4N1KA

Crystal structures of nlrp14 pyrin domain reveal a conformational switch mechanism, regulating its molecular interactions
Total Genus 30
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
30
sequence length
88
structure length
88
Chain Sequence
SSSFFPDFGLLLYLEELNKEELNTFKLFLKETMEPEHGLTPWNEVKKARREDLANLMKKYYPGEKAWSVSLKIFGKMNLKVLCERAKE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structures of the NLRP14 pyrin domain reveal a conformational switch mechanism regulating its molecular interactions.
pubmed doi rcsb
molecule tags Signaling protein
source organism Homo sapiens
molecule keywords NACHT, LRR and PYD domains-containing protein 14
total genus 30
structure length 88
sequence length 88
chains with identical sequence B, C, D
ec nomenclature
pdb deposition date 2013-10-04

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02758 PYRIN PAAD/DAPIN/Pyrin domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.533.10 Mainly Alpha Orthogonal Bundle Death Domain, Fas Death Domain, Fas 4n1kA00
1PN5A 3EZQB 3LQRA 2N83A 4LWDA 1CWWA 1DGNA 2N97A 2A9IA 1WXPA 1A1ZA 2DBDA 2MS7A 4O7QA 2KN6A 2F1SA 4D8OA 2DO9A 1D2ZA 4NQKA 4UZ0A 3YGSC 1E41A 4JQWA 2GF5A 3KATA 2OF5A 4IZAB 4DWNA 2MS8A 4M9ZA 2YVIA 2N1FA 1UCPA 3YGSP 3T6PA 4RHWA 1WMGA 4RHWE 4M9SA 3J63A 4A2QA 2G7RA 4O6XA 2MN4A 4N1KA 3J6JA 1D2ZB 4M9XA 2B1WA 4E9MA 2YGSA 2BBZA 1E3YA 4QOBA 2O71A 1A1WA 2BBRA 2LS7A 2NZ7A 3QF2A 2LWEA 1WH4A 3LQQA 2HM2Q 2P1HA 3MOPA 3CRDA 1C15A 2YU0A 2LWDA 4P4HI 2A5YB 4O9LA 2IB1A 2N00A 2OF5H 2YQFA 1NGRA 2KM6A 2N80A 2L9MA 4ZBWA 4N1JA 3MOPK 4N1LA 2M5VA 3EZQA 2NSNA 4JUPA 1N3KA 2NAQA 1Z6TA 2DBFA 4IZ5E 2N7ZA 3CL3A 4IZ7B 1FADA 2MB9A 4EWIA 1DDFA 4P4HA 2D96A 4A2WA 1CY5A 1ICHA 3MOPG 2DBHA 2L6AA 2MPCA 4O9FA 4I16A 4FH0A 4F42A 1YGOA 2VGQA 2DBGA 4F44A
chains in the Genus database with same CATH superfamily
1PN5A 3EZQB 3LQRA 2N83A 4LWDA 1CWWA 1DGNA 2N97A 2A9IA 1WXPA 1A1ZA 2DBDA 2MS7A 4O7QA 2KN6A 2F1SA 4D8OA 2DO9A 1D2ZA 4NQKA 4UZ0A 3YGSC 1E41A 4JQWA 2GF5A 3KATA 2OF5A 4IZAB 4DWNA 2MS8A 4M9ZA 2YVIA 2N1FA 1UCPA 3YGSP 3T6PA 4RHWA 1WMGA 4RHWE 4M9SA 3J63A 4A2QA 2MJMA 2G7RA 4O6XA 2MN4A 4N1KA 3J6JA 1D2ZB 4M9XA 2B1WA 4E9MA 2YGSA 2BBZA 1E3YA 4QOBA 2O71A 1A1WA 2BBRA 2LS7A 2NZ7A 3QF2A 2LWEA 1WH4A 3LQQA 2HM2Q 2P1HA 3MOPA 3CRDA 1C15A 2YU0A 2LWDA 4P4HI 2A5YB 4O9LA 2IB1A 2N00A 2OF5H 2YQFA 1NGRA 2KM6A 2N80A 2L9MA 4ZBWA 4N1JA 3MOPK 4N1LA 2M5VA 3EZQA 2NSNA 4JUPA 1N3KA 2NAQA 1Z6TA 2XV9A 2DBFA 4IZ5E 2N7ZA 3CL3A 4IZ7B 1FADA 2MB9A 4EWIA 1DDFA 4P4HA 2D96A 4A2WA 1CY5A 3MOPG 1ICHA 2DBHA 2L6AA 2MPCA 4O9FA 4I16A 4FH0A 4F42A 1YGOA 2VGQA 2DBGA 4F44A
