4KM4A

E. coli alkaline phosphatase mutant s102g/r166s in complex with inorganic phosphate
Total Genus 167
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
167
Knots found
sequence length
445
structure length
445
Chain Sequence
MPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDGAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSSKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Ground state destabilization by anionic nucleophiles contributes to the activity of phosphoryl transfer enzymes.
pubmed doi rcsb
source organism Escherichia coli
molecule tags Hydrolase
molecule keywords Alkaline phosphatase
total genus 167
structure length 445
sequence length 445
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2013-05-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 4km4A00
2ZKTA 4LRDA 3SZZA 3BDGA 3UN5A 3MK1A 3T02A 1AJDA 3BDGB 3E2DA 4LRBA 4KJDA 1ANIA 5LIAA 5LQQA 1ALKA 4NWXA 2G9YA 2W8DA 4LRFA 4UPIA 1E1ZP 5L0EA 1AJCA 3LXQA 3WBHA 4UOPA 4KM4A 3NKRA 5TJ3A 3KD8A 2RH6A 3IGZB 4LR2A 5L0BA 1O99A 2GLQA 2W5VA 4LRCA 4CXUA 1ELZA 4CXKA 1B8JA 1Y7AA 3ED4A 2D1GA 1KH9A 5GOVA 1ELXA 3NVLA 1E33P 5KXAA 1ALHA 3UN3A 3WAYA 1E3CP 1E2SP 1ZEBA 5GRRA 3NKMA 1HDHA 3TX0A 4LR8A 2ANHA 2QZUA 3WAXA 5DLTA 2W5XA 4LQYA 1ELYA 1URBA 5K4PA 3NKNA 4B56A 2GA3A 2GSUA 1EW2A 1KHJA 3DYCA 4N7TA 1URAA 3NKPA 3UO0A 1KHNA 1HQAA 1SHQA 5DLWA 4FDIA 4LR7A 1ALIA 1P49A 3M8WA 4KAVA 4GTWA 5LRMA 4NWJA 2W8SA 3DPCA 4LR9A 4UPKA 3IDDA 4TN0A 1EQJA 4UPHA 2GSNA 4MHXA 4UPLA 4GTZA 5LRNA 4ZGAA 2W5RA 1KHKA 4CYRA 4KJGA 1FSUA 3UN2A 3SZYA 1ED9A 1O98A 4UORA 1HJKA 2IUCB 1ED8A 3UNYA 4CXSA 3TG0A 3WAVA 4KAYA 4LRAA 4CYSA 2IFYA 4ZG9A 3BDFA 5EGEA 4LREA 5DLVA 4ZG6A 2XRGA 1KH4A 3A52A 3NKOA 3B5QA 3TWZA 1AJAA 1AUKA 1N2KA 2W5WA 3OT9A 1ZEDA 1EW8A 4FDJA 5INHA 1N2LA 1KHLA 1EW9A 4MY4A 1ZEFA 3CMRA 2GSOA 4MIVA 3M8ZA 3WAWA 1SHNA 1EJJA 3MK0A 4UOOA 5HRTA 2VQRA 3Q3QA 1ALJA 1ANJA 2X98A 3NKQA 1Y6VA 2W5SA 3BDHA 1K7HA 1EI6A 2IUCA 2W5TA 5IJQA 1KH5A 4GTYA 1KH7A 3T00A 4ZG7A 3T01A 2XR9A 4GTXA 4QAXA 5AJ9A 2W5QA 3IGYB 5IJSA 1AJBA 3MK2A 3M7VA 5C66A 5EGHA 5L0KA 4YR1A 3M8YA
chains in the Genus database with same CATH superfamily
