4MCCA

Hintrmd in complex with n-[4-(aminomethyl)benzyl]-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-5-carboxamide
Total Genus 52
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
52
Knots found
sequence length
219
structure length
206
Chain Sequence
b'MWIGVISLFPEMFKAITEFGVTGRAVKHNLLKVECWNPRDFTFDKHKTVDDRPYGGGPGMLMMVQPLRDAIHTAKAAAGEGAKVIYLSPQGRKLDQGGVTELAQNQKLILVCGRYEGIDERLIQTEIDEEWSIGDYVLTGGELPAMTLIDAVARFIPGVLGLLDCPHYTRPEVLEGLTVPPVLMSGHHEEIRKWRLKQSLQRTWLR'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords tRNA (guanine-N(1)-)-methyltransferase
publication title Selective Inhibitors of Bacterial t-RNA-(N(1)G37) Methyltransferase (TrmD) That Demonstrate Novel Ordering of the Lid Domain.
pubmed doi rcsb
source organism Haemophilus influenzae
molecule tags Transferase/transferase inhibitor
total genus 52
structure length 206
sequence length 219
chains with identical sequence B
other databases KnotProt 2.0: K +31
ec nomenclature ec 2.1.1.228: tRNA (guanine(37)-N(1))-methyltransferase.
pdb deposition date 2013-08-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01746 tRNA_m1G_MT tRNA (Guanine-1)-methyltransferase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.1270.20 Mainly Alpha Orthogonal Bundle Trp Operon Repressor; Chain A tRNA(m1g37)methyltransferase, domain 2 4mccA02
3.40.1280.10 Alpha Beta 3-Layer(aba) Sandwich Alpha/beta knot Alpha/beta knot 4mccA01
2EGVA 4YQ1A 3BBHA 2QWVA 1Z85A 5GMBA 3AXZA 3AIAA 2CX8A 4YQKA 4YQIA 1V6ZA 4YVHA 4YQQA 1MXIA 4YPZA 1VHYA 4YQ5A 4YQ4A 4KDZA 4L69A 4X3LA 3DCMX 4YVKA 3ILKA 4MCCA 1VHKA 4CNDA 4YPXA 1X7PA 2V3JA 3N4JA 4MCBA 4YVJA 4RG1A 3KW2A 4FAKA 1IPAA 4YQBA 1ZJRA 4YPYA 4KGNA 3GYQA 4YQGA 1UAMA 2O3AA 3N4KA 3OIIA 1V2XA 1OY5A 4J3CA 1NXZA 1P9PA 3L8UA 3KTYA 1UAKA 1O6DA 2Z0YA 3BBEA 1UALA 4YQOA 3BBDA 4H3ZA 5D9FA 5GM8A 4YVIA 1NS5A 4YQAA 3NK7A 1VH0A 4YVGA 2EGWA 4YQTA 2HA8A 4YQ0A 4MCDA 4CNFA 3IEFA 2V3KA 4YQDA 4X3MA 4YQSA 4YQ6A 4YQRA 4YQ3A 5GMCA 4PZKA 4JALA 1X7OA 3KNUA 1J85A 3KY7A 5FAIA 4YQJA 3AI9X 2I6DA 3OIJA 4YQCA 3NK6A 4JAKA 3ONPA 4CNEA 2YY8A 4YQLA 1TO0A 4YQNA 1GZ0A 3IC6A 4XBOA 4CNGA 4YQPA 5CO4A 4H3YA 3OINA 4IG6A 3E5YA 4YQ7A 4YQ8A 1UAJA 3O7BA 3QUVA 1K3RA 4YQ2A 2QMMA 4YPWA 4YQ9A 4E8BA
