4K12A

Structural basis for host specificity of factor h binding by streptococcus pneumoniae
Total Genus 11
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
11
sequence length
64
structure length
64
Chain Sequence
GSHMSCDIPVFMNARTKNDFTWFKLNDTLDYECHDGYESNTGSTTGSIVCGYNGWSDLPICYER
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural determinants of host specificity of complement Factor H recruitment by Streptococcus pneumoniae.
pubmed doi rcsb
molecule tags Immune system/choline binding protein
source organism Homo sapiens
molecule keywords Complement factor H
total genus 11
structure length 64
sequence length 64
ec nomenclature
pdb deposition date 2013-04-04

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00084 Sushi Sushi repeat (SCR repeat)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 4k12A00
2CG7A 2WIIC 4IGDA 1C1ZA 2JGXA 2RKYA 1QO6A 3M7PA 1QGBA 3KXVA 3MQLA 5FO8C 2W81A 2RL0A 3EJHA 3R62A 1Q3XA 1E8BA 5HZPB 1G4FA 1GKGA 1VVDA 1GKNA 2XWBF 4YNXA 3SW0X 1TPMA 4AYMA 4AYIA 3OXUD 4PZ5A 3L89M 5JPMG 3ZRZA 2CG6A 1OJWA 1E88A 2CKUA 1OJVA 1OJYA 1CKLA 3RJ3D 4ZH1D 1SS2A 5I0QB 3O8EB 3OEDC 1PPQA 1SRZA 2IZ4A 2RLQA 4LOSA 4DJZA 4FXGG 2XWJI 3NFPI 4ONTD 2RLPA 2XRBA 2BZMA 5HYUB 1NWVA 2A55A 1HFIA 2XQWC 5HYPA 1TPNA 4AYDA 1U5MA 2JRAA 1GPZA 4A5WB 1HFHA 1LY2A 4B2SA 4F4OC 1OK9A 3ZD1A 2KMSA 2W80A 2V8EA 1E5GA 2JGWA 1O9AA 2O39C 2B5ID 2QY0A 1H03P 1G4GA 2KRIA 3CALA 3INBC 4C16A 4K12A 1GHQB 3ZD2A 1OK3A 3T5OA 2LOJA 1VVCA 2MCYA 3TVJA 1HCCA 1FBRA 2MCZA 2XRDA 3IU3I 4B2RA 2EC3A 1MD7A 2RKZA 2UWNA 1ELVA 2G7IA 1H2QP 4JHSA 4MUCA 3IX0A 1MD8A 1TPGA 3KZJA 2YRAA 4KKDA 4J38B 2ERJA 1QUBA 2EHFA 1OK1A 4CSYA 1ZJKA 4LOTA 3GXEA 1OK2A 4AYEA 1H04P 1UOTP 2YBYA 3ERBA 1Z92B 3OP8A 4WJG2 3GOVA 1H2PP 2IZ3A 5HYTB
chains in the Genus database with same CATH superfamily
