4L9KA

X-ray study of human serum albumin complexed with camptothecin
Total Genus 223
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
223
sequence length
578
structure length
578
Chain Sequence
SEVAHRFKDLGEENFKALVLIAFAQYLQQCPFEDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTVATLRETYGEMADCCAKQEPERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLFFAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAVARLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLKECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYARRHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFEQLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVVLNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTLSEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLVAASQAA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords SERUM ALBUMIN
publication title Structural studies of several clinically important oncology drugs in complex with human serum albumin.
pubmed doi rcsb
molecule tags Transport protein
total genus 223
structure length 578
sequence length 578
chains with identical sequence B
ec nomenclature
pdb deposition date 2013-06-18

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00273 Serum_albumin Serum albumin family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 4l9kA03
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 4l9kA02
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 4l9kA04
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 4l9kA01
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 4l9kA06
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 4l9kA05
5ID9A 4LB2A 1E7CA 1BM0A 1H9ZA 4JK4A 4OR0A 4Z69A 1BJ5A 5IIXA 1E7GA 2BXDA 4G03A 1HK4A 5GHKA 3LU7A 1KXPD 1E7BA 3V08A 5FUOA 1HK3A 2BXAA 2I30A 2BXHA 3JQZA 3UIVA 2XVQA 1HK2A 1E7AA 1J7EA 2VUEA 2XVWA 5IJFA 1HK5A 5DBYA 2XW1A 2XVUA 2BXGA 4E99A 2YDFA 4L9KA 1N5UA 2BXFA 5IIUA 1TF0A 3A73A 1GNJA 1HK1A 2BXPA 2I2ZA 3B9MA 2BXNA 2BX8A 2BXEA 2XSIA 3LU8A 4N0UD 2XVVA 1LOTA 2BXLA 4J2VA 4HGMB 4K71A 3CX9A 4PO0A 4L8UA 4IW2A 3JRYA 4IW1A 1KW2A 5IJ5A 2BXOA 1E7EA 4F5UA 3SQJA 4EMXA 4N0FD 3B9LA 4LUHA 1GNIA 2BXMA 4L9QA 2XW0A 4LA0A 1MA9A 4F5SA 4K2CA 1J78A 1E78A 1E7HA 4LB9A 5IJEA 4ZBQA 5ID7A 5IIHA 2BXIA 3LU6A 1O9XA 1HA2A 1AO6A 2BXKA 2BXBA 2BXCA 2BXQA 3TDLA 4HGKA 4G04A 4F5TA 1BKEA 4F5VA 3V09A 3V03A 4OT2A 1E7FA 5DQFA 2VUFA 5HOZA 1E7IA 4LUFA 2VDBA 4ZBRA 5IFOA 4S1YA 4BKEA 1UORA
