4L7CA

Structure of keap1 kelch domain with 2-{[(1s)-2-{[(1r,2s)-2-(1h-tetrazol-5-yl)cyclohexyl]carbonyl}-1,2,3,4-tetrahydroisoquinolin-1-yl]methyl}-1h-isoindole-1,3(2h)-dione
Total Genus 63
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
63
sequence length
286
structure length
286
Chain Sequence
RLIYTAGGYFRQSLSYLEAYNPSDGTWLDLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSGRSGVGVAVTLE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Transcription/inhibitor
molecule keywords Kelch-like ECH-associated protein 1
publication title Binding Mode and Structure-Activity Relationships around Direct Inhibitors of the Nrf2-Keap1 Complex.
pubmed doi rcsb
source organism Homo sapiens
total genus 63
structure length 286
sequence length 286
chains with identical sequence B, C
ec nomenclature
pdb deposition date 2013-06-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01344 Kelch_1 Kelch motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.120.10.80 Mainly Beta 6 Propeller Neuraminidase Kelch-type beta propeller 4l7cA00
3VNHA 1ZGKA 3ADEA 3WDZA 2ZZKA 2ZWAA 4IFLX 1X2RA 4L7CA 2WOZA 2VPJA 4L7BA 4N1BA 5FNUA 5FNQA 4IFNX 3ZGCA 4YY8A 3ZGDA 2FLUX 3II7A 3WN7A 5CGJA 4IFJA 4XMBA 4CHBA 4IN4A 5FZNA 2DYHA 1U6DX 2XN4A 5F72C 5FNTA 4ASCA 4IQKA 4CH9A 5FNRA 5FNSA 4L7DA 5FZJA 3VNGA 2Z32A 4ZY3A 4ZGCA 1X2JA 2ZW9A
chains in the Genus database with same CATH superfamily
4XOGA 1NCBN 1V0EA 1F8DA 3TI8A 1IVDA 1POOA 1NNAA 1Z4VA 3K37A 2W20A 4MWWA 1W0OA 1IUBA 4N1BA 4YW1A 2YDPA 5H47A 4D4UA 3PJQA 2HTYA 1C9UA 1EUUA 1IVFA 4MWQA 1SLLA 3TC9A 4D52C 4XE9A 1N1VA 4AH4A 2FP8A 2JKBA 1S18A 4X4AA 4ZGCA 4WEFA 1DIMA 1NN2A 1EURA 1MS5A 1CRZA 1A14N 1F8CA 2SIMA 3B69A 3ZGCA 4HW6A 5FNUA 4FPKA 4WA5A 2BF6A 4C1YA 3TI6A 4YZ4A 1IVCA 1A4GA 3DASA 2QWAA 1V3BA 4GZXA 4M4UA 1NMAN 3P5BL 2CMLA 2F11A 2GVWA 4IYGA 4XHBA 4HZVA 1X2JA 2ZW9A 3UC1A 2IAPA 1NCCN 3U0SA 1W8OA 1W1XA 3WDZA 2HTWA 2QE8A 4H52A 5EO7A 3INBA 3OPZA 4M3MA 4YY8A 3ALXA 3K39A 2F12A 3TIAA 