4L32C

Tankyrase 2 in complex with 2-[4-(4-methylpiperazine-1-carbonyl)phenyl]chromen-4-one
Total Genus 1
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
1
sequence length
47
structure length
47
Chain Sequence
MAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Transferase/transferase inhibitor
molecule keywords Tankyrase-2
publication title Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity.
pubmed doi rcsb
source organism Homo sapiens
total genus 1
structure length 47
sequence length 47
chains with identical sequence D
ec nomenclature ec 2.4.2.30: NAD(+) ADP-ribosyltransferase.
pdb deposition date 2013-06-05
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.1620.50 Alpha Beta 3-Layer(aba) Sandwich YefM-like fold YefM-like fold 4l32C00
5ADQB 5C5QC 4UI6C 4UI3C 4UI8C 5ADRB 4KZLC 4HLKC 4KZUC 4L2GC 5C5RC 5FPFC 4L0IC 4HLGC 4L10C 4L31C 4HKIC 4HLFC 4L0BC 4L0VC 5C5PC 4L0TC 4HKKB 4L33C 4L0SC 5ADSB 4KZQC 4L32C 4L2KC 4L2FC 4L34C 4HLHC 4HKNC 4L09C 4UI7C 4UVPB 4UI4C 5ADTB 4HL5C 4HLMC 4HMHC 4UI5C
chains in the Genus database with same CATH superfamily
5ADQB 5C5QC 4UI6C 4UI3C 4UI8C 5ADRB 4KZLC 4HLKC 4KZUC 4L2GC 5C5RC 3G5OA 5FPFC 4L0IC 3HJ6A 4HLGC 2A6QA 4L10C 4ZM0A 4L31C 3CTOA 2ODKA 3KH2E 4HKIC 4HLFC 4L0BC 4L0VC 4ZM2A 3K6QA 5C5PC 4L0TC 4HKKB 3OEIE 4L33C 4L0SC 5ADSB 4KZQC 4L32C 4ZLXA 4L2KC 3D55A 4L2FC 4HLHC 4L34C 4HKNC 4L09C 4UI7C 4UVPB 2ZIXB 4UI4C 3HS2A 3OEIA 5ADTB 3HRYA 3K33B 4HL5C 4HLMC 4HMHC 4UI5C
chains in the Genus database with same CATH topology
5ADQB 5C5QC 4UI6C 4UI3C 4UI8C 5ADRB 4KZLC 4HLKC 4KZUC 4L2GC 5C5RC 5FPFC 4L0IC 3HJ6A 4HLGC 4L10C 4L31C 4HKIC 4HLFC 4L0BC 4L0VC 5C5PC 4L0TC 4HKKB 4L33C 4L0SC 5ADSB 4KZQC 4L32C 4L2KC 4L2FC 4L34C 4HLHC 4HKNC 4L09C 4UI7C 4UVPB 2ZIXB 4UI4C 5ADTB 4HL5C 4HLMC 4HMHC 4UI5C
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5ADQ B;  5C5Q C;  4UI6 C;  4UI3 C;  4UI8 C;  5ADR B;  4KZL C;  4HLK C;  4KZU C;  4L2G C;  5C5R C;  5FPF C;  4L0I C;  4HLG C;  4L10 C;  4L31 C;  4HKI C;  4HLF C;  4L0B C;  4L0V C;  5C5P C;  4L0T C;  4HKK B;  4L33 C;  4L0S C;  5ADS B;  4KZQ C;  4L32 C;  4L2K C;  4L2F C;  4L34 C;  4HLH C;  4HKN C;  4L09 C;  4UI7 C;  4UVP B;  4UI4 C;  5ADT B;  4HL5 C;  4HLM C;  4HMH C;  4UI5 C; 
#chains in the Genus database with same CATH topology
 5ADQ B;  5C5Q C;  4UI6 C;  4UI3 C;  4UI8 C;  5ADR B;  4KZL C;  4HLK C;  4KZU C;  4L2G C;  5C5R C;  3G5O A;  5FPF C;  4L0I C;  3HJ6 A;  4HLG C;  2A6Q A;  4L10 C;  4ZM0 A;  4L31 C;  3CTO A;  2ODK A;  3KH2 E;  4HKI C;  4HLF C;  4L0B C;  4L0V C;  4ZM2 A;  3K6Q A;  5C5P C;  4L0T C;  4HKK B;  3OEI E;  4L33 C;  4L0S C;  5ADS B;  4KZQ C;  4L32 C;  4ZLX A;  4L2K C;  3D55 A;  4L2F C;  4HLH C;  4L34 C;  4HKN C;  4L09 C;  4UI7 C;  4UVP B;  2ZIX B;  4UI4 C;  3HS2 A;  3OEI A;  5ADT B;  3HRY A;  3K33 B;  4HL5 C;  4HLM C;  4HMH C;  4UI5 C; 
#chains in the Genus database with same CATH homology
 5ADQ B;  5C5Q C;  4UI6 C;  4UI3 C;  4UI8 C;  5ADR B;  4KZL C;  4HLK C;  4KZU C;  4L2G C;  5C5R C;  5FPF C;  4L0I C;  3HJ6 A;  4HLG C;  4L10 C;  4L31 C;  4HKI C;  4HLF C;  4L0B C;  4L0V C;  5C5P C;  4L0T C;  4HKK B;  4L33 C;  4L0S C;  5ADS B;  4KZQ C;  4L32 C;  4L2K C;  4L2F C;  4L34 C;  4HLH C;  4HKN C;  4L09 C;  4UI7 C;  4UVP B;  2ZIX B;  4UI4 C;  5ADT B;  4HL5 C;  4HLM C;  4HMH C;  4UI5 C; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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