4M0RA

Trianthranilate-like analogue bound to anthranilate phosphoribosyltransferase (anprt; trpd).
Total Genus 121
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
121
sequence length
345
structure length
342
Chain Sequence
PSWPQILGRLTDNRDLARGQAAWAMDQIMTGNARPAQIAAFAVAMTMKAPTADEVGELAGVMLSHAHPLPADTVPDDAVDVVGTGVNTVNLSTMAAIVVAAAGVPVVKHGNRAASSLSGGADTLEALGVRIDLGPDLVARSLAEVGIGFCFAPRFHPSYRHAAAVRREIGVPTVFNLLGPLTNPARPRAGLIGCAFADLAEVMAGVFAARRSSVLVVHGDDGLDELTTTTTSTIWRVAAGSVDKLTFDPAGFGFARAQLDQLAGGDAQANAAAVRAVLGGARGPVRDAVVLNAAGAIVAHAGLSSRAEWLPAWEEGLRRASAAIDTGAAEQLLARWVRFGRQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Transferase/transferase inhibitor
molecule keywords Anthranilate phosphoribosyltransferase
publication title Repurposing the Chemical Scaffold of the Anti-Arthritic Drug Lobenzarit to Target Tryptophan Biosynthesis in Mycobacterium tuberculosis.
pubmed doi rcsb
source organism Mycobacterium tuberculosis
total genus 121
structure length 342
sequence length 345
chains with identical sequence B
ec nomenclature ec 2.4.2.18: Anthranilate phosphoribosyltransferase.
pdb deposition date 2013-08-02

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00591 Glycos_transf_3 Glycosyl transferase family, a/b domain
A PF02885 Glycos_trans_3N Glycosyl transferase family, helical bundle domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.970.10 Mainly Alpha Up-down Bundle Transferase, Pyrimidine Nucleoside Phosphorylase; Chain A, domain 3 Transferase, Pyrimidine Nucleoside Phosphorylase; Chain C 4m0rA01
3.40.1030.10 Alpha Beta 3-Layer(aba) Sandwich Pyrimidine Nucleoside Phosphorylase; Chain A, domain 2 Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain 4m0rA02
4IJ1A 4YI7A 4OWSA 4GA6A 1AZYA 4GKMA 3H5QA 3QSAA 4X5BA 4OWMA 2ELCA 1KGZA 5BO2A 4GTNA 1ZYKA 2WK5A 4ZOFA 1ZXYA 5BNEA 5C2LA 2WK6A 2TPTA 4X59A 5BYTA 1O17A 4OWQA 5EP8A 2GVQA 4OWUA 4LHMA 2BPQA 4X46A 3QQSA 3UU1A 4M0RA 4X58A 1BRWA 4ZOJA 2DSJA 1UOUA 3QR9A 4X5EA 4GA5A 4GA4A 4MUOA 5EY3A 4N5VA 4YYYA 4X5DA 4HKMA 4ZOKA 3GBRA 1KHDA 5C7SA 3R6CA 1OTPA 4EADA 1VQUA 4OWVA 5BO3A 4X5AA 5C1RA 4OWNA 4OWOA 4YEKA 1GXBA 4N93A 4XR5A 3QS8A 4N8QA 4X5CA 4EAFA 1ZVWA 1V8GA 2J0FA 4ZTVA 4GIUA 3R88A 3TWPA
chains in the Genus database with same CATH superfamily
1RRZA 4IJ1A 4YI7A 4OWSA 4GA6A 1AZYA 4GKMA 3H5QA 3QSAA 4X5BA 4OWMA 2ELCA 1KGZA 5BO2A 4GTNA 1ZYKA 2WK5A 4ZOFA 1ZXYA 5BNEA 5C2LA 2WK6A 2TPTA 4X59A 1RF8B 5BYTA 1O17A 4OWQA 5EP8A 2GVQA 4OWUA 4LHMA 2BPQA 4X46A 4F3FC 3QQSA 3UU1A 4M0RA 4X58A 1BRWA 4ZOJA 2DSJA 1UOUA 3QR9A 4X5EA 4GA5A 4GA4A 4MUOA 5EY3A 4N5VA 4YYYA 4X5DA 4HKMA 4ZOKA 3GBRA 1KHDA 5C7SA 3R6CA 1OTPA 4EADA 1VQUA 4OWVA 5BO3A 4X5AA 5C1RA 4OWNA 4OWOA 4YEKA 1GXBA 4N93A 4XR5A 3QS8A 4N8QA 4X5CA 4EAFA 1ZVWA 1V8GA 2J0FA 4ZTVA 4GIUA 3R88A 3TWPA
chains in the Genus database with same CATH topology
