4L9KA

X-ray study of human serum albumin complexed with camptothecin
Total Genus 223
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
223
sequence length
578
structure length
578
Chain Sequence
SEVAHRFKDLGEENFKALVLIAFAQYLQQCPFEDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTVATLRETYGEMADCCAKQEPERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLFFAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAVARLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLKECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYARRHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFEQLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVVLNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTLSEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLVAASQAA
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural studies of several clinically important oncology drugs in complex with human serum albumin.
pubmed doi rcsb
molecule keywords SERUM ALBUMIN
molecule tags Transport protein
total genus 223
structure length 578
sequence length 578
chains with identical sequence B
ec nomenclature
pdb deposition date 2013-06-18

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00273 Serum_albumin Serum albumin family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 4l9kA03
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 4l9kA02
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 4l9kA04
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 4l9kA01
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 4l9kA06
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 4l9kA05
2I2ZA 3SQJA 4BKEA 2I30A 3JRYA 1J7EA 3B9LA 4PO0A 4F5UA 3A73A 5DQFA 2XVUA 2BXFA 2XSIA 5ID7A 1E7EA 2VDBA 2BXOA 1BM0A 5GHKA 4L8UA 2BXPA 1E7CA 2VUFA 1E7AA 4IW2A 2BXCA 2BXKA 1E7BA 4K71A 3UIVA 3V09A 1O9XA 1LOTA 1E7IA 4LB9A 4LB2A 5IIUA 4N0UD 2BXGA 1HK5A 3LU8A 4JK4A 2XW1A 2BXMA 4F5TA 2BXBA 4L9KA 1GNJA 1KXPD 2XVVA 4HGKA 5IJEA 4F5SA 1TF0A 1H9ZA 4E99A 1HK2A 4N0FD 1KW2A 3LU7A 4OR0A 1BJ5A 2XVWA 4S1YA 1HK4A 4G03A 5ID9A 1HK1A 1HK3A 4F5VA 4LA0A 1E7GA 4ZBRA 1N5UA 4HGMB 1MA9A 4LUFA 4LUHA 4IW1A 2BXAA 1HA2A 3B9MA 5HOZA 4Z69A 4EMXA 5IIXA 3LU6A 3TDLA 3V03A 5IIHA 1E7HA 2BXQA 5FUOA 2XW0A 2BXEA 4ZBQA 4K2CA 5IJFA 1BKEA 2BXDA 1E78A 2BXLA 5DBYA 4L9QA 3V08A 2BXHA 4OT2A 3CX9A 1AO6A 2BXNA 5IJ5A 1GNIA 2BX8A 2BXIA 5IFOA 2YDFA 4G04A 1J78A 2XVQA 2VUEA 3JQZA 1E7FA 1UORA 4J2VA