chains in the Genus database with same CATH topology
1PN5A 3EZQB 3LQRA 2N83A 4LWDA 1CWWA 1DGNA 2N97A 2A9IA 1WXPA 1A1ZA 2DBDA 2MS7A 4O7QA 2KN6A 2F1SA 4D8OA 2DO9A 1D2ZA 4NQKA 4UZ0A 3YGSC 1E41A 4JQWA 2GF5A 3KATA 2OF5A 4IZAB 4DWNA 2MS8A 4M9ZA 2YVIA 2N1FA 1UCPA 3YGSP 3T6PA 4RHWA 1WMGA 4RHWE 4M9SA 3J63A 4A2QA 2MJMA 2G7RA 4O6XA 2MN4A 4N1KA 3J6JA 1D2ZB 4M9XA 2B1WA 4E9MA 2YGSA 2BBZA 1E3YA 4QOBA 2O71A 1A1WA 2BBRA 2LS7A 2NZ7A 3QF2A 2LWEA 1WH4A 3LQQA 2HM2Q 2P1HA 3MOPA 3CRDA 1C15A 2YU0A 2LWDA 4P4HI 2A5YB 4O9LA 2IB1A 2N00A 2OF5H 2YQFA 1NGRA 2KM6A 2N80A 2L9MA 4ZBWA 4N1JA 3MOPK 4N1LA 2M5VA 3EZQA 2NSNA 4JUPA 1N3KA 2NAQA 1Z6TA 2XV9A 2DBFA 4IZ5E 2N7ZA 3CL3A 4IZ7B 1FADA 2MB9A 4EWIA 1DDFA 4P4HA 2D96A 4A2WA 1CY5A 3MOPG 1ICHA 2DBHA 2L6AA 2MPCA 4O9FA 4I16A 4FH0A 4F42A 1YGOA 2VGQA 2DBGA 4F44A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1PN5 A;  3EZQ B;  3LQR A;  2N83 A;  4LWD A;  1CWW A;  1DGN A;  2N97 A;  2A9I A;  1WXP A;  1A1Z A;  2DBD A;  2MS7 A;  4O7Q A;  2KN6 A;  2F1S A;  4D8O A;  2DO9 A;  1D2Z A;  4NQK A;  4UZ0 A;  3YGS C;  1E41 A;  4JQW A;  2GF5 A;  3KAT A;  2OF5 A;  4IZA B;  4DWN A;  2MS8 A;  4M9Z A;  2YVI A;  2N1F A;  1UCP A;  3YGS P;  3T6P A;  4RHW A;  1WMG A;  4RHW E;  4M9S A;  3J63 A;  4A2Q A;  2G7R A;  4O6X A;  2MN4 A;  4N1K A;  3J6J A;  1D2Z B;  4M9X A;  2B1W A;  4E9M A;  2YGS A;  2BBZ A;  1E3Y A;  4QOB A;  2O71 A;  1A1W A;  2BBR A;  2LS7 A;  2NZ7 A;  3QF2 A;  2LWE A;  1WH4 A;  3LQQ A;  2HM2 Q;  2P1H A;  3MOP A;  3CRD A;  1C15 A;  2YU0 A;  2LWD A;  4P4H I;  2A5Y B;  4O9L A;  2IB1 A;  2N00 A;  2OF5 H;  2YQF A;  1NGR A;  2KM6 A;  2N80 A;  2L9M A;  4ZBW A;  4N1J A;  3MOP K;  4N1L A;  2M5V A;  3EZQ A;  2NSN A;  4JUP A;  1N3K A;  2NAQ A;  1Z6T A;  2DBF A;  4IZ5 E;  2N7Z A;  3CL3 A;  4IZ7 B;  1FAD A;  2MB9 A;  4EWI A;  1DDF A;  4P4H A;  2D96 A;  4A2W A;  1CY5 A;  1ICH A;  3MOP G;  2DBH A;  2L6A A;  2MPC A;  4O9F A;  4I16 A;  4FH0 A;  4F42 A;  1YGO A;  2VGQ A;  2DBG A;  4F44 A; 
#chains in the Genus database with same CATH topology
