4MK0G

Crystal structure of g protein-coupled receptor kinase 2 in complex with a a rationally designed paroxetine derivative
Total Genus 14
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
14
sequence length
59
structure length
59
Chain Sequence
TASIAQARKLVEQLKMEANIDRIKVSKAAADLMAYCEAHAKEDPLLTPVPASENPFREK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Signaling protein/inhibitor
molecule keywords Beta-adrenergic receptor kinase 1
publication title Structural and functional analysis of g protein-coupled receptor kinase inhibition by paroxetine and a rationally designed analog.
pubmed doi rcsb
source organism Homo sapiens
total genus 14
structure length 59
sequence length 59
ec nomenclature
pdb deposition date 2013-09-04
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.260.10 Few Secondary Structures Irregular G Protein Gi Gamma 2 Transducin (heterotrimeric G protein), gamma chain 4mk0G00
5HE2G 3AH8G 4PNKG 5TDHG 3PVWG 5KDOG 3CIKG 3SN6G 5HE1G 5HE3G 3V5WG 5HE0G 1B9XB 1TBGE 1B9YB 3PVUG 1GP2G 1A0RG 1OMWG 2PBIA 3PSCG 3KRXG 1GOTG 2BCJG 1GG2G 4MK0G 1XHMB 4KFMG 2TRCG 3KRWG
chains in the Genus database with same CATH superfamily
5HE2G 3AH8G 4PNKG 5TDHG 3PVWG 5KDOG 3CIKG 3SN6G 5HE1G 5HE3G 3V5WG 5HE0G 1B9XB 1TBGE 1B9YB 1IOJA 3PVUG 1GP2G 1A0RG 1OMWG 2PBIA 3PSCG 3KRXG 1GOTG 2BCJG 1GG2G 4MK0G 1XHMB 4KFMG 2TRCG 3KRWG 1HFES
chains in the Genus database with same CATH topology
5HE2G 3AH8G 4PNKG 5TDHG 3PVWG 5KDOG 3CIKG 3SN6G 5HE1G 5HE3G 3V5WG 5HE0G 1B9XB 1TBGE 1B9YB 3PVUG 1GP2G 1A0RG 1OMWG 2PBIA 3PSCG 3KRXG 1GOTG 2BCJG 1GG2G 4MK0G 1XHMB 4KFMG 2TRCG 3KRWG
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5HE2 G;  3AH8 G;  4PNK G;  5TDH G;  3PVW G;  5KDO G;  3CIK G;  3SN6 G;  5HE1 G;  5HE3 G;  3V5W G;  5HE0 G;  1B9X B;  1TBG E;  1B9Y B;  3PVU G;  1GP2 G;  1A0R G;  1OMW G;  2PBI A;  3PSC G;  3KRX G;  1GOT G;  2BCJ G;  1GG2 G;  4MK0 G;  1XHM B;  4KFM G;  2TRC G;  3KRW G; 
#chains in the Genus database with same CATH topology
 5HE2 G;  3AH8 G;  4PNK G;  5TDH G;  3PVW G;  5KDO G;  3CIK G;  3SN6 G;  5HE1 G;  5HE3 G;  3V5W G;  5HE0 G;  1B9X B;  1TBG E;  1B9Y B;  1IOJ A;  3PVU G;  1GP2 G;  1A0R G;  1OMW G;  2PBI A;  3PSC G;  3KRX G;  1GOT G;  2BCJ G;  1GG2 G;  4MK0 G;  1XHM B;  4KFM G;  2TRC G;  3KRW G;  1HFE S; 
#chains in the Genus database with same CATH homology
 5HE2 G;  3AH8 G;  4PNK G;  5TDH G;  3PVW G;  5KDO G;  3CIK G;  3SN6 G;  5HE1 G;  5HE3 G;  3V5W G;  5HE0 G;  1B9X B;  1TBG E;  1B9Y B;  3PVU G;  1GP2 G;  1A0R G;  1OMW G;  2PBI A;  3PSC G;  3KRX G;  1GOT G;  2BCJ G;  1GG2 G;  4MK0 G;  1XHM B;  4KFM G;  2TRC G;  3KRW G; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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