4KEBA

Human dihydrofolate reductase complexed with nadph and 5-{3-[3-methoxy-5-(isoquin-5-yl)phenyl]but-1-yn-1-yl}6-ethylpyrimidine-2,4-diamine
Total Genus 54
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
54
sequence length
186
structure length
186
Chain Sequence
VGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Elucidating features that drive the design of selective antifolates using crystal structures of human dihydrofolate reductase.
pubmed doi rcsb
molecule keywords Dihydrofolate reductase
molecule tags Oxidoreductase/oxidoreductase inhibitor
source organism Homo sapiens
total genus 54
structure length 186
sequence length 186
chains with identical sequence B
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 2013-04-25

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 4kebA00
3GHCA 2JYBA 1OHKA 1RA2A 1RH3A 1RX5A 4FGHA 1DR5A 4ELFA 3JVXA 1IA1A 2OIPA 3NXRA 1S3YA 1RE7A 2BL9A 1AO8A 3FYVX 3SQYX 2C2SA 1DYJA 4H95A 3DGAA 4Q0DA 4QI9A 1DG7A 5HF0X 3SR5X 3SRUX 1J3IA 3F8ZA 1KLKA 1S3VA 4ECKA 1QZFA 2B3ZA 1JOLA 4P3RA 1DDSA 1IA2A 3FQZA 1TDRA 3F0BX 3FYWX 3F0QX 2W9SA 3F0UX 1RX9A 4DPDA 2KGKA 4KJKA 5HI6A 3KJRA 3E0BA 1IA3A 4KJJA 3TQAA 2HM9A 3DRCA 4LAGX 3SGYA 4PTJA 3IRNA 3RG9A 1RC4A 4I13A 4ELGA 3EEKA 3FQOA 3EEMA 3IA4A 1RX2A 3EEJA 5CC9A 1KMSA 1DRBA 2HQPA 3UM8A 4X5FA 1RA1A 4IXFX 1RB2A 5HQYA 4P3QA 4PDJA 1LY4A 2D0KA 1MVSA 3SRSX 4LAEX 1S3UA 4G95A 3KFYA 5U26A 3FY9X 1HFPA 1CZ3A 4DPHA 1LUDA 3S7AA 3FS6A 3QYLA 1M79A 1U70A 3FQCA 1M7AA 3LG4A 1RD7A 3K45A 3JW3A 4ELEA 1DG5A 2FZJA 1ZDRA 3ROAA 5HQZA 1DR4A 4FGGA 4IXGX 3F8YA 3QFXA 4XECX 1DRFA 3ZPGA 4KFJA 2W3BA 3R33A 4HOGA 1PD8A 3N0HA 5HPBA 5HSRA 5HVBA 1VDRA 2W3MA 1J3JA 4M6LA 5DXVA 1DYRA 3M08A 2W9GA 3CD2A 3I8AX 5U27A 2G6VA 4QJZD 4M7UA 4FHBA 1DYHA 3GYFA 5FDAA 3JWCA 3VCOA 4TU5X 1DDRA 4PSSA 1RA8A 3JW5A 3NTZA 3K74A 4OSGA 4EJ1A 2ANOA 3QG2A 3RO9A 3DAUA 4XT7A 3FL8A 4XE6X 1KMVA 3QLXA 3CL9A 3NRRA 4Q0EA 3DATA 5ECXA 3DG8A 4KAKA 4P66A 3JWFA 3FRDX 3QL3A 4DDRA 3SRWX 1RX8A 3I3RA 3UM5A 4KJLA 4Q67A 3FRFX 4KYAA 3OCHA 3GHVA 6DFRA 4DP3A 1U71A 4PSYA 2ZZAA 3EELA 1SEJA 5EAJA 3NZ9X 4ELHA 4HA9A 4HOEA 3JWMA 3S3VA 5HT4A 1DHIA 1DR3A 1MVTA 2INQA 3TQBA 3FL9A 4HOFA 3TQ8A 2W9TA 4KL9A 1DG8A 4I1NA 1DR6A 3NXVA 1DLSA 2QK8A 3F0SX 2HXVA 3HBBA 3TD8A 1BZFA 3TQ9A 1LY3A 3EX8A 3SH2A 1PD9A 4KEBA 4QLFA 4XT5A 4M6KA 3KJSA 2H2QA 3CSEA 3QLYA 4RGCA 4M6JA 1RB3A 3F91A 4QJCA 4EILA 3SA1A 3QLWA 2L28A 3OAFA 1M78A 4GH8A 3IA5A 3QLSA 1RX1A 3NXTA 1DYIA 4XT6A 1RA9A 4X5GA 2W3VA 2CD2A 1VJ3A 1JOMA 2FZIA 4KBNA 4XT4A 3ZPCA 3SRRX 1DRHA 4M7VA 1OHJA 5HT5A 4P68A 1D1GA 3D80A 3QLRA 7DFRA 1S3WA 5ECCA 4PSTA 4X5IA 4EIZA 5DFRA 4KY4A 4DFRA 3INVA 1AOEA 1JUVA 3EIGA 1DREA 