2ZKTA 4LRDA 3SZZA 3BDGA 3UN5A 3MK1A 3T02A 1AJDA 3BDGB 3E2DA 4LRBA 4KJDA 1ANIA 5LIAA 5LQQA 1ALKA 4NWXA 2G9YA 2W8DA 4LRFA 4UPIA 1E1ZP 5L0EA 1AJCA 3LXQA 3WBHA 4UOPA 4KM4A 3NKRA 5TJ3A 3KD8A 2RH6A 3IGZB 4LR2A 5L0BA 1O99A 2GLQA 2W5VA 4LRCA 4CXUA 1ELZA 4CXKA 1B8JA 1Y7AA 3ED4A 2D1GA 1KH9A 5GOVA 1ELXA 3NVLA 1E33P 5KXAA 1ALHA 3UN3A 3WAYA 1E3CP 1E2SP 1ZEBA 5GRRA 3NKMA 1HDHA 3TX0A 4LR8A 2ANHA 2QZUA 3WAXA 5DLTA 2W5XA 4LQYA 1ELYA 1URBA 5K4PA 3NKNA 4B56A 2GA3A 2GSUA 1EW2A 1KHJA 3DYCA 4N7TA 1URAA 3NKPA 3UO0A 1KHNA 1HQAA 1SHQA 5DLWA 4FDIA 4LR7A 1ALIA 1P49A 3M8WA 4KAVA 4GTWA 5LRMA 4NWJA 2W8SA 3DPCA 4LR9A 4UPKA 3IDDA 4TN0A 1EQJA 4UPHA 2GSNA 4MHXA 4UPLA 4GTZA 5LRNA 4ZGAA 2W5RA 1KHKA 4CYRA 4KJGA 1FSUA 3UN2A 3SZYA 1ED9A 1O98A 4UORA 1HJKA 2IUCB 1ED8A 3UNYA 4CXSA 3TG0A 3WAVA 4KAYA 4LRAA 4CYSA 2IFYA 4ZG9A 3BDFA 5EGEA 4LREA 5DLVA 4ZG6A 2XRGA 1KH4A 3A52A 3NKOA 3B5QA 3TWZA 1AJAA 1AUKA 1N2KA 2W5WA 3OT9A 1ZEDA 1EW8A 4FDJA 5INHA 1N2LA 1KHLA 1EW9A 4MY4A 1ZEFA 3CMRA 2GSOA 4MIVA 3M8ZA 3WAWA 1SHNA 1EJJA 3MK0A 4UOOA 5HRTA 2VQRA 3Q3QA 1ALJA 1ANJA 2X98A 3NKQA 1Y6VA 2W5SA 3BDHA 1K7HA 1EI6A 2IUCA 2W5TA 5IJQA 1KH5A 4GTYA 1KH7A 3T00A 4ZG7A 3T01A 2XR9A 4GTXA 4QAXA 5AJ9A 2W5QA 3IGYB 5IJSA 1AJBA 3MK2A 3M7VA 5C66A 5EGHA 5L0KA 4YR1A 3M8YA
chains in the Genus database with same CATH topology
2ZKTA 4LRDA 3SZZA 3BDGA 3UN5A 3MK1A 3T02A 1AJDA 3BDGB 3E2DA 4LRBA 4KJDA 1ANIA 5LIAA 5LQQA 1ALKA 4NWXA 2G9YA 2W8DA 4LRFA 4UPIA 1E1ZP 5L0EA 1AJCA 3LXQA 3WBHA 4UOPA 4KM4A 3NKRA 5TJ3A 3KD8A 2RH6A 3IGZB 4LR2A 5L0BA 1O99A 2GLQA 2W5VA 4LRCA 4CXUA 1ELZA 4CXKA 1B8JA 1Y7AA 3ED4A 2D1GA 1KH9A 5GOVA 1ELXA 3NVLA 1E33P 5KXAA 1ALHA 3UN3A 3WAYA 1E3CP 1E2SP 1ZEBA 5GRRA 3NKMA 1HDHA 3TX0A 4LR8A 2ANHA 2QZUA 3WAXA 5DLTA 2W5XA 4LQYA 1ELYA 1URBA 5K4PA 3NKNA 4B56A 2GA3A 2GSUA 1EW2A 1KHJA 3DYCA 4N7TA 1URAA 3NKPA 3UO0A 1KHNA 1HQAA 1SHQA 5DLWA 4FDIA 4LR7A 1ALIA 1P49A 3M8WA 4KAVA 4GTWA 5LRMA 4NWJA 2W8SA 3DPCA 4LR9A 4UPKA 3IDDA 4TN0A 1EQJA 4UPHA 2GSNA 4MHXA 4UPLA 4GTZA 5LRNA 4ZGAA 2W5RA 1KHKA 4CYRA 4KJGA 1FSUA 3UN2A 3SZYA 1ED9A 1O98A 4UORA 1HJKA 2IUCB 1ED8A 3UNYA 4CXSA 3TG0A 3WAVA 4KAYA 