4J7BB

Crystal structure of polo-like kinase 1
Total Genus 70
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
70
sequence length
223
structure length
213
Chain Sequence
THLTDMLQQLAVVNAAKPSDRGFIRQEEAEDPACIPVFWISKWVDYSDKYGLGYQLSDNSVGVLFNDSTRLIMCADGDSLQYIDRNSLESYLSVRSYPSALSKKITLLKYFRNYMSEPREGDELTRLPYLRHWFRTKSAIVLHLSNGTVQINFFQDHTKLILCPLMGAVTYINEKREFYTYKMTLIEEFGCCKELASRLRYARNMVEKLMACK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural basis for the inhibition of Polo-like kinase 1
pubmed doi rcsb
molecule tags Transferase
source organism Danio rerio
molecule keywords Polo-like kinase
total genus 70
structure length 213
sequence length 223
chains with identical sequence E
ec nomenclature ec 2.7.11.21: Polo kinase.
pdb deposition date 2013-02-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF00659 POLO_box POLO box duplicated region
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 4j7bB02
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 4j7bB01
4E9DA 5LHZA 3P2ZA 3P37A 4X9VA 3P2WA 4X9WA 4WHHA 2OGQA 3FVHA 3BZIA 4WHLA 4HCOA 1UMWA 3HIHA 4J7BB 4O9WA 4WHKA 3RQ7A 4E67A 4E9CA 4H5XA 5J19A 3P35A 4O6WA 5DMVC 3P36A 4O56A 4RS6A 4LKLA 4LKMA 4DFWA 4H71A 3HIKA 4X9RA 4HY2A 3Q1IA 2OJXA 4XB0A 5DMSA 5DNJA 3C5LA 3P34A 4YYPA 2N19A 1Q4KA 4RCPA 4HABA 1Q4OA
chains in the Genus database with same CATH superfamily
1AUKA 4X9VA 3P2WA 2OGQA 4N9JA 4WHLA 4J7BB 4WHKA 4E67A 4H5XA 3P35A 2VKZG 4DFWA 4H71A 4X9RA 1N2LA 3HFDA 5DNJA 2UV8G 3ED4A 2E50A 3FVHA 1UMWA 2QZUA 1HDHA 4O9WA 1N2KA 5J19A 4E9CA 4O6WA 4NK7A 3P36A 4N7VA 4RS6A 1E2SP 4CYSA 3HIKA 1F32A 4FDIA 2OJXA 4XB0A 1E1ZP 5DMSA 3C5LA 1E2TA 3LM3A 4RCPA 4HABA 4E9DA 5LHZA 4X9WA 4WHHA 3BZIA 4HCOA 3HIHA 4CXUA 1F34B 1E3CP 2I9ZA 2IA9A 4LKLA 3KDRA 5AJ9A 3Q1IA 1A87A 4FDJA 3GYWA 4YYPA 1Q4OA 3LXQA 3P2ZA 3P37A 1E33P 1FSUA 1P49A 3RQ7A 4N7ZA 4NKBA 5DAYA 3HMJG 5DMVC 4CXSA 4CXKA 3GYVA 2I9XA 4O56A 4LKMA 4G7NA 4HY2A 4CYRA 3P34A 2N19A 1Q4KA 3FS3A
chains in the Genus database with same CATH topology
4E9DA 5LHZA 3P2ZA 3P37A 4X9VA 3P2WA 4X9WA 4WHHA 2OGQA 3FVHA 3BZIA 4WHLA 4HCOA 1UMWA 3HIHA 4J7BB 4O9WA 4WHKA 3RQ7A 4E67A 4E9CA 4H5XA 5J19A 3P35A 4O6WA 5DMVC 3P36A 4O56A 4RS6A 4LKLA 4LKMA 4DFWA 4H71A 3HIKA 4X9RA 4HY2A 3Q1IA 2OJXA 4XB0A 5DMSA 5DNJA 3C5LA 3P34A 4YYPA 2N19A 1Q4KA 4RCPA 4HABA 1Q4OA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4E9D A;  5LHZ A;  3P2Z A;  3P37 A;  4X9V A;  3P2W A;  4X9W A;  4WHH A;  2OGQ A;  3FVH A;  3BZI A;  4WHL A;  4HCO A;  1UMW A;  3HIH A;  4J7B B;  4O9W A;  4WHK A;  3RQ7 A;  4E67 A;  4E9C A;  4H5X A;  5J19 A;  3P35 A;  4O6W A;  5DMV C;  3P36 A;  4O56 A;  4RS6 A;  4LKL A;  4LKM A;  4DFW A;  4H71 A;  3HIK A;  4X9R A;  4HY2 A;  3Q1I A;  2OJX A;  4XB0 A;  5DMS A;  5DNJ A;  3C5L A;  3P34 A;  4YYP A;  2N19 A;  1Q4K A;  4RCP A;  4HAB A;  1Q4O A; 
#chains in the Genus database with same CATH topology
 1AUK A;  4X9V A;  3P2W A;  2OGQ A;  4N9J A;  4WHL A;  4J7B B;  4WHK A;  4E67 A;  4H5X A;  3P35 A;  2VKZ G;  4DFW A;  4H71 A;  4X9R A;  1N2L A;  3HFD A;  5DNJ A;  2UV8 G;  3ED4 A;  2E50 A;  3FVH A;  1UMW A;  2QZU A;  1HDH A;  4O9W A;  1N2K A;  5J19 A;  4E9C A;  4O6W A;  4NK7 A;  3P36 A;  4N7V A;  4RS6 A;  1E2S P;  4CYS A;  3HIK A;  1F32 A;  4FDI A;  2OJX A;  4XB0 A;  1E1Z P;  5DMS A;  3C5L A;  1E2T A;  3LM3 A;  4RCP A;  4HAB A;  4E9D A;  5LHZ A;  4X9W A;  4WHH A;  3BZI A;  4HCO A;  3HIH A;  4CXU A;  1F34 B;  1E3C P;  2I9Z A;  2IA9 A;  4LKL A;  3KDR A;  5AJ9 A;  3Q1I A;  1A87 A;  4FDJ A;  3GYW A;  4YYP A;  1Q4O A;  3LXQ A;  3P2Z A;  3P37 A;  1E33 P;  1FSU A;  1P49 A;  3RQ7 A;  4N7Z A;  4NKB A;  5DAY A;  3HMJ G;  5DMV C;  4CXS A;  4CXK A;  3GYV A;  2I9X A;  4O56 A;  4LKM A;  4G7N A;  4HY2 A;  4CYR A;  3P34 A;  2N19 A;  1Q4K A;  3FS3 A; 
#chains in the Genus database with same CATH homology
 4E9D A;  5LHZ A;  3P2Z A;  3P37 A;  4X9V A;  3P2W A;  4X9W A;  4WHH A;  2OGQ A;  3FVH A;  3BZI A;  4WHL A;  4HCO A;  1UMW A;  3HIH A;  4J7B B;  4O9W A;  4WHK A;  3RQ7 A;  4E67 A;  4E9C A;  4H5X A;  5J19 A;  3P35 A;  4O6W A;  5DMV C;  3P36 A;  4O56 A;  4RS6 A;  4LKL A;  4LKM A;  4DFW A;  4H71 A;  3HIK A;  4X9R A;  4HY2 A;  3Q1I A;  2OJX A;  4XB0 A;  5DMS A;  5DNJ A;  3C5L A;  3P34 A;  4YYP A;  2N19 A;  1Q4K A;  4RCP A;  4HAB A;  1Q4O A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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