4KS4A 4IMBA 4X47A 2H2NA 2FP9A 2F0ZA 1E8VA 3O9KA 4KS5A 1CRUA 4XIKA 1L7FA 1MZ5A 2VPJA 2VW1A 4YZ2A 5D9DA 4CPOA 3S8ZA 3V65B 3H73A 2OJHA 5CGJA 1NNBA 1Q7FA 2A75A 3HLHA 5GX5A 4UOUA 1BJIA 4QNPA 4CPMA 5FNRA 3SOVA 3HRPA 1W8NA 3TI5A 4ZY3A 2BZDA 3VNHA 4FZHA 4HIZA 2QWGA 2VK5A 1IUCA 4HZWA 3CKZA 4AHAA 3O4PA 3V64C 4XJAA 4GNBA 3DR2A 4B7MA 4MZAA 5HX0A 1B9TA 4MX0A 2VK7A 4FP2A 4J9TA 4XMAA 4YW2A 4GN8A 2QWEA 1S0JA 2V91A 3I1CA 4FPLA 4XMBA 4YZ5A 1CQ1A 2BATA 2F28A 2QWHA 2W38A 6NN9A 5GX1A 1NCDN 7NN9A 4M4VA 2HTVA 5FWWA 1V3CA 5JYYA 4HHOA 4CPYA 1MR5A 5HUKA 3W09A 3A72A 1NCAN 4K1IA 2VW2A 4FPFA 5EO8A 1IJQA 1N6DA 2YA8A 2QWFA 3ZGDA 4A0PA 3JU4A 4XJ9A 1INGA 2QWKA 1IVGA 5FZNA 4B7JA 1IVEA 4IQKA 4AGIA 4NC5A 4M4NA 1NSCA 3NO0A 3SRGA 3O9JA 4WA4A 5GX2A 3GVKA 4AGTA 4XYXA 3ADEA 3GVJA 1N1SA 3V1SA 3FW0A 3K3AA 4IFNX 2F27A 5F9TA 4YW3A 1B9SA 2XZJA 1WCSA 5M1ZA 2GHSA 4MWRA 1QBIA 4MWJA 1A4QA 3K36A 1V04A 1CVMA 1INFA 2HQSA 3VNGA 1INHA 4MC7A 1ZGKA 2F24A 2YA5A 2XZKA 2QWCA 4GDJA 4I00A 3HLIA 4JF7A 4WA3A 2IAOA 2GVVA 1L7GA 2BERA 3T1EA 3A9HA 4QN7A 1PJXA 1V0ZA 2XN4A 4HZZA 5F72C 1RWIA 3S2KA 4CPNA 4GNCA 4CH9A 1USRA 4GZOA 4L7DA 1DILA 1XOEA 3E5ZA 1VCUA 2F10A 3SALA 2HU4A 2ZB6A 4XJRA 3SANA 3A9GA 3GVLA 4QN5A 4XJQA 4IFLX 3TI3A 2IAUA 4CSDA 1E8UA 5FNQA 3LI4A 5EX7A 4KS3A 2YA6A 1OFZA 4X49A 2HT7A 4H53A 2IATA 2XZIA 1NNCA 2IASA 4GB1A 4HZXA 3G4HA 4XIOA 4MWVA 5NN9A 4R40A 3SREA 1E8TA 1USXA 4FPEA 2HTRA 2HTUA 1S0IA 4XJWA 4KS1A 2QWDA 4D8SA 2ZZKA 4XHXA 2DG1A 2HT8A 1NSDA 3II7A 4O5SA 4GZSA 5D9BA 3SLIA 4CHBA 2X9MA 3TI4A 1Z4YA 2DYHA 1QLGA 2ISMA 2IAVA 1NPEA 3NSSA 2QWIA 4DG6A 2F26A 2IAXA 4XILA 5FZJA 2YA4A 2Z32A 4FOVA 4FOQA 3H6JA 2QWBA 2POOA 1N6FA 2W8BB 4B7QA 4MZEA 4C1YB 4MWUA 3KYAA 2B8HA 4XJ8A 4FPJA 4MJUA 2F29A 1KITA 4FQ4A 2YA7A 2F13A 3TIBA 2FPCA 2DG0A 4ASCA 4FVKA 3AMSA 5B2DA 1K32A 1F8BA 1Z4WA 1ZI0A 4YW4A 1N1YA 2GVXA 5HUMA 1F8EA 4GDIA 2FPBA 1MS9A 4HHQA 2HT5A 3TICA 4L7BA 1SLIA 1W0PA 4MJVA 4G3NA 4FOWA 3KGGA 4B7NA 1V2IA 2P4OA 4GEZA 4JMLA 4DGRA 2W5NA 2DSOA 4D52B 1MS4A 4FPYA 4XMIA 