4MCCA

Hintrmd in complex with n-[4-(aminomethyl)benzyl]-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-5-carboxamide
Total Genus 52
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
52
Knots found
sequence length
219
structure length
206
Chain Sequence
MWIGVISLFPEMFKAITEFGVTGRAVKHNLLKVECWNPRDFTFDKHKTVDDRPYGGGPGMLMMVQPLRDAIHTAKAAAGEGAKVIYLSPQGRKLDQGGVTELAQNQKLILVCGRYEGIDERLIQTEIDEEWSIGDYVLTGGELPAMTLIDAVARFIPGVLGLLDCPHYTRPEVLEGLTVPPVLMSGHHEEIRKWRLKQSLQRTWLR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Selective Inhibitors of Bacterial t-RNA-(N(1)G37) Methyltransferase (TrmD) That Demonstrate Novel Ordering of the Lid Domain.
pubmed doi rcsb
molecule tags Transferase/transferase inhibitor
source organism Haemophilus influenzae
molecule keywords tRNA (guanine-N(1)-)-methyltransferase
total genus 52
structure length 206
sequence length 219
chains with identical sequence B
other databases KnotProt 2.0: K +31
ec nomenclature ec 2.1.1.228: tRNA (guanine(37)-N(1))-methyltransferase.
pdb deposition date 2013-08-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01746 tRNA_m1G_MT tRNA (Guanine-1)-methyltransferase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.1270.20 Mainly Alpha Orthogonal Bundle Trp Operon Repressor; Chain A tRNA(m1g37)methyltransferase, domain 2 4mccA02
3.40.1280.10 Alpha Beta 3-Layer(aba) Sandwich Alpha/beta knot Alpha/beta knot 4mccA01
4YVHA 1TO0A 4J3CA 4YPYA 4L69A 5GM8A 1V2XA 2CX8A 3N4JA 4YQ1A 2I6DA 2YY8A 2HA8A 4YQIA 4FAKA 4YQBA 4YPXA 3ILKA 3N4KA 3KY7A 3O7BA 3IEFA 4YQJA 4H3ZA 1NS5A 3NK6A 4JAKA 4PZKA 2QWVA 4YQOA 5CO4A 4YVIA 3AI9X 4MCCA 4YQ8A 4YQ4A 1J85A 1Z85A 2QMMA 4RG1A 4CNGA 1UALA 1K3RA 1UAMA 4H3YA 3AXZA 4YPZA 3BBEA 1X7PA 4YQQA 4MCDA 4YQSA 3L8UA 1ZJRA 5FAIA 2O3AA 4MCBA 3NK7A 4CNFA 4CNDA 1UAKA 2EGVA 5D9FA 3AIAA 4YVKA 3GYQA 1V6ZA 4E8BA 4X3MA 4YVJA 4YQCA 4YQ5A 4YQ2A 4YQAA 2V3JA 3QUVA 3BBHA 3E5YA 1UAJA 4YVGA 4YQGA 4CNEA 3OIIA 2V3KA 4YQ0A 3KW2A 3KTYA 1GZ0A 4YQTA 1OY5A 3BBDA 3ONPA 4YQ6A 4YQ7A 4YQDA 4YPWA 1VHYA 4YQRA 2EGWA 4IG6A 4YQ3A 1P9PA 4YQPA 4YQ9A 4YQNA 1X7OA 4YQLA 1VH0A 5GMBA 1NXZA 3DCMX 3OIJA 4XBOA 1O6DA 1IPAA 3IC6A 4KDZA 4X3LA 4KGNA 1VHKA 3KNUA 1MXIA 2Z0YA 4JALA 5GMCA 4YQKA 3OINA
