4MDTA

Structure of lpxc bound to the reaction product udp-(3-o-(r-3-hydroxymyristoyl))-glucosamine
Total Genus 91
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
91
sequence length
300
structure length
300
Chain Sequence
MIKQRTLKRIVQATGVGLHTGKKVTLTLRPAPANTGVIYRRTDLNPPVDFPADAKSVRDTMLCTCLVNEHDVRISTVEHLNAALAGLGIDNIVIEVNAPEIPIMDGSAAPFVYLLLDAGIDELNSAKKFVRIKETVRVEDGDKWAEFKPYNGFSLDFTIDFNHPAIDSSNQRYAMNFSADAFMRQISRARTFGFMRDIEYLQSRGLCLGGSFDCAIVVDDYRVLNEDGLRFEDEFVRHKMLDAIGDLFMCGHNIIGAFTAYKSGHALNNKLLQAVLAKQEAWEYVTFQDDAELPLAFKAP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure of the Bacterial Deacetylase LpxC Bound to the Nucleotide Reaction Product Reveals Mechanisms of Oxyanion Stabilization and Proton Transfer.
pubmed doi rcsb
molecule keywords UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase
molecule tags Hydrolase
source organism Escherichia coli
total genus 91
structure length 300
sequence length 300
chains with identical sequence B, C, D
ec nomenclature ec 3.5.1.-:
pdb deposition date 2013-08-23
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.230.20 Alpha Beta 2-Layer Sandwich Ribosomal Protein S5; domain 2 lpxc deacetylase, domain 1 4mdtA01
3.30.1700.10 Alpha Beta 2-Layer Sandwich lpxc deacetylase, domain 1 lpxc deacetylase, domain 2 4mdtA02
4OKGA 3P3CA 3U1YA 1YHCA 1YH8A 4J3DA 3P3EA 4FW3A 5DROA 1P42A 4FW6A 4LCGA 4U3BA 3NZKA 2IESA 2VESA 2J65A 3P76A 3PS2A 2GO3A 4MDTA 4FW4A 3UHMA 4IS9A 1XXEA 4U3DA 2IERA 4LCHA 4FW7A 2GO4A 4LCFA 4MQYA 4OZEA 3PS3A 4FW5A 2O3ZA 5DRRA 5DRPA 3P3GA 3PS1A 5DRQA 2JT2A 4ISAA
chains in the Genus database with same CATH superfamily
4Z7CA 1UDQA 2WP8A 4NBQA 2BA0G 2O1UA 2IESA 3GMEA 1S4EA 4B3ME 4FW4A 4JI5E 4DR5E 2HKEA 4LCHA 1FJGE 3JAMC 1HK7A 3QT6A 4OX9E 2BR2B 1XMQE 1A6FA 2PO2A 4P7AA 1I94I 3CDIA 3P06A 2WP8B 4LF6E 2UXDI 2JT2A 4DR5I 1N33E 4OKGA 2JEAB 4LOMA 5JEAF 4OX9I 4IFDA 1RR9A 1MU5A 4IZJA 5JEAC 2NN6A 1IBMI 4IS9A 4DUZE 4X64E 2HHHE 1Z5BA 4U3DA 1IBKE 4IZKA 1N33I 1N32I 1ZM9A 4LF4E 3GONA 4FN5A 