4KS2A 5FNTA 4FPCA 4FPOB 1L7HA 2F25A 1INWA 2QWJA 4FOYA 4GN9A 4Q1UA 4ZLRA 2IARA 3SOBB 4GZWA 4PWZA 1V3EA 2AEPA 4FPHA 4K1KA 3H72A 2W8BA 4UF7A 4YW5A 2ZWAA 1B9VA 4Q6KA 4GJTA 1IVBA 3WN7A 3L6VA 3CL0A 4FP3A 4K3YA 3BEQA 4FJ6A 2VAQA 1V0FA 2C4AA 1E1AA 1SO7A 2VVZA 3B7EA 4K1JA 1INXA 2AH2A 2IAQA 3D12A 1N7DA 1INYA 4XJUA 1EUTA 4L7CA 3SOQA 5GTQA 1V3DA 4GZPA 4FPGA 4CPZA 1NMBN 1W20A 3D11A 2SILA 1SUUA 1Z50A 1MZ6A 1INVA 2G8SA 1MS1A 4IFJA 1MS0A 1N6EA 2VSMA 1NSBA 3WWAA 4D52A 4QN4A 4GN7A 1U6DX 1C5KA 2H2UA 2AGSA 4YZ1A 1S1DA 4BBWA 2AEQA 5GX3A 4O5TA 1SNTA 4GZTA 4NCSA 1H6LA 2VW0A 3S8VA 1X2RA 3CYEA 4K1HA 2XCYA 5HUNA 5GX4A 2VWDA 3LI5A 4XJZA 1NMCA 1MS3A 4NN9A 4QN3A 1WP5A 2FHRA 2SLIA 3IAXA 4SLIA 3K38A 4IN4A 3BYCA 5D9CA 3AMRA 3ALWA 2C4LA 4WEGA 1EUSA 4X6KA 3NN9A 4MWYA 5FNSA 4MWXA 3SILA 3S94A 2HTQA 3G4EA 1MS8A 2ZB5A 4YZ3A 2RKCA 1Z4ZA 1N1TA 2HU0A 4HZYA 3WW9A 3A71A 2IAWA 2WOZA 3Q6TA 3Q6PA 1W21A 4QN6A 2VSKA 2FLUX 3CL2A 5HUGA 4CPLA 5B2CA 1XOGA 2GVUA 1VCJA 2W5OA 3FVZA 4GNAA 3LI3A 4B7RA 1Z4XA 1RWLA 3H71A 2VK6A 1MWEA 3Q6KA 1WCQA 4GZQA 2YDTA 2IVZA 4MWLA
chains in the Genus database with same CATH topology
3VNHA 1ZGKA 3ADEA 3WDZA 2ZZKA 2ZWAA 4IFLX 1X2RA 4L7CA 2WOZA 2VPJA 4L7BA 4N1BA 5FNUA 5FNQA 4IFNX 3ZGCA 4YY8A 3ZGDA 2FLUX 3II7A 3WN7A 5CGJA 4IFJA 4XMBA 4CHBA 4IN4A 5FZNA 2DYHA 1U6DX 2XN4A 5F72C 5FNTA 4ASCA 4IQKA 4CH9A 5FNRA 5FNSA 4L7DA 5FZJA 3VNGA 2Z32A 4ZY3A 4ZGCA 1X2JA 2ZW9A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3VNH A;  1ZGK A;  3ADE A;  3WDZ A;  2ZZK A;  2ZWA A;  4IFL X;  1X2R A;  4L7C A;  2WOZ A;  2VPJ A;  4L7B A;  4N1B A;  5FNU A;  5FNQ A;  4IFN X;  3ZGC A;  4YY8 A;  3ZGD A;  2FLU X;  3II7 A;  3WN7 A;  5CGJ A;  4IFJ A;  4XMB A;  4CHB A;  4IN4 A;  5FZN A;  2DYH A;  1U6D X;  2XN4 A;  5F72 C;  5FNT A;  4ASC A;  4IQK A;  4CH9 A;  5FNR A;  5FNS A;  4L7D A;  5FZJ A;  3VNG A;  2Z32 A;  4ZY3 A;  4ZGC A;  1X2J A;  2ZW9 A; 
#chains in the Genus database with same CATH topology
