4MK0G

Crystal structure of g protein-coupled receptor kinase 2 in complex with a a rationally designed paroxetine derivative
Total Genus 14
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
14
sequence length
59
structure length
59
Chain Sequence
TASIAQARKLVEQLKMEANIDRIKVSKAAADLMAYCEAHAKEDPLLTPVPASENPFREK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural and functional analysis of g protein-coupled receptor kinase inhibition by paroxetine and a rationally designed analog.
pubmed doi rcsb
molecule tags Signaling protein/inhibitor
source organism Homo sapiens
molecule keywords Beta-adrenergic receptor kinase 1
total genus 14
structure length 59
sequence length 59
ec nomenclature
pdb deposition date 2013-09-04
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.260.10 Few Secondary Structures Irregular G Protein Gi Gamma 2 Transducin (heterotrimeric G protein), gamma chain 4mk0G00
1B9YB 2PBIA 5TDHG 1GOTG 1A0RG 4PNKG 5HE1G 1XHMB 5HE3G 3KRWG 1GG2G 4MK0G 1OMWG 3CIKG 4KFMG 5HE0G 1GP2G 3AH8G 3KRXG 3PVUG 1B9XB 3PVWG 2BCJG 2TRCG 5HE2G 5KDOG 3V5WG 1TBGE 3PSCG 3SN6G
chains in the Genus database with same CATH superfamily
1B9YB 2PBIA 5TDHG 1GOTG 1A0RG 4PNKG 5HE1G 1IOJA 1XHMB 5HE3G 3KRWG 1GG2G 4MK0G 1OMWG 3CIKG 1HFES 4KFMG 5HE0G 1GP2G 3AH8G 3KRXG 1B9XB 3PVWG 3PVUG 2BCJG 2TRCG 5HE2G 5KDOG 3V5WG 1TBGE 3PSCG 3SN6G
chains in the Genus database with same CATH topology
1B9YB 2PBIA 5TDHG 1GOTG 1A0RG 4PNKG 5HE1G 1XHMB 5HE3G 3KRWG 1GG2G 4MK0G 1OMWG 3CIKG 4KFMG 5HE0G 1GP2G 3AH8G 3KRXG 3PVUG 1B9XB 3PVWG 2BCJG 2TRCG 5HE2G 5KDOG 3V5WG 1TBGE 3PSCG 3SN6G
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1B9Y B;  2PBI A;  5TDH G;  1GOT G;  1A0R G;  4PNK G;  5HE1 G;  1XHM B;  5HE3 G;  3KRW G;  1GG2 G;  4MK0 G;  1OMW G;  3CIK G;  4KFM G;  5HE0 G;  1GP2 G;  3AH8 G;  3KRX G;  3PVU G;  1B9X B;  3PVW G;  2BCJ G;  2TRC G;  5HE2 G;  5KDO G;  3V5W G;  1TBG E;  3PSC G;  3SN6 G; 
#chains in the Genus database with same CATH topology
 1B9Y B;  2PBI A;  5TDH G;  1GOT G;  1A0R G;  4PNK G;  5HE1 G;  1IOJ A;  1XHM B;  5HE3 G;  3KRW G;  1GG2 G;  4MK0 G;  1OMW G;  3CIK G;  1HFE S;  4KFM G;  5HE0 G;  1GP2 G;  3AH8 G;  3KRX G;  1B9X B;  3PVW G;  3PVU G;  2BCJ G;  2TRC G;  5HE2 G;  5KDO G;  3V5W G;  1TBG E;  3PSC G;  3SN6 G; 
#chains in the Genus database with same CATH homology
 1B9Y B;  2PBI A;  5TDH G;  1GOT G;  1A0R G;  4PNK G;  5HE1 G;  1XHM B;  5HE3 G;  3KRW G;  1GG2 G;  4MK0 G;  1OMW G;  3CIK G;  4KFM G;  5HE0 G;  1GP2 G;  3AH8 G;  3KRX G;  3PVU G;  1B9X B;  3PVW G;  2BCJ G;  2TRC G;  5HE2 G;  5KDO G;  3V5W G;  1TBG E;  3PSC G;  3SN6 G; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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