chains in the Genus database with same CATH superfamily
4YVHA 1TO0A 4J3CA 4YPYA 4L69A 5GM8A 2XDIA 1V2XA 2CX8A 3N4JA 4YQ1A 2I6DA 2YY8A 2HA8A 4YQIA 4FAKA 4YQBA 4YPXA 3ILKA 3N4KA 1WRSR 3KY7A 3O7BA 3IEFA 3WRPA 4YQJA 4H3ZA 1NS5A 3NK6A 4JAKA 4PZKA 2QWVA 4YQOA 2OZ9R 5CO4A 4YVIA 3AI9X 1WRTR 4MCCA 4YQ8A 4JWFA 4YQ4A 1J85A 1Z85A 2QMMA 4RG1A 4CNGA 1UALA 3KORA 1K3RA 1UAMA 4H3YA 3AXZA 4YPZA 3BBEA 3SSXN 1X7PA 4YQQA 4MCDA 4YQSA 3L8UA 1ZJRA 5FAIA 1MI7R 2O3AA 4MCBA 3NK7A 4CNFA 4CNDA 3SSWN 1UAKA 1TRRA 2EGVA 5D9FA 3AIAA 4YVKA 3GYQA 1CO0A 1V6ZA 4E8BA 4X3MA 4YVJA 4JWGA 4YQCA 4JWJA 4YQ5A 4YQ2A 4YQAA 2V3JA 3QUVA 3BBHA 3E5YA 1UAJA 4YVGA 4YQGA 4CNEA 3OIIA 2V3KA 3FRWA 4YQ0A 3KW2A 3KTYA 1GZ0A 1JHGA 4JWHA 4YQTA 1OY5A 3BBDA 1WRPR 3ONPA 4YQ6A 4YQ7A 4YQDA 4YPWA 1VHYA 4YQRA 2EGWA 4IG6A 4YQ3A 1P9PA 4YQPA 4YQ9A 1TROA 1ZT9A 4YQNA 1X7OA 4YQLA 1VH0A 5GMBA 1NXZA 3DCMX 3OIJA 1RCSA 4XBOA 1O6DA 1IPAA 3IC6A 4KDZA 3G1CA 4X3LA 4KGNA 1VHKA 3KNUA 1MXIA 2Z0YA 4JALA 4FMWA 5GMCA 4YQKA 3OINA
chains in the Genus database with same CATH topology
4YVHA 1TO0A 4J3CA 4YPYA 4L69A 5GM8A 1V2XA 2CX8A 3N4JA 4YQ1A 2I6DA 2YY8A 2HA8A 4YQIA 4FAKA 4YQBA 4YPXA 3ILKA 3N4KA 3KY7A 3O7BA 3IEFA 4YQJA 4H3ZA 1NS5A 3NK6A 4JAKA 4PZKA 2QWVA 4YQOA 5CO4A 4YVIA 3AI9X 4MCCA 4YQ8A 4JWFA 4YQ4A 1J85A 1Z85A 2QMMA 4RG1A 4CNGA 1UALA 1K3RA 1UAMA 4H3YA 3AXZA 4YPZA 3BBEA 1X7PA 4YQQA 4MCDA 4YQSA 3L8UA 1ZJRA 5FAIA 2O3AA 4MCBA 3NK7A 4CNFA 4CNDA 1UAKA 2EGVA 5D9FA 3AIAA 4YVKA 3GYQA 1V6ZA 4E8BA 4X3MA 4YVJA 4JWGA 4YQCA 4JWJA 4YQ5A 4YQ2A 4YQAA 2V3JA 3QUVA 3BBHA 3E5YA 1UAJA 4YVGA 4YQGA 4CNEA 3OIIA 2V3KA 4YQ0A 3KW2A 3KTYA 1GZ0A 4JWHA 4YQTA 1OY5A 3BBDA 3ONPA 4YQ6A 4YQ7A 4YQDA 4YPWA 1VHYA 4YQRA 2EGWA 4IG6A 4YQ3A 1P9PA 4YQPA 4YQ9A 4YQNA 1X7OA 4YQLA 1VH0A 5GMBA 1NXZA 3DCMX 3OIJA 4XBOA 1O6DA 1IPAA 3IC6A 4KDZA 4X3LA 4KGNA 1VHKA 3KNUA 1MXIA 2Z0YA 4JALA 4FMWA 5GMCA 4YQKA 