chains in the Genus database with same CATH superfamily
5ID9A 4LB2A 2V36A 1E7CA 1IJGA 2AGHB 1VFIA 4FJCB 1BM0A 1H9ZA 2DBWA 2ROHA 4JK4A 4OR0A 2E0YA 2DG5A 4Z69A 1BJ5A 4GDLB 2K0NA 5IIXA 5BPKA 3KIKA 1E7GA 2LXSA 2BXDA 2Z8JA 4G03A 3NMUA 4N3ZA 5B5TA 3NVMA 2OZBB 4G01A 1HK4A 5GHKA 3FNMA 2KWFA 3LU7A 1MIWA 2NQOA 2LQIA 1KXPD 3GA9L 1E7BA 2DYOA 3V08A 1KDXA 5FUOA 1HK3A 3BPJA 2BXAA 2I30A 2BXHA 3JQZA 4TQ1A 3WHRA 3FWBC 3UIVA 1JNBA 3FWCC 4W4UB 2XVQA 2AJEA 1FOUA 1HK2A 2EFEA 4WA6B 1E7AA 1J7EA 2VUEA 2XVWA 4GDKB 5IJFA 1NT2B 1MIYA 4TQ0A 1HK5A 5DBYA 1LNSA 2XW1A 2XVUA 3H37A 2EFHA 4C31B 5GINA 2DBUA 3SIVB 2BXGA 4E99A 2YDFA 4L9KA 1N5UA 2BXFA 1MIVA 2GUTA 3A75A 5IIUA 1TF0A 3A73A 1GNJA 1HK1A 2BXPA 2I2ZA 3B9MA 2BXNA 2BX8A 2BXEA 2XSIA 3LU8A 4N0UD 4NAWB 2OT3A 2XVVA 2CKXA 1LOTA 2BXLA 3M99C 4J2VA 4HGMB 4K71A 1VZSA 3CX9A 4PO0A 3WHSA 4L8UA 4OTTA 4IW2A 4MBEC 3KJLA 2DYMA 3JRYA 4IW1A 4M70B 2EFCA 3H3AA 1KW2A 1MUSA 4FK5B 5IJ5A 4ZUXV 1MUHA 2BXOA 4DM0A 1E7EA 2E0XA 3SQJA 2EFDA 4F5UA 4EMXA 4N0FD 3B9LA 4LUHA 2QM6A 1H5WA 4DHXB 2JUHA 1GNIA 2BXMA 3SIUB 4FIPB 4L9QA 2XW0A 4LA0A 4D7XA 1MA9A 4F5SA 3ICXA 2LOQA 4K2CA 1J78A 3MHSB 2Z8IA 1E78A 3GQUA 2DBXA 1E7HA 2NNWA 3WHQA 4BY9C 4LB9A 5IJEA 3PLAA 2LQHA 4ZBQA 5ID7A 1TXUA 2XMOA 5IIHA 2BXIA 4GG2A 3LU6A 1O9XA 1HA2A 4ZBKA 1AO6A 2BXKA 2KBZA 2BXBA 2BXCA 4ZC6A 4Z9OA 2BXQA 3TDLA 4HGKA 4G04A 3GQXA 4F5TA 1SB0A 1BKEA 4OTUA 3W1SA 3ECPA 4I9OA 2LXTA 3NVKA 4F5VA 3V09A 3V03A 4OT2A 5GIOA 1E7FA 5DQFA 2VUFA 3VQIA 5HOZA 1E7IA 5D7GA 1MM8A 4LUFA 3G9KD 2VDBA 4ZBRA 4GDXA 5IFOA 2Z8KA 2QHBA 3NVIA 2QMCA 4ZCGA 4S1YA 4BKEA 1UORA 3MHHB 5GIPA
chains in the Genus database with same CATH topology
5ID9A 4LB2A 2V36A 1E7CA 1IJGA 1VFIA 4FJCB 1BM0A 1H9ZA 2DBWA 2ROHA 4JK4A 4OR0A 2E0YA 2DG5A 4Z69A 1BJ5A 4GDLB 5IIXA 5BPKA 3KIKA 1E7GA 2BXDA 2Z8JA 4G03A 3NMUA 4N3ZA 5B5TA 3NVMA 2OZBB 4G01A 1HK4A 5GHKA 3FNMA 3LU7A 1MIWA 2NQOA 1KXPD 3GA9L 1E7BA 2DYOA 3V08A 5FUOA 1HK3A 2BXAA 2I30A 2BXHA 3JQZA 4TQ1A 3WHRA 3FWBC 3UIVA 1JNBA 3FWCC 4W4UB 2XVQA 2AJEA 1FOUA 1HK2A 2EFEA 4WA6B 1E7AA 1J7EA 2VUEA 2XVWA 4GDKB 5IJFA 1NT2B 1MIYA 4TQ0A 1HK5A 5DBYA 