4JFNA

Crystal structure of the n-terminal, growth factor-like domain of the amyloid precursor protein bound to copper
Total Genus 18
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
18
sequence length
101
structure length
101
Chain Sequence
DGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Metal binding protein
molecule keywords Amyloid beta A4 protein
publication title Amyloid precursor protein dimerization and synaptogenic function depend on copper binding to the growth factor-like domain
pubmed doi rcsb
source organism Homo sapiens
total genus 18
structure length 101
sequence length 101
ec nomenclature
pdb deposition date 2013-02-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02177 APP_N Amyloid A4 N-terminal heparin-binding
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.570.10 Alpha Beta Alpha-Beta Complex Sugar Binding Protein, Amyloid A4 Protein; Chain A Amyloidogenic glycoprotein, heparin-binding domain 4jfnA00
4JFNA 1MWPA 4PQDA 4PWQA 3KTMA
chains in the Genus database with same CATH superfamily
4JFNA 1MWPA 4PQDA 4PWQA 3KTMA
chains in the Genus database with same CATH topology
4JFNA 1MWPA 4PQDA 4PWQA 3KTMA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4JFN A;  1MWP A;  4PQD A;  4PWQ A;  3KTM A; 
#chains in the Genus database with same CATH topology
 4JFN A;  1MWP A;  4PQD A;  4PWQ A;  3KTM A; 
#chains in the Genus database with same CATH homology
 4JFN A;  1MWP A;  4PQD A;  4PWQ A;  3KTM A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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