chains in the Genus database with same CATH superfamily
2EGVA 4YQ1A 3BBHA 2QWVA 1Z85A 5GMBA 3AXZA 3AIAA 3KORA 2CX8A 4YQKA 1WRPR 4YQIA 1V6ZA 4YVHA 4YQQA 4JWJA 1MXIA 3SSXN 4YPZA 1ZT9A 1VHYA 4YQ5A 4YQ4A 4KDZA 4L69A 4X3LA 3DCMX 4YVKA 3ILKA 3WRPA 4MCCA 1VHKA 4CNDA 4YPXA 1X7PA 2V3JA 3N4JA 1RCSA 4MCBA 4YVJA 4RG1A 3KW2A 4FAKA 1IPAA 4YQBA 1ZJRA 4YPYA 4KGNA 3GYQA 1WRSR 4YQGA 1UAMA 2OZ9R 2O3AA 1TRRA 3N4KA 3OIIA 1V2XA 1OY5A 4J3CA 1NXZA 1P9PA 3L8UA 3KTYA 1UAKA 1O6DA 2Z0YA 3BBEA 1UALA 4YQOA 3BBDA 4H3ZA 5D9FA 5GM8A 4YVIA 1NS5A 1TROA 4YQAA 3NK7A 3FRWA 1VH0A 4YVGA 3G1CA 2EGWA 4YQTA 2HA8A 4YQ0A 4MCDA 4CNFA 3IEFA 2V3KA 4YQDA 4X3MA 4YQSA 4YQ6A 4YQRA 4YQ3A 5GMCA 4PZKA 4JALA 1X7OA 3KNUA 1MI7R 1J85A 3KY7A 5FAIA 4YQJA 3SSWN 3AI9X 2I6DA 3OIJA 4YQCA 3NK6A 4JAKA 3ONPA 4CNEA 2YY8A 4YQLA 1TO0A 4YQNA 1GZ0A 3IC6A 4JWFA 4XBOA 1WRTR 4CNGA 4YQPA 5CO4A 2XDIA 4H3YA 3OINA 4IG6A 1CO0A 3E5YA 4JWGA 4YQ7A 4YQ8A 1UAJA 4FMWA 4JWHA 3O7BA 3QUVA 1K3RA 4YQ2A 2QMMA 4YPWA 4YQ9A 4E8BA 1JHGA
chains in the Genus database with same CATH topology
2EGVA 4YQ1A 3BBHA 2QWVA 1Z85A 5GMBA 3AXZA 3AIAA 2CX8A 4YQKA 4YQIA 1V6ZA 4YVHA 4YQQA 4JWJA 1MXIA 4YPZA 1VHYA 4YQ5A 4YQ4A 4KDZA 4L69A 4X3LA 3DCMX 4YVKA 3ILKA 4MCCA 1VHKA 4CNDA 4YPXA 1X7PA 2V3JA 3N4JA 4MCBA 4YVJA 4RG1A 3KW2A 4FAKA 1IPAA 4YQBA 1ZJRA 4YPYA 4KGNA 3GYQA 4YQGA 1UAMA 2O3AA 3N4KA 3OIIA 1V2XA 1OY5A 4J3CA 1NXZA 1P9PA 3L8UA 3KTYA 1UAKA 1O6DA 2Z0YA 3BBEA 1UALA 4YQOA 3BBDA 4H3ZA 5D9FA 5GM8A 4YVIA 1NS5A 4YQAA 3NK7A 1VH0A 4YVGA 2EGWA 4YQTA 2HA8A 4YQ0A 4MCDA 4CNFA 3IEFA 2V3KA 4YQDA 4X3MA 4YQSA 4YQ6A 4YQRA 4YQ3A 5GMCA 4PZKA 4JALA 1X7OA 3KNUA 1J85A 3KY7A 5FAIA 4YQJA 3AI9X 2I6DA 3OIJA 4YQCA 3NK6A 4JAKA 3ONPA 4CNEA 2YY8A 4YQLA 1TO0A 4YQNA 1GZ0A 3IC6A 4JWFA 4XBOA 4CNGA 4YQPA 5CO4A 4H3YA 3OINA 4IG6A 4JWGA 3E5YA 4YQ7A 4YQ8A 1UAJA 4FMWA 4JWHA 3O7BA 3QUVA 1K3RA 4YQ2A 2QMMA 4YPWA 