CM3 A;  3BLU A;  1W78 A;  2CM8 A;  3ZMQ A;  2I6P A;  4ZN5 A;  4QBW A;  5GTJ A;  1FPZ A;  1E0D A;  1OHE A;  4RI5 A;  1C83 A;  5LXQ B;  3MOW A;  2B4S A;  3D9C A;  1L8K A;  2WJP A;  3N0A A;  2X5O A;  4OHH A;  5KA7 A;  2SHP A;  4GE5 A;  2I1Y A;  2UUP A;  3QCL A;  1G7F A;  3D1Q A;  2AZR A;  4S0G A;  3D1H A;  3ZM5 A;  3I36 A;  3QCM A;  1OEV A;  1WAX A;  1BZH A;  2BV5 A;  2I4G A;  2YDU A;  4JMK A;  3QCZ A;  1C84 A;  1JBV A;  1OEU A;  3MVN A;  2F6V A;  3F81 A;  3A5K A;  3QCH A;  4OHD A;  1I9S A;  3QKQ A;  2F6F A;  3V0F A;  5K23 A;  4ERC A;  2QCT A;  2JFG A;  3I7Z A;  1XXP A;  2CM3 A;  1YFO A;  1ZC0 A;  2WTZ A;  2I4H A;  2C46 A;  2I6I A;  4R30 A;  2CM2 A;  2I3U A;  3H2X A;  5AWX A;  5KA1 A;  2H04 A;  3S4O A;  5KA2 A;  3QCI A;  1YTW A;  2NT7 A;  2PI7 A;  2CFV A;  2PT0 A;  2B4O A;  2BIJ A;  4QAH A;  1OHD A;  3F9A A;  2G59 A;  2PBN A;  2CNG A;  1XM2 A;  1W7K A;  3AWF A;  2I6M A;  3M4U A;  3F41 A;  1YTN A;  4NWF A;  1XRI A;  1PTV A;  2QBS A;  2HNQ A;  4DGP A;  2DXP A;  1NL9 A;  1ECV A;  1U25 A;  2HVL A;  2GC5 A;  4GFV A;  4RH9 A;  1NNY A;  2GJT A;  1G1G A;  3S3E A;  2AM2 A;  4ICZ A;  2IMG A;  5BUG A;  2Y2F A;  2F70 A;  2CNH A;  4PVG A;  2GP0 A;  2QDP A;  2UAG A;  4NX8 A;  2H02 A;  3F99 A;  2VEV A;  3EAX A;  4GFU A;  5BX1 A;  5K9V A;  1Q6T A;  1OET A;  2VEU A;  4CVL A;  5BZZ A;  3PS5 A;  2P4D A;  4HJQ A;  4GWF A;  2I6J A;  2MBC A;  1GQY A;  1P15 A;  1PTY A;  1YPT A;  2BZL A;  3SR9 A;  2I42 A;  2AM1 A;  2NZ6 A;  1T49 A;  2J16 B;  1OES A;  2Y1O A;  2VEW A;  4HRF A;  1VHR A;  2A3K A;  1G1H A;  3V0J A;  3NME A;  1Q6P A;  4R0T A;  2GCB A;  1YTS A;  5KAC A;  1RXD A;  4Y2E A;  1YWF A;  1D5R A;  1L8G A;  4QUM A;  3SME A;  1YGR A;  4DGX A;  1G4U S;  4RI4 A;  2CM7 A;  3RGO A;  3V0D A;  5HDE A; 
#chains in the Genus database with same CATH homology
