4KXZA

Crystal structure of tgfb2 in complex with gc2008.
Total Genus 23
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
23
sequence length
112
structure length
112
Chain Sequence
ALDAAYCFRNVQDNCCLRPLYIDFKRDLGWKWIHEPKGYNANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKIEQLSNMIVKSCKCS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Immune system
molecule keywords Transforming growth factor beta-2
publication title Structures of a pan-specific antagonist antibody complexed to different isoforms of TGF beta reveal structural plasticity of antibody-antigen interactions.
pubmed doi rcsb
source organism Homo sapiens
total genus 23
structure length 112
sequence length 112
chains with identical sequence B, D, E
ec nomenclature
pdb deposition date 2013-05-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00019 TGF_beta Transforming growth factor beta like domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.90.10 Mainly Beta Ribbon Cystine Knot Cytokines, subunit B Cystine-knot cytokines 4kxzA00
4HQXA 4EAXA 3E07A 4GLNE 3MJKA 4GLSE 1WAQA 1WQ8A 5BQ8A 4HSAA 1WQ9B 2TGIA 1BNDA 3BK3A 1DZ7A 1B98A 1ES7A 3V2AA 1CZ8V 2V5EB 4N1DA 1KLAA 5F3HI 1QFWB 2VXSA 3IJ2A 2X1XE 2C7WA 3SEKB 2P6AA 2QCQA 1HRPB 1LXIA 5HI4A 1BETA 1BJ1V 1TGKA 1WWWV 1XWDB 2BHKA 5HI5A 1WQ9A 1ZKZA 4EC7A 4LXRJ 2QJAA 1SG1A 2VPFA 4EFVA 4X1JA 2B0UA 3B4VA 3P9WA 2QR0C 1M4UA 4MQWB 2GNNA 1B8MB 1TZHV 4KXZA 3EVSB 3HH2A 4YCGC 5BQBA 1HCNB 1KLCA 2ASKA 1HRPA 1E9JA 1KATW 1MKGA 4UI2B 1HCFA 1XWDA 4UI1A 3FUBB 1VPPV 4HQUA 3S1BV 2GYRA 2XV7A 4EDXV 5BPUA 1BMPA 1REWA 2XACA 3S1KV 2GOOA 2H62A 5FV1V 5HI3A 4ZBNA 1S4YB 4YCIC 5FV2V 4MQWA 3EO1C 1REUA 1FL7B 3RJRA 1AOCA 3BMPA 1NYUB 4KZNA 5BQCA 3BUKA 1HD4A 1LX5A 3QB4A 2KD3A 2GH0C 5HHXA 1MKKA 2VWEA 4LXSJ 4MPLA 4EDWV 1QFWA 3KFDA 2ARVA 2X1WA 4QHUC 4AY9B 4FAOA 4UI0A 5BQ8D 5HK5A 1AGQA 1M4UL 1TZIV 3MJGA 4MIDA 3V6BA 4XPJA 1FL7A 3JVFA 3BDYV 4KV5A 4ZFFC 1TFGA 4WPBA 4UHZA 1QTYR 5HHDA 1KTZA 4QCIC 4BV4L 1B8MA 2FJGV 2IFGE 1BTGA 4AY9A 4QAFC 1HCNA 3QTKA 5HHVA 5BQEB 2QCWA 1VPFA 2FJHV 2QJBA 1SGFB 2R52A 1FLTV 5F3BC 1MJVA 2GYZA 1B8KA 4UHYA 1NYSB 5BQ8B 1BNDB 1FZVA 2ARPA 1TGJA 2H64A 5JZ7A 5AEJA 5HK5E 4HR9A 5E4GA 1RV6V 2QJ9A 2R53A 5HHCA 1JPYA 1PDGA 5BQEA 2PJYA 1NT3A