4KNEA 3QL0A 1RA3A 3FRBX 1PDBA 3SRQX 2C2TA 2GD9A 1DHJA 3FQVA 3FREX 1RX4A 4IXED 2XW7A 4QLGA 3IROA 3IX9A 4QHVA 4ELBA 4LAHX 2LF1A 1DAJA 4KM0A 4G3MA 4H97A 3GI2A 2FZHA 4XT8A 2DHFA 2W3AA 1DR1A 3IRMA 3K47A 5JA3A 5HF2X 4X5HA 2O7PA 3NU0A 3CLBA 2DRCA 1CD2A 3JWKA 1RG7A 1DRAA 1RF7A 3NZBX 4HA7A 2ITHA 3GHWA 1RX6A 3F0XX 1U72A 1DIUA 8DFRA 3SAIA 5HSUA 3K2HA 3QYOA 4OR7A 1J3KA 1IA4A 3NZCX 1HFRA 1DISA 3DFRA 1DF7A 1DR2A 3DL6A 4H96A 2W3WA 3NXOA 1YHOA 1RX3A 3FY8X 2D5NA 4M2XA 3D84X 3NXYA 3QGTA 4KLXA 3M09A 3L3RA 4EIGA 1DR7A 4LEKX 3S9UA 4NX7A 5E8QA 3QLZA 3Q1HA 5HVEA 4NX6A 4CD2A 4KM2A 5JG0X 2ANQA 4QLEA 2CIGA 4KD7A 3NZDA 1HFQA 3KGYA 1DHFA 1BOZA 3FQFA 3NZ6X 3KY8A 2BLAA 3UM6A 5HUIA 1E26A 4KY8A 1RX7A 3JSUA 2P4GA 3DL5A 3FRAX 3NXXA 3NZAX 4Q6AA 4H98A 2AZNA 4PTHA 2BLBA 3FQ0A 5CCCA 2W9HA 4XRBA 3JTWA 4G8ZX 2OBCA 4X5JA 1AI9A 3SA2A 2BLCA 3F0VX 1DLRA 3HJ3A
chains in the Genus database with same CATH superfamily
3GHCA 2JYBA 1OHKA 1RA2A 1RH3A 1RX5A 4FGHA 1DR5A 4ELFA 3JVXA 1IA1A 2OIPA 3NXRA 1S3YA 1RE7A 2BL9A 1AO8A 3FYVX 3SQYX 2C2SA 1DYJA 4H95A 3DGAA 4Q0DA 4QI9A 1DG7A 5HF0X 3SR5X 3SRUX 1J3IA 3F8ZA 1KLKA 1S3VA 4ECKA 1QZFA 2B3ZA 1JOLA 4P3RA 1DDSA 1IA2A 3FQZA 1TDRA 3F0BX 3FYWX 3F0QX 2W9SA 3F0UX 1RX9A 4DPDA 2KGKA 4KJKA 5HI6A 3KJRA 3E0BA 1IA3A 4KJJA 3TQAA 2HM9A 3DRCA 4LAGX 3SGYA 4PTJA 3IRNA 3RG9A 1RC4A 4I13A 4ELGA 3EEKA 3FQOA 3EEMA 3IA4A 1RX2A 3EEJA 5CC9A 1KMSA 1DRBA 2HQPA 3UM8A 4X5FA 1RA1A 4IXFX 1RB2A 5HQYA 4P3QA 4PDJA 1LY4A 2D0KA 1MVSA 3SRSX 4LAEX 1S3UA 4G95A 3KFYA 5U26A 3FY9X 1HFPA 1CZ3A 4DPHA 1LUDA 3S7AA 3FS6A 3QYLA 1M79A 1U70A 3FQCA 1M7AA 3LG4A 1RD7A 3K45A 3JW3A 4ELEA 1DG5A 2FZJA 1ZDRA 3ROAA 5HQZA 1DR4A 4FGGA 4IXGX 3F8YA 3QFXA 4XECX 1DRFA 3ZPGA 4KFJA 2W3BA 3R33A 4HOGA 1PD8A 3N0HA 5HPBA 5HSRA 5HVBA 1VDRA 2W3MA 1J3JA 4M6LA 5DXVA 1DYRA 3M08A 2W9GA 3CD2A 3I8AX 5U27A 2G6VA 4QJZD 4M7UA 4FHBA 1DYHA 3GYFA 5FDAA 3JWCA 3VCOA 4TU5X 1DDRA 4PSSA 1RA8A 3JW5A 3NTZA 3K74A 4OSGA 4EJ1A 2ANOA 3QG2A 3RO9A 3DAUA 4XT7A 3FL8A 4XE6X 1KMVA 3QLXA 3CL9A 3NRRA 4Q0EA 3DATA 5ECXA 3DG8A 4KAKA 4P66A 3JWFA 3FRDX 3QL3A 4DDRA 3SRWX 1RX8A 3I3RA 3UM5A 4KJLA 4Q67A 3FRFX 4KYAA 3OCHA 3GHVA 6DFRA 4DP3A 1U71A 4PSYA 2ZZAA 3EELA 1SEJA 5EAJA 3NZ9X 4ELHA 4HA9A 4HOEA 3JWMA 3S3VA 5HT4A 1DHIA 1DR3A 1MVTA 2INQA 3TQBA 3FL9A 4HOFA 3TQ8A 2W9TA 4KL9A 1DG8A 4I1NA 1DR6A 3NXVA 1DLSA 2QK8A 3F0SX 2HXVA 3HBBA 3TD8A 1BZFA 3TQ9A 1LY3A 3EX8A 3SH2A 1PD9A 4KEBA 4QLFA 4XT5A 4M6KA 3KJSA 2H2QA 3CSEA 3QLYA 4RGCA 4M6JA 1RB3A 3F91A 4QJCA 4EILA 3SA1A 3QLWA 2L28A 3OAFA 1M78A 4GH8A 3IA5A 3QLSA 1RX1A 3NXTA 1DYIA 4XT6A 1RA9A 4X5GA 2W3VA 2CD2A 1VJ3A 1JOMA 2FZIA 4KBNA 4XT4A 3ZPCA 3SRRX 1DRHA 4M7VA 1OHJA 5HT5A 4P68A 1D1GA 3D80A 3QLRA 7DFRA 1S3WA 5ECCA 