4JGWA

The conformation of a docking site for sh3 domains is pre-selected in the guanine nucleotide exchange factor rlf
Total Genus 135
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
135
sequence length
463
structure length
396
Chain Sequence
EEEASVSVWDEEEDGATFTVTSRQYRPLDPLAPLPPPRSSRRLRAGTLEALVRHLLDARTAGADMMFTPALLATHRAFTSTPALFGLVADRLEALESYPPGELERTTGVAISVLSTWLASHPEDFGSEVKGQLDRLESFLLRTGYSADLIRNLRARDSPADPTDVLVFLADHLAEQLTLLDAELFLNLIPSQCLGGLWLCPSVRATVTQFNKVAGAVVSSVLGATSIGEGPREVTVRPLRPPQRARLLEKWIRVAEECRLLRNFSSVYAVVSALQSSPIHRLRAAWGETTRDSLRVFSSLCQIFSRELLTGVVPYLGTFLKDLVMLDAASKDELENGYINFDKRRKEFAILSELLRLQKECRGYDLRPNSDIQQWLQGLQPLTEAQSHRVSCEVEP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The guanine nucleotide exchange factor Rlf interacts with SH3 domain-containing proteins via a binding site with a preselected conformation.
pubmed doi rcsb
source organism Mus musculus
molecule tags Signaling protein
molecule keywords Ral guanine nucleotide dissociation stimulator-like 2
total genus 135
structure length 396
sequence length 463
chains with identical sequence B
ec nomenclature
pdb deposition date 2013-03-04

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00617 RasGEF RasGEF domain
A PF00618 RasGEF_N RasGEF N-terminal motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.840.10 Mainly Alpha Orthogonal Bundle Son of Sevenless (SoS) protein; Chain S, domain 2 Ras guanine-nucleotide exchange factors catalytic domain 4jgwA02
1.20.870.10 Mainly Alpha Up-down Bundle Son of sevenless (SoS) protein; Chain S, domain 1 Son of sevenless (SoS) protein Chain: S domain 1 4jgwA01
2IJES 2BYVE 4US0S 4URVS 4L9MA 4URWS 4URYS 4NYIS 4US2S 4NYJS 4MGIE 4F7ZA 3CF6E 1NVUS 3QXLA 3T6AA 4NYMS 4MGKE 3T6GA 4URUS 4MH0E 1BKDS 4JGWA 4MGZE 5CM9A 1NVVS 3KSYA 4URXS 4URZS 1NVWS 1XD2C 1XD4A 4MGYE 1NVXS 2II0A 4US1S 5CM8A
chains in the Genus database with same CATH superfamily
2IJES 2BYVE 4US0S 4URVS 4L9MA 4URWS 4URYS 4NYIS 4US2S 4NYJS 4MGIE 4F7ZA 3CF6E 1NVUS 3QXLA 3T6AA 4NYMS 4MGKE 3T6GA 4URUS 4MH0E 1BKDS 4JGWA 4MGZE 5CM9A 1NVVS 3KSYA 4URXS 4URZS 1NVWS 1XD2C 1XD4A 4MGYE 1NVXS 2II0A 4US1S 5CM8A
chains in the Genus database with same CATH topology
2IJES 2BYVE 4US0S 4URVS 4L9MA 4URWS 4URYS 4NYIS 4US2S 4NYJS 4MGIE 4F7ZA 3CF6E 1NVUS 3QXLA 3T6AA 4NYMS 4MGKE 3T6GA 4URUS 4MH0E 1BKDS 4JGWA 4MGZE 5CM9A 1NVVS 3KSYA 4URXS 4URZS 1NVWS 1XD2C 1XD4A 4MGYE 1NVXS 2II0A 4US1S 5CM8A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2IJE S;  2BYV E;  4US0 S;  4URV S;  4L9M A;  4URW S;  4URY S;  4NYI S;  4US2 S;  4NYJ S;  4MGI E;  4F7Z A;  3CF6 E;  1NVU S;  3QXL A;  3T6A A;  4NYM S;  4MGK E;  3T6G A;  4URU S;  4MH0 E;  1BKD S;  4JGW A;  4MGZ E;  5CM9 A;  1NVV S;  3KSY A;  4URX S;  4URZ S;  1NVW S;  1XD2 C;  1XD4 A;  4MGY E;  1NVX S;  2II0 A;  4US1 S;  5CM8 A; 
#chains in the Genus database with same CATH topology
 2IJE S;  2BYV E;  4US0 S;  4URV S;  4L9M A;  4URW S;  4URY S;  4NYI S;  4US2 S;  4NYJ S;  4MGI E;  4F7Z A;  3CF6 E;  1NVU S;  3QXL A;  3T6A A;  4NYM S;  4MGK E;  3T6G A;  4URU S;  4MH0 E;  1BKD S;  4JGW A;  4MGZ E;  5CM9 A;  1NVV S;  3KSY A;  4URX S;  4URZ S;  1NVW S;  1XD2 C;  1XD4 A;  4MGY E;  1NVX S;  2II0 A;  4US1 S;  5CM8 A; 
#chains in the Genus database with same CATH homology
 2IJE S;  2BYV E;  4US0 S;  4URV S;  4L9M A;  4URW S;  4URY S;  4NYI S;  4US2 S;  4NYJ S;  4MGI E;  4F7Z A;  3CF6 E;  1NVU S;  3QXL A;  3T6A A;  4NYM S;  4MGK E;  3T6G A;  4URU S;  4MH0 E;  1BKD S;  4JGW A;  4MGZ E;  5CM9 A;  1NVV S;  3KSY A;  4URX S;  4URZ S;  1NVW S;  1XD2 C;  1XD4 A;  4MGY E;  1NVX S;  2II0 A;  4US1 S;  5CM8 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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