4K71A

Crystal structure of a high affinity human serum albumin variant bound to the neonatal fc receptor
Total Genus 223
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
223
sequence length
583
structure length
583
Chain Sequence
HKSEVAHRFKDLGEENFKALVLIAFAQYLQQCPFEDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTVATLRETYGEMADCCAKQEPERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLFFAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAVARLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLKECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYARRHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFEQLGEYKFQNALLVRYTKKVPQMSAPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVVLNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAGTFTFHADICTLSEKERQIKKQTALVELVKHKPKATKEQLKAAMDDFAAFVEKCCKADDKETCFAEEGKKLVAASQAALGL
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Serum albumin
publication title Crystal structure of an HSA/FcRn complex reveals recycling by competitive mimicry of HSA ligands at a pH-dependent hydrophobic interface.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Lipid transport
total genus 223
structure length 583
sequence length 583
chains with identical sequence D
ec nomenclature
pdb deposition date 2013-04-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00273 Serum_albumin Serum albumin family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 4k71A03
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 4k71A02
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 4k71A04
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 4k71A01
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 4k71A05
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 4k71A06
4L8UA 1BKEA 2VUFA 2BXDA 2XVQA 2BXNA 2BXCA 2XW0A 5IIXA 3JQZA 2BXHA 4JK4A 1E7HA 5HOZA 1KW2A 5IJ5A 1N5UA 4G04A 4Z69A 1KXPD 3V09A 4K2CA 1HA2A 4L9QA 4L9KA 4IW2A 1H9ZA 4G03A 3TDLA 1E7IA 4LA0A 4E99A 1E78A 2BXOA 2I30A 4N0FD 4LB2A 3V08A 1E7GA 5ID9A 4IW1A 5FUOA 2VUEA 4ZBRA 1E7BA 2BXBA 3CX9A 1E7AA 5IIUA 2BXIA 1E7CA 1BJ5A 5IJEA 1E7FA 1MA9A 5GHKA 2BXAA 3LU8A 4F5SA 1GNJA 1TF0A 3UIVA 1HK1A 2BXFA 4EMXA 2XVUA 3LU6A 3B9LA 4OR0A 5IJFA 1HK2A 4ZBQA 1GNIA 4S1YA 3JRYA 5ID7A 4HGMB 4LB9A 1E7EA 4HGKA 2XVWA 3LU7A 4N0UD 2BXMA 2BXQA 4F5VA 2BX8A 4F5UA 2XW1A 3B9MA 4F5TA 2I2ZA 1O9XA 2VDBA 2BXPA 3SQJA 4BKEA 2BXKA 4K71A 1UORA 1HK5A 5IFOA 2XVVA 1HK4A 3A73A 1LOTA 2BXEA 2XSIA 4LUHA 3V03A 1J78A 1J7EA 5IIHA 2BXGA 4J2VA 4PO0A 1AO6A 2YDFA 5DBYA 1HK3A 1BM0A 5DQFA 2BXLA 4LUFA 4OT2A