3OINA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4YVH A;  1TO0 A;  4J3C A;  4YPY A;  4L69 A;  5GM8 A;  1V2X A;  2CX8 A;  3N4J A;  4YQ1 A;  2I6D A;  2YY8 A;  2HA8 A;  4YQI A;  4FAK A;  4YQB A;  4YPX A;  3ILK A;  3N4K A;  3KY7 A;  3O7B A;  3IEF A;  4YQJ A;  4H3Z A;  1NS5 A;  3NK6 A;  4JAK A;  4PZK A;  2QWV A;  4YQO A;  5CO4 A;  4YVI A;  3AI9 X;  4MCC A;  4YQ8 A;  4YQ4 A;  1J85 A;  1Z85 A;  2QMM A;  4RG1 A;  4CNG A;  1UAL A;  1K3R A;  1UAM A;  4H3Y A;  3AXZ A;  4YPZ A;  3BBE A;  1X7P A;  4YQQ A;  4MCD A;  4YQS A;  3L8U A;  1ZJR A;  5FAI A;  2O3A A;  4MCB A;  3NK7 A;  4CNF A;  4CND A;  1UAK A;  2EGV A;  5D9F A;  3AIA A;  4YVK A;  3GYQ A;  1V6Z A;  4E8B A;  4X3M A;  4YVJ A;  4YQC A;  4YQ5 A;  4YQ2 A;  4YQA A;  2V3J A;  3QUV A;  3BBH A;  3E5Y A;  1UAJ A;  4YVG A;  4YQG A;  4CNE A;  3OII A;  2V3K A;  4YQ0 A;  3KW2 A;  3KTY A;  1GZ0 A;  4YQT A;  1OY5 A;  3BBD A;  3ONP A;  4YQ6 A;  4YQ7 A;  4YQD A;  4YPW A;  1VHY A;  4YQR A;  2EGW A;  4IG6 A;  4YQ3 A;  1P9P A;  4YQP A;  4YQ9 A;  4YQN A;  1X7O A;  4YQL A;  1VH0 A;  5GMB A;  1NXZ A;  3DCM X;  3OIJ A;  4XBO A;  1O6D A;  1IPA A;  3IC6 A;  4KDZ A;  4X3L A;  4KGN A;  1VHK A;  3KNU A;  1MXI A;  2Z0Y A;  4JAL A;  5GMC A;  4YQK A;  3OIN A; 
#chains in the Genus database with same CATH topology
 4YVH A;  1TO0 A;  4J3C A;  4YPY A;  4L69 A;  5GM8 A;  2XDI A;  1V2X A;  2CX8 A;  3N4J A;  4YQ1 A;  2I6D A;  2YY8 A;  2HA8 A;  4YQI A;  4FAK A;  4YQB A;  4YPX A;  3ILK A;  3N4K A;  1WRS R;  3KY7 A;  3O7B A;  3IEF A;  3WRP A;  4YQJ A;  4H3Z A;  1NS5 A;  3NK6 A;  4JAK A;  4PZK A;  2QWV A;  4YQO A;  2OZ9 R;  5CO4 A;  4YVI A;  3AI9 X;  1WRT R;  4MCC A;  4YQ8 A;  4JWF A;  4YQ4 A;  1J85 A;  1Z85 A;  2QMM A;  4RG1 A;  4CNG A;  1UAL A;  3KOR A;  1K3R A;  1UAM A;  4H3Y A;  3AXZ A;  4YPZ A;  3BBE A;  3SSX N;  1X7P A;  4YQQ A;  4MCD A;  4YQS A;  3L8U A;  1ZJR A;  5FAI A;  1MI7 R;  2O3A A;  4MCB A;  3NK7 A;  4CNF A;  4CND A;  3SSW N;  1UAK A;  1TRR A;  2EGV A;  5D9F A;  3AIA A;  4YVK A;  3GYQ A;  1CO0 A;  1V6Z A;  4E8B A;  