4IJ1A 4YI7A 4OWSA 4GA6A 1AZYA 4GKMA 3H5QA 3QSAA 4X5BA 4OWMA 2ELCA 1KGZA 5BO2A 4GTNA 1ZYKA 2WK5A 4ZOFA 1ZXYA 5BNEA 5C2LA 2WK6A 2TPTA 4X59A 5BYTA 1O17A 4OWQA 5EP8A 2GVQA 4OWUA 4LHMA 2BPQA 4X46A 3QQSA 3UU1A 4M0RA 4X58A 1BRWA 4ZOJA 2DSJA 1UOUA 3QR9A 4X5EA 4GA5A 4GA4A 4MUOA 5EY3A 4N5VA 4YYYA 4X5DA 4HKMA 4ZOKA 3GBRA 1KHDA 5C7SA 3R6CA 1OTPA 4EADA 1VQUA 4OWVA 5BO3A 4X5AA 5C1RA 4OWNA 4OWOA 4YEKA 1GXBA 4N93A 4XR5A 3QS8A 4N8QA 4X5CA 4EAFA 1ZVWA 1V8GA 2J0FA 4ZTVA 4GIUA 3R88A 3TWPA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4IJ1 A;  4YI7 A;  4OWS A;  4GA6 A;  1AZY A;  4GKM A;  3H5Q A;  3QSA A;  4X5B A;  4OWM A;  2ELC A;  1KGZ A;  5BO2 A;  4GTN A;  1ZYK A;  2WK5 A;  4ZOF A;  1ZXY A;  5BNE A;  5C2L A;  2WK6 A;  2TPT A;  4X59 A;  5BYT A;  1O17 A;  4OWQ A;  5EP8 A;  2GVQ A;  4OWU A;  4LHM A;  2BPQ A;  4X46 A;  3QQS A;  3UU1 A;  4M0R A;  4X58 A;  1BRW A;  4ZOJ A;  2DSJ A;  1UOU A;  3QR9 A;  4X5E A;  4GA5 A;  4GA4 A;  4MUO A;  5EY3 A;  4N5V A;  4YYY A;  4X5D A;  4HKM A;  4ZOK A;  3GBR A;  1KHD A;  5C7S A;  3R6C A;  1OTP A;  4EAD A;  1VQU A;  4OWV A;  5BO3 A;  4X5A A;  5C1R A;  4OWN A;  4OWO A;  4YEK A;  1GXB A;  4N93 A;  4XR5 A;  3QS8 A;  4N8Q A;  4X5C A;  4EAF A;  1ZVW A;  1V8G A;  2J0F A;  4ZTV A;  4GIU A;  3R88 A;  3TWP A; 
#chains in the Genus database with same CATH topology
 1RRZ A;  4IJ1 A;  4YI7 A;  4OWS A;  4GA6 A;  1AZY A;  4GKM A;  3H5Q A;  3QSA A;  4X5B A;  4OWM A;  2ELC A;  1KGZ A;  5BO2 A;  4GTN A;  1ZYK A;  2WK5 A;  4ZOF A;  1ZXY A;  5BNE A;  5C2L A;  2WK6 A;  2TPT A;  4X59 A;  1RF8 B;  5BYT A;  1O17 A;  4OWQ A;  5EP8 A;  2GVQ A;  4OWU A;  4LHM A;  2BPQ A;  4X46 A;  4F3F C;  3QQS A;  3UU1 A;  4M0R A;  4X58 A;  1BRW A;  4ZOJ A;  2DSJ A;  1UOU A;  3QR9 A;  4X5E A;  4GA5 A;  4GA4 A;  4MUO A;  5EY3 A;  4N5V A;  4YYY A;  4X5D A;  4HKM A;  4ZOK A;  3GBR A;  1KHD A;  5C7S A;  3R6C A;  1OTP A;  4EAD A;  1VQU A;  4OWV A;  5BO3 A;  4X5A A;  5C1R A;  4OWN A;  4OWO A;  4YEK A;  1GXB A;  4N93 A;  4XR5 A;  3QS8 A;  4N8Q A;  4X5C A;  4EAF A;  1ZVW A;  1V8G A;  2J0F A;  4ZTV A;  4GIU A;  3R88 A;  3TWP A; 
#chains in the Genus database with same CATH homology
 4IJ1 A;  4YI7 A;  4OWS A;  4GA6 A;  1AZY A;  4GKM A;  3H5Q A;  3QSA A;  4X5B A;  4OWM A;  2ELC A;  1KGZ A;  5BO2 A;  4GTN A;  1ZYK A;  2WK5 A;  4ZOF A;  1ZXY A;  5BNE A;  5C2L A;  2WK6 A;  2TPT A;  4X59 A;  5BYT A;  1O17 A;  4OWQ A;  5EP8 A;  2GVQ A;  4OWU A;  4LHM A;  2BPQ A;  4X46 A;  3QQS A;  3UU1 A;  4M0R A;  4X58 A;  1BRW A;  4ZOJ A;  2DSJ A;  1UOU A;  3QR9 A;  4X5E A;  4GA5 A;  4GA4 A;  4MUO A;  5EY3 A;  4N5V A;  4YYY A;  4X5D A;  4HKM A;  4ZOK A;  3GBR A;  1KHD A;  5C7S A;  3R6C A;  1OTP A;  4EAD A;  1VQU A;  4OWV A;  5BO3 A;  4X5A A;  5C1R A;  4OWN A;  4OWO A;  4YEK A;  1GXB A;  4N93 A;  4XR5 A;  3QS8 A;  4N8Q A;  4X5C A;  4EAF A;  1ZVW A;  1V8G A;  2J0F A;  4ZTV A;  4GIU A;  3R88 A;  3TWP A; 
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