4LIKA

Crystal structure of the catalytic subunit of human primase
Total Genus 127
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
127
sequence length
387
structure length
369
Chain Sequence
METFDPTELPELLKLYYRRLFPYSQYYRWLNYGGVIKNYFQHREFSFTLKDDIYIRYQSFNNQSDLEKEMQKMNPYKIDIGAVYSHRPNQHNTVKLGAFQAQEKELVFDIDMTDYDDVRRCCSSADICPKCWTLMTMAIRIIDRALKEDFGFKHRLWVYSGRRGVHCWVCDESVRKLSSAVRSGIVEYLSLVKGGQDVKKKVHLIHPFIRKSINIIKKYFEEYALVNQDILENKESWDKILALVPETIHDELQQSFQKSHNSLQRWEHLKKVALEWEIMLQYCFPRLDINVSKGINHLLKSPFSVHPKTGRISVPIDLQKVDQFDPFTVPTISFICRELDATRDYKKTSLAPYVKVFEHFLENLDKSRK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Insights into Eukaryotic Primer Synthesis from Structures of the p48 Subunit of Human DNA Primase.
pubmed doi rcsb
molecule tags Transferase
source organism Homo sapiens
molecule keywords DNA primase small subunit
total genus 127
structure length 369
sequence length 387
ec nomenclature ec 2.7.7.-:
pdb deposition date 2013-07-02

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01896 DNA_primase_S DNA primase small subunit
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.920.30 Alpha Beta Alpha-Beta Complex DNA primase, PRIM domain DNA primase, PRIM domain 4likA00
2FARA 4BPUA 4RR2A 4LIKA 4MM2A 4LILA 2FAQA 4MHQA 1ZT2A 5EXRA 2FAOA 4LIMA 4BPWA 4BPXA
chains in the Genus database with same CATH superfamily
2FARA 4BPUA 1G71A 4RR2A 2ATZA 4LIKA 4LILA 2FAQA 4MM2A 4MHQA 4BPXA 1ZT2A 5EXRA 2FAOA 1V34A 4LIMA 4BPWA 1V33A
chains in the Genus database with same CATH topology
2FARA 4BPUA 1G71A 4RR2A 4LIKA 4MM2A 4LILA 2FAQA 4BPXA 4MHQA 1ZT2A 5EXRA 2FAOA 1V34A 4LIMA 4BPWA 1V33A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2FAR A;  4BPU A;  4RR2 A;  4LIK A;  4MM2 A;  4LIL A;  2FAQ A;  4MHQ A;  1ZT2 A;  5EXR A;  2FAO A;  4LIM A;  4BPW A;  4BPX A; 
#chains in the Genus database with same CATH topology
 2FAR A;  4BPU A;  1G71 A;  4RR2 A;  2ATZ A;  4LIK A;  4LIL A;  2FAQ A;  4MM2 A;  4MHQ A;  4BPX A;  1ZT2 A;  5EXR A;  2FAO A;  1V34 A;  4LIM A;  4BPW A;  1V33 A; 
#chains in the Genus database with same CATH homology
 2FAR A;  4BPU A;  1G71 A;  4RR2 A;  4LIK A;  4MM2 A;  4LIL A;  2FAQ A;  4BPX A;  4MHQ A;  1ZT2 A;  5EXR A;  2FAO A;  1V34 A;  4LIM A;  4BPW A;  1V33 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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