4X3M A;  4YVJ A;  4JWG A;  4YQC A;  4JWJ A;  4YQ5 A;  4YQ2 A;  4YQA A;  2V3J A;  3QUV A;  3BBH A;  3E5Y A;  1UAJ A;  4YVG A;  4YQG A;  4CNE A;  3OII A;  2V3K A;  3FRW A;  4YQ0 A;  3KW2 A;  3KTY A;  1GZ0 A;  1JHG A;  4JWH A;  4YQT A;  1OY5 A;  3BBD A;  1WRP R;  3ONP A;  4YQ6 A;  4YQ7 A;  4YQD A;  4YPW A;  1VHY A;  4YQR A;  2EGW A;  4IG6 A;  4YQ3 A;  1P9P A;  4YQP A;  4YQ9 A;  1TRO A;  1ZT9 A;  4YQN A;  1X7O A;  4YQL A;  1VH0 A;  5GMB A;  1NXZ A;  3DCM X;  3OIJ A;  1RCS A;  4XBO A;  1O6D A;  1IPA A;  3IC6 A;  4KDZ A;  3G1C A;  4X3L A;  4KGN A;  1VHK A;  3KNU A;  1MXI A;  2Z0Y A;  4JAL A;  4FMW A;  5GMC A;  4YQK A;  3OIN A; 
#chains in the Genus database with same CATH homology
 4YVH A;  1TO0 A;  4J3C A;  4YPY A;  4L69 A;  5GM8 A;  1V2X A;  2CX8 A;  3N4J A;  4YQ1 A;  2I6D A;  2YY8 A;  2HA8 A;  4YQI A;  4FAK A;  4YQB A;  4YPX A;  3ILK A;  3N4K A;  3KY7 A;  3O7B A;  3IEF A;  4YQJ A;  4H3Z A;  1NS5 A;  3NK6 A;  4JAK A;  4PZK A;  2QWV A;  4YQO A;  5CO4 A;  4YVI A;  3AI9 X;  4MCC A;  4YQ8 A;  4JWF A;  4YQ4 A;  1J85 A;  1Z85 A;  2QMM A;  4RG1 A;  4CNG A;  1UAL A;  1K3R A;  1UAM A;  4H3Y A;  3AXZ A;  4YPZ A;  3BBE A;  1X7P A;  4YQQ A;  4MCD A;  4YQS A;  3L8U A;  1ZJR A;  5FAI A;  2O3A A;  4MCB A;  3NK7 A;  4CNF A;  4CND A;  1UAK A;  2EGV A;  5D9F A;  3AIA A;  4YVK A;  3GYQ A;  1V6Z A;  4E8B A;  4X3M A;  4YVJ A;  4JWG A;  4YQC A;  4JWJ A;  4YQ5 A;  4YQ2 A;  4YQA A;  2V3J A;  3QUV A;  3BBH A;  3E5Y A;  1UAJ A;  4YVG A;  4YQG A;  4CNE A;  3OII A;  2V3K A;  4YQ0 A;  3KW2 A;  3KTY A;  1GZ0 A;  4JWH A;  4YQT A;  1OY5 A;  3BBD A;  3ONP A;  4YQ6 A;  4YQ7 A;  4YQD A;  4YPW A;  1VHY A;  4YQR A;  2EGW A;  4IG6 A;  4YQ3 A;  1P9P A;  4YQP A;  4YQ9 A;  4YQN A;  1X7O A;  4YQL A;  1VH0 A;  5GMB A;  1NXZ A;  3DCM X;  3OIJ A;  4XBO A;  1O6D A;  1IPA A;  3IC6 A;  4KDZ A;  4X3L A;  4KGN A;  1VHK A;  3KNU A;  1MXI A;  2Z0Y A;  4JAL A;  4FMW A;  5GMC A;  4YQK A;  3OIN A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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