4KTXA

Crystal structure of the catalytic domain of botulinum neurotoxin bont/a c134s mutant with covalent inhibitor that modifies cys-165 causing disorder in 167-174 stretch
Total Genus 132
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
132
sequence length
428
structure length
428
Chain Sequence
GSHMPFVNKQFNYKDPVNGVDIAYIKIPNAGQMQPVKAFKIHNKIWVIPERDTFTNPEEGDLNPPPEAKQVPVSYYDSTYLSTDNEKDNYLKGVTKLFERIYSTDLGRMLLTSIVRGIPFWGGSTIDTELKVIDTNSINVIQPDGSYRSEELNLVIIGPSADIIQFECKSFGHEVLNLTRNGYGSTQYIRFSPDFTFGFEESLEVDTNPLLGAGKFATDPAVTLAHELIHAGHRLYGIAINPNRVFKVNTNAYYEMSGLEVSFEELRTFGGHDAKFIDSLQENEFRLYYYNKFKDIASTLNKAKSIVGTTASLQYMKNVFKEKYLLSEDTSGKFSVDKLKFDKLYKMLTEIYTEDNFVKFFKVLNRKTYLNFDKAVFKINIVPKVNYTIYDGFNLRNTNLAANFNGQNTEINNMNFTKLKNFTGLFEF
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Covalent modification of the active site cysteine stresses Clostridium botulinum neurotoxin A
rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Clostridium botulinum a
molecule keywords Botulinum neurotoxin A light chain
total genus 132
structure length 428
sequence length 428
ec nomenclature ec 3.4.24.69: Bontoxilysin.
pdb deposition date 2013-05-21
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.1240.10 Alpha Beta Alpha-Beta Complex Zincin-like Metalloproteases ("zincins"), catalytic domain like 4ktxA00
3FIIA 4KUFA 2G7NA 3V0AB 3C88A 2FPQA 2IMAA 2W2DA 2ISEA 1S0BA 1XTGA 3DEBA 2ILPA 5BQMA 4ZJXA 3DSEA 1Z7HA 3V0BB 3V0AA 3NF3A 3FIEA 1ZL5A 3ZUSA 3C89A 4ZKTB 1ZKXA 1E1HA 3ZURA 3BONA 2XHLA 3D3XA 2A97A 2IMBA 2G7PA 4KTXA 3V0BA 3DS9A 1ZN3A 3QW8A 3ZUQA 1YVGA 2NYYA 2IMCA 1G9CA 3QJ0A 3BWIA 2G7KA 3K3QB 1G9AA 3BOOA 1T3AA 2G7QA 4EJ5A 3DDAA 3FFZA 1S0CA 4J1LA 3DDBA 5BQNA 4EL4A 3QW5A 2NP0A 4KS6A 2NZ9A 1F82A 3QW7A 3VUOA 1S0FA 1ZB7A 4ELCA 1T3CA 3C8BA 1I1EA 1S0EA 1S0DA 2ISGA 1G9BA 4HEVA 1F31A 2QN0A 3QW6A 3QIZA 1G9DA 2A8AA 1EPWA 1ZKWA 3BTAA 3C8AA 1XTFA 3QIYA 2ISHA 3BOKA 3QIXA 1S0GA 2ETFA 1ZL6A
chains in the Genus database with same CATH superfamily