chains in the Genus database with same CATH superfamily
2I2ZA 4TQ1A 3SQJA 2NNWA 2KBZA 3WHRA 5D7GA 4GDLB 2OZBB 4BKEA 1MIWA 1LNSA 2I30A 3JRYA 1J7EA 3B9LA 4PO0A 2LXSA 4F5UA 2QHBA 3A73A 2EFDA 2DG5A 4TQ0A 3A75A 2QM6A 5DQFA 4G01A 1MIVA 2XVUA 2BXFA 2XSIA 3PLAA 2EFCA 4NAWB 5ID7A 1E7EA 2DBXA 2BXOA 2VDBA 1BM0A 1VFIA 3GA9L 5GHKA 4L8UA 2OT3A 2BXPA 4DHXB 1E7CA 2VUFA 1MUHA 1E7AA 4IW2A 5GINA 2BXCA 2BXKA 2GUTA 1E7BA 4K71A 4C31B 2LQHA 3UIVA 1O9XA 3V09A 3WHQA 1LOTA 2AJEA 3MHSB 4GG2A 1E7IA 4LB9A 3FWBC 4OTTA 3SIUB 2QMCA 4I9OA 4LB2A 4FIPB 5IIUA 2E0XA 3NVMA 3BPJA 4N0UD 2BXGA 1HK5A 3LU8A 4JK4A 2XW1A 2BXMA 4F5TA 1H5WA 2BXBA 4L9KA 1GNJA 3ECPA 4ZCGA 1KXPD 2LQIA 2Z8KA 2XVVA 4ZC6A 2V36A 4HGKA 4FJCB 1TXUA 3G9KD 3H37A 5IJEA 4F5SA 1TF0A 1H9ZA 4E99A 2CKXA 1HK2A 2LXTA 4N0FD 1KW2A 3LU7A 1FOUA 4OR0A 4ZBKA 1BJ5A 2XVWA 3ICXA 4S1YA 1HK4A 2LOQA 2ROHA 4G03A 3W1SA 1HK1A 5ID9A 1HK3A 4F5VA 4ZUXV 4LA0A 5BPKA 2EFEA 1E7GA 4ZBRA 2JUHA 3NVKA 1N5UA 2DYOA 1MA9A 2DBWA 4HGMB 2Z8JA 5B5TA 4GDXA 4LUFA 4LUHA 1MM8A 3KJLA 4IW1A 2E0YA 2BXAA 1IJGA 1SB0A 4MBEC 1HA2A 2DYMA 3B9MA 5HOZA 4D7XA 4Z69A 3SIVB 1JNBA 4EMXA 5IIXA 3M99C 4Z9OA 3LU6A 3GQXA 2EFHA 4FK5B 4GDKB 3TDLA 3V03A 5IIHA 3GQUA 2AGHB 1E7HA 2BXQA 2K0NA 2Z8IA 5FUOA 2XW0A 4DM0A 2DBUA 2XMOA 1MIYA 2BXEA 3FNMA 4ZBQA 4K2CA 5IJFA 1BKEA 2BXDA 1E78A 2BXLA 5DBYA 4W4UB 3NMUA 4L9QA 3V08A 2NQOA 4BY9C 2BXHA 4OT2A 3CX9A 1AO6A 2BXNA 3FWCC 4OTUA 5GIPA 1KDXA 3NVIA 5IJ5A 1NT2B 1GNIA 2BX8A 2BXIA 5IFOA 3WHSA 5GIOA 3H3AA 4WA6B 2YDFA 4G04A 1J78A 2XVQA 3KIKA 3MHHB 2VUEA 3JQZA 2KWFA 4N3ZA 1E7FA 1VZSA 4M70B 1UORA 4J2VA 3VQIA 1MUSA
chains in the Genus database with same CATH topology
2I2ZA 4TQ1A 3SQJA 2NNWA 2KBZA 3WHRA 5D7GA 4GDLB 2OZBB 4BKEA 1MIWA 1LNSA 2I30A 3JRYA 1J7EA 3B9LA 4PO0A 4F5UA 2QHBA 3A73A 2EFDA 2DG5A 4TQ0A 3A75A 2QM6A 5DQFA 4G01A 1MIVA 2XVUA 2BXFA 2XSIA 3PLAA 2EFCA 4NAWB 5ID7A 1E7EA 2DBXA 2BXOA 2VDBA 1BM0A 1VFIA 3GA9L 5GHKA 4L8UA 2OT3A 2BXPA 4DHXB 1E7CA 2VUFA 1E7AA 4IW2A 5GINA 2BXCA 2BXKA 1E7BA 4K71A 4C31B 3UIVA 3V09A 1O9XA 3WHQA 1LOTA 2AJEA 3MHSB 4GG2A 1E7IA 4LB9A 3FWBC 4OTTA 3SIUB 2QMCA 4LB2A 4FIPB 