4PSTA 4X5IA 4EIZA 5DFRA 4KY4A 4DFRA 3INVA 1AOEA 1JUVA 3EIGA 1DREA 4KNEA 3QL0A 1RA3A 3FRBX 1PDBA 3SRQX 2C2TA 2GD9A 1DHJA 3FQVA 3FREX 1RX4A 4IXED 2XW7A 4QLGA 3IROA 3IX9A 4QHVA 4ELBA 4LAHX 2LF1A 1DAJA 4KM0A 4G3MA 4H97A 3GI2A 2FZHA 4XT8A 2DHFA 2W3AA 1DR1A 3IRMA 3K47A 5JA3A 5HF2X 4X5HA 2O7PA 3NU0A 3CLBA 2DRCA 1CD2A 3JWKA 1RG7A 1DRAA 1RF7A 3NZBX 4HA7A 2ITHA 3GHWA 1RX6A 3F0XX 1U72A 1DIUA 8DFRA 3SAIA 5HSUA 3K2HA 3QYOA 4OR7A 1J3KA 1IA4A 3NZCX 1HFRA 1DISA 3DFRA 1DF7A 1DR2A 3DL6A 4H96A 2W3WA 3NXOA 1YHOA 1RX3A 3FY8X 2D5NA 4M2XA 3D84X 3NXYA 3QGTA 4KLXA 3M09A 3L3RA 4EIGA 1DR7A 4LEKX 3S9UA 4NX7A 5E8QA 3QLZA 3Q1HA 5HVEA 4NX6A 4CD2A 4KM2A 5JG0X 2ANQA 4QLEA 2CIGA 4KD7A 3NZDA 1HFQA 3KGYA 1DHFA 1BOZA 3FQFA 3NZ6X 3KY8A 2BLAA 3UM6A 5HUIA 1E26A 4KY8A 1RX7A 3JSUA 2P4GA 3DL5A 3FRAX 3NXXA 3NZAX 4Q6AA 4H98A 2AZNA 4PTHA 2BLBA 3FQ0A 5CCCA 2W9HA 4XRBA 3JTWA 4G8ZX 2OBCA 4X5JA 1AI9A 3SA2A 2BLCA 3F0VX 1DLRA 3HJ3A
chains in the Genus database with same CATH topology
3GHCA 2JYBA 1OHKA 1RA2A 1RH3A 1RX5A 4FGHA 1DR5A 4ELFA 3JVXA 1IA1A 2OIPA 3NXRA 1S3YA 1RE7A 2BL9A 1AO8A 3FYVX 3SQYX 2C2SA 1DYJA 4H95A 3DGAA 4Q0DA 4QI9A 1DG7A 5HF0X 3SR5X 3SRUX 1J3IA 3F8ZA 1KLKA 1S3VA 4ECKA 1QZFA 2B3ZA 1JOLA 4P3RA 1DDSA 1IA2A 3FQZA 1TDRA 3F0BX 3FYWX 3F0QX 2W9SA 3F0UX 1RX9A 4DPDA 2KGKA 4KJKA 5HI6A 3KJRA 3E0BA 1IA3A 4KJJA 3TQAA 2HM9A 3DRCA 4LAGX 3SGYA 4PTJA 3IRNA 3RG9A 1RC4A 4I13A 4ELGA 3EEKA 3FQOA 3EEMA 3IA4A 1RX2A 3EEJA 5CC9A 1KMSA 1DRBA 2HQPA 3UM8A 4X5FA 1RA1A 4IXFX 1RB2A 5HQYA 4P3QA 4PDJA 1LY4A 2D0KA 1MVSA 3SRSX 4LAEX 1S3UA 4G95A 3KFYA 5U26A 3FY9X 1HFPA 1CZ3A 4DPHA 1LUDA 3S7AA 3FS6A 3QYLA 1M79A 1U70A 3FQCA 1M7AA 3LG4A 1RD7A 3K45A 3JW3A 4ELEA 1DG5A 2FZJA 1ZDRA 3ROAA 5HQZA 1DR4A 4FGGA 4IXGX 3F8YA 3QFXA 4XECX 1DRFA 3ZPGA 4KFJA 2W3BA 3R33A 4HOGA 1PD8A 3N0HA 5HPBA 5HSRA 5HVBA 1VDRA 2W3MA 1J3JA 4M6LA 5DXVA 1DYRA 3M08A 2W9GA 3CD2A 3I8AX 5U27A 2G6VA 4QJZD 4M7UA 4FHBA 1DYHA 3GYFA 5FDAA 3JWCA 3VCOA 4TU5X 1DDRA 4PSSA 1RA8A 3JW5A 3NTZA 3K74A 4OSGA 4EJ1A 2ANOA 3QG2A 3RO9A 3DAUA 4XT7A 3FL8A 4XE6X 1KMVA 3QLXA 3CL9A 3NRRA 4Q0EA 3DATA 5ECXA 3DG8A 4KAKA 4P66A 3JWFA 3FRDX 3QL3A 4DDRA 3SRWX 1RX8A 3I3RA 3UM5A 4KJLA 4Q67A 3FRFX 4KYAA 3OCHA 3GHVA 6DFRA 4DP3A 1U71A 4PSYA 2ZZAA 3EELA 1SEJA 5EAJA 3NZ9X 4ELHA 4HA9A 4HOEA 3JWMA 3S3VA 5HT4A 1DHIA 1DR3A 1MVTA 2INQA 3TQBA 3FL9A 4HOFA 3TQ8A 2W9TA 4KL9A 1DG8A 4I1NA 1DR6A 3NXVA 1DLSA 2QK8A 3F0SX 2HXVA 3HBBA 3TD8A 1BZFA 3TQ9A 1LY3A 3EX8A 3SH2A 1PD9A 4KEBA 4QLFA 4XT5A 4M6KA 3KJSA 2H2QA 3CSEA 3QLYA 4RGCA 4M6JA 1RB3A 3F91A 4QJCA 4EILA 3SA1A 3QLWA 2L28A 3OAFA 1M78A 4GH8A 3IA5A 3QLSA 1RX1A 3NXTA 1DYIA 4XT6A 1RA9A 4X5GA 2W3VA 2CD2A 1VJ3A 1JOMA 2FZIA 4KBNA 4XT4A 3ZPCA 3SRRX 