1LNSA 2XW1A 2XVUA 3H37A 2EFHA 4C31B 5GINA 2DBUA 3SIVB 2BXGA 4E99A 2YDFA 4L9KA 1N5UA 2BXFA 1MIVA 5IIUA 3A75A 1TF0A 3A73A 1GNJA 1HK1A 2BXPA 2I2ZA 3B9MA 2BXNA 2BX8A 2BXEA 2XSIA 3LU8A 4N0UD 4NAWB 2OT3A 2XVVA 2CKXA 1LOTA 2BXLA 3M99C 4J2VA 4HGMB 4K71A 1VZSA 3CX9A 4PO0A 3WHSA 4L8UA 4OTTA 4IW2A 4MBEC 3KJLA 2DYMA 3JRYA 4IW1A 4M70B 2EFCA 3H3AA 1KW2A 4FK5B 5IJ5A 4ZUXV 2BXOA 1E7EA 2E0XA 3SQJA 2EFDA 4F5UA 4EMXA 4N0FD 3B9LA 4LUHA 2QM6A 1H5WA 4DHXB 2JUHA 1GNIA 2BXMA 3SIUB 4FIPB 4L9QA 2XW0A 4LA0A 1MA9A 4F5SA 3ICXA 2LOQA 4K2CA 1J78A 3MHSB 2Z8IA 1E78A 3GQUA 2DBXA 1E7HA 2NNWA 3WHQA 4BY9C 4LB9A 5IJEA 3PLAA 4ZBQA 5ID7A 1TXUA 2XMOA 5IIHA 2BXIA 4GG2A 3LU6A 1O9XA 1HA2A 4ZBKA 1AO6A 2BXKA 2KBZA 2BXBA 2BXCA 4ZC6A 4Z9OA 2BXQA 3TDLA 4HGKA 4G04A 3GQXA 4F5TA 1BKEA 4OTUA 3W1SA 3NVKA 4F5VA 3V09A 3V03A 4OT2A 5GIOA 1E7FA 5DQFA 2VUFA 3VQIA 5HOZA 1E7IA 5D7GA 4LUFA 3G9KD 2VDBA 4ZBRA 4GDXA 5IFOA 2Z8KA 2QHBA 3NVIA 2QMCA 4ZCGA 4S1YA 4BKEA 1UORA 3MHHB 5GIPA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5ID9 A;  4LB2 A;  1E7C A;  1BM0 A;  1H9Z A;  4JK4 A;  4OR0 A;  4Z69 A;  1BJ5 A;  5IIX A;  1E7G A;  2BXD A;  4G03 A;  1HK4 A;  5GHK A;  3LU7 A;  1KXP D;  1E7B A;  3V08 A;  5FUO A;  1HK3 A;  2BXA A;  2I30 A;  2BXH A;  3JQZ A;  3UIV A;  2XVQ A;  1HK2 A;  1E7A A;  1J7E A;  2VUE A;  2XVW A;  5IJF A;  1HK5 A;  5DBY A;  2XW1 A;  2XVU A;  2BXG A;  4E99 A;  2YDF A;  4L9K A;  1N5U A;  2BXF A;  5IIU A;  1TF0 A;  3A73 A;  1GNJ A;  1HK1 A;  2BXP A;  2I2Z A;  3B9M A;  2BXN A;  2BX8 A;  2BXE A;  2XSI A;  3LU8 A;  4N0U D;  2XVV A;  1LOT A;  2BXL A;  4J2V A;  4HGM B;  4K71 A;  3CX9 A;  4PO0 A;  4L8U A;  4IW2 A;  3JRY A;  4IW1 A;  1KW2 A;  5IJ5 A;  2BXO A;  1E7E A;  4F5U A;  3SQJ A;  4EMX A;  4N0F D;  3B9L A;  4LUH A;  1GNI A;  2BXM A;  4L9Q A;  2XW0 A;  4LA0 A;  1MA9 A;  4F5S A;  4K2C A;  1J78 A;  1E78 A;  1E7H A;  4LB9 A;  5IJE A;  4ZBQ A;  5ID7 A;  5IIH A;  2BXI A;  3LU6 A;  1O9X A;  1HA2 A;  1AO6 A;  2BXK A;  2BXB A;  2BXC A;  2BXQ A;  3TDL A;  4HGK A;  4G04 A;  4F5T A;  1BKE A;  4F5V A;  3V09 A;  3V03 A;  4OT2 A;  1E7F A;  5DQF A;  2VUF A;  5HOZ A;  1E7I A;  4LUF A;  2VDB A;  4ZBR A;  5IFO A;  4S1Y A;  4BKE A;  1UOR A; 
#chains in the Genus database with same CATH topology