3K17A 1H73A 3PYEA 4LFBI 5DRRA 2O1TA 2UXCE 3WU3A 2HHHI 1MG7A 3J81Q 4IFDB 2GS8A 1XNQE 1Z0TA 5C0XD 4DV6I 4IZJB 5C0XC 4LF4I 3LPSA 3WU6A 3B82A 2AE8A 1XMOI 4IZKB 4X66I 4LF8E 1HNXE 4DPUA 4OO1D 2Q2EB 4JI6I 4GKJI 3J80C 2O1VA 2Z5CA 4JI8E 4QNJA 5FWKA 1HNZE 1N0UA 1Z59A 4DU7A 4AIDA 5DRPA 2WW4A 5GMEA 4LF8I 3U1YA 2C39A 4OO1E 4ZVIA 1PIEA 5K36D 4FW3A 1MX0A 5K36C 3ZKDA 3JAMQ 3P76A 5FLXC 3QT7A 1UDNA 1N0VC 1Z0VA 1XXEA 2BA1D 2HK3A 3WU4A 2UUCE 2Z5CB 4DR7E 5JEAA 3GLLA 1OJ4A 2E5LE 4JI2I 4IFDF 1D6TA 3U1KA 4YHHI 4WUBA 1FNMA 4B3SE 5EKWA 5EL9A 1B62A 4GKKI 2C39B 1NHIA 3T1HI 1E3HA 5BR8I 1EA6A 4JG4A 5DNLA 5DROA 2E5LI 2X7IA 2UUBE 2HKJA 3OTOE 4MYTA 2BV3A 3PS2A 3UHMA 5IT9C 4B3SI 1J5EE 5C0XA 1XHKA 1OYSA 4DR3E 1NZ0A 3Q1QA 2DEIA 4AM3A 3CWVA 4MQYA 1U2RA 4JI1E 3OTOI 3PS3A 2XEXA 2PNLA 2UXBI 1FKAE 1BKNA 3PYGA 1UDSA 4PU9A 4DUYE 4JV5E 1HNWI 1EI1A 1FI4A 4JI7E 1Y60A 4DPWA 4FWGA 2JEAA 5C0XB 2IOQA 2E1RA 4DV7I 3ZZUA 5LMUE 2UU9E 3J80Q 4DPYA 4DUYI 4JI3E 4NXMI 4PRXA 5K36A 4DV2E 3LNUA 4Z7YA 4HYMA 4FW5A 1Z0BA 2V2QA 4HY1A 4B3MI 5LMUI 2UU9I 4JI3I 4M1KA 4FWHA 4JI5I 4NXNE 2BA1G 4WUCA 1H7SA 2AJ4A 5FLXQ 3M85D 1YHCA 1FJGI 4DV2I 2R3VA 1XMQI 4BA2A 2HFSA 1VI7A 5IWAE 5K36B 2A2DA 4MYUA 2BM0A 4FW7A 4LF6I 4LF9E 1Y4UA 5GMDA 4KQVA 4JI4E 1ZM2A 4FWDA 3P3GA 3HJCA 4P52A 5C0XF 4DUZI 4X64I 2ZITA 2F1DA 3L7ZB 1IBKI 5IT9Q 4J3DA 2GQ0A 1B63A 4BA2B 4JI0E 3LTOA 3ZZ0A 4DV4E 4DU8A 3CDJA 2WNRB 2JE6B 2UXCI 4B3RE 2EFGA 4FW9A 4URLA 1XNQI 4OO1C 4OZEA 4JI0I 3DD6A 2LJPA 2V8PA 2DEJA 2O3ZA 2ZM6E 2CZ9A 1Z0EA 2V2ZA 4DR1E 4AQYE 2OI2A 5A2QC 3WU5A 5K36F 1HNXI 1RHYA 3QT5A 5LL6R 3J7AM 4U3BA 2Z5BB 3B4TA 4B3TE 4DR6E 4JI8I 1HNZI 2PO0B 2ZM6I 4DR2E 4YY3E 1PVGA 4AQYI 4USMA 1E3PA 2A2CA 4MU3A 2V34A 3D4JA 1KTVA 1VISA 4DR6I 3V2UC 3PS1A 2HFUA 1WUUA 3F0NA 4LFCE 4K0KE 1ELOA 3GCMA 3HULA 2UUCI 4DR7I 4R1FA 4DV1E 1P42A 2UUAE 4LFAE 2CGEA 4HXZA 4MU0A 3H4LA 4JYAE 1Z0WA 4GQUA 4X65E 3B8HA 4K0KI 4RPFA 4PRVA 1N36E 1N34E 2PO1A 4DV3E 1H7UA 4LCFA 4IZJD 2UUBI 3Q6NA 4LF7E 2C38A 4LFAI 2NN6D 1OYPA 2VQEE 4X62E 4ISAA 4ED4A 4X65I 1J5EI 1FWLA 1NHHA 2V2VA 