chains in the Genus database with same CATH superfamily
3KJLA 4L8UA 1BKEA 2LQHA 3NVMA 2VUFA 2BXDA 2XVQA 4ZBKA 1MUSA 2JUHA 2BXNA 2CKXA 3GA9L 4Z9OA 2BXCA 2XW0A 2QM6A 5IIXA 3JQZA 3ICXA 2BXHA 4JK4A 1E7HA 5HOZA 1KW2A 5IJ5A 1N5UA 4G04A 4Z69A 3SIVB 1KXPD 3NMUA 3V09A 3FWCC 1HA2A 4K2CA 4L9QA 4L9KA 1MIVA 4DHXB 4IW2A 4N3ZA 1H9ZA 2GUTA 4G03A 3TDLA 3A75A 4MBEC 1E7IA 4LA0A 4E99A 1E78A 2BXOA 2K0NA 2NQOA 2AJEA 3NVIA 2I30A 4N0FD 4LB2A 3V08A 1E7GA 1NT2B 5ID9A 3GQUA 2Z8IA 1H5WA 4IW1A 5FUOA 2NNWA 2VUEA 4FK5B 4ZBRA 1E7BA 2BXBA 3CX9A 1E7AA 5IIUA 3WHSA 3WHQA 4GDLB 2ROHA 2BXIA 1E7CA 1BJ5A 5IJEA 3SIUB 4I9OA 4OTTA 2V36A 1E7FA 1MA9A 5B5TA 5D7GA 2EFDA 3BPJA 3H37A 5GHKA 3GQXA 5GIOA 2BXAA 1TXUA 3LU8A 4F5SA 2OT3A 1GNJA 3MHHB 1MIYA 1TF0A 2LOQA 3UIVA 5BPKA 3ECPA 4FIPB 3W1SA 1HK1A 2BXFA 4EMXA 2XVUA 3LU6A 3B9LA 3KIKA 3FNMA 1VFIA 4OR0A 4G01A 5IJFA 1HK2A 2Z8JA 4W4UB 1GNIA 4ZBQA 1MM8A 4S1YA 2QHBA 3JRYA 5ID7A 4HGMB 2E0YA 4NAWB 4D7XA 4LB9A 1E7EA 3WHRA 2DYMA 4HGKA 5GIPA 3NVKA 2XVWA 4GDXA 3H3AA 4TQ0A 4DM0A 1FOUA 2LXSA 2QMCA 2LQIA 1VZSA 3LU7A 4N0UD 2EFHA 4TQ1A 4ZCGA 2BXMA 2BXQA 4F5VA 2DBWA 2BX8A 4OTUA 4F5UA 3PLAA 4BY9C 2XW1A 2EFEA 1MUHA 2E0XA 3B9MA 2DG5A 2I2ZA 4F5TA 2DYOA 1O9XA 2VDBA 2BXPA 1SB0A 3SQJA 4BKEA 2OZBB 1KDXA 2BXKA 4K71A 4M70B 3VQIA 1UORA 1HK5A 1JNBA 5IFOA 2XVVA 1HK4A 3A73A 3M99C 3G9KD 1LOTA 4WA6B 2BXEA 2XSIA 4LUHA 3V03A 1J78A 1IJGA 1J7EA 5IIHA 2BXGA 4J2VA 4PO0A 1AO6A 2XMOA 4GDKB 2YDFA 5DBYA 2DBUA 2Z8KA 3MHSB 4FJCB 4GG2A 2LXTA 1LNSA 3FWBC 1HK3A 5GINA 1MIWA 1BM0A 5DQFA 2DBXA 2AGHB 2BXLA 4LUFA 2KWFA 4OT2A 2EFCA 4C31B 4ZC6A 4ZUXV 2KBZA
chains in the Genus database with same CATH topology
3KJLA 4L8UA 1BKEA 3NVMA 2VUFA 2BXDA 2XVQA 4ZBKA 2JUHA 2BXNA 2CKXA 3GA9L 4Z9OA 2BXCA 2XW0A 2QM6A 5IIXA 3JQZA 3ICXA 2BXHA 4JK4A 1E7HA 5HOZA 1KW2A 5IJ5A 1N5UA 4G04A 4Z69A 3SIVB 1KXPD 3NMUA 3V09A 3FWCC 1HA2A 4K2CA 4L9QA 4L9KA 1MIVA 4DHXB 4IW2A 4N3ZA 1H9ZA 4G03A 3TDLA 3A75A 4MBEC 1E7IA 4LA0A 4E99A 1E78A 2BXOA 2NQOA 2AJEA 3NVIA 2I30A 4N0FD 