 1PN5 A;  3EZQ B;  3LQR A;  2N83 A;  4LWD A;  1CWW A;  1DGN A;  2N97 A;  2A9I A;  1WXP A;  1A1Z A;  2DBD A;  2MS7 A;  4O7Q A;  2KN6 A;  2F1S A;  4D8O A;  2DO9 A;  1D2Z A;  4NQK A;  4UZ0 A;  3YGS C;  1E41 A;  4JQW A;  2GF5 A;  3KAT A;  2OF5 A;  4IZA B;  4DWN A;  2MS8 A;  4M9Z A;  2YVI A;  2N1F A;  1UCP A;  3YGS P;  3T6P A;  4RHW A;  1WMG A;  4RHW E;  4M9S A;  3J63 A;  4A2Q A;  2MJM A;  2G7R A;  4O6X A;  2MN4 A;  4N1K A;  3J6J A;  1D2Z B;  4M9X A;  2B1W A;  4E9M A;  2YGS A;  2BBZ A;  1E3Y A;  4QOB A;  2O71 A;  1A1W A;  2BBR A;  2LS7 A;  2NZ7 A;  3QF2 A;  2LWE A;  1WH4 A;  3LQQ A;  2HM2 Q;  2P1H A;  3MOP A;  3CRD A;  1C15 A;  2YU0 A;  2LWD A;  4P4H I;  2A5Y B;  4O9L A;  2IB1 A;  2N00 A;  2OF5 H;  2YQF A;  1NGR A;  2KM6 A;  2N80 A;  2L9M A;  4ZBW A;  4N1J A;  3MOP K;  4N1L A;  2M5V A;  3EZQ A;  2NSN A;  4JUP A;  1N3K A;  2NAQ A;  1Z6T A;  2XV9 A;  2DBF A;  4IZ5 E;  2N7Z A;  3CL3 A;  4IZ7 B;  1FAD A;  2MB9 A;  4EWI A;  1DDF A;  4P4H A;  2D96 A;  4A2W A;  1CY5 A;  3MOP G;  1ICH A;  2DBH A;  2L6A A;  2MPC A;  4O9F A;  4I16 A;  4FH0 A;  4F42 A;  1YGO A;  2VGQ A;  2DBG A;  4F44 A; 
#chains in the Genus database with same CATH homology
 1PN5 A;  3EZQ B;  3LQR A;  2N83 A;  4LWD A;  1CWW A;  1DGN A;  2N97 A;  2A9I A;  1WXP A;  1A1Z A;  2DBD A;  2MS7 A;  4O7Q A;  2KN6 A;  2F1S A;  4D8O A;  2DO9 A;  1D2Z A;  4NQK A;  4UZ0 A;  3YGS C;  1E41 A;  4JQW A;  2GF5 A;  3KAT A;  2OF5 A;  4IZA B;  4DWN A;  2MS8 A;  4M9Z A;  2YVI A;  2N1F A;  1UCP A;  3YGS P;  3T6P A;  4RHW A;  1WMG A;  4RHW E;  4M9S A;  3J63 A;  4A2Q A;  2MJM A;  2G7R A;  4O6X A;  2MN4 A;  4N1K A;  3J6J A;  1D2Z B;  4M9X A;  2B1W A;  4E9M A;  2YGS A;  2BBZ A;  1E3Y A;  4QOB A;  2O71 A;  1A1W A;  2BBR A;  2LS7 A;  2NZ7 A;  3QF2 A;  2LWE A;  1WH4 A;  3LQQ A;  2HM2 Q;  2P1H A;  3MOP A;  3CRD A;  1C15 A;  2YU0 A;  2LWD A;  4P4H I;  2A5Y B;  4O9L A;  2IB1 A;  2N00 A;  2OF5 H;  2YQF A;  1NGR A;  2KM6 A;  2N80 A;  2L9M A;  4ZBW A;  4N1J A;  3MOP K;  4N1L A;  2M5V A;  3EZQ A;  2NSN A;  4JUP A;  1N3K A;  2NAQ A;  1Z6T A;  2XV9 A;  2DBF A;  4IZ5 E;  2N7Z A;  3CL3 A;  4IZ7 B;  1FAD A;  2MB9 A;  4EWI A;  1DDF A;  4P4H A;  2D96 A;  4A2W A;  1CY5 A;  3MOP G;  1ICH A;  2DBH A;  2L6A A;  2MPC A;  4O9F A;  4I16 A;  4FH0 A;  4F42 A;  1YGO A;  2VGQ A;  2DBG A;  4F44 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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