1Y5YA 1Y4SA 4OO1A 4DR3I 3PRYA 1IBLE 4IFDE 4LCGA 5LMNE 3NZKA 2VESA 4JI1I 2NN6E 3T1YE 4LF7I 1XNRE 4DPTA 4KHPE 1H74A 2PO1B 5ELWA 4JV5I 2C38B 1IBLI 4JI7I 3QT8A 3M7ND 5LMNI 3T1YI 1PKPA 1FWKA 4DXLA 4OO1B 1R6MA 2VQFE 2O1WA 2BM1A 3H1CA 3P3EA 4DV0E 3L7ZA 2CG9A 1I94E 2NPFA 2UXDE 3Q6MA 1QZRA 4AIMA 1RREA 2PNMA 2ZBKB 2Z5EA 5DNXA 2VQFI 4NXNI 2WNRA 3KRNA 2JE6A 2GO4A 4DV0I 2PNZA 1IBME 2IOPA 2R42A 1N32E 1KIJA 5IWAI 4HACA 4EMDA 5JEAD 4LF9I 4DV5E 2X36A 3ZZTA 4LFBE 1ZM4A 4JI4I 4MDTA 1Z0GA 2C37A 2Z5BA 3ZKBA 4DV6E 2PO0A 2PNZB 4XTJA 2PO2B 5JEAE 4OO1F 1UEKA 4DV5I 1XMOE 2HK2A 4X66E 1R6LA 4USKA 2VF3A 4HACB 4DV4I 4DR4E 2CVEA 4B3RI 1ZXMA 4JI6E 2NN6B 1YH8A 4GKJE 3ZM7A 3PYDA 1KVKA 2C37B 4UT4A 1ZXNA 2J65A 3M7NG 1OYRA 1NHJA 4QNKA 4BA1A 2J7KA 5C0XE 2IERA 4MU1A 4DR1I 4DR4I 2BA0D 4DPXA 3M85G 4UTGA 3V5RA 1USVA 4B3TI 1H72C 4DR2I 4YY3I 3M6AA 4JI2E 4YHHE 4FW6A 4BA1B 2GO3A 4GKKE 2JEBA 3J7AG 1S16A 5BR8E 3T1HE 4LFCI 4LPFA 5K36E 3B78A 3HKMA 1HR0E 1DARA 1UDOA 4IFDD 2F4VE 4DV1I 4IFDC 2NN6F 2UUAI 1Y6ZA 1Z0CA 2NN6C 5DRQA 4JYAI 3P3CA 1KKHA 3K1JA 2JEBB 1N34I 1N36I 1HR0I 2UXBE 1K47A 4DV3I 3J81C 2F4VI 4LF5E 5JEAB 5L3JA 1HNWE 3K85A 2VQEI 4X62I 4I3HA 1Z5CA 1USUA 5A2QQ 4DV7E 4MU4A 4WUDA 1ZM3A 2BR2A 4LF5I 4N3OA 4NXME 1XNRI 1Z5AA 4KHPI 3PYFA
chains in the Genus database with same CATH topology
4OKGA 3P3CA 3U1YA 1YHCA 1YH8A 4J3DA 3P3EA 4FW3A 5DROA 1P42A 4FW6A 4LCGA 4U3BA 3NZKA 2IESA 2VESA 2J65A 3P76A 3PS2A 2GO3A 4MDTA 4FW4A 3UHMA 4IS9A 1XXEA 4U3DA 2IERA 4LCHA 4FW7A 2GO4A 4LCFA 4MQYA 4OZEA 3PS3A 4FW5A 2O3ZA 5DRRA 5DRPA 3P3GA 3PS1A 5DRQA 2JT2A 4ISAA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4OKG A;  3P3C A;  3U1Y A;  1YHC A;  1YH8 A;  4J3D A;  3P3E A;  4FW3 A;  5DRO A;  1P42 A;  4FW6 A;  4LCG A;  4U3B A;  3NZK A;  2IES A;  2VES A;  2J65 A;  3P76 A;  3PS2 A;  2GO3 A;  4MDT A;  4FW4 A;  3UHM A;  4IS9 A;  1XXE A;  4U3D A;  2IER A;  4LCH A;  4FW7 A;  2GO4 A;  4LCF A;  4MQY A;  4OZE A;  3PS3 A;  4FW5 A;  2O3Z A;  5DRR A;  5DRP A;  3P3G A;  3PS1 A;  5DRQ A;  2JT2 A;  4ISA A; 
