4JZBA

Crystal structure of leshmaniasis major farnesyl diphosphate synthase in complex with 1-(2-hydroxy-2,2-diphosphonoethyl)-3-phenylpyridinium, ipp and ca2+
Total Genus 157
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
157
sequence length
361
structure length
361
Chain Sequence
AHMERFQKVYEEVQEFLLGDAEKRFEMDVHRKGYLKSMMDTTCLGGKYNRGLCVVDVAEAMAKDTQMDAAAMERVLHDACVCGWMIEMLQAHFLVEDDIMDHSKTRRGKPCWYLHPGVTAQVAINDGLILLAWATQMALHYFADRPFLAEVLRVFHDVDLTTTIGQLYDVTSMVDSAKLDAKVAHANTTDYVEYTPFNHRRIVVYKTAYYTYWLPLVMGLLVSGTLEKVDKKATHKVAMVMGEYFQVQDDVMDCFTPPEKLGKIGTDIEDAKCSWLAVTFLTTAPAEKVAEFKANYGSTDPAAVAVIKQLYTEQNLLARFEEYEKAVVAEVEQLIAALEAQNAAFAASVKVLWSKTYKRQK
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural and thermodynamic basis of the inhibition of Leishmania major farnesyl diphosphate synthase by nitrogen-containing bisphosphonates.
pubmed doi rcsb
molecule tags Transferase/transferase inhibitor
source organism Leishmania major
molecule keywords Farnesyl pyrophosphate synthase
total genus 157
structure length 361
sequence length 361
chains with identical sequence B
ec nomenclature ec 2.5.1.1: Dimethylallyltranstransferase.
pdb deposition date 2013-04-02

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00348 polyprenyl_synt Polyprenyl synthetase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.600.10 Mainly Alpha Orthogonal Bundle Farnesyl Diphosphate Synthase Farnesyl Diphosphate Synthase 4jzbA00
1WL3A 3WEIA 4ZQ8A 3WCBA 4NFJF 3SDVA 3ICNA 1UBXA 3ICKA 5IL3A 3ACWA 5AYPA 3VJBA 4XQRF 4LUUA 3QQVA 1YYQA 1RQJA 1HM4A 1N22A 3RMGA 4KQ5A 3OACB 2Z7IA 3WCJA 3KRCB 5IK6A 4H5EF 1EZFA 2AZKA 3LK5A 4GP2A 3TC1A 3N0GA 3WCHA 3S4JA 3WE9A 2QISA 2ONHA 4DXJA 3WCIA 3PYAA 1VG7A 5HN9A 1WL1A 3S9VA 5ER8A 2ZY1A 3VJ8A 4GP1A 4KFAA 1V4HA 3PKOA 5IN8A 2E91A 3KRAB 4E1EA 3WJOA 2Z7HA 3WSAA 4LZ0A 3KRFA 3TFPA 3N5HF 2F7MF 2RAHA 5E8KA 3ACXA 3EFQA 3ICZA 3SDQA 4L2XF 4EA2A 4OGUA 1VG4A 4OKMA 5B01A 4DWBA 1HX9A 3N1VF 3LJIA 3M01A 1N21A 4LZ3A 3MAVA 2Z4YA 4LA5A 2J1PA 3LSNA 4RXCA 5IKHA 1HXCA 4KQUA 1UBWA 3MZVA 1V4IA 3NRIA 3VJEA 3WCGA 4KQSA 3WC9A 5ERMA 2AEKA 2ZEUA 5DGMF 2AELA 2E8UA 3OYRA 4DEMF 2Q9ZA 2E92A 4LIXA 2Q9YA 3VJDA 5JV2F 4KVYA 2F94F 2F92F 3NF2A 2E93A 5DGSF 1YHKA 5DHKA 3LMDA 3NPKA 4LFEA 3AQBB 3N3LF 3ZCDA 4N9UA 4EA1A 4PVYF 3WEHA 5B0IA 5DHIA 2FORA 1YYRA 5EROA 3SDUA 3M00A 4DWGA 1V4EA 3LLWA 2ONGA 2Q80A 5EATA 5DIQF 5KSXF 1YHMA 4LPGF 3WEKA 1DGPA 1YQ7A 5IVGA 3ICMA 5HN8A 1DI1A 4KK2A 4LXWA 4H5CF 4XQSF 4QPFA 3KROA 3M0GA 1YJ4A 4OKZA 3P8RA 3WJNA 5B02A 1YHLA 2AZJA 3Q1OA 5H9DA 4LLSA 2I19A 3TS7A 1WKZA 3SDTA 4LFGA 4QXSF 4HD1A 2PS8A 4JVJF 2OGDA 3PDEA 4JZXA 4PVXF 2DH4A 4LFVF 2J1OA 4NFKF 5IMIA 3CKEA 5HNAA 1YYTA 4KPJA 3NPRA 1N1BA 2E8WA 1PS1A 3P5PA 2Z52A 2ZEVA 2E4OA 2PS6A 4RXAA 2F89F 4OMHA 3VJCA 3VJ9A 5B0JA 4RNQA 3Q2QA 3N6KF 5IKAA 3OABA 4LLTA 1HM7A 3PH7A 4RYPA 4K10A 3TFVA 3EZ3A 5B0KA 3UCAA 4FP4A 5EAUA 5JUZF 5AELA 2OPNA 4DZWA 3AE0A 3N45F 2E8VA 