chains in the Genus database with same CATH superfamily
4HQXA 4EAXA 3E07A 4GLNE 3MJKA 4GLSE 1WAQA 1WQ8A 5BQ8A 4HSAA 1WQ9B 2TGIA 1BNDA 3BK3A 1DZ7A 1B98A 1ES7A 3V2AA 1CZ8V 2V5EB 4N1DA 1KLAA 5F3HI 1QFWB 2VXSA 3IJ2A 2X1XE 2C7WA 3SEKB 2P6AA 2QCQA 1HRPB 1LXIA 5HI4A 1BETA 1BJ1V 1TGKA 1WWWV 1XWDB 2BHKA 5HI5A 1WQ9A 1ZKZA 4EC7A 4LXRJ 2QJAA 1SG1A 2VPFA 4EFVA 4X1JA 2B0UA 3B4VA 3P9WA 2QR0C 1M4UA 4MQWB 2GNNA 1B8MB 1TZHV 4KXZA 3EVSB 3HH2A 4YCGC 5BQBA 1HCNB 1KLCA 2ASKA 1HRPA 1E9JA 1KATW 1MKGA 4UI2B 1HCFA 1XWDA 4UI1A 3FUBB 1VPPV 4HQUA 3S1BV 2GYRA 2XV7A 4EDXV 5BPUA 1BMPA 1REWA 2XACA 3S1KV 2GOOA 2H62A 5FV1V 5HI3A 4ZBNA 1S4YB 4YCIC 5FV2V 4MQWA 3EO1C 1REUA 1FL7B 3RJRA 1AOCA 3BMPA 1NYUB 4KZNA 5BQCA 3BUKA 1HD4A 1LX5A 3QB4A 2KD3A 2GH0C 5HHXA 1MKKA 2VWEA 4LXSJ 4MPLA 4EDWV 1QFWA 3KFDA 2ARVA 2X1WA 4QHUC 4AY9B 4FAOA 4UI0A 5BQ8D 5HK5A 1AGQA 1M4UL 1TZIV 3MJGA 4MIDA 3V6BA 4XPJA 1FL7A 3JVFA 3BDYV 4KV5A 4ZFFC 1TFGA 4WPBA 4UHZA 1QTYR 5HHDA 1KTZA 4QCIC 4BV4L 1B8MA 2FJGV 2IFGE 1BTGA 4AY9A 4QAFC 1HCNA 3QTKA 5HHVA 5BQEB 2QCWA 1VPFA 2FJHV 2QJBA 1SGFB 2R52A 1FLTV 5F3BC 1MJVA 2GYZA 1B8KA 4UHYA 1NYSB 5BQ8B 1BNDB 1FZVA 2ARPA 1TGJA 2H64A 5JZ7A 5AEJA 5HK5E 4HR9A 5E4GA 1RV6V 2QJ9A 2R53A 5HHCA 1JPYA 1PDGA 5BQEA 2PJYA 1NT3A
chains in the Genus database with same CATH topology
4HQXA 4EAXA 3E07A 4GLNE 3MJKA 4GLSE 1WAQA 1WQ8A 5BQ8A 4HSAA 1WQ9B 2TGIA 1BNDA 3BK3A 1DZ7A 1B98A 1ES7A 3V2AA 1CZ8V 2V5EB 4N1DA 1KLAA 5F3HI 1QFWB 2VXSA 3IJ2A 2X1XE 2C7WA 3SEKB 2P6AA 2QCQA 1HRPB 1LXIA 5HI4A 1BETA 1BJ1V 1TGKA 1WWWV 1XWDB 2BHKA 5HI5A 1WQ9A 1ZKZA 4EC7A 4LXRJ 2QJAA 1SG1A 2VPFA 4EFVA 4X1JA 2B0UA 3B4VA 3P9WA 2QR0C 1M4UA 4MQWB 2GNNA 1B8MB 1TZHV 4KXZA 3EVSB 3HH2A 4YCGC 5BQBA 1HCNB 1KLCA 2ASKA 1HRPA 1E9JA 1KATW 1MKGA 4UI2B 1HCFA 1XWDA 4UI1A 3FUBB 1VPPV 4HQUA 3S1BV 2GYRA 2XV7A 4EDXV 5BPUA 1BMPA 1REWA 2XACA 3S1KV 2GOOA 2H62A 5FV1V 5HI3A 4ZBNA 1S4YB 4YCIC 