4J5PA

Crystal structure of a covalently bound alpha-ketoheterocycle inhibitor (phenhexyl/oxadiazole/pyridine) to a humanized variant of fatty acid amide hydrolase
Total Genus 225
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
225
sequence length
544
structure length
544
Chain Sequence
GRQKARGAATRARQKQRASLETMDKAVQRFRLQNPDLDSEALLTLPLLQLVQKLQSGELSPEAVFFTYLGKAWEVNKGTNCVTSYLTDCETQLSQAPRQGLLYGVPVSLKECFSYKGHDSTLGLSLNEGMPSESDCVVVQVLKLQGAVPFVHTNVPQSMFSYDCSNPLFGQTMNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSAFCGICGLKPTGNRLSKSGLKGCVYGQTAVQLSLGPMARDVESLALCLKALLCEHLFTLDPTVPPLPFREEVYRSSRPLRVGYYETDNYTMPSPAMRRALIETKQRLEAAGHTLIPFLPNNIPYALEVLSTGGLFSDGGRSFLQNFKGDFVDPCLGDLILILRLPSWFKRLLSLLLKPLFPRLAAFLNNMRPRSAEKLWKLQHEIEMYRQSVIAQWKAMNLDVLLTPMLGPALDLNTPGRATGAVSYTMLYNCLDFPAGVVPVTTVTAEDDAQMELYKGYFGDIWDIILKKAMKNSVGLPVAVQCVALPWQEELCLRFMREVEQLMTPQK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Hydrolase/hydrolase inhibitor
molecule keywords Fatty-acid amide hydrolase 1
publication title Rational design of Fatty Acid amide hydrolase inhibitors that act by covalently bonding to two active site residues.
pubmed doi rcsb
source organism Rattus norvegicus
total genus 225
structure length 544
sequence length 544
chains with identical sequence B
ec nomenclature ec 3.5.1.99: Fatty acid amide hydrolase.
pdb deposition date 2013-02-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01425 Amidase Amidase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.1300.10 Alpha Beta Alpha-Beta Complex Amidase signature (AS) enzymes Amidase signature (AS) domain 4j5pA00
4GYRA 1OCLA 2DC0A 3QKVA 2WJ1A 1MT5A 2WAPA 3A2PA 3K7FA 3LJ6A 5AC3A 4HBPA 1M21A 1OBJA 3IP4A 5EWQA 1O9QA 3QJ9A 2DF4A 4J5PA 3KFUE 1O9OA 3A1IA 4N0IA 4GYSA 4DO3A 3QK5A 2GI3A 1OBLA 2G5IA 4WJ3A 4YJ6A 4ISTA 4N0HA 3AL0A 1OBIA 2WJ2A 1M22A 1OCMA 3LJ7A 3QJ8A 3H0RA 4ISSA 4CP8A 2G5HA 3OJ8A 3PPMA 2F2AA 4YJIA 1O9PA 3PR0A 1OBKA 3K84A 3A2QA 3H0MA 3K83A 1O9NA 2DQNA 3A1KA 3H0LA 1OCKA 1OCHA 2VYAA
chains in the Genus database with same CATH superfamily
4GYRA 1OCLA 2DC0A 3QKVA 2WJ1A 1MT5A 2WAPA 3A2PA 3K7FA 3LJ6A 5AC3A 4HBPA 1M21A 1OBJA 3IP4A 5EWQA 1O9QA 3QJ9A 2DF4A 4J5PA 3KFUE 1O9OA 3A1IA 4N0IA 4GYSA 4DO3A 3QK5A 2GI3A 1OBLA 2G5IA 4WJ3A 4YJ6A 4ISTA 4N0HA 3AL0A 1OBIA 2WJ2A 1M22A 1OCMA 3LJ7A 3QJ8A 3H0RA 4ISSA 4CP8A 2G5HA 3OJ8A 3PPMA 2F2AA 4YJIA 1O9PA 3PR0A 1OBKA 3K84A 3A2QA 3H0MA 3K83A 1O9NA 2DQNA 3A1KA 3H0LA 1OCKA 1OCHA 2VYAA
chains in the Genus database with same CATH topology