5CG5A 3WCMA 1HXAA 2Z4WA 2E90A 3VJAA 5JV1F 1YV5A 5B03A 1WMWA 5ILJA 5DJPF 4LA6A 4JZBA 4RXDA 1VG6A 4NFIF 5JA0F 3N46F 2Z4XA 4KVWA 3SAEA 5ILHA 5A0JA 3IPIA 2O1OA 5E8HA 3KRFB 5ILZA 3ID0A 4E9UA 3WCAA 3WJKA 1WL2A 2EWGA 3Q2ZA 1FPSA 4KWDA 2ZCQA 4MC0A 3LGKA 5A0KA 2E8XA 4RXEA 4MC3A 3PYBA 3OACA 3KRCA 3RYWA 3V1VA 4XQTF 5A0IA 3WCFA 3DYHA 4P0VA 5AFXA 5DW7A 3WCLA 2H8OA 3G4DA 3V66A 5CG6A 1VG2A 4JYXA 3WCEA 3DYGA 5IMNA 1JFGA 4KKMA 3P41A 5ILYA 2PS4A 3APZA 3WCDA 3LGZB 2ZCSA 3Q30A 1UBYA 3KRAA 3AQ0A 3BNXA 4LTZA 3KBKA 2AETA 5AHUB 3WEFA 4N1ZF 5DJRF 2E94A 3AQCB 3W7FA 2AZLA 4EA0A 5IL8A 1ZW5A 2F8CF 3IBAA 1V4KA 2Z4VA 4UMJA 3LOMA 4FJQA 2Z50A 1WY0A 1UBVA 5HN7A 2Z4ZA 4LPHF 3KRPA 2OA6A 3N0FA 4WK5A 2OPMA 3DYFA 4JXYA 1N24A 1RQIA 3N5JF 4KUXA 5B0LA 1KIZA 4Q23A 2FTZA 2Q58A 5IM1A 4DI5A 1KIYA 3KROB 3B7LA 5E8LA 3ZMCA 4KVDA 3LEEA 5I1UA 4LZCA 2VF6A 3CP6A 2E95A 4KVIA 3LG5A 5IK0A 4P0XA 4P0WA 4GA3A 2ZCRA 4NUAA 3WEJA 4MC8A 5IK9A 1WL0A 3N3DA 4DHDA 5ILKA 1VG3A 1JFAA 3ADZA 4KPDA 3P8LA 3SDRA 5DGNF 2F9KF 3M9UA 2P1CA 3BNYA 1RTRA 5ERNA 2E8TA 1N23A 4NKFA 3RYEA 3ZOUA 5C05A 3QKCA 1YYSA 4F6VA 1HXGA 4LOBA 3KRPB 3N1WF 3RBMA 3ZMBA 3ACYA 3ASXA 4OMGA 4NG6A 2PS5A 5B0MA 4NKEA 3LZ9A 3LVSA 4GAXA 5DZ2A 3EGTA 5B00A 1N1ZA 5JV0F 2PS7A 4JXNA 3LDWA 4F6XA 3WCCA 1N20A 4H5DF 3TFNA 3CC9A 3OABB 1YYUA 2J5CA 5ILIA 5DJVF 3WEGA 5IMPA 3G4FA 2F8ZF 4LTVA 3M02A 5ILDA 3WSBA 4F62A 3N49F 3P5RA 5EASA 2ZCOA 3KB9A 2Z78A 3V1XA 3ZL6A 4E9ZA 1V4JA
chains in the Genus database with same CATH superfamily
1WL3A 3WEIA 4ZQ8A 3WCBA 4NFJF 3SDVA 3ICNA 1UBXA 3ICKA 5IL3A 3ACWA 5AYPA 3VJBA 4XQRF 4LUUA 3QQVA 1YYQA 1RQJA 1HM4A 1N22A 3RMGA 4KQ5A 3OACB 2Z7IA 3WCJA 3KRCB 5IK6A 4H5EF 1EZFA 2AZKA 3LK5A 4GP2A 3TC1A 3N0GA 3WCHA 3S4JA 3WE9A 2QISA 2ONHA 4DXJA 3WCIA 3PYAA 1VG7A 5HN9A 1WL1A 3S9VA 5ER8A 2ZY1A 3VJ8A 4GP1A 4KFAA 1V4HA 3PKOA 5IN8A 2E91A 3KRAB 4E1EA 3WJOA 2Z7HA 3WSAA 4LZ0A 3KRFA 3TFPA 3N5HF 2F7MF 2RAHA 5E8KA 3ACXA 3EFQA 3ICZA 3SDQA 4L2XF 4EA2A 4OGUA 1VG4A 4OKMA 5B01A 4DWBA 1HX9A 3N1VF 3LJIA 3M01A 1N21A 4LZ3A 3MAVA 2Z4YA 4LA5A 2J1PA 3LSNA 4RXCA 5IKHA 1HXCA 4KQUA 1UBWA 3MZVA 1V4IA 3NRIA 3VJEA 3WCGA 4KQSA 3WC9A 5ERMA 2AEKA 2ZEUA 5DGMF 2AELA 2E8UA 3OYRA 4DEMF 2Q9ZA 2E92A 4LIXA 2Q9YA 3VJDA 5JV2F 4KVYA 2F94F 2F92F 3NF2A 2E93A 5DGSF 1YHKA 5DHKA 3LMDA 3NPKA 4LFEA 3AQBB 3N3LF 3ZCDA 4N9UA 4EA1A 4PVYF 3WEHA 5B0IA 5DHIA 2FORA 1YYRA 5EROA 3SDUA 3M00A 4DWGA 1V4EA 3LLWA 2ONGA 2Q80A 5EATA 5DIQF 5KSXF 1YHMA 4LPGF 3WEKA 1DGPA 1YQ7A 5IVGA 3ICMA 5HN8A 1DI1A 4KK2A 4LXWA 4H5CF 4XQSF 4QPFA 3KROA 3M0GA 1YJ4A 4OKZA 3P8RA 3WJNA 5B02A 1YHLA 2AZJA 3Q1OA 5H9DA 4LLSA 2I19A 3TS7A 1WKZA 3SDTA 4LFGA 4QXSF 4HD1A 2PS8A 4JVJF 2OGDA 3PDEA 4JZXA 4PVXF 2DH4A 4LFVF 2J1OA 4NFKF 5IMIA 3CKEA 5HNAA 1YYTA 4KPJA 3NPRA 1N1BA 2E8WA 1PS1A 3P5PA 2Z52A 2ZEVA 2E4OA 2PS6A 4RXAA 2F89F 4OMHA 3VJCA 3VJ9A 5B0JA 4RNQA 3Q2QA 3N6KF 5IKAA 3OABA 4LLTA 1HM7A 3PH7A 4RYPA 4K10A 3TFVA 3EZ3A 5B0KA 3UCAA 4FP4A 5EAUA 5JUZF 5AELA 2OPNA 4DZWA 3AE0A 3N45F 