5IIUA 2E0XA 3NVMA 4N0UD 2BXGA 1HK5A 3LU8A 4JK4A 2XW1A 2BXMA 4F5TA 1H5WA 2BXBA 4L9KA 1GNJA 4ZCGA 1KXPD 2Z8KA 2XVVA 4ZC6A 2V36A 4HGKA 4FJCB 1TXUA 3G9KD 3H37A 5IJEA 4F5SA 1TF0A 1H9ZA 4E99A 2CKXA 1HK2A 4N0FD 1KW2A 3LU7A 1FOUA 4OR0A 4ZBKA 1BJ5A 2XVWA 3ICXA 4S1YA 1HK4A 2LOQA 2ROHA 4G03A 3W1SA 1HK1A 5ID9A 1HK3A 4F5VA 4ZUXV 4LA0A 5BPKA 2EFEA 1E7GA 4ZBRA 2JUHA 3NVKA 1N5UA 2DYOA 1MA9A 2DBWA 4HGMB 2Z8JA 5B5TA 4GDXA 4LUFA 4LUHA 3KJLA 4IW1A 2E0YA 2BXAA 1IJGA 4MBEC 1HA2A 2DYMA 3B9MA 5HOZA 4Z69A 3SIVB 1JNBA 4EMXA 5IIXA 3M99C 4Z9OA 3LU6A 3GQXA 2EFHA 4FK5B 4GDKB 3TDLA 3V03A 5IIHA 3GQUA 1E7HA 2BXQA 2Z8IA 5FUOA 2XW0A 2DBUA 2XMOA 1MIYA 2BXEA 3FNMA 4ZBQA 4K2CA 5IJFA 1BKEA 2BXDA 1E78A 2BXLA 5DBYA 4W4UB 3NMUA 4L9QA 3V08A 2NQOA 4BY9C 2BXHA 4OT2A 3CX9A 1AO6A 2BXNA 3FWCC 4OTUA 5GIPA 3NVIA 5IJ5A 1NT2B 1GNIA 2BX8A 2BXIA 5IFOA 3WHSA 5GIOA 3H3AA 4WA6B 2YDFA 4G04A 1J78A 2XVQA 3KIKA 3MHHB 2VUEA 3JQZA 4N3ZA 1E7FA 1VZSA 4M70B 1UORA 4J2VA 3VQIA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2I2Z A;  3SQJ A;  4BKE A;  2I30 A;  3JRY A;  1J7E A;  3B9L A;  4PO0 A;  4F5U A;  3A73 A;  5DQF A;  2XVU A;  2BXF A;  2XSI A;  5ID7 A;  1E7E A;  2VDB A;  2BXO A;  1BM0 A;  5GHK A;  4L8U A;  2BXP A;  1E7C A;  2VUF A;  1E7A A;  4IW2 A;  2BXC A;  2BXK A;  1E7B A;  4K71 A;  3UIV A;  3V09 A;  1O9X A;  1LOT A;  1E7I A;  4LB9 A;  4LB2 A;  5IIU A;  4N0U D;  2BXG A;  1HK5 A;  3LU8 A;  4JK4 A;  2XW1 A;  2BXM A;  4F5T A;  2BXB A;  4L9K A;  1GNJ A;  1KXP D;  2XVV A;  4HGK A;  5IJE A;  4F5S A;  1TF0 A;  1H9Z A;  4E99 A;  1HK2 A;  4N0F D;  1KW2 A;  3LU7 A;  4OR0 A;  1BJ5 A;  2XVW A;  4S1Y A;  1HK4 A;  4G03 A;  5ID9 A;  1HK1 A;  1HK3 A;  4F5V A;  4LA0 A;  1E7G A;  4ZBR A;  1N5U A;  4HGM B;  1MA9 A;  4LUF A;  4LUH A;  4IW1 A;  2BXA A;  1HA2 A;  3B9M A;  5HOZ A;  4Z69 A;  4EMX A;  5IIX A;  3LU6 A;  3TDL A;  3V03 A;  5IIH A;  1E7H A;  2BXQ A;  5FUO A;  2XW0 A;  2BXE A;  4ZBQ A;  4K2C A;  5IJF A;  1BKE A;  2BXD A;  1E78 A;  2BXL A;  5DBY A;  4L9Q A;  3V08 A;  2BXH A;  4OT2 A;  3CX9 A;  1AO6 A;  2BXN A;  5IJ5 A;  1GNI A;  2BX8 A;  2BXI A;  5IFO A;  2YDF A;  4G04 A;  1J78 A;  2XVQ A;  2VUE A;  3JQZ A;  1E7F A;  1UOR A;  4J2V A; 
#chains in the Genus database with same CATH topology
