4KTXA

Crystal structure of the catalytic domain of botulinum neurotoxin bont/a c134s mutant with covalent inhibitor that modifies cys-165 causing disorder in 167-174 stretch
Total Genus 132
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
132
sequence length
428
structure length
428
Chain Sequence
GSHMPFVNKQFNYKDPVNGVDIAYIKIPNAGQMQPVKAFKIHNKIWVIPERDTFTNPEEGDLNPPPEAKQVPVSYYDSTYLSTDNEKDNYLKGVTKLFERIYSTDLGRMLLTSIVRGIPFWGGSTIDTELKVIDTNSINVIQPDGSYRSEELNLVIIGPSADIIQFECKSFGHEVLNLTRNGYGSTQYIRFSPDFTFGFEESLEVDTNPLLGAGKFATDPAVTLAHELIHAGHRLYGIAINPNRVFKVNTNAYYEMSGLEVSFEELRTFGGHDAKFIDSLQENEFRLYYYNKFKDIASTLNKAKSIVGTTASLQYMKNVFKEKYLLSEDTSGKFSVDKLKFDKLYKMLTEIYTEDNFVKFFKVLNRKTYLNFDKAVFKINIVPKVNYTIYDGFNLRNTNLAANFNGQNTEINNMNFTKLKNFTGLFEF
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Hydrolase/hydrolase inhibitor
molecule keywords Botulinum neurotoxin A light chain
publication title Covalent modification of the active site cysteine stresses Clostridium botulinum neurotoxin A
rcsb
source organism Clostridium botulinum a
total genus 132
structure length 428
sequence length 428
ec nomenclature ec 3.4.24.69: Bontoxilysin.
pdb deposition date 2013-05-21
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.1240.10 Alpha Beta Alpha-Beta Complex Zincin-like Metalloproteases ("zincins"), catalytic domain like 4ktxA00
4ZKTB 2NZ9A 2IMCA 3VUOA 2G7PA 4ZJXA 3DDBA 1Z7HA 3V0AA 5BQMA 4KS6A 2ISEA 1YVGA 2XHLA 3ZUSA 3BONA 3ZUQA 1F31A 1ZKWA 2A8AA 1ZN3A 3FFZA 4ELCA 4KUFA 3QIXA 3K3QB 4J1LA 3FIIA 1G9CA 3V0BA 1EPWA 1T3AA 3QJ0A 3BTAA 1XTGA 3DSEA 3ZURA 2ISHA 3BOKA 1G9BA 2ILPA 2G7QA 3DEBA 1I1EA 2G7KA 2G7NA 3C88A 3QW8A 2ETFA 3QW7A 3DS9A 1ZKXA 1S0FA 4EJ5A 3DDAA 3V0AB 2QN0A 2IMBA 3C8BA 1S0CA 3QIZA 4KTXA 4HEVA 2NYYA 1F82A 3C89A 2NP0A 3BOOA 1S0BA 2A97A 1ZB7A 3D3XA 3QW5A 2ISGA 2IMAA 1E1HA 1ZL6A 3C8AA 3V0BB 1S0GA 1T3CA 5BQNA 1ZL5A 1G9DA 1XTFA 3QIYA 2FPQA 1S0EA 3NF3A 1S0DA 1G9AA 3QW6A 4EL4A 2W2DA 3FIEA 3BWIA
chains in the Genus database with same CATH superfamily