 4XOG A;  1NCB N;  1V0E A;  1F8D A;  3TI8 A;  1IVD A;  1POO A;  1NNA A;  1Z4V A;  3K37 A;  2W20 A;  4MWW A;  1W0O A;  1IUB A;  4N1B A;  4YW1 A;  2YDP A;  5H47 A;  4D4U A;  3PJQ A;  2HTY A;  1C9U A;  1EUU A;  1IVF A;  4MWQ A;  1SLL A;  3TC9 A;  4D52 C;  4XE9 A;  1N1V A;  4AH4 A;  2FP8 A;  2JKB A;  1S18 A;  4X4A A;  4ZGC A;  4WEF A;  1DIM A;  1NN2 A;  1EUR A;  1MS5 A;  1CRZ A;  1A14 N;  1F8C A;  2SIM A;  3B69 A;  3ZGC A;  4HW6 A;  5FNU A;  4FPK A;  4WA5 A;  2BF6 A;  4C1Y A;  3TI6 A;  4YZ4 A;  1IVC A;  1A4G A;  3DAS A;  2QWA A;  1V3B A;  4GZX A;  4M4U A;  1NMA N;  3P5B L;  2CML A;  2F11 A;  2GVW A;  4IYG A;  4XHB A;  4HZV A;  1X2J A;  2ZW9 A;  3UC1 A;  2IAP A;  1NCC N;  3U0S A;  1W8O A;  1W1X A;  3WDZ A;  2HTW A;  2QE8 A;  4H52 A;  5EO7 A;  3INB A;  3OPZ A;  4M3M A;  4YY8 A;  3ALX A;  3K39 A;  2F12 A;  3TIA A;  4KS4 A;  4IMB A;  4X47 A;  2H2N A;  2FP9 A;  2F0Z A;  1E8V A;  3O9K A;  4KS5 A;  1CRU A;  4XIK A;  1L7F A;  1MZ5 A;  2VPJ A;  2VW1 A;  4YZ2 A;  5D9D A;  4CPO A;  3S8Z A;  3V65 B;  3H73 A;  2OJH A;  5CGJ A;  1NNB A;  1Q7F A;  2A75 A;  3HLH A;  5GX5 A;  4UOU A;  1BJI A;  4QNP A;  4CPM A;  5FNR A;  3SOV A;  3HRP A;  1W8N A;  3TI5 A;  4ZY3 A;  2BZD A;  3VNH A;  4FZH A;  4HIZ A;  2QWG A;  2VK5 A;  1IUC A;  4HZW A;  3CKZ A;  4AHA A;  3O4P A;  3V64 C;  4XJA A;  4GNB A;  3DR2 A;  4B7M A;  4MZA A;  5HX0 A;  1B9T A;  4MX0 A;  2VK7 A;  4FP2 A;  4J9T A;  4XMA A;  4YW2 A;  4GN8 A;  2QWE A;  1S0J A;  2V91 A;  3I1C A;  4FPL A;  4XMB A;  4YZ5 A;  1CQ1 A;  2BAT A;  2F28 A;  2QWH A;  2W38 A;  6NN9 A;  5GX1 A;  1NCD N;  7NN9 A;  4M4V A;  2HTV A;  5FWW A;  1V3C A;  5JYY A;  4HHO A;  4CPY A;  1MR5 A;  5HUK A;  3W09 A;  3A72 A;  1NCA N;  4K1I A;  2VW2 A;  4FPF A;  5EO8 A;  1IJQ A;  1N6D A;  2YA8 A;  2QWF A;  3ZGD A;  4A0P A;  3JU4 A;  4XJ9 A;  1ING A;  2QWK A;  1IVG A;  5FZN A;  4B7J A;  1IVE A;  4IQK A;  4AGI A;  4NC5 A;  4M4N A;  1NSC A;  3NO0 A;  3SRG A;  3O9J A;  4WA4 A;  5GX2 A;  3GVK A;  4AGT A;  4XYX A;  3ADE A;  3GVJ A;  1N1S A;  3V1S A;  3FW0 