4LB2A 3V08A 1E7GA 1NT2B 5ID9A 3GQUA 2Z8IA 1H5WA 4IW1A 5FUOA 2NNWA 2VUEA 4FK5B 4ZBRA 1E7BA 2BXBA 3CX9A 1E7AA 5IIUA 3WHSA 3WHQA 4GDLB 2ROHA 2BXIA 1E7CA 1BJ5A 5IJEA 3SIUB 4OTTA 2V36A 1E7FA 1MA9A 5B5TA 5D7GA 2EFDA 3H37A 5GHKA 3GQXA 5GIOA 2BXAA 1TXUA 3LU8A 4F5SA 2OT3A 1GNJA 3MHHB 1MIYA 1TF0A 2LOQA 3UIVA 5BPKA 4FIPB 3W1SA 1HK1A 2BXFA 4EMXA 2XVUA 3LU6A 3B9LA 3KIKA 3FNMA 1VFIA 4OR0A 4G01A 5IJFA 1HK2A 2Z8JA 4W4UB 1GNIA 4ZBQA 4S1YA 2QHBA 3JRYA 5ID7A 4HGMB 2E0YA 4NAWB 5GIPA 4LB9A 1E7EA 3WHRA 2DYMA 4HGKA 3NVKA 2XVWA 4GDXA 3H3AA 4TQ0A 1FOUA 2QMCA 1VZSA 3LU7A 4N0UD 2EFHA 4TQ1A 4ZCGA 2BXMA 2BXQA 4F5VA 2DBWA 2BX8A 4OTUA 4F5UA 3PLAA 4BY9C 2XW1A 2EFEA 2E0XA 3B9MA 2DG5A 2I2ZA 4F5TA 2DYOA 1O9XA 2VDBA 2BXPA 2OZBB 3SQJA 4BKEA 2BXKA 4K71A 4M70B 3VQIA 1UORA 1HK5A 1JNBA 5IFOA 2XVVA 1HK4A 3A73A 3M99C 3G9KD 1LOTA 4WA6B 2BXEA 2XSIA 4LUHA 3V03A 1J78A 1IJGA 1J7EA 5IIHA 2BXGA 4J2VA 4PO0A 1AO6A 2XMOA 4GDKB 2YDFA 5DBYA 2DBUA 2Z8KA 3MHSB 4FJCB 4GG2A 3FWBC 1LNSA 5GINA 1HK3A 1MIWA 1BM0A 5DQFA 2DBXA 2BXLA 4LUFA 4OT2A 2EFCA 4C31B 4ZC6A 4ZUXV 2KBZA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4L8U A;  1BKE A;  2VUF A;  2BXD A;  2XVQ A;  2BXN A;  2BXC A;  2XW0 A;  5IIX A;  3JQZ A;  2BXH A;  4JK4 A;  1E7H A;  5HOZ A;  1KW2 A;  5IJ5 A;  1N5U A;  4G04 A;  4Z69 A;  1KXP D;  3V09 A;  4K2C A;  1HA2 A;  4L9Q A;  4L9K A;  4IW2 A;  1H9Z A;  4G03 A;  3TDL A;  1E7I A;  4LA0 A;  4E99 A;  1E78 A;  2BXO A;  2I30 A;  4N0F D;  4LB2 A;  3V08 A;  1E7G A;  5ID9 A;  4IW1 A;  5FUO A;  2VUE A;  4ZBR A;  1E7B A;  2BXB A;  3CX9 A;  1E7A A;  5IIU A;  2BXI A;  1E7C A;  1BJ5 A;  5IJE A;  1E7F A;  1MA9 A;  5GHK A;  2BXA A;  3LU8 A;  4F5S A;  1GNJ A;  1TF0 A;  3UIV A;  1HK1 A;  2BXF A;  4EMX A;  2XVU A;  3LU6 A;  3B9L A;  4OR0 A;  5IJF A;  1HK2 A;  4ZBQ A;  1GNI A;  4S1Y A;  3JRY A;  5ID7 A;  4HGM B;  4LB9 A;  1E7E A;  4HGK A;  2XVW A;  3LU7 A;  4N0U D;  2BXM A;  2BXQ A;  4F5V A;  2BX8 A;  4F5U A;  2XW1 A;  3B9M A;  4F5T A;  2I2Z A;  1O9X A;  2VDB A;  2BXP A;  3SQJ A;  4BKE A;  2BXK A;  4K71 A;  1UOR A;  1HK5 A;  5IFO A;  2XVV A;  1HK4 A;  3A73 A;  1LOT A;  2BXE A;  2XSI A;  4LUH A;  3V03 A;  1J78 A;  1J7E A;  5IIH A;  2BXG A;  4J2V A;  4PO0 A;  1AO6 A;  2YDF A;  5DBY A;  1HK3 A;  1BM0 A;  5DQF A;  2BXL A;  4LUF A;  4OT2 A; 