5FV2V 4MQWA 3EO1C 1REUA 1FL7B 3RJRA 1AOCA 3BMPA 1NYUB 4KZNA 5BQCA 3BUKA 1HD4A 1LX5A 3QB4A 2KD3A 2GH0C 5HHXA 1MKKA 2VWEA 4LXSJ 4MPLA 4EDWV 1QFWA 3KFDA 2ARVA 2X1WA 4QHUC 4AY9B 4FAOA 4UI0A 5BQ8D 5HK5A 1AGQA 1M4UL 1TZIV 3MJGA 4MIDA 3V6BA 4XPJA 1FL7A 3JVFA 3BDYV 4KV5A 4ZFFC 1TFGA 4WPBA 4UHZA 1QTYR 5HHDA 1KTZA 4QCIC 4BV4L 1B8MA 2FJGV 2IFGE 1BTGA 4AY9A 4QAFC 1HCNA 3QTKA 5HHVA 5BQEB 2QCWA 1VPFA 2FJHV 2QJBA 1SGFB 2R52A 1FLTV 5F3BC 1MJVA 2GYZA 1B8KA 4UHYA 1NYSB 5BQ8B 1BNDB 1FZVA 2ARPA 1TGJA 2H64A 5JZ7A 5AEJA 5HK5E 4HR9A 5E4GA 1RV6V 2QJ9A 2R53A 5HHCA 1JPYA 1PDGA 5BQEA 2PJYA 1NT3A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4HQX A;  4EAX A;  3E07 A;  4GLN E;  3MJK A;  4GLS E;  1WAQ A;  1WQ8 A;  5BQ8 A;  4HSA A;  1WQ9 B;  2TGI A;  1BND A;  3BK3 A;  1DZ7 A;  1B98 A;  1ES7 A;  3V2A A;  1CZ8 V;  2V5E B;  4N1D A;  1KLA A;  5F3H I;  1QFW B;  2VXS A;  3IJ2 A;  2X1X E;  2C7W A;  3SEK B;  2P6A A;  2QCQ A;  1HRP B;  1LXI A;  5HI4 A;  1BET A;  1BJ1 V;  1TGK A;  1WWW V;  1XWD B;  2BHK A;  5HI5 A;  1WQ9 A;  1ZKZ A;  4EC7 A;  4LXR J;  2QJA A;  1SG1 A;  2VPF A;  4EFV A;  4X1J A;  2B0U A;  3B4V A;  3P9W A;  2QR0 C;  1M4U A;  4MQW B;  2GNN A;  1B8M B;  1TZH V;  4KXZ A;  3EVS B;  3HH2 A;  4YCG C;  5BQB A;  1HCN B;  1KLC A;  2ASK A;  1HRP A;  1E9J A;  1KAT W;  1MKG A;  4UI2 B;  1HCF A;  1XWD A;  4UI1 A;  3FUB B;  1VPP V;  4HQU A;  3S1B V;  2GYR A;  2XV7 A;  4EDX V;  5BPU A;  1BMP A;  1REW A;  2XAC A;  3S1K V;  2GOO A;  2H62 A;  5FV1 V;  5HI3 A;  4ZBN A;  1S4Y B;  4YCI C;  5FV2 V;  4MQW A;  3EO1 C;  1REU A;  1FL7 B;  3RJR A;  1AOC A;  3BMP A;  1NYU B;  4KZN A;  5BQC A;  3BUK A;  1HD4 A;  1LX5 A;  3QB4 A;  2KD3 A;  2GH0 C;  5HHX A;  1MKK A;  2VWE A;  4LXS J;  4MPL A;  4EDW V;  1QFW A;  3KFD A;  2ARV A;  2X1W A;  4QHU C;  4AY9 B;  4FAO A;  4UI0 A;  5BQ8 D;  5HK5 A;  1AGQ A;  1M4U L;  1TZI V;  3MJG A;  4MID A;  3V6B A;  4XPJ A;  1FL7 A;  3JVF A;  3BDY V;  4KV5 A;  4ZFF C;  1TFG A;  4WPB A;  4UHZ A;  1QTY R;  5HHD A;  1KTZ A;  4QCI C;  4BV4 L;  1B8M A;  2FJG V;  2IFG E;  1BTG A;  4AY9 