 2I5X A;  1LYV A;  3S3F A;  1FQ1 A;  3D1O A;  4D3R A;  1ONZ A;  3CWE A;  2HNP A;  4WOH A;  2E0T A;  2Q05 A;  2QBQ A;  1SUG A;  4RHG A;  3GXH A;  2OC3 A;  3S3K A;  3AWE A;  1I9T A;  2CMC A;  2C7S A;  2HXP A;  1ONY A;  3BLT A;  1NWL A;  2PQ5 A;  3I80 A;  3QCN A;  2CNE A;  2QDM A;  5M43 A;  1YN9 A;  1GWZ A;  1FPR A;  3V0H A;  2CJZ A;  5KA9 A;  3EB1 A;  2F6Z A;  2HC2 A;  3QCC A;  5KAA A;  5KA3 A;  3QCK A;  4BJO A;  1Q1M A;  1KAK A;  2HCM A;  4WU2 A;  4ZRT A;  4RH5 A;  3ZM3 A;  2VEX A;  2CMA A;  4JNB A;  1G1F A;  4KYQ A;  1MKP A;  1EEN A;  1Q6M A;  2R0B A;  3ZM2 A;  2B3O A;  3D42 A;  2ZN7 A;  3S4E A;  4PYH A;  3RGQ A;  1KAV A;  2GWO A;  1ZZW A;  4B04 A;  3O4T A;  2I3R A;  5KA8 A;  4GS0 A;  5K24 A;  5IBM A;  2QDC A;  1NZ7 A;  2A8B A;  1NWE A;  3MOZ A;  1A5Y A;  1OEM X;  5KA0 A;  1AAX A;  1I57 A;  1OHC A;  2VEY A;  2CNI A;  3GXG A;  1Q6N A;  4OHI A;  1G7G A;  3BM8 A;  3O5X A;  2CNF A;  1JF7 A;  4IKC A;  4YR8 B;  3RZ2 A;  3QCD A;  5MMZ B;  1R6H A;  5K25 A;  4KYR A;  1Q6J A;  2PSZ A;  4WU3 A;  1J4X A;  2H4G A;  4I8N A;  2NLK A;  3S3H A;  4H34 A;  1X24 A;  3QCF A;  3ZM0 A;  4ZI4 A;  2BGD A;  3ZM1 A;  2RF6 A;  2HY3 A;  1M3G A;  2Q47 A;  4QBE A;  2ZMM A;  3V0I A;  4GE2 A;  5J8R A;  1JLN A;  2WGP A;  4H1O A;  4WTY A;  5IBS A;  3RO1 A;  3OLR A;  1C87 A;  1GFY A;  4RKK A;  2QCJ A;  3QCE A;  4NYH A;  2Y96 A;  1YGU A;  3EMU A;  2B4U A;  2JJD A;  1OEO X;  3ZMP A;  1QZ0 A;  2F46 A;  2I75 A;  4RDD A;  4AZ1 A;  2FJN A;  2OUD A;  2ESB A;  2H4K A;  1PH0 A;  3V0E A;  3OMH A;  1C88 A;  4Z6B A;  2F6Y A;  3QCG A;  3QCB A;  5EHP A;  5I6V A;  3F9B A;  4GE6 A;  2BGE A;  4R0S A;  1BZC A;  1BZJ A;  4GRY A;  2PA5 A;  1Q6S A;  2QBP A;  1U26 A;  3A5J A;  1WRM A;  4BPC A;  4KI9 A;  3O3L A;  1G4W R;  2H03 A;  2QEP A;  1ZCK A;  3LJ8 A;  4JBC A;  4Y14 A;  1XXV A;  1ZCL A;  2F6W A;  3O4S A;  1NO6 A;  1QXK A;  3BRH A;  3V0G A;  2F71 A;  1LQF A;  4D3P A;  1T4J A;  4D3Q A;  2B4P A;  3U96 A;  1PTT A;  1YZ4 A;  1V3A A;  2QBR A;  1C85 A;  2HB1 A;  1RPM A;  1LAR A;  2NT2 A;  3MMJ A;  5K22 A;  2J16 A;  5K9W A;  1EEO A;  2H4V A;  3B7O A;  2M3V A;  4QAP A;  4MBB A;  2NV5 A;  3EU0 A;  5KA4 A;  1WCH A;  4OHE A;  3QKP A;  2CMB A;  1XBO A;  2OZ5 A;  5EHR A;  2J17 A;  2FJM A;  1C86 A;  4HJP