1DRHA 4M7VA 1OHJA 5HT5A 4P68A 1D1GA 3D80A 3QLRA 7DFRA 1S3WA 5ECCA 4PSTA 4X5IA 4EIZA 5DFRA 4KY4A 4DFRA 3INVA 1AOEA 1JUVA 3EIGA 1DREA 4KNEA 3QL0A 1RA3A 3FRBX 1PDBA 3SRQX 2C2TA 2GD9A 1DHJA 3FQVA 3FREX 1RX4A 4IXED 2XW7A 4QLGA 3IROA 3IX9A 4QHVA 4ELBA 4LAHX 2LF1A 1DAJA 4KM0A 4G3MA 4H97A 3GI2A 2FZHA 4XT8A 2DHFA 2W3AA 1DR1A 3IRMA 3K47A 5JA3A 5HF2X 4X5HA 2O7PA 3NU0A 3CLBA 2DRCA 1CD2A 3JWKA 1RG7A 1DRAA 1RF7A 3NZBX 4HA7A 2ITHA 3GHWA 1RX6A 3F0XX 1U72A 1DIUA 8DFRA 3SAIA 5HSUA 3K2HA 3QYOA 4OR7A 1J3KA 1IA4A 3NZCX 1HFRA 1DISA 3DFRA 1DF7A 1DR2A 3DL6A 4H96A 2W3WA 3NXOA 1YHOA 1RX3A 3FY8X 2D5NA 4M2XA 3D84X 3NXYA 3QGTA 4KLXA 3M09A 3L3RA 4EIGA 1DR7A 4LEKX 3S9UA 4NX7A 5E8QA 3QLZA 3Q1HA 5HVEA 4NX6A 4CD2A 4KM2A 5JG0X 2ANQA 4QLEA 2CIGA 4KD7A 3NZDA 1HFQA 3KGYA 1DHFA 1BOZA 3FQFA 3NZ6X 3KY8A 2BLAA 3UM6A 5HUIA 1E26A 4KY8A 1RX7A 3JSUA 2P4GA 3DL5A 3FRAX 3NXXA 3NZAX 4Q6AA 4H98A 2AZNA 4PTHA 2BLBA 3FQ0A 5CCCA 2W9HA 4XRBA 3JTWA 4G8ZX 2OBCA 4X5JA 1AI9A 3SA2A 2BLCA 3F0VX 1DLRA 3HJ3A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3GHC A;  2JYB A;  1OHK A;  1RA2 A;  1RH3 A;  1RX5 A;  4FGH A;  1DR5 A;  4ELF A;  3JVX A;  1IA1 A;  2OIP A;  3NXR A;  1S3Y A;  1RE7 A;  2BL9 A;  1AO8 A;  3FYV X;  3SQY X;  2C2S A;  1DYJ A;  4H95 A;  3DGA A;  4Q0D A;  4QI9 A;  1DG7 A;  5HF0 X;  3SR5 X;  3SRU X;  1J3I A;  3F8Z A;  1KLK A;  1S3V A;  4ECK A;  1QZF A;  2B3Z A;  1JOL A;  4P3R A;  1DDS A;  1IA2 A;  3FQZ A;  1TDR A;  3F0B X;  3FYW X;  3F0Q X;  2W9S A;  3F0U X;  1RX9 A;  4DPD A;  2KGK A;  4KJK A;  5HI6 A;  3KJR A;  3E0B A;  1IA3 A;  4KJJ A;  3TQA A;  2HM9 A;  3DRC A;  4LAG X;  3SGY A;  4PTJ A;  3IRN A;  3RG9 A;  1RC4 A;  4I13 A;  4ELG A;  3EEK A;  3FQO A;  3EEM A;  3IA4 A;  1RX2 A;  3EEJ A;  5CC9 A;  1KMS A;  1DRB A;  2HQP A;  3UM8 A;  4X5F A;  1RA1 A;  4IXF X;  1RB2 A;  5HQY A;  4P3Q A;  4PDJ A;  1LY4 A;  2D0K A;  1MVS A;  3SRS X;  4LAE X;  1S3U A;  4G95 A;  3KFY A;  5U26 A;  3FY9 X;  1HFP A;  1CZ3 A;  4DPH A;  1LUD A;  3S7A A;  3FS6 A;  3QYL A;  1M79 A;  1U70 A;  3FQC A;  1M7A A;  3LG4 A;  1RD7 A;  3K45 A;  3JW3 A;  4ELE A;  1DG5 A;  2FZJ A;  1ZDR A;  3ROA A;  5HQZ A;  1DR4 A;  4FGG A;  4IXG X;  3F8Y A;  3QFX A;  4XEC X;  1DRF A;  3ZPG A;  4KFJ A;  2W3B A;  3R33 A;  4HOG A;  1PD8 A;  3N0H A;  5HPB A;  5HSR A;  5HVB A;  1VDR A;  2W3M A;  1J3J A;  4M6L A;  5DXV A;  1DYR A;  3M08 A;  2W9G A;  3CD2 A;  3I8A X;  5U27 A;  2G6V A;  4QJZ D;  4M7U A;  4FHB A;  1DYH A;  3GYF A;  5FDA A;  3JWC A;  3VCO A;  4TU5 X;  1DDR A;  4PSS A;  1RA8 A;  3JW5 A;  3NTZ A;  3K74 A;  4OSG A;  4EJ1 A;  2ANO A;  3QG2 A;  3RO9 A;  3DAU A;  4XT7 A;  3FL8 A;  4XE6 X;  1KMV A;  3QLX A;  3CL9 A;  3NRR A;  