2E8VA 5CG5A 3WCMA 1HXAA 2Z4WA 2E90A 3VJAA 5JV1F 1YV5A 5B03A 1WMWA 5ILJA 5DJPF 4LA6A 4JZBA 4RXDA 1VG6A 4NFIF 5JA0F 3N46F 2Z4XA 4KVWA 3SAEA 5ILHA 5A0JA 3IPIA 2O1OA 5E8HA 3KRFB 5ILZA 3ID0A 4E9UA 3WCAA 3WJKA 1WL2A 2EWGA 3Q2ZA 1FPSA 4KWDA 2ZCQA 4MC0A 3LGKA 5A0KA 2E8XA 4RXEA 4MC3A 3PYBA 3OACA 3KRCA 3RYWA 3V1VA 4XQTF 5A0IA 3WCFA 3DYHA 4P0VA 5AFXA 5DW7A 3WCLA 2H8OA 3G4DA 3V66A 5CG6A 1VG2A 4JYXA 3WCEA 3DYGA 5IMNA 1JFGA 4KKMA 3P41A 5ILYA 2PS4A 3APZA 3WCDA 3LGZB 2ZCSA 3Q30A 1UBYA 3KRAA 3AQ0A 3BNXA 4LTZA 3KBKA 2AETA 5AHUB 3WEFA 4N1ZF 5DJRF 2E94A 3AQCB 3W7FA 2AZLA 4EA0A 5IL8A 1ZW5A 2F8CF 3IBAA 1V4KA 2Z4VA 4UMJA 3LOMA 4FJQA 2Z50A 1WY0A 1UBVA 5HN7A 2Z4ZA 4LPHF 3KRPA 2OA6A 3N0FA 4WK5A 2OPMA 3DYFA 4JXYA 1N24A 1RQIA 3N5JF 4KUXA 5B0LA 1KIZA 4Q23A 2FTZA 2Q58A 5IM1A 4DI5A 1KIYA 3KROB 3B7LA 5E8LA 3ZMCA 4KVDA 3LEEA 5I1UA 4LZCA 2VF6A 3CP6A 2E95A 4KVIA 3LG5A 5IK0A 4P0XA 4P0WA 4GA3A 2ZCRA 4NUAA 3WEJA 4MC8A 5IK9A 1WL0A 3N3DA 4DHDA 5ILKA 1VG3A 1JFAA 3ADZA 4KPDA 3P8LA 3SDRA 5DGNF 2F9KF 3M9UA 2P1CA 3BNYA 1RTRA 5ERNA 2E8TA 1N23A 4NKFA 3RYEA 3ZOUA 5C05A 3QKCA 1YYSA 4F6VA 1HXGA 4LOBA 3KRPB 3N1WF 3RBMA 3ZMBA 3ACYA 3ASXA 4OMGA 4NG6A 2PS5A 5B0MA 4NKEA 3LZ9A 3LVSA 4GAXA 5DZ2A 3EGTA 5B00A 1N1ZA 5JV0F 2PS7A 4JXNA 3LDWA 4F6XA 3WCCA 1N20A 4H5DF 3TFNA 3CC9A 3OABB 1YYUA 2J5CA 5ILIA 5DJVF 3WEGA 5IMPA 3G4FA 2F8ZF 4LTVA 3M02A 5ILDA 3WSBA 4F62A 3N49F 3P5RA 5EASA 2ZCOA 3KB9A 2Z78A 3V1XA 3ZL6A 4E9ZA 1V4JA
chains in the Genus database with same CATH topology
1WL3A 3WEIA 4ZQ8A 3WCBA 4NFJF 3SDVA 3ICNA 1UBXA 3ICKA 5IL3A 3ACWA 5AYPA 3VJBA 4XQRF 4LUUA 3QQVA 1YYQA 1RQJA 1HM4A 1N22A 3RMGA 4KQ5A 3OACB 2Z7IA 3WCJA 3KRCB 5IK6A 4H5EF 1EZFA 2AZKA 3LK5A 4GP2A 3TC1A 3N0GA 3WCHA 3S4JA 3WE9A 2QISA 2ONHA 4DXJA 3WCIA 3PYAA 1VG7A 5HN9A 1WL1A 3S9VA 5ER8A 2ZY1A 3VJ8A 4GP1A 4KFAA 1V4HA 3PKOA 5IN8A 2E91A 3KRAB 4E1EA 3WJOA 2Z7HA 3WSAA 4LZ0A 3KRFA 3TFPA 3N5HF 2F7MF 2RAHA 5E8KA 3ACXA 3EFQA 3ICZA 3SDQA 4L2XF 4EA2A 4OGUA 1VG4A 4OKMA 5B01A 4DWBA 1HX9A 3N1VF 3LJIA 3M01A 1N21A 4LZ3A 3MAVA 2Z4YA 4LA5A 2J1PA 3LSNA 4RXCA 5IKHA 1HXCA 4KQUA 1UBWA 3MZVA 1V4IA 3NRIA 3VJEA 3WCGA 4KQSA 3WC9A 5ERMA 2AEKA 2ZEUA 5DGMF 2AELA 2E8UA 3OYRA 4DEMF 2Q9ZA 2E92A 4LIXA 2Q9YA 3VJDA 5JV2F 4KVYA 2F94F 2F92F 3NF2A 2E93A 5DGSF 1YHKA 5DHKA 3LMDA 3NPKA 4LFEA 3AQBB 3N3LF 3ZCDA 4N9UA 4EA1A 4PVYF 3WEHA 5B0IA 5DHIA 2FORA 1YYRA 5EROA 3SDUA 3M00A 4DWGA 1V4EA 3LLWA 2ONGA 2Q80A 5EATA 5DIQF 5KSXF 1YHMA 4LPGF 3WEKA 1DGPA 1YQ7A 5IVGA 3ICMA 5HN8A 1DI1A 4KK2A 4LXWA 4H5CF 4XQSF 4QPFA 3KROA 3M0GA 1YJ4A 4OKZA 3P8RA 3WJNA 5B02A 1YHLA 2AZJA 3Q1OA 5H9DA 4LLSA 2I19A 3TS7A 1WKZA 3SDTA 4LFGA 4QXSF 4HD1A 2PS8A 4JVJF 2OGDA 3PDEA 4JZXA 4PVXF 2DH4A 4LFVF 2J1OA 4NFKF 5IMIA 3CKEA 5HNAA 1YYTA 4KPJA 3NPRA 1N1BA 2E8WA 1PS1A 3P5PA 2Z52A 2ZEVA 2E4OA 2PS6A 4RXAA 2F89F 4OMHA 3VJCA 3VJ9A 5B0JA 4RNQA 3Q2QA 3N6KF 5IKAA 3OABA 4LLTA 1HM7A 3PH7A 4RYPA 4K10A 3TFVA 3EZ3A 5B0KA 3UCAA 4FP4A 5EAUA 5JUZF 5AELA 2OPNA 4DZWA 3AE0A 3N45F 