 2I2Z A;  4TQ1 A;  3SQJ A;  2NNW A;  2KBZ A;  3WHR A;  5D7G A;  4GDL B;  2OZB B;  4BKE A;  1MIW A;  1LNS A;  2I30 A;  3JRY A;  1J7E A;  3B9L A;  4PO0 A;  2LXS A;  4F5U A;  2QHB A;  3A73 A;  2EFD A;  2DG5 A;  4TQ0 A;  3A75 A;  2QM6 A;  5DQF A;  4G01 A;  1MIV A;  2XVU A;  2BXF A;  2XSI A;  3PLA A;  2EFC A;  4NAW B;  5ID7 A;  1E7E A;  2DBX A;  2BXO A;  2VDB A;  1BM0 A;  1VFI A;  3GA9 L;  5GHK A;  4L8U A;  2OT3 A;  2BXP A;  4DHX B;  1E7C A;  2VUF A;  1MUH A;  1E7A A;  4IW2 A;  5GIN A;  2BXC A;  2BXK A;  2GUT A;  1E7B A;  4K71 A;  4C31 B;  2LQH A;  3UIV A;  1O9X A;  3V09 A;  3WHQ A;  1LOT A;  2AJE A;  3MHS B;  4GG2 A;  1E7I A;  4LB9 A;  3FWB C;  4OTT A;  3SIU B;  2QMC A;  4I9O A;  4LB2 A;  4FIP B;  5IIU A;  2E0X A;  3NVM A;  3BPJ A;  4N0U D;  2BXG A;  1HK5 A;  3LU8 A;  4JK4 A;  2XW1 A;  2BXM A;  4F5T A;  1H5W A;  2BXB A;  4L9K A;  1GNJ A;  3ECP A;  4ZCG A;  1KXP D;  2LQI A;  2Z8K A;  2XVV A;  4ZC6 A;  2V36 A;  4HGK A;  4FJC B;  1TXU A;  3G9K D;  3H37 A;  5IJE A;  4F5S A;  1TF0 A;  1H9Z A;  4E99 A;  2CKX A;  1HK2 A;  2LXT A;  4N0F D;  1KW2 A;  3LU7 A;  1FOU A;  4OR0 A;  4ZBK A;  1BJ5 A;  2XVW A;  3ICX A;  4S1Y A;  1HK4 A;  2LOQ A;  2ROH A;  4G03 A;  3W1S A;  1HK1 A;  5ID9 A;  1HK3 A;  4F5V A;  4ZUX V;  4LA0 A;  5BPK A;  2EFE A;  1E7G A;  4ZBR A;  2JUH A;  3NVK A;  1N5U A;  2DYO A;  1MA9 A;  2DBW A;  4HGM B;  2Z8J A;  5B5T A;  4GDX A;  4LUF A;  4LUH A;  1MM8 A;  3KJL A;  4IW1 A;  2E0Y A;  2BXA A;  1IJG A;  1SB0 A;  4MBE C;  1HA2 A;  2DYM A;  3B9M A;  5HOZ A;  4D7X A;  4Z69 A;  3SIV B;  1JNB A;  4EMX A;  5IIX A;  3M99 C;  4Z9O A;  3LU6 A;  3GQX A;  2EFH A;  4FK5 B;  4GDK B;  3TDL A;  3V03 A;  5IIH A;  3GQU A;  2AGH B;  1E7H A;  2BXQ A;  2K0N A;  2Z8I A;  5FUO A;  2XW0 A;  4DM0 A;  2DBU A;  2XMO A;  1MIY A;  2BXE A;  3FNM A;  4ZBQ A;  4K2C A;  5IJF A;  1BKE A;  2BXD A;  1E78 A;  2BXL A;  5DBY A;  4W4U B;  3NMU A;  4L9Q A;  3V08 A;  2NQO A;  4BY9 C;  2BXH A;  4OT2 A;  3CX9 A;  1AO6 A;  2BXN A;  3FWC C;  4OTU A;  5GIP A;  1KDX A;  3NVI A;  5IJ5 A;  1NT2 B;  1GNI A;  2BX8 A;  2BXI A;  5IFO A;  3WHS A;  5GIO A;  3H3A A;  4WA6 B;  2YDF A;  4G04 A;  1J78 A;  2XVQ A;  3KIK A;  3MHH B;  2VUE A;  3JQZ A;  2KWF A;  4N3Z A;  1E7F A;  1VZS A;  4M70 B;  1UOR A;  4J2V A;  3VQI A;  1MUS A; 