#chains in the Genus database with same CATH topology
 4Z7C A;  1UDQ A;  2WP8 A;  4NBQ A;  2BA0 G;  2O1U A;  2IES A;  3GME A;  1S4E A;  4B3M E;  4FW4 A;  4JI5 E;  4DR5 E;  2HKE A;  4LCH A;  1FJG E;  3JAM C;  1HK7 A;  3QT6 A;  4OX9 E;  2BR2 B;  1XMQ E;  1A6F A;  2PO2 A;  4P7A A;  1I94 I;  3CDI A;  3P06 A;  2WP8 B;  4LF6 E;  2UXD I;  2JT2 A;  4DR5 I;  1N33 E;  4OKG A;  2JEA B;  4LOM A;  5JEA F;  4OX9 I;  4IFD A;  1RR9 A;  1MU5 A;  4IZJ A;  5JEA C;  2NN6 A;  1IBM I;  4IS9 A;  4DUZ E;  4X64 E;  2HHH E;  1Z5B A;  4U3D A;  1IBK E;  4IZK A;  1N33 I;  1N32 I;  1ZM9 A;  4LF4 E;  3GON A;  4FN5 A;  3K17 A;  1H73 A;  3PYE A;  4LFB I;  5DRR A;  2O1T A;  2UXC E;  3WU3 A;  2HHH I;  1MG7 A;  3J81 Q;  4IFD B;  2GS8 A;  1XNQ E;  1Z0T A;  5C0X D;  4DV6 I;  4IZJ B;  5C0X C;  4LF4 I;  3LPS A;  3WU6 A;  3B82 A;  2AE8 A;  1XMO I;  4IZK B;  4X66 I;  4LF8 E;  1HNX E;  4DPU A;  4OO1 D;  2Q2E B;  4JI6 I;  4GKJ I;  3J80 C;  2O1V A;  2Z5C A;  4JI8 E;  4QNJ A;  5FWK A;  1HNZ E;  1N0U A;  1Z59 A;  4DU7 A;  4AID A;  5DRP A;  2WW4 A;  5GME A;  4LF8 I;  3U1Y A;  2C39 A;  4OO1 E;  4ZVI A;  1PIE A;  5K36 D;  4FW3 A;  1MX0 A;  5K36 C;  3ZKD A;  3JAM Q;  3P76 A;  5FLX C;  3QT7 A;  1UDN A;  1N0V C;  1Z0V A;  1XXE A;  2BA1 D;  2HK3 A;  3WU4 A;  2UUC E;  2Z5C B;  4DR7 E;  5JEA A;  3GLL A;  1OJ4 A;  2E5L E;  4JI2 I;  4IFD F;  1D6T A;  3U1K A;  4YHH I;  4WUB A;  1FNM A;  4B3S E;  5EKW A;  5EL9 A;  1B62 A;  4GKK I;  2C39 B;  1NHI A;  3T1H I;  1E3H A;  5BR8 I;  1EA6 A;  4JG4 A;  5DNL A;  5DRO A;  2E5L I;  2X7I A;  2UUB E;  2HKJ A;  3OTO E;  4MYT A;  2BV3 A;  3PS2 A;  3UHM A;  5IT9 C;  4B3S I;  1J5E E;  5C0X A;  1XHK A;  1OYS A;  4DR3 E;  1NZ0 A;  3Q1Q A;  2DEI A;  4AM3 A;  3CWV A;  4MQY A;  1U2R A;  4JI1 E;  3OTO I;  3PS3 A;  2XEX A;  2PNL A;  2UXB I;  1FKA E;  1BKN A;  3PYG A;  1UDS A;  4PU9 A;  4DUY E;  4JV5 E;  1HNW I;  1EI1 A;  1FI4 A;  4JI7 E;  1Y60 A;  4DPW A;  4FWG A;  2JEA A;  5C0X B;  2IOQ A;  2E1R A;  4DV7 I;  3ZZU A;  5LMU E;  2UU9 E;  3J80 Q;  4DPY A;  4DUY I;  