2E8VA 5CG5A 3WCMA 1HXAA 2Z4WA 2E90A 3VJAA 5JV1F 1YV5A 5B03A 1WMWA 5ILJA 5DJPF 4LA6A 4JZBA 4RXDA 1VG6A 4NFIF 5JA0F 3N46F 2Z4XA 4KVWA 3SAEA 5ILHA 5A0JA 3IPIA 2O1OA 5E8HA 3KRFB 5ILZA 3ID0A 4E9UA 3WCAA 3WJKA 1WL2A 2EWGA 3Q2ZA 1FPSA 4KWDA 2ZCQA 4MC0A 3LGKA 5A0KA 2E8XA 4RXEA 4MC3A 3PYBA 3OACA 3KRCA 3RYWA 3V1VA 4XQTF 5A0IA 3WCFA 3DYHA 4P0VA 5AFXA 5DW7A 3WCLA 2H8OA 3G4DA 3V66A 5CG6A 1VG2A 4JYXA 3WCEA 3DYGA 5IMNA 1JFGA 4KKMA 3P41A 5ILYA 2PS4A 3APZA 3WCDA 3LGZB 2ZCSA 3Q30A 1UBYA 3KRAA 3AQ0A 3BNXA 4LTZA 3KBKA 2AETA 5AHUB 3WEFA 4N1ZF 5DJRF 2E94A 3AQCB 3W7FA 2AZLA 4EA0A 5IL8A 1ZW5A 2F8CF 3IBAA 1V4KA 2Z4VA 4UMJA 3LOMA 4FJQA 2Z50A 1WY0A 1UBVA 5HN7A 2Z4ZA 4LPHF 3KRPA 2OA6A 3N0FA 4WK5A 2OPMA 3DYFA 4JXYA 1N24A 1RQIA 3N5JF 4KUXA 5B0LA 1KIZA 4Q23A 2FTZA 2Q58A 5IM1A 4DI5A 1KIYA 3KROB 3B7LA 5E8LA 3ZMCA 4KVDA 3LEEA 5I1UA 4LZCA 2VF6A 3CP6A 2E95A 4KVIA 3LG5A 5IK0A 4P0XA 4P0WA 4GA3A 2ZCRA 4NUAA 3WEJA 4MC8A 5IK9A 1WL0A 3N3DA 4DHDA 5ILKA 1VG3A 1JFAA 3ADZA 4KPDA 3P8LA 3SDRA 5DGNF 2F9KF 3M9UA 2P1CA 3BNYA 1RTRA 5ERNA 2E8TA 1N23A 4NKFA 3RYEA 3ZOUA 5C05A 3QKCA 1YYSA 4F6VA 1HXGA 4LOBA 3KRPB 3N1WF 3RBMA 3ZMBA 3ACYA 3ASXA 4OMGA 4NG6A 2PS5A 5B0MA 4NKEA 3LZ9A 3LVSA 4GAXA 5DZ2A 3EGTA 5B00A 1N1ZA 5JV0F 2PS7A 4JXNA 3LDWA 4F6XA 3WCCA 1N20A 4H5DF 3TFNA 3CC9A 3OABB 1YYUA 2J5CA 5ILIA 5DJVF 3WEGA 5IMPA 3G4FA 2F8ZF 4LTVA 3M02A 5ILDA 3WSBA 4F62A 3N49F 3P5RA 5EASA 2ZCOA 3KB9A 2Z78A 3V1XA 3ZL6A 4E9ZA 1V4JA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1WL3 A;  3WEI A;  4ZQ8 A;  3WCB A;  4NFJ F;  3SDV A;  3ICN A;  1UBX A;  3ICK A;  5IL3 A;  3ACW A;  5AYP A;  3VJB A;  4XQR F;  4LUU A;  3QQV A;  1YYQ A;  1RQJ A;  1HM4 A;  1N22 A;  3RMG A;  4KQ5 A;  3OAC B;  2Z7I A;  3WCJ A;  3KRC B;  5IK6 A;  4H5E F;  1EZF A;  2AZK A;  3LK5 A;  4GP2 A;  3TC1 A;  3N0G A;  3WCH A;  3S4J A;  3WE9 A;  2QIS A;  2ONH A;  4DXJ A;  3WCI A;  3PYA A;  1VG7 A;  5HN9 A;  1WL1 A;  3S9V A;  5ER8 A;  2ZY1 A;  3VJ8 A;  4GP1 A;  4KFA A;  1V4H A;  3PKO A;  5IN8 A;  2E91 A;  3KRA B;  4E1E A;  3WJO A;  2Z7H A;  3WSA A;  4LZ0 A;  3KRF A;  3TFP A;  3N5H F;  2F7M F;  2RAH A;  5E8K A;  3ACX A;  3EFQ A;  3ICZ A;  3SDQ A;  4L2X F;  4EA2 A;  4OGU A;  1VG4 A;  4OKM A;  5B01 A;  4DWB A;  1HX9 A;  3N1V F;  3LJI A;  3M01 A;  1N21 A;  4LZ3 A;  3MAV A;  2Z4Y A;  4LA5 A;  2J1P A;  3LSN A;  4RXC A;  5IKH A;  1HXC A;  4KQU A;  1UBW A;  3MZV A;  1V4I A;  3NRI A;  3VJE A;  3WCG A;  4KQS A;  3WC9 A;  5ERM A;  2AEK A;  2ZEU A;  5DGM F;  2AEL A;  2E8U A;  3OYR A;  4DEM F;  2Q9Z A;  2E92 A;  4LIX A;  2Q9Y A;  3VJD A;  5JV2 F;  4KVY A;  2F94 F;  2F92 F;  3NF2 A;  2E93 A;  5DGS F;  1YHK A;  5DHK A;  3LMD A;  3NPK A;  4LFE A;  3AQB B;  3N3L F;  3ZCD A;  4N9U A;  4EA1 A;  4PVY F;  3WEH A;  5B0I A;  5DHI A;  2FOR A;  1YYR A;  5ERO A;  3SDU A;  3M00 A;  4DWG A;  1V4E A;  3LLW A;  2ONG A;  2Q80 A;  5EAT A;  5DIQ F;  5KSX F;  1YHM A;  4LPG F;  3WEK A;  1DGP A;  1YQ7 A;  5IVG A;  3ICM A;  