2CG7A 2WIIC 4IGDA 1C1ZA 2JGXA 2RKYA 4YIZA 1QO6A 3M7PA 1QGBA 3WSXA 3KXVA 3MQLA 5FO8C 2W81A 2RL0A 3EJHA 3R62A 1Q3XA 1E8BA 5HZPB 2Y8SA 1G4FA 1RLHA 1VVDA 3FGRA 1GKNA 2XWBF 3K3TA 4YNXA 1TPMA 5DN4A 3SW0X 3VWOA 4AYMA 4AYIA 3OXUD 4PZ5A 3FGTA 5DN5A 3L89M 5JPMG 3ZRZA 2CG6A 4N7EA 1OJWA 1E88A 2CKUA 1OJVA 1OJYA 3CI0J 1CKLA 3RJ3D 4ZH1D 1SS2A 5I0QB 3O8EB 3OEDC 1PPQA 1SRZA 2IZ4A 2RLQA 4LOSA 4DJZA 4FXGG 2XWJI 3NFPI 4ONTD 2RLPA 2XRBA 2BZMA 5HYUB 3F6KA 1NWVA 2A55A 1HFIA 2ZYCA 2XQWC 5HYPA 1TPNA 4AYDA 2Y8RA 4PO7A 1U5MA 2JRAA 1GPZA 4A5WB 1HFHA 1LY2A 4B2SA 4F4OC 1OK9A 3ZD1A 2KMSA 2W80A 2V8EA 1E5GA 2JGWA 3NJAA 1O9AA 2O39C 2B5ID 2QY0A 1H03P 4BWCA 1G4GA 2Y8TA 2KRIA 3CALA 3INBC 4C16A 4K12A 1GKGA 1GHQB 4APLA 3ZD2A 1OK3A 3T5OA 2I2LA 2LOJA 1VVCA 2MCYA 3TVJA 1HCCA 1FBRA 2MCZA 2XRDA 3IU3I 4B2RA 2EC3A 1MD7A 2RKZA 2UWNA 4MSLA 1ELVA 2G7IA 1H2QP 4JHSA 4MUCA 2X2ZA 3IX0A 1MD8A 1TPGA 3KZJA 2YRAA 4KKDA 3ZLEA 3WSYA 4J38B 2ERJA 1QUBA 2EHFA 3ZLDA 1OK1A 4CSYA 1ZJKA 4LOTA 3GXEA 1OK2A 4AYEA 1H04P 1UOTP 2YBYA 3ERBA 1Z92B 3OP8A 4WJG2 3GOVA 1H2PP 2IZ3A 5HYTB
chains in the Genus database with same CATH topology
2CG7A 2WIIC 4IGDA 1C1ZA 2JGXA 2RKYA 1QO6A 3M7PA 1QGBA 3KXVA 3MQLA 5FO8C 2W81A 2RL0A 3EJHA 3R62A 1Q3XA 1E8BA 5HZPB 1G4FA 1GKGA 1VVDA 1GKNA 2XWBF 4YNXA 3SW0X 1TPMA 4AYMA 4AYIA 3OXUD 4PZ5A 3L89M 5JPMG 3ZRZA 2CG6A 1OJWA 1E88A 2CKUA 1OJVA 1OJYA 1CKLA 3RJ3D 4ZH1D 1SS2A 5I0QB 3O8EB 3OEDC 1PPQA 1SRZA 2IZ4A 2RLQA 4LOSA 4DJZA 4FXGG 2XWJI 3NFPI 4ONTD 2RLPA 2XRBA 2BZMA 5HYUB 1NWVA 2A55A 1HFIA 2XQWC 5HYPA 1TPNA 4AYDA 1U5MA 2JRAA 1GPZA 4A5WB 1HFHA 1LY2A 4B2SA 4F4OC 1OK9A 3ZD1A 2KMSA 2W80A 2V8EA 1E5GA 2JGWA 1O9AA 2O39C 2B5ID 2QY0A 1H03P 1G4GA 2KRIA 3CALA 3INBC 4C16A 4K12A 1GHQB 3ZD2A 1OK3A 3T5OA 2LOJA 1VVCA 2MCYA 3TVJA 1HCCA 1FBRA 2MCZA 2XRDA 3IU3I 4B2RA 2EC3A 1MD7A 2RKZA 2UWNA 1ELVA 2G7IA 1H2QP 4JHSA 4MUCA 3IX0A 1MD8A 1TPGA 3KZJA 2YRAA 4KKDA 4J38B 2ERJA 1QUBA 2EHFA 1OK1A 4CSYA 1ZJKA 4LOTA 3GXEA 1OK2A 4AYEA 1H04P 1UOTP 2YBYA 3ERBA 1Z92B 3OP8A 4WJG2 3GOVA 1H2PP 2IZ3A 5HYTB
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2CG7 A;  2WII C;  4IGD A;  1C1Z A;  2JGX A;  2RKY A;  1QO6 A;  3M7P A;  1QGB A;  3KXV A;  3MQL A;  5FO8 C;  2W81 A;  2RL0 A;  3EJH A;  3R62 A;  1Q3X A;  1E8B A;  5HZP B;  1G4F A;  1GKG A;  1VVD A;  1GKN A;  2XWB F;  4YNX A;  3SW0 X;  1TPM A;  4AYM A;  4AYI A;  3OXU D;  4PZ5 A;  3L89 M;  5JPM G;  3ZRZ A;  2CG6 A;  1OJW A;  1E88 A;  2CKU A;  1OJV A;  1OJY A;  1CKL A;  3RJ3 D;  4ZH1 D;  1SS2 A;  5I0Q B;  3O8E B;  3OED C;  1PPQ A;  1SRZ A;  2IZ4 A;  2RLQ A;  4LOS A;  4DJZ A;  4FXG G;  2XWJ I;  3NFP I;  4ONT D;  2RLP A;  2XRB A;  2BZM A;  5HYU B;  1NWV A;  2A55 A;  1HFI A;  2XQW C;  5HYP A;  1TPN A;  4AYD A;  1U5M A;  2JRA A;  1GPZ A;  4A5W B;  1HFH A;  1LY2 A;  4B2S A;  4F4O C;  1OK9 A;  3ZD1 A;  2KMS A;  2W80 A;  2V8E A;  1E5G A;  2JGW A;  1O9A A;  2O39 C;  2B5I D;  2QY0 A;  1H03 P;  1G4G A;  2KRI A;  3CAL A;  3INB C;  4C16 A;  4K12 A;  1GHQ B;  3ZD2 A;  1OK3 A;  3T5O A;  2LOJ A;  1VVC A;  2MCY A;  3TVJ A;  1HCC A;  1FBR A;  2MCZ A;  2XRD A;  3IU3 I;  4B2R A;  2EC3 A;  1MD7 A;  2RKZ A;  2UWN A;  1ELV A;  2G7I A;  1H2Q P;  4JHS A;  4MUC A;  3IX0 A;  1MD8 A;  1TPG A;  3KZJ A;  2YRA A;  4KKD A;  4J38 B;  2ERJ A;  1QUB A;  2EHF A;  1OK1 A;  4CSY A;  1ZJK A;  4LOT A;  3GXE A;  1OK2 A;  4AYE A;  1H04 P;  1UOT P;  2YBY A;  3ERB A;  1Z92 B;  3OP8 A;  4WJG 2;  3GOV A;  1H2P P;  2IZ3 A;  5HYT B; 
#chains in the Genus database with same CATH topology
 2CG7 A;  2WII C;  4IGD A;  1C1Z A;  2JGX A;  2RKY A;  4YIZ A;  1QO6 A;  3M7P A;  1QGB A;  3WSX A;  3KXV A;  3MQL A;  5FO8 C;  2W81 A;  2RL0 A;  3EJH A;  3R62 A;  1Q3X A;  1E8B A;  5HZP B;  2Y8S A;  1G4F A;  1RLH A;  1VVD A;  3FGR A;  1GKN A;  2XWB F;  3K3T A;  4YNX A;  1TPM A;  5DN4 A;  3SW0 X;  3VWO A;  4AYM A;  4AYI A;  3OXU D;  4PZ5 A;  3FGT A;  5DN5 A;  3L89 M;  5JPM G;  3ZRZ A;  2CG6 A;  4N7E A;  1OJW A;  1E88 A;  2CKU A;  1OJV A;  1OJY A;  3CI0 J;  1CKL A;  3RJ3 D;  4ZH1 D;  1SS2 A;  5I0Q B;  3O8E B;  3OED C;  1PPQ A;  1SRZ A;  2IZ4 A;  2RLQ A;  4LOS A;  4DJZ A;  4FXG G;  2XWJ I;  3NFP I;  4ONT D;  2RLP A;  2XRB A;  2BZM A;  5HYU B;  3F6K A;  1NWV A;  2A55 A;  1HFI A;  2ZYC A;  2XQW C;  5HYP A;  1TPN A;  4AYD A;  2Y8R A;  4PO7 A;  1U5M A;  2JRA A;  1GPZ A;  4A5W B;  1HFH A;  1LY2 A;  4B2S A;  4F4O C;  1OK9 A;  3ZD1 A;  2KMS A;  2W80 A;  2V8E A;  1E5G A;  2JGW A;  3NJA A;  1O9A A;  2O39 C;  2B5I D;  2QY0 A;  1H03 P;  4BWC A;  1G4G A;  2Y8T A;  2KRI A;  