4YQ9A 4E8BA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2EGV A;  4YQ1 A;  3BBH A;  2QWV A;  1Z85 A;  5GMB A;  3AXZ A;  3AIA A;  2CX8 A;  4YQK A;  4YQI A;  1V6Z A;  4YVH A;  4YQQ A;  1MXI A;  4YPZ A;  1VHY A;  4YQ5 A;  4YQ4 A;  4KDZ A;  4L69 A;  4X3L A;  3DCM X;  4YVK A;  3ILK A;  4MCC A;  1VHK A;  4CND A;  4YPX A;  1X7P A;  2V3J A;  3N4J A;  4MCB A;  4YVJ A;  4RG1 A;  3KW2 A;  4FAK A;  1IPA A;  4YQB A;  1ZJR A;  4YPY A;  4KGN A;  3GYQ A;  4YQG A;  1UAM A;  2O3A A;  3N4K A;  3OII A;  1V2X A;  1OY5 A;  4J3C A;  1NXZ A;  1P9P A;  3L8U A;  3KTY A;  1UAK A;  1O6D A;  2Z0Y A;  3BBE A;  1UAL A;  4YQO A;  3BBD A;  4H3Z A;  5D9F A;  5GM8 A;  4YVI A;  1NS5 A;  4YQA A;  3NK7 A;  1VH0 A;  4YVG A;  2EGW A;  4YQT A;  2HA8 A;  4YQ0 A;  4MCD A;  4CNF A;  3IEF A;  2V3K A;  4YQD A;  4X3M A;  4YQS A;  4YQ6 A;  4YQR A;  4YQ3 A;  5GMC A;  4PZK A;  4JAL A;  1X7O A;  3KNU A;  1J85 A;  3KY7 A;  5FAI A;  4YQJ A;  3AI9 X;  2I6D A;  3OIJ A;  4YQC A;  3NK6 A;  4JAK A;  3ONP A;  4CNE A;  2YY8 A;  4YQL A;  1TO0 A;  4YQN A;  1GZ0 A;  3IC6 A;  4XBO A;  4CNG A;  4YQP A;  5CO4 A;  4H3Y A;  3OIN A;  4IG6 A;  3E5Y A;  4YQ7 A;  4YQ8 A;  1UAJ A;  3O7B A;  3QUV A;  1K3R A;  4YQ2 A;  2QMM A;  4YPW A;  4YQ9 A;  4E8B A; 
#chains in the Genus database with same CATH topology
 2EGV A;  4YQ1 A;  3BBH A;  2QWV A;  1Z85 A;  5GMB A;  3AXZ A;  3AIA A;  3KOR A;  2CX8 A;  4YQK A;  1WRP R;  4YQI A;  1V6Z A;  4YVH A;  4YQQ A;  4JWJ A;  1MXI A;  3SSX N;  4YPZ A;  1ZT9 A;  1VHY A;  4YQ5 A;  4YQ4 A;  4KDZ A;  4L69 A;  4X3L A;  3DCM X;  4YVK A;  3ILK A;  3WRP A;  4MCC A;  1VHK A;  4CND A;  4YPX A;  1X7P A;  2V3J A;  3N4J A;  1RCS A;  4MCB A;  4YVJ A;  4RG1 A;  3KW2 A;  4FAK A;  1IPA A;  4YQB A;  1ZJR A;  4YPY A;  4KGN A;  3GYQ A;  1WRS R;  4YQG A;  1UAM A;  2OZ9 R;  2O3A A;  1TRR A;  3N4K A;  3OII A;  1V2X A;  1OY5 A;  4J3C A;  1NXZ A;  1P9P A;  3L8U A;  3KTY A;  1UAK A;  1O6D A;  2Z0Y A;  3BBE A;  1UAL A;  4YQO A;  3BBD A;  4H3Z A;  5D9F A;  5GM8 A;  4YVI A;  1NS5 A;  1TRO A;  4YQA A;  3NK7 