A;  3K3A A;  4IFN X;  2F27 A;  5F9T A;  4YW3 A;  1B9S A;  2XZJ A;  1WCS A;  5M1Z A;  2GHS A;  4MWR A;  1QBI A;  4MWJ A;  1A4Q A;  3K36 A;  1V04 A;  1CVM A;  1INF A;  2HQS A;  3VNG A;  1INH A;  4MC7 A;  1ZGK A;  2F24 A;  2YA5 A;  2XZK A;  2QWC A;  4GDJ A;  4I00 A;  3HLI A;  4JF7 A;  4WA3 A;  2IAO A;  2GVV A;  1L7G A;  2BER A;  3T1E A;  3A9H A;  4QN7 A;  1PJX A;  1V0Z A;  2XN4 A;  4HZZ A;  5F72 C;  1RWI A;  3S2K A;  4CPN A;  4GNC A;  4CH9 A;  1USR A;  4GZO A;  4L7D A;  1DIL A;  1XOE A;  3E5Z A;  1VCU A;  2F10 A;  3SAL A;  2HU4 A;  2ZB6 A;  4XJR A;  3SAN A;  3A9G A;  3GVL A;  4QN5 A;  4XJQ A;  4IFL X;  3TI3 A;  2IAU A;  4CSD A;  1E8U A;  5FNQ A;  3LI4 A;  5EX7 A;  4KS3 A;  2YA6 A;  1OFZ A;  4X49 A;  2HT7 A;  4H53 A;  2IAT A;  2XZI A;  1NNC A;  2IAS A;  4GB1 A;  4HZX A;  3G4H A;  4XIO A;  4MWV A;  5NN9 A;  4R40 A;  3SRE A;  1E8T A;  1USX A;  4FPE A;  2HTR A;  2HTU A;  1S0I A;  4XJW A;  4KS1 A;  2QWD A;  4D8S A;  2ZZK A;  4XHX A;  2DG1 A;  2HT8 A;  1NSD A;  3II7 A;  4O5S A;  4GZS A;  5D9B A;  3SLI A;  4CHB A;  2X9M A;  3TI4 A;  1Z4Y A;  2DYH A;  1QLG A;  2ISM A;  2IAV A;  1NPE A;  3NSS A;  2QWI A;  4DG6 A;  2F26 A;  2IAX A;  4XIL A;  5FZJ A;  2YA4 A;  2Z32 A;  4FOV A;  4FOQ A;  3H6J A;  2QWB A;  2POO A;  1N6F A;  2W8B B;  4B7Q A;  4MZE A;  4C1Y B;  4MWU A;  3KYA A;  2B8H A;  4XJ8 A;  4FPJ A;  4MJU A;  2F29 A;  1KIT A;  4FQ4 A;  2YA7 A;  2F13 A;  3TIB A;  2FPC A;  2DG0 A;  4ASC A;  4FVK A;  3AMS A;  5B2D A;  1K32 A;  1F8B A;  1Z4W A;  1ZI0 A;  4YW4 A;  1N1Y A;  2GVX A;  5HUM A;  1F8E A;  4GDI A;  2FPB A;  1MS9 A;  4HHQ A;  2HT5 A;  3TIC A;  4L7B A;  1SLI A;  1W0P A;  4MJV A;  4G3N A;  4FOW A;  3KGG A;  4B7N A;  1V2I A;  2P4O A;  4GEZ A;  4JML A;  4DGR A;  2W5N A;  2DSO A;  4D52 B;  1MS4 A;  4FPY A;  4XMI A;  4KS2 A;  5FNT A;  4FPC A;  4FPO B;  1L7H A;  2F25 A;  1INW A;  2QWJ A;  4FOY A;  4GN9 A;  4Q1U A;  4ZLR A;  2IAR A;  3SOB B;  4GZW A;  4PWZ A;  1V3E A;  2AEP A;  4FPH A;  4K1K A;  3H72 A;  