4JI3 E;  4NXM I;  4PRX A;  5K36 A;  4DV2 E;  3LNU A;  4Z7Y A;  4HYM A;  4FW5 A;  1Z0B A;  2V2Q A;  4HY1 A;  4B3M I;  5LMU I;  2UU9 I;  4JI3 I;  4M1K A;  4FWH A;  4JI5 I;  4NXN E;  2BA1 G;  4WUC A;  1H7S A;  2AJ4 A;  5FLX Q;  3M85 D;  1YHC A;  1FJG I;  4DV2 I;  2R3V A;  1XMQ I;  4BA2 A;  2HFS A;  1VI7 A;  5IWA E;  5K36 B;  2A2D A;  4MYU A;  2BM0 A;  4FW7 A;  4LF6 I;  4LF9 E;  1Y4U A;  5GMD A;  4KQV A;  4JI4 E;  1ZM2 A;  4FWD A;  3P3G A;  3HJC A;  4P52 A;  5C0X F;  4DUZ I;  4X64 I;  2ZIT A;  2F1D A;  3L7Z B;  1IBK I;  5IT9 Q;  4J3D A;  2GQ0 A;  1B63 A;  4BA2 B;  4JI0 E;  3LTO A;  3ZZ0 A;  4DV4 E;  4DU8 A;  3CDJ A;  2WNR B;  2JE6 B;  2UXC I;  4B3R E;  2EFG A;  4FW9 A;  4URL A;  1XNQ I;  4OO1 C;  4OZE A;  4JI0 I;  3DD6 A;  2LJP A;  2V8P A;  2DEJ A;  2O3Z A;  2ZM6 E;  2CZ9 A;  1Z0E A;  2V2Z A;  4DR1 E;  4AQY E;  2OI2 A;  5A2Q C;  3WU5 A;  5K36 F;  1HNX I;  1RHY A;  3QT5 A;  5LL6 R;  3J7A M;  4U3B A;  2Z5B B;  3B4T A;  4B3T E;  4DR6 E;  4JI8 I;  1HNZ I;  2PO0 B;  2ZM6 I;  4DR2 E;  4YY3 E;  1PVG A;  4AQY I;  4USM A;  1E3P A;  2A2C A;  4MU3 A;  2V34 A;  3D4J A;  1KTV A;  1VIS A;  4DR6 I;  3V2U C;  3PS1 A;  2HFU A;  1WUU A;  3F0N A;  4LFC E;  4K0K E;  1ELO A;  3GCM A;  3HUL A;  2UUC I;  4DR7 I;  4R1F A;  4DV1 E;  1P42 A;  2UUA E;  4LFA E;  2CGE A;  4HXZ A;  4MU0 A;  3H4L A;  4JYA E;  1Z0W A;  4GQU A;  4X65 E;  3B8H A;  4K0K I;  4RPF A;  4PRV A;  1N36 E;  1N34 E;  2PO1 A;  4DV3 E;  1H7U A;  4LCF A;  4IZJ D;  2UUB I;  3Q6N A;  4LF7 E;  2C38 A;  4LFA I;  2NN6 D;  1OYP A;  2VQE E;  4X62 E;  4ISA A;  4ED4 A;  4X65 I;  1J5E I;  1FWL A;  1NHH A;  2V2V A;  1Y5Y A;  1Y4S A;  4OO1 A;  4DR3 I;  3PRY A;  1IBL E;  4IFD E;  4LCG A;  5LMN E;  3NZK A;  2VES A;  4JI1 I;  2NN6 E;  3T1Y E;  4LF7 I;  1XNR E;  4DPT A;  4KHP E;  1H74 A;  2PO1 B;  5ELW A;  4JV5 I;  2C38 B;  1IBL I;  4JI7 I;  3QT8 A;  3M7N D;  5LMN I;  3T1Y I;  1PKP A;  1FWK A;  4DXL A;  4OO1 B;  1R6M A;  2VQF E;  2O1W A;  2BM1 A;  3H1C A;  3P3E A;  4DV0 E;  3L7Z A;  2CG9 A;  1I94 E;  2NPF A;  