#chains in the Genus database with same CATH homology
 2I2Z A;  4TQ1 A;  3SQJ A;  2NNW A;  2KBZ A;  3WHR A;  5D7G A;  4GDL B;  2OZB B;  4BKE A;  1MIW A;  1LNS A;  2I30 A;  3JRY A;  1J7E A;  3B9L A;  4PO0 A;  4F5U A;  2QHB A;  3A73 A;  2EFD A;  2DG5 A;  4TQ0 A;  3A75 A;  2QM6 A;  5DQF A;  4G01 A;  1MIV A;  2XVU A;  2BXF A;  2XSI A;  3PLA A;  2EFC A;  4NAW B;  5ID7 A;  1E7E A;  2DBX A;  2BXO A;  2VDB A;  1BM0 A;  1VFI A;  3GA9 L;  5GHK A;  4L8U A;  2OT3 A;  2BXP A;  4DHX B;  1E7C A;  2VUF A;  1E7A A;  4IW2 A;  5GIN A;  2BXC A;  2BXK A;  1E7B A;  4K71 A;  4C31 B;  3UIV A;  3V09 A;  1O9X A;  3WHQ A;  1LOT A;  2AJE A;  3MHS B;  4GG2 A;  1E7I A;  4LB9 A;  3FWB C;  4OTT A;  3SIU B;  2QMC A;  4LB2 A;  4FIP B;  5IIU A;  2E0X A;  3NVM A;  4N0U D;  2BXG A;  1HK5 A;  3LU8 A;  4JK4 A;  2XW1 A;  2BXM A;  4F5T A;  1H5W A;  2BXB A;  4L9K A;  1GNJ A;  4ZCG A;  1KXP D;  2Z8K A;  2XVV A;  4ZC6 A;  2V36 A;  4HGK A;  4FJC B;  1TXU A;  3G9K D;  3H37 A;  5IJE A;  4F5S A;  1TF0 A;  1H9Z A;  4E99 A;  2CKX A;  1HK2 A;  4N0F D;  1KW2 A;  3LU7 A;  1FOU A;  4OR0 A;  4ZBK A;  1BJ5 A;  2XVW A;  3ICX A;  4S1Y A;  1HK4 A;  2LOQ A;  2ROH A;  4G03 A;  3W1S A;  1HK1 A;  5ID9 A;  1HK3 A;  4F5V A;  4ZUX V;  4LA0 A;  5BPK A;  2EFE A;  1E7G A;  4ZBR A;  2JUH A;  3NVK A;  1N5U A;  2DYO A;  1MA9 A;  2DBW A;  4HGM B;  2Z8J A;  5B5T A;  4GDX A;  4LUF A;  4LUH A;  3KJL A;  4IW1 A;  2E0Y A;  2BXA A;  1IJG A;  4MBE C;  1HA2 A;  2DYM A;  3B9M A;  5HOZ A;  4Z69 A;  3SIV B;  1JNB A;  4EMX A;  5IIX A;  3M99 C;  4Z9O A;  3LU6 A;  3GQX A;  2EFH A;  4FK5 B;  4GDK B;  3TDL A;  3V03 A;  5IIH A;  3GQU A;  1E7H A;  2BXQ A;  2Z8I A;  5FUO A;  2XW0 A;  2DBU A;  2XMO A;  1MIY A;  2BXE A;  3FNM A;  4ZBQ A;  4K2C A;  5IJF A;  1BKE A;  2BXD A;  1E78 A;  2BXL A;  5DBY A;  4W4U B;  3NMU A;  4L9Q A;  3V08 A;  2NQO A;  4BY9 C;  2BXH A;  4OT2 A;  3CX9 A;  1AO6 A;  2BXN A;  3FWC C;  4OTU A;  5GIP A;  3NVI A;  5IJ5 A;  1NT2 B;  1GNI A;  2BX8 A;  2BXI A;  5IFO A;  3WHS A;  5GIO A;  3H3A A;  4WA6 B;  2YDF A;  4G04 A;  1J78 A;  2XVQ A;  3KIK A;  3MHH B;  2VUE A;  3JQZ A;  4N3Z A;  1E7F A;  1VZS A;  4M70 B;  1UOR A;  4J2V A;  3VQI A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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