5HN8 A;  1DI1 A;  4KK2 A;  4LXW A;  4H5C F;  4XQS F;  4QPF A;  3KRO A;  3M0G A;  1YJ4 A;  4OKZ A;  3P8R A;  3WJN A;  5B02 A;  1YHL A;  2AZJ A;  3Q1O A;  5H9D A;  4LLS A;  2I19 A;  3TS7 A;  1WKZ A;  3SDT A;  4LFG A;  4QXS F;  4HD1 A;  2PS8 A;  4JVJ F;  2OGD A;  3PDE A;  4JZX A;  4PVX F;  2DH4 A;  4LFV F;  2J1O A;  4NFK F;  5IMI A;  3CKE A;  5HNA A;  1YYT A;  4KPJ A;  3NPR A;  1N1B A;  2E8W A;  1PS1 A;  3P5P A;  2Z52 A;  2ZEV A;  2E4O A;  2PS6 A;  4RXA A;  2F89 F;  4OMH A;  3VJC A;  3VJ9 A;  5B0J A;  4RNQ A;  3Q2Q A;  3N6K F;  5IKA A;  3OAB A;  4LLT A;  1HM7 A;  3PH7 A;  4RYP A;  4K10 A;  3TFV A;  3EZ3 A;  5B0K A;  3UCA A;  4FP4 A;  5EAU A;  5JUZ F;  5AEL A;  2OPN A;  4DZW A;  3AE0 A;  3N45 F;  2E8V A;  5CG5 A;  3WCM A;  1HXA A;  2Z4W A;  2E90 A;  3VJA A;  5JV1 F;  1YV5 A;  5B03 A;  1WMW A;  5ILJ A;  5DJP F;  4LA6 A;  4JZB A;  4RXD A;  1VG6 A;  4NFI F;  5JA0 F;  3N46 F;  2Z4X A;  4KVW A;  3SAE A;  5ILH A;  5A0J A;  3IPI A;  2O1O A;  5E8H A;  3KRF B;  5ILZ A;  3ID0 A;  4E9U A;  3WCA A;  3WJK A;  1WL2 A;  2EWG A;  3Q2Z A;  1FPS A;  4KWD A;  2ZCQ A;  4MC0 A;  3LGK A;  5A0K A;  2E8X A;  4RXE A;  4MC3 A;  3PYB A;  3OAC A;  3KRC A;  3RYW A;  3V1V A;  4XQT F;  5A0I A;  3WCF A;  3DYH A;  4P0V A;  5AFX A;  5DW7 A;  3WCL A;  2H8O A;  3G4D A;  3V66 A;  5CG6 A;  1VG2 A;  4JYX A;  3WCE A;  3DYG A;  5IMN A;  1JFG A;  4KKM A;  3P41 A;  5ILY A;  2PS4 A;  3APZ A;  3WCD A;  3LGZ B;  2ZCS A;  3Q30 A;  1UBY A;  3KRA A;  3AQ0 A;  3BNX A;  4LTZ A;  3KBK A;  2AET A;  5AHU B;  3WEF A;  4N1Z F;  5DJR F;  2E94 A;  3AQC B;  3W7F A;  2AZL A;  4EA0 A;  5IL8 A;  1ZW5 A;  2F8C F;  3IBA A;  1V4K A;  2Z4V A;  4UMJ A;  3LOM A;  4FJQ A;  2Z50 A;  1WY0 A;  1UBV A;  5HN7 A;  2Z4Z A;  4LPH F;  3KRP A;  2OA6 A;  3N0F A;  4WK5 A;  2OPM A;  3DYF A;  4JXY A;  1N24 A;  1RQI A;  3N5J F;  4KUX A;  5B0L A;  1KIZ A;  4Q23 A;  2FTZ A;  2Q58 A;  5IM1 A;  4DI5 A;  1KIY A;  3KRO B;  3B7L A;  5E8L A;  3ZMC A;  4KVD A;  3LEE A;  5I1U A;  4LZC A;  2VF6 A;  3CP6 A;  2E95 A;  4KVI A;  3LG5 A;  5IK0 A;  4P0X A;  4P0W A;  4GA3 A;  2ZCR A;  4NUA A;  3WEJ A;  4MC8 A;  5IK9 A;  1WL0 A;  3N3D A;  4DHD A;  5ILK A;  1VG3 A;  1JFA A;  3ADZ A;  4KPD A;  3P8L A;  3SDR A;  5DGN F;  2F9K F;  3M9U A;  2P1C A;  3BNY A;  1RTR A;  5ERN A;  2E8T A;  1N23 A;  4NKF A;  3RYE A;  3ZOU A;  5C05 A;  3QKC A;  1YYS A;  4F6V A;  1HXG A;  4LOB A;  3KRP B;  3N1W F;  3RBM A;  3ZMB A;  3ACY A;  3ASX A;  4OMG A;  4NG6 A;  2PS5 A;  5B0M A;  4NKE A;  3LZ9 A;  3LVS A;  4GAX A;  5DZ2 A;  3EGT A;  5B00 A;  1N1Z A;  5JV0 F;  2PS7 A;  4JXN A;  3LDW A;  4F6X A;  3WCC A;  1N20 A;  4H5D F;  3TFN A;  3CC9 A;  3OAB B;  1YYU A;  2J5C A;  5ILI A;  5DJV F;  3WEG A;  5IMP A;  3G4F A;  2F8Z F;  4LTV A;  3M02 A;  5ILD A;  3WSB A;  4F62 A;  3N49 F;  3P5R A;  5EAS A;  2ZCO A;  3KB9 A;  2Z78 A;  3V1X A;  3ZL6 A;  4E9Z A;  1V4J A; 
#chains in the Genus database with same CATH topology