A;  4QAF C;  1HCN A;  3QTK A;  5HHV A;  5BQE B;  2QCW A;  1VPF A;  2FJH V;  2QJB A;  1SGF B;  2R52 A;  1FLT V;  5F3B C;  1MJV A;  2GYZ A;  1B8K A;  4UHY A;  1NYS B;  5BQ8 B;  1BND B;  1FZV A;  2ARP A;  1TGJ A;  2H64 A;  5JZ7 A;  5AEJ A;  5HK5 E;  4HR9 A;  5E4G A;  1RV6 V;  2QJ9 A;  2R53 A;  5HHC A;  1JPY A;  1PDG A;  5BQE A;  2PJY A;  1NT3 A; 
#chains in the Genus database with same CATH topology
 4HQX A;  4EAX A;  3E07 A;  4GLN E;  3MJK A;  4GLS E;  1WAQ A;  1WQ8 A;  5BQ8 A;  4HSA A;  1WQ9 B;  2TGI A;  1BND A;  3BK3 A;  1DZ7 A;  1B98 A;  1ES7 A;  3V2A A;  1CZ8 V;  2V5E B;  4N1D A;  1KLA A;  5F3H I;  1QFW B;  2VXS A;  3IJ2 A;  2X1X E;  2C7W A;  3SEK B;  2P6A A;  2QCQ A;  1HRP B;  1LXI A;  5HI4 A;  1BET A;  1BJ1 V;  1TGK A;  1WWW V;  1XWD B;  2BHK A;  5HI5 A;  1WQ9 A;  1ZKZ A;  4EC7 A;  4LXR J;  2QJA A;  1SG1 A;  2VPF A;  4EFV A;  4X1J A;  2B0U A;  3B4V A;  3P9W A;  2QR0 C;  1M4U A;  4MQW B;  2GNN A;  1B8M B;  1TZH V;  4KXZ A;  3EVS B;  3HH2 A;  4YCG C;  5BQB A;  1HCN B;  1KLC A;  2ASK A;  1HRP A;  1E9J A;  1KAT W;  1MKG A;  4UI2 B;  1HCF A;  1XWD A;  4UI1 A;  3FUB B;  1VPP V;  4HQU A;  3S1B V;  2GYR A;  2XV7 A;  4EDX V;  5BPU A;  1BMP A;  1REW A;  2XAC A;  3S1K V;  2GOO A;  2H62 A;  5FV1 V;  5HI3 A;  4ZBN A;  1S4Y B;  4YCI C;  5FV2 V;  4MQW A;  3EO1 C;  1REU A;  1FL7 B;  3RJR A;  1AOC A;  3BMP A;  1NYU B;  4KZN A;  5BQC A;  3BUK A;  1HD4 A;  1LX5 A;  3QB4 A;  2KD3 A;  2GH0 C;  5HHX A;  1MKK A;  2VWE A;  4LXS J;  4MPL A;  4EDW V;  1QFW A;  3KFD A;  2ARV A;  2X1W A;  4QHU C;  4AY9 B;  4FAO A;  4UI0 A;  5BQ8 D;  5HK5 A;  1AGQ A;  1M4U L;  1TZI V;  3MJG A;  4MID A;  3V6B A;  4XPJ A;  1FL7 A;  3JVF A;  3BDY V;  4KV5 A;  4ZFF C;  1TFG A;  4WPB A;  4UHZ A;  1QTY R;  5HHD A;  1KTZ A;  4QCI C;  4BV4 L;  1B8M A;  2FJG V;  2IFG E;  1BTG A;  4AY9 A;  4QAF C;  1HCN A;  3QTK A;  5HHV A;  5BQE B;  2QCW A;  1VPF A;  2FJH V;  2QJB A;  1SGF B;  2R52 A;  1FLT V;  5F3B C;  1MJV A;  2GYZ A;  1B8K A;  4UHY A;  1NYS B;  5BQ8 B;  1BND B;  1FZV A;  2ARP A;  1TGJ A;  2H64 A;  5JZ7 A;  5AEJ A;  5HK5 E;  4HR9 A;  5E4G A;  1RV6 V;  2QJ9 A;  2R53 A;  5HHC A;  1JPY A;  1PDG A;  5BQE A;  2PJY A;  1NT3 A; 