3CAL A;  3INB C;  4C16 A;  4K12 A;  1GKG A;  1GHQ B;  4APL A;  3ZD2 A;  1OK3 A;  3T5O A;  2I2L A;  2LOJ A;  1VVC A;  2MCY A;  3TVJ A;  1HCC A;  1FBR A;  2MCZ A;  2XRD A;  3IU3 I;  4B2R A;  2EC3 A;  1MD7 A;  2RKZ A;  2UWN A;  4MSL A;  1ELV A;  2G7I A;  1H2Q P;  4JHS A;  4MUC A;  2X2Z A;  3IX0 A;  1MD8 A;  1TPG A;  3KZJ A;  2YRA A;  4KKD A;  3ZLE A;  3WSY A;  4J38 B;  2ERJ A;  1QUB A;  2EHF A;  3ZLD A;  1OK1 A;  4CSY A;  1ZJK A;  4LOT A;  3GXE A;  1OK2 A;  4AYE A;  1H04 P;  1UOT P;  2YBY A;  3ERB A;  1Z92 B;  3OP8 A;  4WJG 2;  3GOV A;  1H2P P;  2IZ3 A;  5HYT B; 
#chains in the Genus database with same CATH homology
 2CG7 A;  2WII C;  4IGD A;  1C1Z A;  2JGX A;  2RKY A;  1QO6 A;  3M7P A;  1QGB A;  3KXV A;  3MQL A;  5FO8 C;  2W81 A;  2RL0 A;  3EJH A;  3R62 A;  1Q3X A;  1E8B A;  5HZP B;  1G4F A;  1GKG A;  1VVD A;  1GKN A;  2XWB F;  4YNX A;  3SW0 X;  1TPM A;  4AYM A;  4AYI A;  3OXU D;  4PZ5 A;  3L89 M;  5JPM G;  3ZRZ A;  2CG6 A;  1OJW A;  1E88 A;  2CKU A;  1OJV A;  1OJY A;  1CKL A;  3RJ3 D;  4ZH1 D;  1SS2 A;  5I0Q B;  3O8E B;  3OED C;  1PPQ A;  1SRZ A;  2IZ4 A;  2RLQ A;  4LOS A;  4DJZ A;  4FXG G;  2XWJ I;  3NFP I;  4ONT D;  2RLP A;  2XRB A;  2BZM A;  5HYU B;  1NWV A;  2A55 A;  1HFI A;  2XQW C;  5HYP A;  1TPN A;  4AYD A;  1U5M A;  2JRA A;  1GPZ A;  4A5W B;  1HFH A;  1LY2 A;  4B2S A;  4F4O C;  1OK9 A;  3ZD1 A;  2KMS A;  2W80 A;  2V8E A;  1E5G A;  2JGW A;  1O9A A;  2O39 C;  2B5I D;  2QY0 A;  1H03 P;  1G4G A;  2KRI A;  3CAL A;  3INB C;  4C16 A;  4K12 A;  1GHQ B;  3ZD2 A;  1OK3 A;  3T5O A;  2LOJ A;  1VVC A;  2MCY A;  3TVJ A;  1HCC A;  1FBR A;  2MCZ A;  2XRD A;  3IU3 I;  4B2R A;  2EC3 A;  1MD7 A;  2RKZ A;  2UWN A;  1ELV A;  2G7I A;  1H2Q P;  4JHS A;  4MUC A;  3IX0 A;  1MD8 A;  1TPG A;  3KZJ A;  2YRA A;  4KKD A;  4J38 B;  2ERJ A;  1QUB A;  2EHF A;  1OK1 A;  4CSY A;  1ZJK A;  4LOT A;  3GXE A;  1OK2 A;  4AYE A;  1H04 P;  1UOT P;  2YBY A;  3ERB A;  1Z92 B;  3OP8 A;  4WJG 2;  3GOV A;  1H2P P;  2IZ3 A;  5HYT B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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