4Q0E A;  3DAT A;  5ECX A;  3DG8 A;  4KAK A;  4P66 A;  3JWF A;  3FRD X;  3QL3 A;  4DDR A;  3SRW X;  1RX8 A;  3I3R A;  3UM5 A;  4KJL A;  4Q67 A;  3FRF X;  4KYA A;  3OCH A;  3GHV A;  6DFR A;  4DP3 A;  1U71 A;  4PSY A;  2ZZA A;  3EEL A;  1SEJ A;  5EAJ A;  3NZ9 X;  4ELH A;  4HA9 A;  4HOE A;  3JWM A;  3S3V A;  5HT4 A;  1DHI A;  1DR3 A;  1MVT A;  2INQ A;  3TQB A;  3FL9 A;  4HOF A;  3TQ8 A;  2W9T A;  4KL9 A;  1DG8 A;  4I1N A;  1DR6 A;  3NXV A;  1DLS A;  2QK8 A;  3F0S X;  2HXV A;  3HBB A;  3TD8 A;  1BZF A;  3TQ9 A;  1LY3 A;  3EX8 A;  3SH2 A;  1PD9 A;  4KEB A;  4QLF A;  4XT5 A;  4M6K A;  3KJS A;  2H2Q A;  3CSE A;  3QLY A;  4RGC A;  4M6J A;  1RB3 A;  3F91 A;  4QJC A;  4EIL A;  3SA1 A;  3QLW A;  2L28 A;  3OAF A;  1M78 A;  4GH8 A;  3IA5 A;  3QLS A;  1RX1 A;  3NXT A;  1DYI A;  4XT6 A;  1RA9 A;  4X5G A;  2W3V A;  2CD2 A;  1VJ3 A;  1JOM A;  2FZI A;  4KBN A;  4XT4 A;  3ZPC A;  3SRR X;  1DRH A;  4M7V A;  1OHJ A;  5HT5 A;  4P68 A;  1D1G A;  3D80 A;  3QLR A;  7DFR A;  1S3W A;  5ECC A;  4PST A;  4X5I A;  4EIZ A;  5DFR A;  4KY4 A;  4DFR A;  3INV A;  1AOE A;  1JUV A;  3EIG A;  1DRE A;  4KNE A;  3QL0 A;  1RA3 A;  3FRB X;  1PDB A;  3SRQ X;  2C2T A;  2GD9 A;  1DHJ A;  3FQV A;  3FRE X;  1RX4 A;  4IXE D;  2XW7 A;  4QLG A;  3IRO A;  3IX9 A;  4QHV A;  4ELB A;  4LAH X;  2LF1 A;  1DAJ A;  4KM0 A;  4G3M A;  4H97 A;  3GI2 A;  2FZH A;  4XT8 A;  2DHF A;  2W3A A;  1DR1 A;  3IRM A;  3K47 A;  5JA3 A;  5HF2 X;  4X5H A;  2O7P A;  3NU0 A;  3CLB A;  2DRC A;  1CD2 A;  3JWK A;  1RG7 A;  1DRA A;  1RF7 A;  3NZB X;  4HA7 A;  2ITH A;  3GHW A;  1RX6 A;  3F0X X;  1U72 A;  1DIU A;  8DFR A;  3SAI A;  5HSU A;  3K2H A;  3QYO A;  4OR7 A;  1J3K A;  1IA4 A;  3NZC X;  1HFR A;  1DIS A;  3DFR A;  1DF7 A;  1DR2 A;  3DL6 A;  4H96 A;  2W3W A;  3NXO A;  1YHO A;  1RX3 A;  3FY8 X;  2D5N A;  4M2X A;  3D84 X;  3NXY A;  3QGT A;  4KLX A;  3M09 A;  3L3R A;  4EIG A;  1DR7 A;  4LEK X;  3S9U A;  4NX7 A;  5E8Q A;  3QLZ A;  3Q1H A;  5HVE A;  4NX6 A;  4CD2 A;  4KM2 A;  5JG0 X;  2ANQ A;  4QLE A;  2CIG A;  4KD7 A;  3NZD A;  1HFQ A;  3KGY A;  1DHF A;  1BOZ A;  3FQF A;  3NZ6 X;  3KY8 A;  2BLA A;  3UM6 A;  5HUI A;  1E26 A;  4KY8 A;  1RX7 A;  3JSU A;  2P4G A;  3DL5 A;  3FRA X;  3NXX A;  3NZA X;  4Q6A A;  4H98 A;  2AZN A;  4PTH A;  2BLB A;  3FQ0 A;  5CCC A;  2W9H A;  4XRB A;  3JTW A;  4G8Z X;  2OBC A;  4X5J A;  1AI9 A;  3SA2 A;  2BLC A;  3F0V X;  1DLR A;  3HJ3 A; 
#chains in the Genus database with same CATH topology