4ZKTB 3CQBA 2NZ9A 2IMCA 3VUOA 4JIUA 2G7PA 4ZJXA 3DDBA 1Z7HA 3V0AA 5BQMA 4QHFA 4KS6A 2ISEA 1YVGA 2XHLA 3ZUSA 3BONA 3ZUQA 3E11A 1F31A 4IL3A 1ZKWA 2EJQA 2A8AA 1ZN3A 3FFZA 4ELCA 4KUFA 3QIXA 3K3QB 4J1LA 3FIIA 1G9CA 3V0BA 1EPWA 1T3AA 3QJ0A 3BTAA 1XTGA 3DSEA 3ZURA 2ISHA 3BOKA 1G9BA 2ILPA 2G7QA 3DEBA 1I1EA 2G7KA 2G7NA 3C88A 3QW8A 2ETFA 3QW7A 3DS9A 1ZKXA 1S0FA 4EJ5A 3DDAA 3V0AB 2QN0A 2IMBA 3C8BA 1S0CA 4AW6A 3QIZA 4KTXA 4HEVA 2NYYA 1F82A 3C89A 2NP0A 3BOOA 1S0BA 2A97A 1ZB7A 3D3XA 3QW5A 2ISGA 2IMAA 1E1HA 1ZL6A 3C8AA 3V0BB 1S0GA 2YPTA 1T3CA 5BQNA 1ZL5A 1G9DA 1XTFA 4JIXA 3QIYA 2FPQA 1S0EA 3NF3A 1S0DA 1G9AA 3QW6A 4EL4A 2W2DA 3FIEA 3BWIA
chains in the Genus database with same CATH topology
4ZKTB 2NZ9A 2IMCA 3VUOA 2G7PA 4ZJXA 3DDBA 1Z7HA 3V0AA 5BQMA 4KS6A 2ISEA 1YVGA 2XHLA 3ZUSA 3BONA 3ZUQA 1F31A 1ZKWA 2A8AA 1ZN3A 3FFZA 4ELCA 4KUFA 3QIXA 3K3QB 4J1LA 3FIIA 1G9CA 3V0BA 1EPWA 1T3AA 3QJ0A 3BTAA 1XTGA 3DSEA 3ZURA 2ISHA 3BOKA 1G9BA 2ILPA 2G7QA 3DEBA 1I1EA 2G7KA 2G7NA 3C88A 3QW8A 2ETFA 3QW7A 3DS9A 1ZKXA 1S0FA 4EJ5A 3DDAA 3V0AB 2QN0A 2IMBA 3C8BA 1S0CA 3QIZA 4KTXA 4HEVA 2NYYA 1F82A 3C89A 2NP0A 3BOOA 1S0BA 2A97A 1ZB7A 3D3XA 3QW5A 2ISGA 2IMAA 1E1HA 1ZL6A 3C8AA 3V0BB 1S0GA 1T3CA 5BQNA 1ZL5A 1G9DA 1XTFA 3QIYA 2FPQA 1S0EA 3NF3A 1S0DA 1G9AA 3QW6A 4EL4A 2W2DA 3FIEA 3BWIA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4ZKT B;  2NZ9 A;  2IMC A;  3VUO A;  2G7P A;  4ZJX A;  3DDB A;  1Z7H A;  3V0A A;  5BQM A;  4KS6 A;  2ISE A;  1YVG A;  2XHL A;  3ZUS A;  3BON A;  3ZUQ A;  1F31 A;  1ZKW A;  2A8A A;  1ZN3 A;  3FFZ A;  4ELC A;  4KUF A;  3QIX A;  3K3Q B;  4J1L A;  3FII A;  1G9C A;  3V0B A;  1EPW A;  1T3A A;  3QJ0 A;  3BTA A;  1XTG A;  3DSE A;  3ZUR A;  2ISH A;  3BOK A;  1G9B A;  2ILP A;  2G7Q A;  3DEB A;  1I1E A;  2G7K A;  2G7N A;  3C88 A;  3QW8 A;  2ETF A;  3QW7 A;  3DS9 A;  1ZKX A;  1S0F A;  4EJ5 A;  3DDA A;  3V0A B;  2QN0 A;  2IMB A;  3C8B A;  1S0C A;  3QIZ A;  4KTX A;  4HEV A;  2NYY A;  1F82 A;  3C89 A;  2NP0 A;  3BOO A;  1S0B A;  2A97 A;  1ZB7 A;  3D3X A;  3QW5 A;  2ISG A;  2IMA A;  1E1H A;  1ZL6 A;  3C8A A;  3V0B B;  1S0G A;  1T3C A;  5BQN A;  1ZL5 A;  1G9D A;  1XTF A;  3QIY A;  2FPQ A;  1S0E A;  3NF3 A;  1S0D A;  1G9A A;  3QW6 A;  4EL4 A;  2W2D A;  3FIE A;  3BWI A; 