2UXD E;  3Q6M A;  1QZR A;  4AIM A;  1RRE A;  2PNM A;  2ZBK B;  2Z5E A;  5DNX A;  2VQF I;  4NXN I;  2WNR A;  3KRN A;  2JE6 A;  2GO4 A;  4DV0 I;  2PNZ A;  1IBM E;  2IOP A;  2R42 A;  1N32 E;  1KIJ A;  5IWA I;  4HAC A;  4EMD A;  5JEA D;  4LF9 I;  4DV5 E;  2X36 A;  3ZZT A;  4LFB E;  1ZM4 A;  4JI4 I;  4MDT A;  1Z0G A;  2C37 A;  2Z5B A;  3ZKB A;  4DV6 E;  2PO0 A;  2PNZ B;  4XTJ A;  2PO2 B;  5JEA E;  4OO1 F;  1UEK A;  4DV5 I;  1XMO E;  2HK2 A;  4X66 E;  1R6L A;  4USK A;  2VF3 A;  4HAC B;  4DV4 I;  4DR4 E;  2CVE A;  4B3R I;  1ZXM A;  4JI6 E;  2NN6 B;  1YH8 A;  4GKJ E;  3ZM7 A;  3PYD A;  1KVK A;  2C37 B;  4UT4 A;  1ZXN A;  2J65 A;  3M7N G;  1OYR A;  1NHJ A;  4QNK A;  4BA1 A;  2J7K A;  5C0X E;  2IER A;  4MU1 A;  4DR1 I;  4DR4 I;  2BA0 D;  4DPX A;  3M85 G;  4UTG A;  3V5R A;  1USV A;  4B3T I;  1H72 C;  4DR2 I;  4YY3 I;  3M6A A;  4JI2 E;  4YHH E;  4FW6 A;  4BA1 B;  2GO3 A;  4GKK E;  2JEB A;  3J7A G;  1S16 A;  5BR8 E;  3T1H E;  4LFC I;  4LPF A;  5K36 E;  3B78 A;  3HKM A;  1HR0 E;  1DAR A;  1UDO A;  4IFD D;  2F4V E;  4DV1 I;  4IFD C;  2NN6 F;  2UUA I;  1Y6Z A;  1Z0C A;  2NN6 C;  5DRQ A;  4JYA I;  3P3C A;  1KKH A;  3K1J A;  2JEB B;  1N34 I;  1N36 I;  1HR0 I;  2UXB E;  1K47 A;  4DV3 I;  3J81 C;  2F4V I;  4LF5 E;  5JEA B;  5L3J A;  1HNW E;  3K85 A;  2VQE I;  4X62 I;  4I3H A;  1Z5C A;  1USU A;  5A2Q Q;  4DV7 E;  4MU4 A;  4WUD A;  1ZM3 A;  2BR2 A;  4LF5 I;  4N3O A;  4NXM E;  1XNR I;  1Z5A A;  4KHP I;  3PYF A; 
#chains in the Genus database with same CATH homology
 4OKG A;  3P3C A;  3U1Y A;  1YHC A;  1YH8 A;  4J3D A;  3P3E A;  4FW3 A;  5DRO A;  1P42 A;  4FW6 A;  4LCG A;  4U3B A;  3NZK A;  2IES A;  2VES A;  2J65 A;  3P76 A;  3PS2 A;  2GO3 A;  4MDT A;  4FW4 A;  3UHM A;  4IS9 A;  1XXE A;  4U3D A;  2IER A;  4LCH A;  4FW7 A;  2GO4 A;  4LCF A;  4MQY A;  4OZE A;  3PS3 A;  4FW5 A;  2O3Z A;  5DRR A;  5DRP A;  3P3G A;  3PS1 A;  5DRQ A;  2JT2 A;  4ISA A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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