 3GHC A;  2JYB A;  1OHK A;  1RA2 A;  1RH3 A;  1RX5 A;  4FGH A;  1DR5 A;  4ELF A;  3JVX A;  1IA1 A;  2OIP A;  3NXR A;  1S3Y A;  1RE7 A;  2BL9 A;  1AO8 A;  3FYV X;  3SQY X;  2C2S A;  1DYJ A;  4H95 A;  3DGA A;  4Q0D A;  4QI9 A;  1DG7 A;  5HF0 X;  3SR5 X;  3SRU X;  1J3I A;  3F8Z A;  1KLK A;  1S3V A;  4ECK A;  1QZF A;  2B3Z A;  1JOL A;  4P3R A;  1DDS A;  1IA2 A;  3FQZ A;  1TDR A;  3F0B X;  3FYW X;  3F0Q X;  2W9S A;  3F0U X;  1RX9 A;  4DPD A;  2KGK A;  4KJK A;  5HI6 A;  3KJR A;  3E0B A;  1IA3 A;  4KJJ A;  3TQA A;  2HM9 A;  3DRC A;  4LAG X;  3SGY A;  4PTJ A;  3IRN A;  3RG9 A;  1RC4 A;  4I13 A;  4ELG A;  3EEK A;  3FQO A;  3EEM A;  3IA4 A;  1RX2 A;  3EEJ A;  5CC9 A;  1KMS A;  1DRB A;  2HQP A;  3UM8 A;  4X5F A;  1RA1 A;  4IXF X;  1RB2 A;  5HQY A;  4P3Q A;  4PDJ A;  1LY4 A;  2D0K A;  1MVS A;  3SRS X;  4LAE X;  1S3U A;  4G95 A;  3KFY A;  5U26 A;  3FY9 X;  1HFP A;  1CZ3 A;  4DPH A;  1LUD A;  3S7A A;  3FS6 A;  3QYL A;  1M79 A;  1U70 A;  3FQC A;  1M7A A;  3LG4 A;  1RD7 A;  3K45 A;  3JW3 A;  4ELE A;  1DG5 A;  2FZJ A;  1ZDR A;  3ROA A;  5HQZ A;  1DR4 A;  4FGG A;  4IXG X;  3F8Y A;  3QFX A;  4XEC X;  1DRF A;  3ZPG A;  4KFJ A;  2W3B A;  3R33 A;  4HOG A;  1PD8 A;  3N0H A;  5HPB A;  5HSR A;  5HVB A;  1VDR A;  2W3M A;  1J3J A;  4M6L A;  5DXV A;  1DYR A;  3M08 A;  2W9G A;  3CD2 A;  3I8A X;  5U27 A;  2G6V A;  4QJZ D;  4M7U A;  4FHB A;  1DYH A;  3GYF A;  5FDA A;  3JWC A;  3VCO A;  4TU5 X;  1DDR A;  4PSS A;  1RA8 A;  3JW5 A;  3NTZ A;  3K74 A;  4OSG A;  4EJ1 A;  2ANO A;  3QG2 A;  3RO9 A;  3DAU A;  4XT7 A;  3FL8 A;  4XE6 X;  1KMV A;  3QLX A;  3CL9 A;  3NRR A;  4Q0E A;  3DAT A;  5ECX A;  3DG8 A;  4KAK A;  4P66 A;  3JWF A;  3FRD X;  3QL3 A;  4DDR A;  3SRW X;  1RX8 A;  3I3R A;  3UM5 A;  4KJL A;  4Q67 A;  3FRF X;  4KYA A;  3OCH A;  3GHV A;  6DFR A;  4DP3 A;  1U71 A;  4PSY A;  2ZZA A;  3EEL A;  1SEJ A;  5EAJ A;  3NZ9 X;  4ELH A;  4HA9 A;  4HOE A;  3JWM A;  3S3V A;  5HT4 A;  1DHI A;  1DR3 A;  1MVT A;  2INQ A;  3TQB A;  3FL9 A;  4HOF A;  3TQ8 A;  2W9T A;  4KL9 A;  1DG8 A;  4I1N A;  1DR6 A;  3NXV A;  1DLS A;  2QK8 A;  3F0S X;  2HXV A;  3HBB A;  3TD8 A;  1BZF A;  3TQ9 A;  1LY3 A;  3EX8 A;  3SH2 A;  1PD9 A;  4KEB A;  4QLF A;  4XT5 A;  4M6K A;  3KJS A;  2H2Q A;  3CSE A;  3QLY A;  4RGC A;  4M6J A;  1RB3 A;  3F91 A;  4QJC A;  4EIL A;  3SA1 A;  3QLW A;  2L28 A;  3OAF A;  1M78 A;  4GH8 A;  3IA5 A;  3QLS A;  1RX1 A;  3NXT A;  1DYI A;  4XT6 A;  1RA9 A;  4X5G A;  2W3V A;  2CD2 A;  1VJ3 A;  1JOM A;  2FZI A;  4KBN A;  4XT4 A;  3ZPC A;  3SRR X;  1DRH A;  4M7V A;  1OHJ A;  5HT5 A;  4P68 A;  1D1G A;  3D80 A;  3QLR A;  7DFR A;  1S3W A;  5ECC A;  4PST A;  4X5I A;  4EIZ A;  5DFR A;  4KY4 A;  4DFR A;  3INV A;  1AOE A;  1JUV A;  3EIG A;  1DRE A;  4KNE A;  3QL0 A;  1RA3 A;  3FRB X;  1PDB A;  3SRQ X;  2C2T A;  2GD9 A;  1DHJ A;  3FQV A;  3FRE X;  1RX4 A;  4IXE D;  2XW7 A;  4QLG