#chains in the Genus database with same CATH homology
 4HQX A;  4EAX A;  3E07 A;  4GLN E;  3MJK A;  4GLS E;  1WAQ A;  1WQ8 A;  5BQ8 A;  4HSA A;  1WQ9 B;  2TGI A;  1BND A;  3BK3 A;  1DZ7 A;  1B98 A;  1ES7 A;  3V2A A;  1CZ8 V;  2V5E B;  4N1D A;  1KLA A;  5F3H I;  1QFW B;  2VXS A;  3IJ2 A;  2X1X E;  2C7W A;  3SEK B;  2P6A A;  2QCQ A;  1HRP B;  1LXI A;  5HI4 A;  1BET A;  1BJ1 V;  1TGK A;  1WWW V;  1XWD B;  2BHK A;  5HI5 A;  1WQ9 A;  1ZKZ A;  4EC7 A;  4LXR J;  2QJA A;  1SG1 A;  2VPF A;  4EFV A;  4X1J A;  2B0U A;  3B4V A;  3P9W A;  2QR0 C;  1M4U A;  4MQW B;  2GNN A;  1B8M B;  1TZH V;  4KXZ A;  3EVS B;  3HH2 A;  4YCG C;  5BQB A;  1HCN B;  1KLC A;  2ASK A;  1HRP A;  1E9J A;  1KAT W;  1MKG A;  4UI2 B;  1HCF A;  1XWD A;  4UI1 A;  3FUB B;  1VPP V;  4HQU A;  3S1B V;  2GYR A;  2XV7 A;  4EDX V;  5BPU A;  1BMP A;  1REW A;  2XAC A;  3S1K V;  2GOO A;  2H62 A;  5FV1 V;  5HI3 A;  4ZBN A;  1S4Y B;  4YCI C;  5FV2 V;  4MQW A;  3EO1 C;  1REU A;  1FL7 B;  3RJR A;  1AOC A;  3BMP A;  1NYU B;  4KZN A;  5BQC A;  3BUK A;  1HD4 A;  1LX5 A;  3QB4 A;  2KD3 A;  2GH0 C;  5HHX A;  1MKK A;  2VWE A;  4LXS J;  4MPL A;  4EDW V;  1QFW A;  3KFD A;  2ARV A;  2X1W A;  4QHU C;  4AY9 B;  4FAO A;  4UI0 A;  5BQ8 D;  5HK5 A;  1AGQ A;  1M4U L;  1TZI V;  3MJG A;  4MID A;  3V6B A;  4XPJ A;  1FL7 A;  3JVF A;  3BDY V;  4KV5 A;  4ZFF C;  1TFG A;  4WPB A;  4UHZ A;  1QTY R;  5HHD A;  1KTZ A;  4QCI C;  4BV4 L;  1B8M A;  2FJG V;  2IFG E;  1BTG A;  4AY9 A;  4QAF C;  1HCN A;  3QTK A;  5HHV A;  5BQE B;  2QCW A;  1VPF A;  2FJH V;  2QJB A;  1SGF B;  2R52 A;  1FLT V;  5F3B C;  1MJV A;  2GYZ A;  1B8K A;  4UHY A;  1NYS B;  5BQ8 B;  1BND B;  1FZV A;  2ARP A;  1TGJ A;  2H64 A;  5JZ7 A;  5AEJ A;  5HK5 E;  4HR9 A;  5E4G A;  1RV6 V;  2QJ9 A;  2R53 A;  5HHC A;  1JPY A;  1PDG A;  5BQE A;  2PJY A;  1NT3 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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