 1WL3 A;  3WEI A;  4ZQ8 A;  3WCB A;  4NFJ F;  3SDV A;  3ICN A;  1UBX A;  3ICK A;  5IL3 A;  3ACW A;  5AYP A;  3VJB A;  4XQR F;  4LUU A;  3QQV A;  1YYQ A;  1RQJ A;  1HM4 A;  1N22 A;  3RMG A;  4KQ5 A;  3OAC B;  2Z7I A;  3WCJ A;  3KRC B;  5IK6 A;  4H5E F;  1EZF A;  2AZK A;  3LK5 A;  4GP2 A;  3TC1 A;  3N0G A;  3WCH A;  3S4J A;  3WE9 A;  2QIS A;  2ONH A;  4DXJ A;  3WCI A;  3PYA A;  1VG7 A;  5HN9 A;  1WL1 A;  3S9V A;  5ER8 A;  2ZY1 A;  3VJ8 A;  4GP1 A;  4KFA A;  1V4H A;  3PKO A;  5IN8 A;  2E91 A;  3KRA B;  4E1E A;  3WJO A;  2Z7H A;  3WSA A;  4LZ0 A;  3KRF A;  3TFP A;  3N5H F;  2F7M F;  2RAH A;  5E8K A;  3ACX A;  3EFQ A;  3ICZ A;  3SDQ A;  4L2X F;  4EA2 A;  4OGU A;  1VG4 A;  4OKM A;  5B01 A;  4DWB A;  1HX9 A;  3N1V F;  3LJI A;  3M01 A;  1N21 A;  4LZ3 A;  3MAV A;  2Z4Y A;  4LA5 A;  2J1P A;  3LSN A;  4RXC A;  5IKH A;  1HXC A;  4KQU A;  1UBW A;  3MZV A;  1V4I A;  3NRI A;  3VJE A;  3WCG A;  4KQS A;  3WC9 A;  5ERM A;  2AEK A;  2ZEU A;  5DGM F;  2AEL A;  2E8U A;  3OYR A;  4DEM F;  2Q9Z A;  2E92 A;  4LIX A;  2Q9Y A;  3VJD A;  5JV2 F;  4KVY A;  2F94 F;  2F92 F;  3NF2 A;  2E93 A;  5DGS F;  1YHK A;  5DHK A;  3LMD A;  3NPK A;  4LFE A;  3AQB B;  3N3L F;  3ZCD A;  4N9U A;  4EA1 A;  4PVY F;  3WEH A;  5B0I A;  5DHI A;  2FOR A;  1YYR A;  5ERO A;  3SDU A;  3M00 A;  4DWG A;  1V4E A;  3LLW A;  2ONG A;  2Q80 A;  5EAT A;  5DIQ F;  5KSX F;  1YHM A;  4LPG F;  3WEK A;  1DGP A;  1YQ7 A;  5IVG A;  3ICM A;  5HN8 A;  1DI1 A;  4KK2 A;  4LXW A;  4H5C F;  4XQS F;  4QPF A;  3KRO A;  3M0G A;  1YJ4 A;  4OKZ A;  3P8R A;  3WJN A;  5B02 A;  1YHL A;  2AZJ A;  3Q1O A;  5H9D A;  4LLS A;  2I19 A;  3TS7 A;  1WKZ A;  3SDT A;  4LFG A;  4QXS F;  4HD1 A;  2PS8 A;  4JVJ F;  2OGD A;  3PDE A;  4JZX A;  4PVX F;  2DH4 A;  4LFV F;  2J1O A;  4NFK F;  5IMI A;  3CKE A;  5HNA A;  1YYT A;  4KPJ A;  3NPR A;  1N1B A;  2E8W A;  1PS1 A;  3P5P A;  2Z52 A;  2ZEV A;  2E4O A;  2PS6 A;  4RXA A;  2F89 F;  4OMH A;  3VJC A;  3VJ9 A;  5B0J A;  4RNQ A;  3Q2Q A;  3N6K F;  5IKA A;  3OAB A;  4LLT A;  1HM7 A;  3PH7 A;  4RYP A;  4K10 A;  3TFV A;  3EZ3 A;  5B0K A;  3UCA A;  4FP4 A;  5EAU A;  5JUZ F;  5AEL A;  2OPN A;  4DZW A;  3AE0 A;  3N45 F;  2E8V A;  5CG5 A;  3WCM A;  1HXA A;  2Z4W A;  2E90 A;  3VJA A;  5JV1 F;  1YV5 A;  5B03 A;  1WMW A;  5ILJ A;  5DJP F;  4LA6 A;  4JZB A;  4RXD A;  1VG6 A;  4NFI F;  5JA0 F;  3N46 F;  2Z4X A;  4KVW A;  3SAE A;  5ILH A;  5A0J A;  3IPI A;  2O1O A;  5E8H A;  3KRF B;  5ILZ A;  3ID0 A;  4E9U A;  3WCA A;  3WJK A;  1WL2 A;  2EWG A;  3Q2Z A;  1FPS A;  4KWD A;  2ZCQ A;  4MC0 A;  3LGK A;  5A0K A;  2E8X A;  4RXE A;  4MC3 A;  3PYB A;  3OAC A;  3KRC A;  3RYW A;  3V1V A;  4XQT F;  5A0I A;  3WCF A;  3DYH A;  4P0V A;  5AFX A;  5DW7 A;  3WCL A;  2H8O A;  3G4D A;  3V66 A;  5CG6 A;  1VG2 A;  4JYX A;  3WCE A;  3DYG A;  5IMN A;  1JFG A;  4KKM A;  3P41 A;  5ILY A;  2PS4 A;  3APZ A;  3WCD A;  3LGZ B;  2ZCS A;  3Q30 A;  1UBY A;  3KRA A;  3AQ0 A;  3BNX