A;  3IRO A;  3IX9 A;  4QHV A;  4ELB A;  4LAH X;  2LF1 A;  1DAJ A;  4KM0 A;  4G3M A;  4H97 A;  3GI2 A;  2FZH A;  4XT8 A;  2DHF A;  2W3A A;  1DR1 A;  3IRM A;  3K47 A;  5JA3 A;  5HF2 X;  4X5H A;  2O7P A;  3NU0 A;  3CLB A;  2DRC A;  1CD2 A;  3JWK A;  1RG7 A;  1DRA A;  1RF7 A;  3NZB X;  4HA7 A;  2ITH A;  3GHW A;  1RX6 A;  3F0X X;  1U72 A;  1DIU A;  8DFR A;  3SAI A;  5HSU A;  3K2H A;  3QYO A;  4OR7 A;  1J3K A;  1IA4 A;  3NZC X;  1HFR A;  1DIS A;  3DFR A;  1DF7 A;  1DR2 A;  3DL6 A;  4H96 A;  2W3W A;  3NXO A;  1YHO A;  1RX3 A;  3FY8 X;  2D5N A;  4M2X A;  3D84 X;  3NXY A;  3QGT A;  4KLX A;  3M09 A;  3L3R A;  4EIG A;  1DR7 A;  4LEK X;  3S9U A;  4NX7 A;  5E8Q A;  3QLZ A;  3Q1H A;  5HVE A;  4NX6 A;  4CD2 A;  4KM2 A;  5JG0 X;  2ANQ A;  4QLE A;  2CIG A;  4KD7 A;  3NZD A;  1HFQ A;  3KGY A;  1DHF A;  1BOZ A;  3FQF A;  3NZ6 X;  3KY8 A;  2BLA A;  3UM6 A;  5HUI A;  1E26 A;  4KY8 A;  1RX7 A;  3JSU A;  2P4G A;  3DL5 A;  3FRA X;  3NXX A;  3NZA X;  4Q6A A;  4H98 A;  2AZN A;  4PTH A;  2BLB A;  3FQ0 A;  5CCC A;  2W9H A;  4XRB A;  3JTW A;  4G8Z X;  2OBC A;  4X5J A;  1AI9 A;  3SA2 A;  2BLC A;  3F0V X;  1DLR A;  3HJ3 A; 
#chains in the Genus database with same CATH homology
 3GHC A;  2JYB A;  1OHK A;  1RA2 A;  1RH3 A;  1RX5 A;  4FGH A;  1DR5 A;  4ELF A;  3JVX A;  1IA1 A;  2OIP A;  3NXR A;  1S3Y A;  1RE7 A;  2BL9 A;  1AO8 A;  3FYV X;  3SQY X;  2C2S A;  1DYJ A;  4H95 A;  3DGA A;  4Q0D A;  4QI9 A;  1DG7 A;  5HF0 X;  3SR5 X;  3SRU X;  1J3I A;  3F8Z A;  1KLK A;  1S3V A;  4ECK A;  1QZF A;  2B3Z A;  1JOL A;  4P3R A;  1DDS A;  1IA2 A;  3FQZ A;  1TDR A;  3F0B X;  3FYW X;  3F0Q X;  2W9S A;  3F0U X;  1RX9 A;  4DPD A;  2KGK A;  4KJK A;  5HI6 A;  3KJR A;  3E0B A;  1IA3 A;  4KJJ A;  3TQA A;  2HM9 A;  3DRC A;  4LAG X;  3SGY A;  4PTJ A;  3IRN A;  3RG9 A;  1RC4 A;  4I13 A;  4ELG A;  3EEK A;  3FQO A;  3EEM A;  3IA4 A;  1RX2 A;  3EEJ A;  5CC9 A;  1KMS A;  1DRB A;  2HQP A;  3UM8 A;  4X5F A;  1RA1 A;  4IXF X;  1RB2 A;  5HQY A;  4P3Q A;  4PDJ A;  1LY4 A;  2D0K A;  1MVS A;  3SRS X;  4LAE X;  1S3U A;  4G95 A;  3KFY A;  5U26 A;  3FY9 X;  1HFP A;  1CZ3 A;  4DPH A;  1LUD A;  3S7A A;  3FS6 A;  3QYL A;  1M79 A;  1U70 A;  3FQC A;  1M7A A;  3LG4 A;  1RD7 A;  3K45 A;  3JW3 A;  4ELE A;  1DG5 A;  2FZJ A;  1ZDR A;  3ROA A;  5HQZ A;  1DR4 A;  4FGG A;  4IXG X;  3F8Y A;  3QFX A;  4XEC X;  1DRF A;  3ZPG A;  4KFJ A;  2W3B A;  3R33 A;  4HOG A;  1PD8 A;  3N0H A;  5HPB A;  5HSR A;  5HVB A;  1VDR A;  2W3M A;  1J3J A;  4M6L A;  5DXV A;  1DYR A;  3M08 A;  2W9G A;  3CD2 A;  3I8A X;  5U27 A;  2G6V A;  4QJZ D;  4M7U A;  4FHB A;  1DYH A;  3GYF A;  5FDA A;  3JWC A;  3VCO A;  4TU5 X;  1DDR A;  4PSS A;  1RA8 