4MI5A

Crystal structure of the ezh2 set domain
Total Genus 45
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
45
sequence length
214
structure length
208
Chain Sequence
GSLQPCDHPRQPCDSSCPCVIAQNFCEKFCQCSSECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGEELFFDYRYSQA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Transferase
source organism Homo sapiens
publication title Structural Context of Disease-Associated Mutations and Putative Mechanism of Autoinhibition Revealed by X-Ray Crystallographic Analysis of the EZH2-SET Domain.
pubmed doi rcsb
molecule keywords Histone-lysine N-methyltransferase EZH2
total genus 45
structure length 208
sequence length 214
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2013-08-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
A PF18264 preSET_CXC CXC domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 4mi5A00
4J7FA 5HQ8A 2RFIA 4H12A 5KJLA 5F5EA 2JV0A 3PDNA 3M54A 2W5ZA 5ARGA 4YPUA 3K5KA 3M56A 4I51A 4C1QA 5F6KC 3DB5A 5CCMA 3OPEA 5TEGA 3N71A 5EG2A 3MO0A 3SWCA 5TH7A 4RZ0A 4YPAA 4BUPA 3BO5A 4MI0A 3RJWA 5T0MA 3M57A 3DALA 1MUFA 5TTFA 3RAYA 4J7IA 3QWPA 4QEPA 3IHXA 3M55A 4LDGA 4IJ8A 4J8OA 3S7JA 1N3JA 2O8JA 1ML9A 5JHNA 3S7BA 4FMUA 5HI7A 3M59A 3QWWA 3TG4A 5KJKA 3OOIA 4Z4PA 4YPEA 3F9ZA 4NJ5A 3RIBA 3RQ4A 3OXGA 1N6AA 1PEGA 3VV0A 3MO2A 3F9WA 4J83A 1MVXA 5T5GA 3CBPA 4YNDA 5T0KA 4QENA 4JDSA 4NVQA 2QPWA 4QEOA 5KJNA 5LSZA 2BQZA 3TG5A 1XQHA 2F69A 3RU0A 5LSXA 5JIYA 3MO5A 2W5YA 5F59A 5EX0A 3SW9A 4YNMA 3F9YA 1MT6A 3KMTA 3F9XA 3S8PA 5JJ0A 3OS5A 1MVHA 5EX3A 5F6LA 2R3AA 5JINA 3M53A 3S7DA 4O30A 3KMAA 4O6FA 5CPRB 5AYFA 3MEKA 4IJDA 1ZKKA 2G46A 1O9SA 3CBOA 4WUYA 5ARFA 3VUZA 5CCLA 1H3IA 1N6CA 3FPDA 3S7FA 4JLGA 3M5AA 3CBMA 4E47A 3M58A 4YNPA 4AU7A 3OXFA 3EP0A 3KMJA 3OXLA 4MI5A 5KJMA 2IGQA 3HNAA 3QWVA
chains in the Genus database with same CATH superfamily
4J7FA 5HQ8A 2RFIA 4H12A 5KJLA 5F5EA 2JV0A 3PDNA 3M54A 2W5ZA 5ARGA 4YPUA 3K5KA 3M56A 4I51A 4C1QA 5F6KC 3DB5A 5CCMA 3OPEA 5TEGA 3N71A 5EG2A 3MO0A 3SWCA 5TH7A 4RZ0A 4YPAA 4BUPA 3BO5A 4MI0A 3RJWA 5T0MA 3M57A 3DALA 1MUFA 5TTFA 3RAYA 4J7IA 3QWPA 4QEPA 3IHXA 3M55A 4LDGA 4IJ8A 4J8OA 3S7JA 1N3JA 2O8JA 1ML9A 5JHNA 3S7BA 4FMUA 5HI7A 3M59A 3QWWA 3TG4A 5KJKA 3OOIA 4Z4PA 4YPEA 3F9ZA 4NJ5A 3RIBA 3RQ4A 3OXGA 1N6AA 1PEGA 3VV0A 3MO2A 3F9WA 4J83A 1MVXA 5T5GA 3CBPA 4YNDA 5T0KA 4QENA 4JDSA 4NVQA 2QPWA 4QEOA 5KJNA 5LSZA 2BQZA 3TG5A 1XQHA 2F69A 3RU0A 5LSXA 5JIYA 3MO5A 2W5YA 5F59A 5EX0A 3SW9A 4YNMA 3F9YA 1MT6A 3KMTA 3F9XA 3S8PA 5JJ0A 3OS5A 1MVHA 5EX3A 5F6LA 2R3AA 5JINA 3M53A 3S7DA 4O30A 3KMAA 4O6FA 5CPRB 5AYFA 3MEKA 4IJDA 1ZKKA 2G46A 1O9SA 3CBOA 4WUYA 5ARFA 3VUZA 5CCLA 1H3IA 1N6CA 3FPDA 3S7FA 4JLGA 3M5AA 3CBMA 4E47A 3M58A 4YNPA 4AU7A 3OXFA 3EP0A 3KMJA 3OXLA 4MI5A 5KJMA 2IGQA 3HNAA 3QWVA
chains in the Genus database with same CATH topology
4J7FA 5HQ8A 2RFIA 4H12A 5KJLA 5F5EA 2JV0A 3PDNA 3M54A 2W5ZA 5ARGA 4YPUA 3K5KA 3M56A 4I51A 4C1QA 5F6KC 3DB5A 5CCMA 3OPEA 5TEGA 3N71A 5EG2A 3MO0A 3SWCA 5TH7A 4RZ0A 4YPAA 4BUPA 3BO5A 4MI0A 3RJWA 5T0MA 3M57A 3DALA 1MUFA 5TTFA 3RAYA 4J7IA 3QWPA 4QEPA 3IHXA 3M55A 4LDGA 4IJ8A 4J8OA 3S7JA 1N3JA 2O8JA 1ML9A 5JHNA 3S7BA 4FMUA 5HI7A 3M59A 3QWWA 3TG4A 5KJKA 3OOIA 4Z4PA 4YPEA 3F9ZA 4NJ5A 3RIBA 3RQ4A 3OXGA 1N6AA 1PEGA 3VV0A 3MO2A 3F9WA 4J83A 1MVXA 5T5GA 3CBPA 4YNDA 5T0KA 4QENA 4JDSA 4NVQA 2QPWA 4QEOA 5KJNA 5LSZA 2BQZA 3TG5A 1XQHA 2F69A 3RU0A 5LSXA 5JIYA 3MO5A 2W5YA 5F59A 5EX0A 3SW9A 4YNMA 3F9YA 1MT6A 3KMTA 3F9XA 3S8PA 5JJ0A 3OS5A 1MVHA 5EX3A 5F6LA 2R3AA 5JINA 3M53A 3S7DA 4O30A 3KMAA 4O6FA 5CPRB 5AYFA 3MEKA 4IJDA 1ZKKA 2G46A 1O9SA 3CBOA 4WUYA 5ARFA 3VUZA 5CCLA 1H3IA 1N6CA 3FPDA 3S7FA 4JLGA 3M5AA 3CBMA 4E47A 3M58A 4YNPA 4AU7A 3OXFA 3EP0A 3KMJA 3OXLA 4MI5A 5KJMA 2IGQA 3HNAA 3QWVA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4J7F A;  5HQ8 A;  2RFI A;  4H12 A;  5KJL A;  5F5E A;  2JV0 A;  3PDN A;  3M54 A;  2W5Z A;  5ARG A;  4YPU A;  3K5K A;  3M56 A;  4I51 A;  4C1Q A;  5F6K C;  3DB5 A;  5CCM A;  3OPE A;  5TEG A;  3N71 A;  5EG2 A;  3MO0 A;  3SWC A;  5TH7 A;  4RZ0 