A;  2P6X A;  2G6Z A;  2HC1 A;  2OOQ A;  5KAB A;  4QUN A;  2FH7 A;  2B07 A;  1T48 A;  1U24 A;  1PA1 A;  2I4E A;  4NND A;  2AHS A;  1PTU A;  4NWG A;  2NTA A;  4GRZ A;  2I6O A;  4JMJ A;  1PA9 A;  4OHL A;  4YAA A;  4J51 A;  3D44 A;  5BZX A;  5KAD A;  3AWG A;  3EZZ A;  4TVV A;  2B49 A;  3O4U A;  1PXH A;  3ZV2 A;  3QCJ A;  1PYN A;  2F6T A;  3CM3 A;  3BLU A;  2CM8 A;  3ZMQ A;  2I6P A;  4ZN5 A;  4QBW A;  5GTJ A;  1FPZ A;  1OHE A;  4RI5 A;  1C83 A;  5LXQ B;  3MOW A;  2B4S A;  3D9C A;  1L8K A;  3N0A A;  4OHH A;  5KA7 A;  2SHP A;  4GE5 A;  2I1Y A;  3QCL A;  1G7F A;  3D1Q A;  2AZR A;  4S0G A;  3D1H A;  3I36 A;  3QCM A;  1OEV A;  1WAX A;  1BZH A;  2BV5 A;  2I4G A;  2YDU A;  4JMK A;  1C84 A;  1OEU A;  2F6V A;  3F81 A;  3A5K A;  3QCH A;  4OHD A;  1I9S A;  3QKQ A;  2F6F A;  3V0F A;  5K23 A;  4ERC A;  2QCT A;  3I7Z A;  1XXP A;  2CM3 A;  1YFO A;  1ZC0 A;  2I4H A;  2C46 A;  2I6I A;  4R30 A;  2CM2 A;  2I3U A;  3H2X A;  5AWX A;  5KA1 A;  2H04 A;  3S4O A;  5KA2 A;  3QCI A;  1YTW A;  2NT7 A;  2PI7 A;  2CFV A;  2PT0 A;  2B4O A;  2BIJ A;  4QAH A;  1OHD A;  3F9A A;  2G59 A;  2PBN A;  2CNG A;  3M4U A;  1XM2 A;  3AWF A;  2I6M A;  3F41 A;  1YTN A;  4NWF A;  1XRI A;  1PTV A;  2QBS A;  2HNQ A;  4DGP A;  2DXP A;  1NL9 A;  1ECV A;  1U25 A;  2HVL A;  4GFV A;  4RH9 A;  1NNY A;  2GJT A;  1G1G A;  3S3E A;  4ICZ A;  2IMG A;  5BUG A;  2Y2F A;  2F70 A;  2CNH A;  4PVG A;  2GP0 A;  2QDP A;  4NX8 A;  2H02 A;  3F99 A;  2VEV A;  3EAX A;  4GFU A;  5BX1 A;  5K9V A;  1Q6T A;  1OET A;  2VEU A;  5BZZ A;  3PS5 A;  2P4D A;  4HJQ A;  4GWF A;  2I6J A;  2MBC A;  1P15 A;  1PTY A;  1YPT A;  2BZL A;  3SR9 A;  2I42 A;  2NZ6 A;  1T49 A;  2J16 B;  1OES A;  2VEW A;  4HRF A;  1VHR A;  2A3K A;  1G1H A;  3V0J A;  3NME A;  1Q6P A;  4R0T A;  1YTS A;  5KAC A;  1RXD A;  4Y2E A;  1YWF A;  1D5R A;  1L8G A;  4QUM A;  3SME A;  1YGR A;  4DGX A;  1G4U S;  4RI4 A;  2CM7 A;  3RGO A;  3V0D A;  5HDE A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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