A;  3JW5 A;  3NTZ A;  3K74 A;  4OSG A;  4EJ1 A;  2ANO A;  3QG2 A;  3RO9 A;  3DAU A;  4XT7 A;  3FL8 A;  4XE6 X;  1KMV A;  3QLX A;  3CL9 A;  3NRR A;  4Q0E A;  3DAT A;  5ECX A;  3DG8 A;  4KAK A;  4P66 A;  3JWF A;  3FRD X;  3QL3 A;  4DDR A;  3SRW X;  1RX8 A;  3I3R A;  3UM5 A;  4KJL A;  4Q67 A;  3FRF X;  4KYA A;  3OCH A;  3GHV A;  6DFR A;  4DP3 A;  1U71 A;  4PSY A;  2ZZA A;  3EEL A;  1SEJ A;  5EAJ A;  3NZ9 X;  4ELH A;  4HA9 A;  4HOE A;  3JWM A;  3S3V A;  5HT4 A;  1DHI A;  1DR3 A;  1MVT A;  2INQ A;  3TQB A;  3FL9 A;  4HOF A;  3TQ8 A;  2W9T A;  4KL9 A;  1DG8 A;  4I1N A;  1DR6 A;  3NXV A;  1DLS A;  2QK8 A;  3F0S X;  2HXV A;  3HBB A;  3TD8 A;  1BZF A;  3TQ9 A;  1LY3 A;  3EX8 A;  3SH2 A;  1PD9 A;  4KEB A;  4QLF A;  4XT5 A;  4M6K A;  3KJS A;  2H2Q A;  3CSE A;  3QLY A;  4RGC A;  4M6J A;  1RB3 A;  3F91 A;  4QJC A;  4EIL A;  3SA1 A;  3QLW A;  2L28 A;  3OAF A;  1M78 A;  4GH8 A;  3IA5 A;  3QLS A;  1RX1 A;  3NXT A;  1DYI A;  4XT6 A;  1RA9 A;  4X5G A;  2W3V A;  2CD2 A;  1VJ3 A;  1JOM A;  2FZI A;  4KBN A;  4XT4 A;  3ZPC A;  3SRR X;  1DRH A;  4M7V A;  1OHJ A;  5HT5 A;  4P68 A;  1D1G A;  3D80 A;  3QLR A;  7DFR A;  1S3W A;  5ECC A;  4PST A;  4X5I A;  4EIZ A;  5DFR A;  4KY4 A;  4DFR A;  3INV A;  1AOE A;  1JUV A;  3EIG A;  1DRE A;  4KNE A;  3QL0 A;  1RA3 A;  3FRB X;  1PDB A;  3SRQ X;  2C2T A;  2GD9 A;  1DHJ A;  3FQV A;  3FRE X;  1RX4 A;  4IXE D;  2XW7 A;  4QLG A;  3IRO A;  3IX9 A;  4QHV A;  4ELB A;  4LAH X;  2LF1 A;  1DAJ A;  4KM0 A;  4G3M A;  4H97 A;  3GI2 A;  2FZH A;  4XT8 A;  2DHF A;  2W3A A;  1DR1 A;  3IRM A;  3K47 A;  5JA3 A;  5HF2 X;  4X5H A;  2O7P A;  3NU0 A;  3CLB A;  2DRC A;  1CD2 A;  3JWK A;  1RG7 A;  1DRA A;  1RF7 A;  3NZB X;  4HA7 A;  2ITH A;  3GHW A;  1RX6 A;  3F0X X;  1U72 A;  1DIU A;  8DFR A;  3SAI A;  5HSU A;  3K2H A;  3QYO A;  4OR7 A;  1J3K A;  1IA4 A;  3NZC X;  1HFR A;  1DIS A;  3DFR A;  1DF7 A;  1DR2 A;  3DL6 A;  4H96 A;  2W3W A;  3NXO A;  1YHO A;  1RX3 A;  3FY8 X;  2D5N A;  4M2X A;  3D84 X;  3NXY A;  3QGT A;  4KLX A;  3M09 A;  3L3R A;  4EIG A;  1DR7 A;  4LEK X;  3S9U A;  4NX7 A;  5E8Q A;  3QLZ A;  3Q1H A;  5HVE A;  4NX6 A;  4CD2 A;  4KM2 A;  5JG0 X;  2ANQ A;  4QLE A;  2CIG A;  4KD7 A;  3NZD A;  1HFQ A;  3KGY A;  1DHF A;  1BOZ A;  3FQF A;  3NZ6 X;  3KY8 A;  2BLA A;  3UM6 A;  5HUI A;  1E26 A;  4KY8 A;  1RX7 A;  3JSU A;  2P4G A;  3DL5 A;  3FRA X;  3NXX A;  3NZA X;  4Q6A A;  4H98 A;  2AZN A;  4PTH A;  2BLB A;  3FQ0 A;  5CCC A;  2W9H A;  4XRB A;  3JTW A;  4G8Z X;  2OBC A;  4X5J A;  1AI9 A;  3SA2 A;  2BLC A;  3F0V X;  1DLR A;  3HJ3 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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