4GYRA 1OCLA 2DC0A 3QKVA 2WJ1A 1MT5A 2WAPA 3A2PA 3K7FA 3LJ6A 5AC3A 4HBPA 1M21A 1OBJA 3IP4A 5EWQA 1O9QA 3QJ9A 2DF4A 4J5PA 3KFUE 1O9OA 3A1IA 4N0IA 4GYSA 4DO3A 3QK5A 2GI3A 1OBLA 2G5IA 4WJ3A 4YJ6A 4ISTA 4N0HA 3AL0A 1OBIA 2WJ2A 1M22A 1OCMA 3LJ7A 3QJ8A 3H0RA 4ISSA 4CP8A 2G5HA 3OJ8A 3PPMA 2F2AA 4YJIA 1O9PA 3PR0A 1OBKA 3K84A 3A2QA 3H0MA 3K83A 1O9NA 2DQNA 3A1KA 3H0LA 1OCKA 1OCHA 2VYAA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4GYR A;  1OCL A;  2DC0 A;  3QKV A;  2WJ1 A;  1MT5 A;  2WAP A;  3A2P A;  3K7F A;  3LJ6 A;  5AC3 A;  4HBP A;  1M21 A;  1OBJ A;  3IP4 A;  5EWQ A;  1O9Q A;  3QJ9 A;  2DF4 A;  4J5P A;  3KFU E;  1O9O A;  3A1I A;  4N0I A;  4GYS A;  4DO3 A;  3QK5 A;  2GI3 A;  1OBL A;  2G5I A;  4WJ3 A;  4YJ6 A;  4IST A;  4N0H A;  3AL0 A;  1OBI A;  2WJ2 A;  1M22 A;  1OCM A;  3LJ7 A;  3QJ8 A;  3H0R A;  4ISS A;  4CP8 A;  2G5H A;  3OJ8 A;  3PPM A;  2F2A A;  4YJI A;  1O9P A;  3PR0 A;  1OBK A;  3K84 A;  3A2Q A;  3H0M A;  3K83 A;  1O9N A;  2DQN A;  3A1K A;  3H0L A;  1OCK A;  1OCH A;  2VYA A; 
#chains in the Genus database with same CATH topology
 4GYR A;  1OCL A;  2DC0 A;  3QKV A;  2WJ1 A;  1MT5 A;  2WAP A;  3A2P A;  3K7F A;  3LJ6 A;  5AC3 A;  4HBP A;  1M21 A;  1OBJ A;  3IP4 A;  5EWQ A;  1O9Q A;  3QJ9 A;  2DF4 A;  4J5P A;  3KFU E;  1O9O A;  3A1I A;  4N0I A;  4GYS A;  4DO3 A;  3QK5 A;  2GI3 A;  1OBL A;  2G5I A;  4WJ3 A;  4YJ6 A;  4IST A;  4N0H A;  3AL0 A;  1OBI A;  2WJ2 A;  1M22 A;  1OCM A;  3LJ7 A;  3QJ8 A;  3H0R A;  4ISS A;  4CP8 A;  2G5H A;  3OJ8 A;  3PPM A;  2F2A A;  4YJI A;  1O9P A;  3PR0 A;  1OBK A;  3K84 A;  3A2Q A;  3H0M A;  3K83 A;  1O9N A;  2DQN A;  3A1K A;  3H0L A;  1OCK A;  1OCH A;  2VYA A; 
#chains in the Genus database with same CATH homology
 4GYR A;  1OCL A;  2DC0 A;  3QKV A;  2WJ1 A;  1MT5 A;  2WAP A;  3A2P A;  3K7F A;  3LJ6 A;  5AC3 A;  4HBP A;  1M21 A;  1OBJ A;  3IP4 A;  5EWQ A;  1O9Q A;  3QJ9 A;  2DF4 A;  4J5P A;  3KFU E;  1O9O A;  3A1I A;  4N0I A;  4GYS A;  4DO3 A;  3QK5 A;  2GI3 A;  1OBL A;  2G5I A;  4WJ3 A;  4YJ6 A;  4IST A;  4N0H A;  3AL0 A;  1OBI A;  2WJ2 A;  1M22 A;  1OCM A;  3LJ7 A;  3QJ8 A;  3H0R A;  4ISS A;  4CP8 A;  2G5H A;  3OJ8 A;  3PPM A;  2F2A A;  4YJI A;  1O9P A;  3PR0 A;  1OBK A;  3K84 A;  3A2Q A;  3H0M A;  3K83 A;  1O9N A;  2DQN A;  3A1K A;  3H0L A;  1OCK A;  1OCH A;  2VYA A; 
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similar chains in the Genus database (?% sequence similarity)
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#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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