A;  4LTZ A;  3KBK A;  2AET A;  5AHU B;  3WEF A;  4N1Z F;  5DJR F;  2E94 A;  3AQC B;  3W7F A;  2AZL A;  4EA0 A;  5IL8 A;  1ZW5 A;  2F8C F;  3IBA A;  1V4K A;  2Z4V A;  4UMJ A;  3LOM A;  4FJQ A;  2Z50 A;  1WY0 A;  1UBV A;  5HN7 A;  2Z4Z A;  4LPH F;  3KRP A;  2OA6 A;  3N0F A;  4WK5 A;  2OPM A;  3DYF A;  4JXY A;  1N24 A;  1RQI A;  3N5J F;  4KUX A;  5B0L A;  1KIZ A;  4Q23 A;  2FTZ A;  2Q58 A;  5IM1 A;  4DI5 A;  1KIY A;  3KRO B;  3B7L A;  5E8L A;  3ZMC A;  4KVD A;  3LEE A;  5I1U A;  4LZC A;  2VF6 A;  3CP6 A;  2E95 A;  4KVI A;  3LG5 A;  5IK0 A;  4P0X A;  4P0W A;  4GA3 A;  2ZCR A;  4NUA A;  3WEJ A;  4MC8 A;  5IK9 A;  1WL0 A;  3N3D A;  4DHD A;  5ILK A;  1VG3 A;  1JFA A;  3ADZ A;  4KPD A;  3P8L A;  3SDR A;  5DGN F;  2F9K F;  3M9U A;  2P1C A;  3BNY A;  1RTR A;  5ERN A;  2E8T A;  1N23 A;  4NKF A;  3RYE A;  3ZOU A;  5C05 A;  3QKC A;  1YYS A;  4F6V A;  1HXG A;  4LOB A;  3KRP B;  3N1W F;  3RBM A;  3ZMB A;  3ACY A;  3ASX A;  4OMG A;  4NG6 A;  2PS5 A;  5B0M A;  4NKE A;  3LZ9 A;  3LVS A;  4GAX A;  5DZ2 A;  3EGT A;  5B00 A;  1N1Z A;  5JV0 F;  2PS7 A;  4JXN A;  3LDW A;  4F6X A;  3WCC A;  1N20 A;  4H5D F;  3TFN A;  3CC9 A;  3OAB B;  1YYU A;  2J5C A;  5ILI A;  5DJV F;  3WEG A;  5IMP A;  3G4F A;  2F8Z F;  4LTV A;  3M02 A;  5ILD A;  3WSB A;  4F62 A;  3N49 F;  3P5R A;  5EAS A;  2ZCO A;  3KB9 A;  2Z78 A;  3V1X A;  3ZL6 A;  4E9Z A;  1V4J A; 
#chains in the Genus database with same CATH homology
 1WL3 A;  3WEI A;  4ZQ8 A;  3WCB A;  4NFJ F;  3SDV A;  3ICN A;  1UBX A;  3ICK A;  5IL3 A;  3ACW A;  5AYP A;  3VJB A;  4XQR F;  4LUU A;  3QQV A;  1YYQ A;  1RQJ A;  1HM4 A;  1N22 A;  3RMG A;  4KQ5 A;  3OAC B;  2Z7I A;  3WCJ A;  3KRC B;  5IK6 A;  4H5E F;  1EZF A;  2AZK A;  3LK5 A;  4GP2 A;  3TC1 A;  3N0G A;  3WCH A;  3S4J A;  3WE9 A;  2QIS A;  2ONH A;  4DXJ A;  3WCI A;  3PYA A;  1VG7 A;  5HN9 A;  1WL1 A;  3S9V A;  5ER8 A;  2ZY1 A;  3VJ8 A;  4GP1 A;  4KFA A;  1V4H A;  3PKO A;  5IN8 A;  2E91 A;  3KRA B;  4E1E A;  3WJO A;  2Z7H A;  3WSA A;  4LZ0 A;  3KRF A;  3TFP A;  3N5H F;  2F7M F;  2RAH A;  5E8K A;  3ACX A;  3EFQ A;  3ICZ A;  3SDQ A;  4L2X F;  4EA2 A;  4OGU A;  1VG4 A;  4OKM A;  5B01 A;  4DWB A;  1HX9 A;  3N1V F;  3LJI A;  3M01 A;  1N21 A;  4LZ3 A;  3MAV A;  2Z4Y A;  4LA5 A;  2J1P A;  3LSN A;  4RXC A;  5IKH A;  1HXC A;  4KQU A;  1UBW A;  3MZV A;  1V4I A;  3NRI A;  3VJE A;  3WCG A;  4KQS A;  3WC9 A;  5ERM A;  2AEK A;  2ZEU A;  5DGM F;  2AEL A;  2E8U A;  3OYR A;  4DEM F;  2Q9Z A;  2E92 A;  4LIX A;  2Q9Y A;  3VJD A;  5JV2 F;  4KVY A;  2F94 F;  2F92 F;  3NF2 A;  2E93 A;  5DGS F;  1YHK A;  5DHK A;  3LMD A;  3NPK A;  4LFE A;  3AQB B;  3N3L F;  3ZCD A;  4N9U A;  4EA1 A;  4PVY F;  3WEH A;  5B0I A;  5DHI A;  2FOR A;  1YYR A;  5ERO A;  3SDU A;  3M00 A;  4DWG A;  1V4E A;  3LLW A;  2ONG A;  2Q80 A;  5EAT A;  5DIQ F;  5KSX F;  1YHM A;  4LPG F;  3WEK A;  1DGP A;  1YQ7 A;  5IVG A;  3ICM A;  5HN8 A;  1DI1 A;  4KK2 A;  4LXW A;  4H5C F;  