4J7BB

Crystal structure of polo-like kinase 1
Total Genus 70
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
70
sequence length
223
structure length
213
Chain Sequence
THLTDMLQQLAVVNAAKPSDRGFIRQEEAEDPACIPVFWISKWVDYSDKYGLGYQLSDNSVGVLFNDSTRLIMCADGDSLQYIDRNSLESYLSVRSYPSALSKKITLLKYFRNYMSEPREGDELTRLPYLRHWFRTKSAIVLHLSNGTVQINFFQDHTKLILCPLMGAVTYINEKREFYTYKMTLIEEFGCCKELASRLRYARNMVEKLMACK
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Polo-like kinase
publication title Structural basis for the inhibition of Polo-like kinase 1
pubmed doi rcsb
source organism Danio rerio
molecule tags Transferase
total genus 70
structure length 213
sequence length 223
chains with identical sequence E
ec nomenclature ec 2.7.11.21: Polo kinase.
pdb deposition date 2013-02-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF00659 POLO_box POLO box duplicated region
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 4j7bB02
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 4j7bB01
2N19A 4RCPA 3P35A 4WHKA 4H71A 3P2WA 3Q1IA 4O6WA 4X9WA 4J7BB 4E9DA 4LKMA 3RQ7A 4X9VA 5LHZA 3BZIA 4E67A 4HABA 5DMVC 3HIKA 3P34A 4WHLA 5J19A 5DNJA 3C5LA 4O56A 4E9CA 3P2ZA 1UMWA 4HY2A 3P36A 4RS6A 2OJXA 3HIHA 3P37A 4WHHA 4X9RA 4H5XA 2OGQA 1Q4OA 4YYPA 1Q4KA 4O9WA 4LKLA 4XB0A 4DFWA 4HCOA 3FVHA 5DMSA
chains in the Genus database with same CATH superfamily
2N19A 2I9ZA 3P35A 2VKZG 4H71A 4CXSA 3Q1IA 4O6WA 1F34B 2UV8G 5AJ9A 3HIKA 3P34A 1P49A 4E9CA 3P2ZA 4CYSA 1E2SP 4H5XA 4NKBA 2E50A 3LM3A 4CYRA 3FVHA 1E2TA 4N9JA 4RCPA 4N7VA 3HMJG 1F32A 4WHLA 5J19A 2I9XA 4N7ZA 4HY2A 3GYVA 3P36A 3HFDA 4X9RA 2OGQA 4XB0A 4DFWA 4FDIA 1N2LA 1N2KA 1HDHA 1AUKA 3GYWA 1E1ZP 4J7BB 3RQ7A 3BZIA 4E67A 3ED4A 5DMVC 5DNJA 3C5LA 3FS3A 4O56A 3HIHA 3P37A 1Q4KA 4O9WA 1A87A 3LXQA 4NK7A 4G7NA 4FDJA 5DMSA 5LHZA 4CXUA 4WHKA 3P2WA 4X9WA 4E9DA 1FSUA 4LKMA 4X9VA 4HABA 1UMWA 1E33P 2QZUA 4RS6A 2OJXA 4WHHA 2IA9A 1Q4OA 4YYPA 5DAYA 3KDRA 4LKLA 4CXKA 1E3CP 4HCOA
chains in the Genus database with same CATH topology
2N19A 4RCPA 3P35A 4WHKA 4H71A 3P2WA 3Q1IA 4O6WA 4X9WA 4J7BB 4E9DA 4LKMA 3RQ7A 4X9VA 5LHZA 3BZIA 4E67A 4HABA 5DMVC 3HIKA 3P34A 4WHLA 5J19A 5DNJA 3C5LA 4O56A 4E9CA 3P2ZA 1UMWA 4HY2A 3P36A 4RS6A 2OJXA 3HIHA 3P37A 4WHHA 4X9RA 4H5XA 2OGQA 1Q4OA 4YYPA 1Q4KA 4O9WA 4LKLA 4XB0A 4DFWA 4HCOA 3FVHA 5DMSA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2N19 A;  4RCP A;  3P35 A;  4WHK A;  4H71 A;  3P2W A;  3Q1I A;  4O6W A;  4X9W A;  4J7B B;  4E9D A;  4LKM A;  3RQ7 A;  4X9V A;  5LHZ A;  3BZI A;  4E67 A;  4HAB A;  5DMV C;  3HIK A;  3P34 A;  4WHL A;  5J19 A;  5DNJ A;  3C5L A;  4O56 A;  4E9C A;  3P2Z A;  1UMW A;  4HY2 A;  3P36 A;  4RS6 A;  2OJX A;  3HIH A;  3P37 A;  4WHH A;  4X9R A;  4H5X A;  2OGQ A;  1Q4O A;  4YYP A;  1Q4K A;  4O9W A;  4LKL A;  4XB0 A;  4DFW A;  4HCO A;  3FVH A;  5DMS A; 
#chains in the Genus database with same CATH topology
 2N19 A;  2I9Z A;  3P35 A;  2VKZ G;  4H71 A;  4CXS A;  3Q1I A;  4O6W A;  1F34 B;  2UV8 G;  5AJ9 A;  3HIK A;  3P34 A;  1P49 A;  4E9C A;  3P2Z A;  4CYS A;  1E2S P;  4H5X A;  4NKB A;  2E50 A;  3LM3 A;  4CYR A;  3FVH A;  1E2T A;  4N9J A;  4RCP A;  4N7V A;  3HMJ G;  1F32 A;  4WHL A;  5J19 A;  2I9X A;  4N7Z A;  4HY2 A;  3GYV A;  3P36 A;  3HFD A;  4X9R A;  2OGQ A;  4XB0 A;  4DFW A;  4FDI A;  1N2L A;  1N2K A;  1HDH A;  1AUK A;  3GYW A;  1E1Z P;  4J7B B;  3RQ7 A;  3BZI A;  4E67 A;  3ED4 A;  5DMV C;  5DNJ A;  3C5L A;  3FS3 A;  4O56 A;  3HIH A;  3P37 A;  1Q4K A;  4O9W A;  1A87 A;  3LXQ A;  4NK7 A;  4G7N A;  4FDJ A;  5DMS A;  5LHZ A;  4CXU A;  4WHK A;  3P2W A;  4X9W A;  4E9D A;  1FSU A;  4LKM A;  4X9V A;  4HAB A;  1UMW A;  1E33 P;  2QZU A;  4RS6 A;  2OJX A;  4WHH A;  2IA9 A;  1Q4O A;  4YYP A;  5DAY A;  3KDR A;  4LKL A;  4CXK A;  1E3C P;  4HCO A; 
#chains in the Genus database with same CATH homology
 2N19 A;  4RCP A;  3P35 A;  4WHK A;  4H71 A;  3P2W A;  3Q1I A;  4O6W A;  4X9W A;  4J7B B;  4E9D A;  4LKM A;  3RQ7 A;  4X9V A;  5LHZ A;  3BZI A;  4E67 A;  4HAB A;  5DMV C;  3HIK A;  3P34 A;  4WHL A;  5J19 A;  5DNJ A;  3C5L A;  4O56 A;  4E9C A;  3P2Z A;  1UMW A;  4HY2 A;  3P36 A;  4RS6 A;  2OJX A;  3HIH A;  3P37 A;  4WHH A;  4X9R A;  4H5X A;  2OGQ A;  1Q4O A;  4YYP A;  1Q4K A;  4O9W A;  4LKL A;  4XB0 A;  4DFW A;  4HCO A;  3FVH A;  5DMS A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...