4LRAA 4CYSA 2IFYA 4ZG9A 3BDFA 5EGEA 4LREA 5DLVA 4ZG6A 2XRGA 1KH4A 3A52A 3NKOA 3B5QA 3TWZA 1AJAA 1AUKA 1N2KA 2W5WA 3OT9A 1ZEDA 1EW8A 4FDJA 5INHA 1N2LA 1KHLA 1EW9A 4MY4A 1ZEFA 3CMRA 2GSOA 4MIVA 3M8ZA 3WAWA 1SHNA 1EJJA 3MK0A 4UOOA 5HRTA 2VQRA 3Q3QA 1ALJA 1ANJA 2X98A 3NKQA 1Y6VA 2W5SA 3BDHA 1K7HA 1EI6A 2IUCA 2W5TA 5IJQA 1KH5A 4GTYA 1KH7A 3T00A 4ZG7A 3T01A 2XR9A 4GTXA 4QAXA 5AJ9A 2W5QA 3IGYB 5IJSA 1AJBA 3MK2A 3M7VA 5C66A 5EGHA 5L0KA 4YR1A 3M8YA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2ZKT A;  4LRD A;  3SZZ A;  3BDG A;  3UN5 A;  3MK1 A;  3T02 A;  1AJD A;  3BDG B;  3E2D A;  4LRB A;  4KJD A;  1ANI A;  5LIA A;  5LQQ A;  1ALK A;  4NWX A;  2G9Y A;  2W8D A;  4LRF A;  4UPI A;  1E1Z P;  5L0E A;  1AJC A;  3LXQ A;  3WBH A;  4UOP A;  4KM4 A;  3NKR A;  5TJ3 A;  3KD8 A;  2RH6 A;  3IGZ B;  4LR2 A;  5L0B A;  1O99 A;  2GLQ A;  2W5V A;  4LRC A;  4CXU A;  1ELZ A;  4CXK A;  1B8J A;  1Y7A A;  3ED4 A;  2D1G A;  1KH9 A;  5GOV A;  1ELX A;  3NVL A;  1E33 P;  5KXA A;  1ALH A;  3UN3 A;  3WAY A;  1E3C P;  1E2S P;  1ZEB A;  5GRR A;  3NKM A;  1HDH A;  3TX0 A;  4LR8 A;  2ANH A;  2QZU A;  3WAX A;  5DLT A;  2W5X A;  4LQY A;  1ELY A;  1URB A;  5K4P A;  3NKN A;  4B56 A;  2GA3 A;  2GSU A;  1EW2 A;  1KHJ A;  3DYC A;  4N7T A;  1URA A;  3NKP A;  3UO0 A;  1KHN A;  1HQA A;  1SHQ A;  5DLW A;  4FDI A;  4LR7 A;  1ALI A;  1P49 A;  3M8W A;  4KAV A;  4GTW A;  5LRM A;  4NWJ A;  2W8S A;  3DPC A;  4LR9 A;  4UPK A;  3IDD A;  4TN0 A;  1EQJ A;  4UPH A;  2GSN A;  4MHX A;  4UPL A;  4GTZ A;  5LRN A;  4ZGA A;  2W5R A;  1KHK A;  4CYR A;  4KJG A;  1FSU A;  3UN2 A;  3SZY A;  1ED9 A;  1O98 A;  4UOR A;  1HJK A;  2IUC B;  1ED8 A;  3UNY A;  4CXS A;  3TG0 A;  3WAV A;  4KAY A;  4LRA A;  4CYS A;  2IFY A;  4ZG9 A;  3BDF A;  5EGE A;  4LRE A;  5DLV A;  4ZG6 A;  2XRG A;  1KH4 A;  3A52 A;  3NKO A;  3B5Q A;  3TWZ A;  1AJA A;  1AUK A;  1N2K A;  2W5W A;  3OT9 A;  1ZED A;  1EW8 A;  4FDJ A;  5INH A;  1N2L A;  1KHL A;  1EW9 A;  4MY4 A;  1ZEF A;  3CMR A;  2GSO A;  4MIV A;  3M8Z A;  3WAW A;  1SHN A;  1EJJ A;  3MK0 A;  4UOO A;  5HRT A;  2VQR A;  3Q3Q A;  1ALJ A;  1ANJ A;  2X98 A;  3NKQ A;  1Y6V A;  2W5S A;  3BDH A;  1K7H A;  1EI6 A;  2IUC A;  2W5T A;  5IJQ A;  1KH5 A;  4GTY A;  1KH7 A;  3T00 A;  4ZG7 A;  3T01 A;  2XR9 A;  4GTX A;  4QAX A;  5AJ9 A;  2W5Q A;  3IGY B;  5IJS A;  1AJB A;  3MK2 A;  3M7V A;  5C66 A;  5EGH A;  5L0K A;  4YR1 A;  3M8Y A; 