4XQS F;  4QPF A;  3KRO A;  3M0G A;  1YJ4 A;  4OKZ A;  3P8R A;  3WJN A;  5B02 A;  1YHL A;  2AZJ A;  3Q1O A;  5H9D A;  4LLS A;  2I19 A;  3TS7 A;  1WKZ A;  3SDT A;  4LFG A;  4QXS F;  4HD1 A;  2PS8 A;  4JVJ F;  2OGD A;  3PDE A;  4JZX A;  4PVX F;  2DH4 A;  4LFV F;  2J1O A;  4NFK F;  5IMI A;  3CKE A;  5HNA A;  1YYT A;  4KPJ A;  3NPR A;  1N1B A;  2E8W A;  1PS1 A;  3P5P A;  2Z52 A;  2ZEV A;  2E4O A;  2PS6 A;  4RXA A;  2F89 F;  4OMH A;  3VJC A;  3VJ9 A;  5B0J A;  4RNQ A;  3Q2Q A;  3N6K F;  5IKA A;  3OAB A;  4LLT A;  1HM7 A;  3PH7 A;  4RYP A;  4K10 A;  3TFV A;  3EZ3 A;  5B0K A;  3UCA A;  4FP4 A;  5EAU A;  5JUZ F;  5AEL A;  2OPN A;  4DZW A;  3AE0 A;  3N45 F;  2E8V A;  5CG5 A;  3WCM A;  1HXA A;  2Z4W A;  2E90 A;  3VJA A;  5JV1 F;  1YV5 A;  5B03 A;  1WMW A;  5ILJ A;  5DJP F;  4LA6 A;  4JZB A;  4RXD A;  1VG6 A;  4NFI F;  5JA0 F;  3N46 F;  2Z4X A;  4KVW A;  3SAE A;  5ILH A;  5A0J A;  3IPI A;  2O1O A;  5E8H A;  3KRF B;  5ILZ A;  3ID0 A;  4E9U A;  3WCA A;  3WJK A;  1WL2 A;  2EWG A;  3Q2Z A;  1FPS A;  4KWD A;  2ZCQ A;  4MC0 A;  3LGK A;  5A0K A;  2E8X A;  4RXE A;  4MC3 A;  3PYB A;  3OAC A;  3KRC A;  3RYW A;  3V1V A;  4XQT F;  5A0I A;  3WCF A;  3DYH A;  4P0V A;  5AFX A;  5DW7 A;  3WCL A;  2H8O A;  3G4D A;  3V66 A;  5CG6 A;  1VG2 A;  4JYX A;  3WCE A;  3DYG A;  5IMN A;  1JFG A;  4KKM A;  3P41 A;  5ILY A;  2PS4 A;  3APZ A;  3WCD A;  3LGZ B;  2ZCS A;  3Q30 A;  1UBY A;  3KRA A;  3AQ0 A;  3BNX A;  4LTZ A;  3KBK A;  2AET A;  5AHU B;  3WEF A;  4N1Z F;  5DJR F;  2E94 A;  3AQC B;  3W7F A;  2AZL A;  4EA0 A;  5IL8 A;  1ZW5 A;  2F8C F;  3IBA A;  1V4K A;  2Z4V A;  4UMJ A;  3LOM A;  4FJQ A;  2Z50 A;  1WY0 A;  1UBV A;  5HN7 A;  2Z4Z A;  4LPH F;  3KRP A;  2OA6 A;  3N0F A;  4WK5 A;  2OPM A;  3DYF A;  4JXY A;  1N24 A;  1RQI A;  3N5J F;  4KUX A;  5B0L A;  1KIZ A;  4Q23 A;  2FTZ A;  2Q58 A;  5IM1 A;  4DI5 A;  1KIY A;  3KRO B;  3B7L A;  5E8L A;  3ZMC A;  4KVD A;  3LEE A;  5I1U A;  4LZC A;  2VF6 A;  3CP6 A;  2E95 A;  4KVI A;  3LG5 A;  5IK0 A;  4P0X A;  4P0W A;  4GA3 A;  2ZCR A;  4NUA A;  3WEJ A;  4MC8 A;  5IK9 A;  1WL0 A;  3N3D A;  4DHD A;  5ILK A;  1VG3 A;  1JFA A;  3ADZ A;  4KPD A;  3P8L A;  3SDR A;  5DGN F;  2F9K F;  3M9U A;  2P1C A;  3BNY A;  1RTR A;  5ERN A;  2E8T A;  1N23 A;  4NKF A;  3RYE A;  3ZOU A;  5C05 A;  3QKC A;  1YYS A;  4F6V A;  1HXG A;  4LOB A;  3KRP B;  3N1W F;  3RBM A;  3ZMB A;  3ACY A;  3ASX A;  4OMG A;  4NG6 A;  2PS5 A;  5B0M A;  4NKE A;  3LZ9 A;  3LVS A;  4GAX A;  5DZ2 A;  3EGT A;  5B00 A;  1N1Z A;  5JV0 F;  2PS7 A;  4JXN A;  3LDW A;  4F6X A;  3WCC A;  1N20 A;  4H5D F;  3TFN A;  3CC9 A;  3OAB B;  1YYU A;  2J5C A;  5ILI A;  5DJV F;  3WEG A;  5IMP A;  3G4F A;  2F8Z F;  4LTV A;  3M02 A;  5ILD A;  3WSB A;  4F62 A;  3N49 F;  3P5R A;  5EAS A;  2ZCO A;  3KB9 A;  2Z78 A;  3V1X A;  3ZL6 A;  4E9Z A;  1V4J A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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