A;  3FRW A;  1VH0 A;  4YVG A;  3G1C A;  2EGW A;  4YQT A;  2HA8 A;  4YQ0 A;  4MCD A;  4CNF A;  3IEF A;  2V3K A;  4YQD A;  4X3M A;  4YQS A;  4YQ6 A;  4YQR A;  4YQ3 A;  5GMC A;  4PZK A;  4JAL A;  1X7O A;  3KNU A;  1MI7 R;  1J85 A;  3KY7 A;  5FAI A;  4YQJ A;  3SSW N;  3AI9 X;  2I6D A;  3OIJ A;  4YQC A;  3NK6 A;  4JAK A;  3ONP A;  4CNE A;  2YY8 A;  4YQL A;  1TO0 A;  4YQN A;  1GZ0 A;  3IC6 A;  4JWF A;  4XBO A;  1WRT R;  4CNG A;  4YQP A;  5CO4 A;  2XDI A;  4H3Y A;  3OIN A;  4IG6 A;  1CO0 A;  3E5Y A;  4JWG A;  4YQ7 A;  4YQ8 A;  1UAJ A;  4FMW A;  4JWH A;  3O7B A;  3QUV A;  1K3R A;  4YQ2 A;  2QMM A;  4YPW A;  4YQ9 A;  4E8B A;  1JHG A; 
#chains in the Genus database with same CATH homology
 2EGV A;  4YQ1 A;  3BBH A;  2QWV A;  1Z85 A;  5GMB A;  3AXZ A;  3AIA A;  2CX8 A;  4YQK A;  4YQI A;  1V6Z A;  4YVH A;  4YQQ A;  4JWJ A;  1MXI A;  4YPZ A;  1VHY A;  4YQ5 A;  4YQ4 A;  4KDZ A;  4L69 A;  4X3L A;  3DCM X;  4YVK A;  3ILK A;  4MCC A;  1VHK A;  4CND A;  4YPX A;  1X7P A;  2V3J A;  3N4J A;  4MCB A;  4YVJ A;  4RG1 A;  3KW2 A;  4FAK A;  1IPA A;  4YQB A;  1ZJR A;  4YPY A;  4KGN A;  3GYQ A;  4YQG A;  1UAM A;  2O3A A;  3N4K A;  3OII A;  1V2X A;  1OY5 A;  4J3C A;  1NXZ A;  1P9P A;  3L8U A;  3KTY A;  1UAK A;  1O6D A;  2Z0Y A;  3BBE A;  1UAL A;  4YQO A;  3BBD A;  4H3Z A;  5D9F A;  5GM8 A;  4YVI A;  1NS5 A;  4YQA A;  3NK7 A;  1VH0 A;  4YVG A;  2EGW A;  4YQT A;  2HA8 A;  4YQ0 A;  4MCD A;  4CNF A;  3IEF A;  2V3K A;  4YQD A;  4X3M A;  4YQS A;  4YQ6 A;  4YQR A;  4YQ3 A;  5GMC A;  4PZK A;  4JAL A;  1X7O A;  3KNU A;  1J85 A;  3KY7 A;  5FAI A;  4YQJ A;  3AI9 X;  2I6D A;  3OIJ A;  4YQC A;  3NK6 A;  4JAK A;  3ONP A;  4CNE A;  2YY8 A;  4YQL A;  1TO0 A;  4YQN A;  1GZ0 A;  3IC6 A;  4JWF A;  4XBO A;  4CNG A;  4YQP A;  5CO4 A;  4H3Y A;  3OIN A;  4IG6 A;  4JWG A;  3E5Y A;  4YQ7 A;  4YQ8 A;  1UAJ A;  4FMW A;  4JWH A;  3O7B A;  3QUV A;  1K3R A;  4YQ2 A;  2QMM A;  4YPW A;  4YQ9 A;  4E8B A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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