4JIUA 3FIIA 4KUFA 2G7NA 3V0AB 3C88A 2FPQA 2IMAA 2W2DA 2ISEA 1S0BA 1XTGA 3DEBA 2ILPA 5BQMA 4ZJXA 3DSEA 1Z7HA 3V0BB 3V0AA 3NF3A 3FIEA 1ZL5A 3ZUSA 3C89A 4ZKTB 1ZKXA 1E1HA 3ZURA 3BONA 2XHLA 3D3XA 2A97A 2IMBA 2G7PA 4KTXA 3V0BA 3DS9A 1ZN3A 3QW8A 3ZUQA 2YPTA 1YVGA 2NYYA 2EJQA 2IMCA 1G9CA 3QJ0A 3BWIA 4JIXA 2G7KA 3K3QB 1G9AA 3BOOA 1T3AA 2G7QA 4EJ5A 3CQBA 3DDAA 3FFZA 1S0CA 4J1LA 3DDBA 5BQNA 4EL4A 4QHFA 3QW5A 2NP0A 4KS6A 2NZ9A 1F82A 3QW7A 3VUOA 4AW6A 1S0FA 1ZB7A 4ELCA 1T3CA 3C8BA 1I1EA 1S0EA 1S0DA 3E11A 2ISGA 1G9BA 4HEVA 1F31A 2QN0A 3QW6A 3QIZA 1G9DA 2A8AA 1EPWA 1ZKWA 3BTAA 3C8AA 1XTFA 3QIYA 2ISHA 4IL3A 3BOKA 3QIXA 1S0GA 2ETFA 1ZL6A
chains in the Genus database with same CATH topology
3FIIA 4KUFA 2G7NA 3V0AB 3C88A 2FPQA 2IMAA 2W2DA 2ISEA 1S0BA 1XTGA 3DEBA 2ILPA 5BQMA 4ZJXA 3DSEA 1Z7HA 3V0BB 3V0AA 3NF3A 3FIEA 1ZL5A 3ZUSA 3C89A 4ZKTB 1ZKXA 1E1HA 3ZURA 3BONA 2XHLA 3D3XA 2A97A 2IMBA 2G7PA 4KTXA 3V0BA 3DS9A 1ZN3A 3QW8A 3ZUQA 1YVGA 2NYYA 2IMCA 1G9CA 3QJ0A 3BWIA 2G7KA 3K3QB 1G9AA 3BOOA 1T3AA 2G7QA 4EJ5A 3DDAA 3FFZA 1S0CA 4J1LA 3DDBA 5BQNA 4EL4A 3QW5A 2NP0A 4KS6A 2NZ9A 1F82A 3QW7A 3VUOA 1S0FA 1ZB7A 4ELCA 1T3CA 3C8BA 1I1EA 1S0EA 1S0DA 2ISGA 1G9BA 4HEVA 1F31A 2QN0A 3QW6A 3QIZA 1G9DA 2A8AA 1EPWA 1ZKWA 3BTAA 3C8AA 1XTFA 3QIYA 2ISHA 3BOKA 3QIXA 1S0GA 2ETFA 1ZL6A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3FII A;  4KUF A;  2G7N A;  3V0A B;  3C88 A;  2FPQ A;  2IMA A;  2W2D A;  2ISE A;  1S0B A;  1XTG A;  3DEB A;  2ILP A;  5BQM A;  4ZJX A;  3DSE A;  1Z7H A;  3V0B B;  3V0A A;  3NF3 A;  3FIE A;  1ZL5 A;  3ZUS A;  3C89 A;  4ZKT B;  1ZKX A;  1E1H A;  3ZUR A;  3BON A;  2XHL A;  3D3X A;  2A97 A;  2IMB A;  2G7P A;  4KTX A;  3V0B A;  3DS9 A;  1ZN3 A;  3QW8 A;  3ZUQ A;  1YVG A;  2NYY A;  2IMC A;  1G9C A;  3QJ0 A;  3BWI A;  2G7K A;  3K3Q B;  1G9A A;  3BOO A;  1T3A A;  2G7Q A;  4EJ5 A;  3DDA A;  3FFZ A;  1S0C A;  4J1L A;  3DDB A;  5BQN A;  4EL4 A;  3QW5 A;  2NP0 A;  4KS6 A;  2NZ9 A;  1F82 A;  3QW7 A;  3VUO A;  1S0F A;  1ZB7 A;  4ELC A;  1T3C A;  3C8B A;  1I1E A;  1S0E A;  1S0D A;  2ISG A;  1G9B A;  4HEV A;  1F31 A;  2QN0 A;  3QW6 A;  3QIZ A;  1G9D A;  2A8A A;  1EPW A;  1ZKW A;  3BTA A;  3C8A A;  1XTF A;  3QIY A;  2ISH A;  3BOK A;  3QIX A;  1S0G A;  2ETF A;  1ZL6 A; 