 5ID9 A;  4LB2 A;  2V36 A;  1E7C A;  1IJG A;  2AGH B;  1VFI A;  4FJC B;  1BM0 A;  1H9Z A;  2DBW A;  2ROH A;  4JK4 A;  4OR0 A;  2E0Y A;  2DG5 A;  4Z69 A;  1BJ5 A;  4GDL B;  2K0N A;  5IIX A;  5BPK A;  3KIK A;  1E7G A;  2LXS A;  2BXD A;  2Z8J A;  4G03 A;  3NMU A;  4N3Z A;  5B5T A;  3NVM A;  2OZB B;  4G01 A;  1HK4 A;  5GHK A;  3FNM A;  2KWF A;  3LU7 A;  1MIW A;  2NQO A;  2LQI A;  1KXP D;  3GA9 L;  1E7B A;  2DYO A;  3V08 A;  1KDX A;  5FUO A;  1HK3 A;  3BPJ A;  2BXA A;  2I30 A;  2BXH A;  3JQZ A;  4TQ1 A;  3WHR A;  3FWB C;  3UIV A;  1JNB A;  3FWC C;  4W4U B;  2XVQ A;  2AJE A;  1FOU A;  1HK2 A;  2EFE A;  4WA6 B;  1E7A A;  1J7E A;  2VUE A;  2XVW A;  4GDK B;  5IJF A;  1NT2 B;  1MIY A;  4TQ0 A;  1HK5 A;  5DBY A;  1LNS A;  2XW1 A;  2XVU A;  3H37 A;  2EFH A;  4C31 B;  5GIN A;  2DBU A;  3SIV B;  2BXG A;  4E99 A;  2YDF A;  4L9K A;  1N5U A;  2BXF A;  1MIV A;  2GUT A;  3A75 A;  5IIU A;  1TF0 A;  3A73 A;  1GNJ A;  1HK1 A;  2BXP A;  2I2Z A;  3B9M A;  2BXN A;  2BX8 A;  2BXE A;  2XSI A;  3LU8 A;  4N0U D;  4NAW B;  2OT3 A;  2XVV A;  2CKX A;  1LOT A;  2BXL A;  3M99 C;  4J2V A;  4HGM B;  4K71 A;  1VZS A;  3CX9 A;  4PO0 A;  3WHS A;  4L8U A;  4OTT A;  4IW2 A;  4MBE C;  3KJL A;  2DYM A;  3JRY A;  4IW1 A;  4M70 B;  2EFC A;  3H3A A;  1KW2 A;  1MUS A;  4FK5 B;  5IJ5 A;  4ZUX V;  1MUH A;  2BXO A;  4DM0 A;  1E7E A;  2E0X A;  3SQJ A;  2EFD A;  4F5U A;  4EMX A;  4N0F D;  3B9L A;  4LUH A;  2QM6 A;  1H5W A;  4DHX B;  2JUH A;  1GNI A;  2BXM A;  3SIU B;  4FIP B;  4L9Q A;  2XW0 A;  4LA0 A;  4D7X A;  1MA9 A;  4F5S A;  3ICX A;  2LOQ A;  4K2C A;  1J78 A;  3MHS B;  2Z8I A;  1E78 A;  3GQU A;  2DBX A;  1E7H A;  2NNW A;  3WHQ A;  4BY9 C;  4LB9 A;  5IJE A;  3PLA A;  2LQH A;  4ZBQ A;  5ID7 A;  1TXU A;  2XMO A;  5IIH A;  2BXI A;  4GG2 A;  3LU6 A;  1O9X A;  1HA2 A;  4ZBK A;  1AO6 A;  2BXK A;  2KBZ A;  2BXB A;  2BXC A;  4ZC6 A;  4Z9O A;  2BXQ A;  3TDL A;  4HGK A;  4G04 A;  3GQX A;  4F5T A;  1SB0 A;  1BKE A;  4OTU A;  3W1S A;  3ECP A;  4I9O A;  2LXT A;  3NVK A;  4F5V A;  3V09 A;  3V03 A;  4OT2 A;  5GIO A;  1E7F A;  5DQF A;  2VUF A;  3VQI A;  5HOZ A;  1E7I A;  5D7G A;  1MM8 A;  4LUF A;  3G9K D;  2VDB A;  4ZBR A;  4GDX A;  5IFO A;  2Z8K A;  2QHB A;  3NVI A;  2QMC A;  4ZCG A;  4S1Y A;  4BKE A;  1UOR A;  3MHH B;  5GIP A; 