#chains in the Genus database with same CATH topology
 2ZKT A;  4LRD A;  3SZZ A;  3BDG A;  3UN5 A;  3MK1 A;  3T02 A;  1AJD A;  3BDG B;  3E2D A;  4LRB A;  4KJD A;  1ANI A;  5LIA A;  5LQQ A;  1ALK A;  4NWX A;  2G9Y A;  2W8D A;  4LRF A;  4UPI A;  1E1Z P;  5L0E A;  1AJC A;  3LXQ A;  3WBH A;  4UOP A;  4KM4 A;  3NKR A;  5TJ3 A;  3KD8 A;  2RH6 A;  3IGZ B;  4LR2 A;  5L0B A;  1O99 A;  2GLQ A;  2W5V A;  4LRC A;  4CXU A;  1ELZ A;  4CXK A;  1B8J A;  1Y7A A;  3ED4 A;  2D1G A;  1KH9 A;  5GOV A;  1ELX A;  3NVL A;  1E33 P;  5KXA A;  1ALH A;  3UN3 A;  3WAY A;  1E3C P;  1E2S P;  1ZEB A;  5GRR A;  3NKM A;  1HDH A;  3TX0 A;  4LR8 A;  2ANH A;  2QZU A;  3WAX A;  5DLT A;  2W5X A;  4LQY A;  1ELY A;  1URB A;  5K4P A;  3NKN A;  4B56 A;  2GA3 A;  2GSU A;  1EW2 A;  1KHJ A;  3DYC A;  4N7T A;  1URA A;  3NKP A;  3UO0 A;  1KHN A;  1HQA A;  1SHQ A;  5DLW A;  4FDI A;  4LR7 A;  1ALI A;  1P49 A;  3M8W A;  4KAV A;  4GTW A;  5LRM A;  4NWJ A;  2W8S A;  3DPC A;  4LR9 A;  4UPK A;  3IDD A;  4TN0 A;  1EQJ A;  4UPH A;  2GSN A;  4MHX A;  4UPL A;  4GTZ A;  5LRN A;  4ZGA A;  2W5R A;  1KHK A;  4CYR A;  4KJG A;  1FSU A;  3UN2 A;  3SZY A;  1ED9 A;  1O98 A;  4UOR A;  1HJK A;  2IUC B;  1ED8 A;  3UNY A;  4CXS A;  3TG0 A;  3WAV A;  4KAY A;  4LRA A;  4CYS A;  2IFY A;  4ZG9 A;  3BDF A;  5EGE A;  4LRE A;  5DLV A;  4ZG6 A;  2XRG A;  1KH4 A;  3A52 A;  3NKO A;  3B5Q A;  3TWZ A;  1AJA A;  1AUK A;  1N2K A;  2W5W A;  3OT9 A;  1ZED A;  1EW8 A;  4FDJ A;  5INH A;  1N2L A;  1KHL A;  1EW9 A;  4MY4 A;  1ZEF A;  3CMR A;  2GSO A;  4MIV A;  3M8Z A;  3WAW A;  1SHN A;  1EJJ A;  3MK0 A;  4UOO A;  5HRT A;  2VQR A;  3Q3Q A;  1ALJ A;  1ANJ A;  2X98 A;  3NKQ A;  1Y6V A;  2W5S A;  3BDH A;  1K7H A;  1EI6 A;  2IUC A;  2W5T A;  5IJQ A;  1KH5 A;  4GTY A;  1KH7 A;  3T00 A;  4ZG7 A;  3T01 A;  2XR9 A;  4GTX A;  4QAX A;  5AJ9 A;  2W5Q A;  3IGY B;  5IJS A;  1AJB A;  3MK2 A;  3M7V A;  5C66 A;  5EGH A;  5L0K A;  4YR1 A;  3M8Y A; 