#chains in the Genus database with same CATH topology
 3KJL A;  4L8U A;  1BKE A;  2LQH A;  3NVM A;  2VUF A;  2BXD A;  2XVQ A;  4ZBK A;  1MUS A;  2JUH A;  2BXN A;  2CKX A;  3GA9 L;  4Z9O A;  2BXC A;  2XW0 A;  2QM6 A;  5IIX A;  3JQZ A;  3ICX A;  2BXH A;  4JK4 A;  1E7H A;  5HOZ A;  1KW2 A;  5IJ5 A;  1N5U A;  4G04 A;  4Z69 A;  3SIV B;  1KXP D;  3NMU A;  3V09 A;  3FWC C;  1HA2 A;  4K2C A;  4L9Q A;  4L9K A;  1MIV A;  4DHX B;  4IW2 A;  4N3Z A;  1H9Z A;  2GUT A;  4G03 A;  3TDL A;  3A75 A;  4MBE C;  1E7I A;  4LA0 A;  4E99 A;  1E78 A;  2BXO A;  2K0N A;  2NQO A;  2AJE A;  3NVI A;  2I30 A;  4N0F D;  4LB2 A;  3V08 A;  1E7G A;  1NT2 B;  5ID9 A;  3GQU A;  2Z8I A;  1H5W A;  4IW1 A;  5FUO A;  2NNW A;  2VUE A;  4FK5 B;  4ZBR A;  1E7B A;  2BXB A;  3CX9 A;  1E7A A;  5IIU A;  3WHS A;  3WHQ A;  4GDL B;  2ROH A;  2BXI A;  1E7C A;  1BJ5 A;  5IJE A;  3SIU B;  4I9O A;  4OTT A;  2V36 A;  1E7F A;  1MA9 A;  5B5T A;  5D7G A;  2EFD A;  3BPJ A;  3H37 A;  5GHK A;  3GQX A;  5GIO A;  2BXA A;  1TXU A;  3LU8 A;  4F5S A;  2OT3 A;  1GNJ A;  3MHH B;  1MIY A;  1TF0 A;  2LOQ A;  3UIV A;  5BPK A;  3ECP A;  4FIP B;  3W1S A;  1HK1 A;  2BXF A;  4EMX A;  2XVU A;  3LU6 A;  3B9L A;  3KIK A;  3FNM A;  1VFI A;  4OR0 A;  4G01 A;  5IJF A;  1HK2 A;  2Z8J A;  4W4U B;  1GNI A;  4ZBQ A;  1MM8 A;  4S1Y A;  2QHB A;  3JRY A;  5ID7 A;  4HGM B;  2E0Y A;  4NAW B;  4D7X A;  4LB9 A;  1E7E A;  3WHR A;  2DYM A;  4HGK A;  5GIP A;  3NVK A;  2XVW A;  4GDX A;  3H3A A;  4TQ0 A;  4DM0 A;  1FOU A;  2LXS A;  2QMC A;  2LQI A;  1VZS A;  3LU7 A;  4N0U D;  2EFH A;  4TQ1 A;  4ZCG A;  2BXM A;  2BXQ A;  4F5V A;  2DBW A;  2BX8 A;  4OTU A;  4F5U A;  3PLA A;  4BY9 C;  2XW1 A;  2EFE A;  1MUH A;  2E0X A;  3B9M A;  2DG5 A;  2I2Z A;  4F5T A;  2DYO A;  1O9X A;  2VDB A;  2BXP A;  1SB0 A;  3SQJ A;  4BKE A;  2OZB B;  1KDX A;  2BXK A;  4K71 A;  4M70 B;  3VQI A;  1UOR A;  1HK5 A;  1JNB A;  5IFO A;  2XVV A;  1HK4 A;  3A73 A;  3M99 C;  3G9K D;  1LOT A;  4WA6 B;  2BXE A;  2XSI A;  4LUH A;  3V03 A;  1J78 A;  1IJG A;  1J7E A;  5IIH A;  2BXG A;  4J2V A;  4PO0 A;  1AO6 A;  2XMO A;  4GDK B;  2YDF A;  5DBY A;  2DBU A;  2Z8K A;  3MHS B;  4FJC B;  4GG2 A;  2LXT A;  1LNS A;  3FWB C;  1HK3 A;  5GIN A;  1MIW A;  1BM0 A;  5DQF A;  2DBX A;  2AGH B;  2BXL A;  4LUF A;  2KWF A;  4OT2 A;  2EFC A;  4C31 B;  4ZC6 A;  4ZUX V;  2KBZ A; 