#chains in the Genus database with same CATH topology
 4ZKT B;  3CQB A;  2NZ9 A;  2IMC A;  3VUO A;  4JIU A;  2G7P A;  4ZJX A;  3DDB A;  1Z7H A;  3V0A A;  5BQM A;  4QHF A;  4KS6 A;  2ISE A;  1YVG A;  2XHL A;  3ZUS A;  3BON A;  3ZUQ A;  3E11 A;  1F31 A;  4IL3 A;  1ZKW A;  2EJQ A;  2A8A A;  1ZN3 A;  3FFZ A;  4ELC A;  4KUF A;  3QIX A;  3K3Q B;  4J1L A;  3FII A;  1G9C A;  3V0B A;  1EPW A;  1T3A A;  3QJ0 A;  3BTA A;  1XTG A;  3DSE A;  3ZUR A;  2ISH A;  3BOK A;  1G9B A;  2ILP A;  2G7Q A;  3DEB A;  1I1E A;  2G7K A;  2G7N A;  3C88 A;  3QW8 A;  2ETF A;  3QW7 A;  3DS9 A;  1ZKX A;  1S0F A;  4EJ5 A;  3DDA A;  3V0A B;  2QN0 A;  2IMB A;  3C8B A;  1S0C A;  4AW6 A;  3QIZ A;  4KTX A;  4HEV A;  2NYY A;  1F82 A;  3C89 A;  2NP0 A;  3BOO A;  1S0B A;  2A97 A;  1ZB7 A;  3D3X A;  3QW5 A;  2ISG A;  2IMA A;  1E1H A;  1ZL6 A;  3C8A A;  3V0B B;  1S0G A;  2YPT A;  1T3C A;  5BQN A;  1ZL5 A;  1G9D A;  1XTF A;  4JIX A;  3QIY A;  2FPQ A;  1S0E A;  3NF3 A;  1S0D A;  1G9A A;  3QW6 A;  4EL4 A;  2W2D A;  3FIE A;  3BWI A; 
#chains in the Genus database with same CATH homology
 4ZKT B;  2NZ9 A;  2IMC A;  3VUO A;  2G7P A;  4ZJX A;  3DDB A;  1Z7H A;  3V0A A;  5BQM A;  4KS6 A;  2ISE A;  1YVG A;  2XHL A;  3ZUS A;  3BON A;  3ZUQ A;  1F31 A;  1ZKW A;  2A8A A;  1ZN3 A;  3FFZ A;  4ELC A;  4KUF A;  3QIX A;  3K3Q B;  4J1L A;  3FII A;  1G9C A;  3V0B A;  1EPW A;  1T3A A;  3QJ0 A;  3BTA A;  1XTG A;  3DSE A;  3ZUR A;  2ISH A;  3BOK A;  1G9B A;  2ILP A;  2G7Q A;  3DEB A;  1I1E A;  2G7K A;  2G7N A;  3C88 A;  3QW8 A;  2ETF A;  3QW7 A;  3DS9 A;  1ZKX A;  1S0F A;  4EJ5 A;  3DDA A;  3V0A B;  2QN0 A;  2IMB A;  3C8B A;  1S0C A;  3QIZ A;  4KTX A;  4HEV A;  2NYY A;  1F82 A;  3C89 A;  2NP0 A;  3BOO A;  1S0B A;  2A97 A;  1ZB7 A;  3D3X A;  3QW5 A;  2ISG A;  2IMA A;  1E1H A;  1ZL6 A;  3C8A A;  3V0B B;  1S0G A;  1T3C A;  5BQN A;  1ZL5 A;  1G9D A;  1XTF A;  3QIY A;  2FPQ A;  1S0E A;  3NF3 A;  1S0D A;  1G9A A;  3QW6 A;  4EL4 A;  2W2D A;  3FIE A;  3BWI A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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