A;  4YPA A;  4BUP A;  3BO5 A;  4MI0 A;  3RJW A;  5T0M A;  3M57 A;  3DAL A;  1MUF A;  5TTF A;  3RAY A;  4J7I A;  3QWP A;  4QEP A;  3IHX A;  3M55 A;  4LDG A;  4IJ8 A;  4J8O A;  3S7J A;  1N3J A;  2O8J A;  1ML9 A;  5JHN A;  3S7B A;  4FMU A;  5HI7 A;  3M59 A;  3QWW A;  3TG4 A;  5KJK A;  3OOI A;  4Z4P A;  4YPE A;  3F9Z A;  4NJ5 A;  3RIB A;  3RQ4 A;  3OXG A;  1N6A A;  1PEG A;  3VV0 A;  3MO2 A;  3F9W A;  4J83 A;  1MVX A;  5T5G A;  3CBP A;  4YND A;  5T0K A;  4QEN A;  4JDS A;  4NVQ A;  2QPW A;  4QEO A;  5KJN A;  5LSZ A;  2BQZ A;  3TG5 A;  1XQH A;  2F69 A;  3RU0 A;  5LSX A;  5JIY A;  3MO5 A;  2W5Y A;  5F59 A;  5EX0 A;  3SW9 A;  4YNM A;  3F9Y A;  1MT6 A;  3KMT A;  3F9X A;  3S8P A;  5JJ0 A;  3OS5 A;  1MVH A;  5EX3 A;  5F6L A;  2R3A A;  5JIN A;  3M53 A;  3S7D A;  4O30 A;  3KMA A;  4O6F A;  5CPR B;  5AYF A;  3MEK A;  4IJD A;  1ZKK A;  2G46 A;  1O9S A;  3CBO A;  4WUY A;  5ARF A;  3VUZ A;  5CCL A;  1H3I A;  1N6C A;  3FPD A;  3S7F A;  4JLG A;  3M5A A;  3CBM A;  4E47 A;  3M58 A;  4YNP A;  4AU7 A;  3OXF A;  3EP0 A;  3KMJ A;  3OXL A;  4MI5 A;  5KJM A;  2IGQ A;  3HNA A;  3QWV A; 
#chains in the Genus database with same CATH topology
 4J7F A;  5HQ8 A;  2RFI A;  4H12 A;  5KJL A;  5F5E A;  2JV0 A;  3PDN A;  3M54 A;  2W5Z A;  5ARG A;  4YPU A;  3K5K A;  3M56 A;  4I51 A;  4C1Q A;  5F6K C;  3DB5 A;  5CCM A;  3OPE A;  5TEG A;  3N71 A;  5EG2 A;  3MO0 A;  3SWC A;  5TH7 A;  4RZ0 A;  4YPA A;  4BUP A;  3BO5 A;  4MI0 A;  3RJW A;  5T0M A;  3M57 A;  3DAL A;  1MUF A;  5TTF A;  3RAY A;  4J7I A;  3QWP A;  4QEP A;  3IHX A;  3M55 A;  4LDG A;  4IJ8 A;  4J8O A;  3S7J A;  1N3J A;  2O8J A;  1ML9 A;  5JHN A;  3S7B A;  4FMU A;  5HI7 A;  3M59 A;  3QWW A;  3TG4 A;  5KJK A;  3OOI A;  4Z4P A;  4YPE A;  3F9Z A;  4NJ5 A;  3RIB A;  3RQ4 A;  3OXG A;  1N6A A;  1PEG A;  3VV0 A;  3MO2 A;  3F9W A;  4J83 A;  1MVX A;  5T5G A;  3CBP A;  4YND A;  5T0K A;  4QEN A;  4JDS A;  4NVQ A;  2QPW A;  4QEO A;  5KJN A;  5LSZ A;  2BQZ A;  3TG5 A;  1XQH A;  2F69 A;  3RU0 A;  5LSX A;  5JIY A;  3MO5 A;  