#chains in the Genus database with same CATH homology
 5ID9 A;  4LB2 A;  2V36 A;  1E7C A;  1IJG A;  1VFI A;  4FJC B;  1BM0 A;  1H9Z A;  2DBW A;  2ROH A;  4JK4 A;  4OR0 A;  2E0Y A;  2DG5 A;  4Z69 A;  1BJ5 A;  4GDL B;  5IIX A;  5BPK A;  3KIK A;  1E7G A;  2BXD A;  2Z8J A;  4G03 A;  3NMU A;  4N3Z A;  5B5T A;  3NVM A;  2OZB B;  4G01 A;  1HK4 A;  5GHK A;  3FNM A;  3LU7 A;  1MIW A;  2NQO A;  1KXP D;  3GA9 L;  1E7B A;  2DYO A;  3V08 A;  5FUO A;  1HK3 A;  2BXA A;  2I30 A;  2BXH A;  3JQZ A;  4TQ1 A;  3WHR A;  3FWB C;  3UIV A;  1JNB A;  3FWC C;  4W4U B;  2XVQ A;  2AJE A;  1FOU A;  1HK2 A;  2EFE A;  4WA6 B;  1E7A A;  1J7E A;  2VUE A;  2XVW A;  4GDK B;  5IJF A;  1NT2 B;  1MIY A;  4TQ0 A;  1HK5 A;  5DBY A;  1LNS A;  2XW1 A;  2XVU A;  3H37 A;  2EFH A;  4C31 B;  5GIN A;  2DBU A;  3SIV B;  2BXG A;  4E99 A;  2YDF A;  4L9K A;  1N5U A;  2BXF A;  1MIV A;  5IIU A;  3A75 A;  1TF0 A;  3A73 A;  1GNJ A;  1HK1 A;  2BXP A;  2I2Z A;  3B9M A;  2BXN A;  2BX8 A;  2BXE A;  2XSI A;  3LU8 A;  4N0U D;  4NAW B;  2OT3 A;  2XVV A;  2CKX A;  1LOT A;  2BXL A;  3M99 C;  4J2V A;  4HGM B;  4K71 A;  1VZS A;  3CX9 A;  4PO0 A;  3WHS A;  4L8U A;  4OTT A;  4IW2 A;  4MBE C;  3KJL A;  2DYM A;  3JRY A;  4IW1 A;  4M70 B;  2EFC A;  3H3A A;  1KW2 A;  4FK5 B;  5IJ5 A;  4ZUX V;  2BXO A;  1E7E A;  2E0X A;  3SQJ A;  2EFD A;  4F5U A;  4EMX A;  4N0F D;  3B9L A;  4LUH A;  2QM6 A;  1H5W A;  4DHX B;  2JUH A;  1GNI A;  2BXM A;  3SIU B;  4FIP B;  4L9Q A;  2XW0 A;  4LA0 A;  1MA9 A;  4F5S A;  3ICX A;  2LOQ A;  4K2C A;  1J78 A;  3MHS B;  2Z8I A;  1E78 A;  3GQU A;  2DBX A;  1E7H A;  2NNW A;  3WHQ A;  4BY9 C;  4LB9 A;  5IJE A;  3PLA A;  4ZBQ A;  5ID7 A;  1TXU A;  2XMO A;  5IIH A;  2BXI A;  4GG2 A;  3LU6 A;  1O9X A;  1HA2 A;  4ZBK A;  1AO6 A;  2BXK A;  2KBZ A;  2BXB A;  2BXC A;  4ZC6 A;  4Z9O A;  2BXQ A;  3TDL A;  4HGK A;  4G04 A;  3GQX A;  4F5T A;  1BKE A;  4OTU A;  3W1S A;  3NVK A;  4F5V A;  3V09 A;  3V03 A;  4OT2 A;  5GIO A;  1E7F A;  5DQF A;  2VUF A;  3VQI A;  5HOZ A;  1E7I A;  5D7G A;  4LUF A;  3G9K D;  2VDB A;  4ZBR A;  4GDX A;  5IFO A;  2Z8K A;  2QHB A;  3NVI A;  2QMC A;  4ZCG A;  4S1Y A;  4BKE A;  1UOR A;  3MHH B;  5GIP A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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