#chains in the Genus database with same CATH homology
 2ZKT A;  4LRD A;  3SZZ A;  3BDG A;  3UN5 A;  3MK1 A;  3T02 A;  1AJD A;  3BDG B;  3E2D A;  4LRB A;  4KJD A;  1ANI A;  5LIA A;  5LQQ A;  1ALK A;  4NWX A;  2G9Y A;  2W8D A;  4LRF A;  4UPI A;  1E1Z P;  5L0E A;  1AJC A;  3LXQ A;  3WBH A;  4UOP A;  4KM4 A;  3NKR A;  5TJ3 A;  3KD8 A;  2RH6 A;  3IGZ B;  4LR2 A;  5L0B A;  1O99 A;  2GLQ A;  2W5V A;  4LRC A;  4CXU A;  1ELZ A;  4CXK A;  1B8J A;  1Y7A A;  3ED4 A;  2D1G A;  1KH9 A;  5GOV A;  1ELX A;  3NVL A;  1E33 P;  5KXA A;  1ALH A;  3UN3 A;  3WAY A;  1E3C P;  1E2S P;  1ZEB A;  5GRR A;  3NKM A;  1HDH A;  3TX0 A;  4LR8 A;  2ANH A;  2QZU A;  3WAX A;  5DLT A;  2W5X A;  4LQY A;  1ELY A;  1URB A;  5K4P A;  3NKN A;  4B56 A;  2GA3 A;  2GSU A;  1EW2 A;  1KHJ A;  3DYC A;  4N7T A;  1URA A;  3NKP A;  3UO0 A;  1KHN A;  1HQA A;  1SHQ A;  5DLW A;  4FDI A;  4LR7 A;  1ALI A;  1P49 A;  3M8W A;  4KAV A;  4GTW A;  5LRM A;  4NWJ A;  2W8S A;  3DPC A;  4LR9 A;  4UPK A;  3IDD A;  4TN0 A;  1EQJ A;  4UPH A;  2GSN A;  4MHX A;  4UPL A;  4GTZ A;  5LRN A;  4ZGA A;  2W5R A;  1KHK A;  4CYR A;  4KJG A;  1FSU A;  3UN2 A;  3SZY A;  1ED9 A;  1O98 A;  4UOR A;  1HJK A;  2IUC B;  1ED8 A;  3UNY A;  4CXS A;  3TG0 A;  3WAV A;  4KAY A;  4LRA A;  4CYS A;  2IFY A;  4ZG9 A;  3BDF A;  5EGE A;  4LRE A;  5DLV A;  4ZG6 A;  2XRG A;  1KH4 A;  3A52 A;  3NKO A;  3B5Q A;  3TWZ A;  1AJA A;  1AUK A;  1N2K A;  2W5W A;  3OT9 A;  1ZED A;  1EW8 A;  4FDJ A;  5INH A;  1N2L A;  1KHL A;  1EW9 A;  4MY4 A;  1ZEF A;  3CMR A;  2GSO A;  4MIV A;  3M8Z A;  3WAW A;  1SHN A;  1EJJ A;  3MK0 A;  4UOO A;  5HRT A;  2VQR A;  3Q3Q A;  1ALJ A;  1ANJ A;  2X98 A;  3NKQ A;  1Y6V A;  2W5S A;  3BDH A;  1K7H A;  1EI6 A;  2IUC A;  2W5T A;  5IJQ A;  1KH5 A;  4GTY A;  1KH7 A;  3T00 A;  4ZG7 A;  3T01 A;  2XR9 A;  4GTX A;  4QAX A;  5AJ9 A;  2W5Q A;  3IGY B;  5IJS A;  1AJB A;  3MK2 A;  3M7V A;  5C66 A;  5EGH A;  5L0K A;  4YR1 A;  3M8Y A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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