#chains in the Genus database with same CATH topology
 4JIU A;  3FII A;  4KUF A;  2G7N A;  3V0A B;  3C88 A;  2FPQ A;  2IMA A;  2W2D A;  2ISE A;  1S0B A;  1XTG A;  3DEB A;  2ILP A;  5BQM A;  4ZJX A;  3DSE A;  1Z7H A;  3V0B B;  3V0A A;  3NF3 A;  3FIE A;  1ZL5 A;  3ZUS A;  3C89 A;  4ZKT B;  1ZKX A;  1E1H A;  3ZUR A;  3BON A;  2XHL A;  3D3X A;  2A97 A;  2IMB A;  2G7P A;  4KTX A;  3V0B A;  3DS9 A;  1ZN3 A;  3QW8 A;  3ZUQ A;  2YPT A;  1YVG A;  2NYY A;  2EJQ A;  2IMC A;  1G9C A;  3QJ0 A;  3BWI A;  4JIX A;  2G7K A;  3K3Q B;  1G9A A;  3BOO A;  1T3A A;  2G7Q A;  4EJ5 A;  3CQB A;  3DDA A;  3FFZ A;  1S0C A;  4J1L A;  3DDB A;  5BQN A;  4EL4 A;  4QHF A;  3QW5 A;  2NP0 A;  4KS6 A;  2NZ9 A;  1F82 A;  3QW7 A;  3VUO A;  4AW6 A;  1S0F A;  1ZB7 A;  4ELC A;  1T3C A;  3C8B A;  1I1E A;  1S0E A;  1S0D A;  3E11 A;  2ISG A;  1G9B A;  4HEV A;  1F31 A;  2QN0 A;  3QW6 A;  3QIZ A;  1G9D A;  2A8A A;  1EPW A;  1ZKW A;  3BTA A;  3C8A A;  1XTF A;  3QIY A;  2ISH A;  4IL3 A;  3BOK A;  3QIX A;  1S0G A;  2ETF A;  1ZL6 A; 
#chains in the Genus database with same CATH homology
 3FII A;  4KUF A;  2G7N A;  3V0A B;  3C88 A;  2FPQ A;  2IMA A;  2W2D A;  2ISE A;  1S0B A;  1XTG A;  3DEB A;  2ILP A;  5BQM A;  4ZJX A;  3DSE A;  1Z7H A;  3V0B B;  3V0A A;  3NF3 A;  3FIE A;  1ZL5 A;  3ZUS A;  3C89 A;  4ZKT B;  1ZKX A;  1E1H A;  3ZUR A;  3BON A;  2XHL A;  3D3X A;  2A97 A;  2IMB A;  2G7P A;  4KTX A;  3V0B A;  3DS9 A;  1ZN3 A;  3QW8 A;  3ZUQ A;  1YVG A;  2NYY A;  2IMC A;  1G9C A;  3QJ0 A;  3BWI A;  2G7K A;  3K3Q B;  1G9A A;  3BOO A;  1T3A A;  2G7Q A;  4EJ5 A;  3DDA A;  3FFZ A;  1S0C A;  4J1L A;  3DDB A;  5BQN A;  4EL4 A;  3QW5 A;  2NP0 A;  4KS6 A;  2NZ9 A;  1F82 A;  3QW7 A;  3VUO A;  1S0F A;  1ZB7 A;  4ELC A;  1T3C A;  3C8B A;  1I1E A;  1S0E A;  1S0D A;  2ISG A;  1G9B A;  4HEV A;  1F31 A;  2QN0 A;  3QW6 A;  3QIZ A;  1G9D A;  2A8A A;  1EPW A;  1ZKW A;  3BTA A;  3C8A A;  1XTF A;  3QIY A;  2ISH A;  3BOK A;  3QIX A;  1S0G A;  2ETF A;  1ZL6 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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