2W5Y A;  5F59 A;  5EX0 A;  3SW9 A;  4YNM A;  3F9Y A;  1MT6 A;  3KMT A;  3F9X A;  3S8P A;  5JJ0 A;  3OS5 A;  1MVH A;  5EX3 A;  5F6L A;  2R3A A;  5JIN A;  3M53 A;  3S7D A;  4O30 A;  3KMA A;  4O6F A;  5CPR B;  5AYF A;  3MEK A;  4IJD A;  1ZKK A;  2G46 A;  1O9S A;  3CBO A;  4WUY A;  5ARF A;  3VUZ A;  5CCL A;  1H3I A;  1N6C A;  3FPD A;  3S7F A;  4JLG A;  3M5A A;  3CBM A;  4E47 A;  3M58 A;  4YNP A;  4AU7 A;  3OXF A;  3EP0 A;  3KMJ A;  3OXL A;  4MI5 A;  5KJM A;  2IGQ A;  3HNA A;  3QWV A; 
#chains in the Genus database with same CATH homology
 4J7F A;  5HQ8 A;  2RFI A;  4H12 A;  5KJL A;  5F5E A;  2JV0 A;  3PDN A;  3M54 A;  2W5Z A;  5ARG A;  4YPU A;  3K5K A;  3M56 A;  4I51 A;  4C1Q A;  5F6K C;  3DB5 A;  5CCM A;  3OPE A;  5TEG A;  3N71 A;  5EG2 A;  3MO0 A;  3SWC A;  5TH7 A;  4RZ0 A;  4YPA A;  4BUP A;  3BO5 A;  4MI0 A;  3RJW A;  5T0M A;  3M57 A;  3DAL A;  1MUF A;  5TTF A;  3RAY A;  4J7I A;  3QWP A;  4QEP A;  3IHX A;  3M55 A;  4LDG A;  4IJ8 A;  4J8O A;  3S7J A;  1N3J A;  2O8J A;  1ML9 A;  5JHN A;  3S7B A;  4FMU A;  5HI7 A;  3M59 A;  3QWW A;  3TG4 A;  5KJK A;  3OOI A;  4Z4P A;  4YPE A;  3F9Z A;  4NJ5 A;  3RIB A;  3RQ4 A;  3OXG A;  1N6A A;  1PEG A;  3VV0 A;  3MO2 A;  3F9W A;  4J83 A;  1MVX A;  5T5G A;  3CBP A;  4YND A;  5T0K A;  4QEN A;  4JDS A;  4NVQ A;  2QPW A;  4QEO A;  5KJN A;  5LSZ A;  2BQZ A;  3TG5 A;  1XQH A;  2F69 A;  3RU0 A;  5LSX A;  5JIY A;  3MO5 A;  2W5Y A;  5F59 A;  5EX0 A;  3SW9 A;  4YNM A;  3F9Y A;  1MT6 A;  3KMT A;  3F9X A;  3S8P A;  5JJ0 A;  3OS5 A;  1MVH A;  5EX3 A;  5F6L A;  2R3A A;  5JIN A;  3M53 A;  3S7D A;  4O30 A;  3KMA A;  4O6F A;  5CPR B;  5AYF A;  3MEK A;  4IJD A;  1ZKK A;  2G46 A;  1O9S A;  3CBO A;  4WUY A;  5ARF A;  3VUZ A;  5CCL A;  1H3I A;  1N6C A;  3FPD A;  3S7F A;  4JLG A;  3M5A A;  3CBM A;  4E47 A;  3M58 A;  4YNP A;  4AU7 A;  3OXF A;  3EP0 A;  3KMJ A;  3OXL A;  4MI5 A;  5KJM A;  2IGQ A;  3HNA A;  3QWV A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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