#chains in the Genus database with same CATH homology
 3KJL A;  4L8U A;  1BKE A;  3NVM A;  2VUF A;  2BXD A;  2XVQ A;  4ZBK A;  2JUH A;  2BXN A;  2CKX A;  3GA9 L;  4Z9O A;  2BXC A;  2XW0 A;  2QM6 A;  5IIX A;  3JQZ A;  3ICX A;  2BXH A;  4JK4 A;  1E7H A;  5HOZ A;  1KW2 A;  5IJ5 A;  1N5U A;  4G04 A;  4Z69 A;  3SIV B;  1KXP D;  3NMU A;  3V09 A;  3FWC C;  1HA2 A;  4K2C A;  4L9Q A;  4L9K A;  1MIV A;  4DHX B;  4IW2 A;  4N3Z A;  1H9Z A;  4G03 A;  3TDL A;  3A75 A;  4MBE C;  1E7I A;  4LA0 A;  4E99 A;  1E78 A;  2BXO A;  2NQO A;  2AJE A;  3NVI A;  2I30 A;  4N0F D;  4LB2 A;  3V08 A;  1E7G A;  1NT2 B;  5ID9 A;  3GQU A;  2Z8I A;  1H5W A;  4IW1 A;  5FUO A;  2NNW A;  2VUE A;  4FK5 B;  4ZBR A;  1E7B A;  2BXB A;  3CX9 A;  1E7A A;  5IIU A;  3WHS A;  3WHQ A;  4GDL B;  2ROH A;  2BXI A;  1E7C A;  1BJ5 A;  5IJE A;  3SIU B;  4OTT A;  2V36 A;  1E7F A;  1MA9 A;  5B5T A;  5D7G A;  2EFD A;  3H37 A;  5GHK A;  3GQX A;  5GIO A;  2BXA A;  1TXU A;  3LU8 A;  4F5S A;  2OT3 A;  1GNJ A;  3MHH B;  1MIY A;  1TF0 A;  2LOQ A;  3UIV A;  5BPK A;  4FIP B;  3W1S A;  1HK1 A;  2BXF A;  4EMX A;  2XVU A;  3LU6 A;  3B9L A;  3KIK A;  3FNM A;  1VFI A;  4OR0 A;  4G01 A;  5IJF A;  1HK2 A;  2Z8J A;  4W4U B;  1GNI A;  4ZBQ A;  4S1Y A;  2QHB A;  3JRY A;  5ID7 A;  4HGM B;  2E0Y A;  4NAW B;  5GIP A;  4LB9 A;  1E7E A;  3WHR A;  2DYM A;  4HGK A;  3NVK A;  2XVW A;  4GDX A;  3H3A A;  4TQ0 A;  1FOU A;  2QMC A;  1VZS A;  3LU7 A;  4N0U D;  2EFH A;  4TQ1 A;  4ZCG A;  2BXM A;  2BXQ A;  4F5V A;  2DBW A;  2BX8 A;  4OTU A;  4F5U A;  3PLA A;  4BY9 C;  2XW1 A;  2EFE A;  2E0X A;  3B9M A;  2DG5 A;  2I2Z A;  4F5T A;  2DYO A;  1O9X A;  2VDB A;  2BXP A;  2OZB B;  3SQJ A;  4BKE A;  2BXK A;  4K71 A;  4M70 B;  3VQI A;  1UOR A;  1HK5 A;  1JNB A;  5IFO A;  2XVV A;  1HK4 A;  3A73 A;  3M99 C;  3G9K D;  1LOT A;  4WA6 B;  2BXE A;  2XSI A;  4LUH A;  3V03 A;  1J78 A;  1IJG A;  1J7E A;  5IIH A;  2BXG A;  4J2V A;  4PO0 A;  1AO6 A;  2XMO A;  4GDK B;  2YDF A;  5DBY A;  2DBU A;  2Z8K A;  3MHS B;  4FJC B;  4GG2 A;  3FWB C;  1LNS A;  5GIN A;  1HK3 A;  1MIW A;  1BM0 A;  5DQF A;  2DBX A;  2BXL A;  4LUF A;  4OT2 A;  2EFC A;  4C31 B;  4ZC6 A;  4ZUX V;  2KBZ A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...