2W8B A;  4UF7 A;  4YW5 A;  2ZWA A;  1B9V A;  4Q6K A;  4GJT A;  1IVB A;  3WN7 A;  3L6V A;  3CL0 A;  4FP3 A;  4K3Y A;  3BEQ A;  4FJ6 A;  2VAQ A;  1V0F A;  2C4A A;  1E1A A;  1SO7 A;  2VVZ A;  3B7E A;  4K1J A;  1INX A;  2AH2 A;  2IAQ A;  3D12 A;  1N7D A;  1INY A;  4XJU A;  1EUT A;  4L7C A;  3SOQ A;  5GTQ A;  1V3D A;  4GZP A;  4FPG A;  4CPZ A;  1NMB N;  1W20 A;  3D11 A;  2SIL A;  1SUU A;  1Z50 A;  1MZ6 A;  1INV A;  2G8S A;  1MS1 A;  4IFJ A;  1MS0 A;  1N6E A;  2VSM A;  1NSB A;  3WWA A;  4D52 A;  4QN4 A;  4GN7 A;  1U6D X;  1C5K A;  2H2U A;  2AGS A;  4YZ1 A;  1S1D A;  4BBW A;  2AEQ A;  5GX3 A;  4O5T A;  1SNT A;  4GZT A;  4NCS A;  1H6L A;  2VW0 A;  3S8V A;  1X2R A;  3CYE A;  4K1H A;  2XCY A;  5HUN A;  5GX4 A;  2VWD A;  3LI5 A;  4XJZ A;  1NMC A;  1MS3 A;  4NN9 A;  4QN3 A;  1WP5 A;  2FHR A;  2SLI A;  3IAX A;  4SLI A;  3K38 A;  4IN4 A;  3BYC A;  5D9C A;  3AMR A;  3ALW A;  2C4L A;  4WEG A;  1EUS A;  4X6K A;  3NN9 A;  4MWY A;  5FNS A;  4MWX A;  3SIL A;  3S94 A;  2HTQ A;  3G4E A;  1MS8 A;  2ZB5 A;  4YZ3 A;  2RKC A;  1Z4Z A;  1N1T A;  2HU0 A;  4HZY A;  3WW9 A;  3A71 A;  2IAW A;  2WOZ A;  3Q6T A;  3Q6P A;  1W21 A;  4QN6 A;  2VSK A;  2FLU X;  3CL2 A;  5HUG A;  4CPL A;  5B2C A;  1XOG A;  2GVU A;  1VCJ A;  2W5O A;  3FVZ A;  4GNA A;  3LI3 A;  4B7R A;  1Z4X A;  1RWL A;  3H71 A;  2VK6 A;  1MWE A;  3Q6K A;  1WCQ A;  4GZQ A;  2YDT A;  2IVZ A;  4MWL A; 
#chains in the Genus database with same CATH homology
 3VNH A;  1ZGK A;  3ADE A;  3WDZ A;  2ZZK A;  2ZWA A;  4IFL X;  1X2R A;  4L7C A;  2WOZ A;  2VPJ A;  4L7B A;  4N1B A;  5FNU A;  5FNQ A;  4IFN X;  3ZGC A;  4YY8 A;  3ZGD A;  2FLU X;  3II7 A;  3WN7 A;  5CGJ A;  4IFJ A;  4XMB A;  4CHB A;  4IN4 A;  5FZN A;  2DYH A;  1U6D X;  2XN4 A;  5F72 C;  5FNT A;  4ASC A;  4IQK A;  4CH9 A;  5FNR A;  5FNS A;  4L7D A;  5FZJ A;  3VNG A;  2Z32 A;  4ZY3 A;  4ZGC A;  1X2J A;  2ZW9 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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