4N9UA

The role of lysine 200 in the human farnesyl pyrophosphate synthase catalytic mechanism and the mode of inhibition by the nitrogen-containing bisphosphonates
Total Genus 135
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
135
sequence length
342
structure length
338
Chain Sequence
DVYAQEKQDFVQHFSQIVRVLTEHPEIGDAIARLKEVLEYNTIGGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRRGQICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLDLLTAPQGNVDLVRFTEKRYKSIVKYGTAFYSFYLPIAAAMYMAGIDGEKEHANAKKILLEMGEFFQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKEAEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIY
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The role of lysine 200 in the human farnesyl pyrophosphate synthase catalytic mechanism and the mode of inhibition by the nitrogen-containing bisphosphonates
rcsb
molecule tags Transferase
source organism Homo sapiens
molecule keywords Farnesyl pyrophosphate synthase
total genus 135
structure length 338
sequence length 342
ec nomenclature ec 2.5.1.1: Dimethylallyltranstransferase.
pdb deposition date 2013-10-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00348 polyprenyl_synt Polyprenyl synthetase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.600.10 Mainly Alpha Orthogonal Bundle Farnesyl Diphosphate Synthase Farnesyl Diphosphate Synthase 4n9uA00
5DIQF 4RXCA 3IPIA 4LZ3A 4JYXA 2QISA 3N46F 3LLWA 3WSBA 3N5JF 3DYFA 3CC9A 3KROA 5CG6A 4RNQA 3DYHA 3VJ8A 5IKAA 3N0GA 3KRPA 3KRCB 4GP1A 2Z4XA 3PKOA 2F8ZF 1DI1A 3WEGA 1N22A 3KRFB 4NUAA 1HXAA 3CP6A 3OABB 4LXWA 4LZ0A 1V4IA 5E8KA 1WL2A 1UBXA 4KQSA 2EWGA 2F9KF 3ICNA 3WEFA 4LZCA 3IBAA 1YHLA 3WCGA 5AHUB 3WE9A 4LA6A 5ILDA 3W7FA 4N9UA 4GAXA 3WCJA 1YV5A 3TS7A 4NKFA 1WMWA 3BNYA 2E4OA 3N45F 2P1CA 1UBYA 3AE0A 4KVYA 3SDQA 3ID0A 4KVIA 4LFVF 4EA2A 2OGDA 5ILKA 3EGTA 4RYPA 4KVDA 3AQBB 3CKEA 4KQUA 4KPDA 1WL1A 2OA6A 3SDUA 4PVYF 3OACB 3M02A 3WCCA 4KKMA 3WEJA 1ZW5A 2Z4ZA 3N3DA 3SDVA 4LIXA 2E94A 3ZMBA 5DW7A 5CG5A 1VG4A 2J1OA 3RYEA 3M00A 4DWGA 1VG3A 1UBVA 3WEIA 2Z7IA 5IMPA 5IL3A 2Z7HA 3KRAB 3LG5A 2J5CA 1HX9A 2ONHA 5DHIA 5IN8A 1RTRA 2Z4VA 4DXJA 1JFGA 2F7MF 5ILZA 5B0KA 2PS4A 4F6XA 1RQJA 3PH7A 4E9UA 3PYBA 3ZOUA 3Q2QA 4OGUA 3WJOA 2ONGA 3LVSA 3EFQA 5E8HA 4KK2A 2I19A 5DGNF 4KQ5A 3S4JA 5B02A 3M0GA 1FPSA 3ZMCA 1N1BA 2Q58A 3V66A 4LFGA 5ERMA 3WCLA 3NF2A 4LOBA 4DWBA 2F89F 5DJPF 4KFAA 1WKZA 2F92F 1YHMA 3PDEA 4NKEA 2E8TA 4KPJA 4LPHF 3WEHA 1YHKA 2OPNA 1DGPA 4NFIF 5ERNA 4DHDA 1EZFA 1YQ7A 2ZY1A 3LOMA 4LLTA 5DGSF 5A0KA 4P0WA 2Q9YA 1YYRA 3AQ0A 3Q2ZA 5ILYA 4LA5A 3P5PA 3N5HF 1JFAA 3LSNA 2AZLA 4NFKF 4N1ZF 3KROB 4L2XF 4UMJA 5IK6A 1V4HA 3SDTA 1N21A 5B0LA 5AELA 3WCEA 1VG2A 2ZCQA 1PS1A 1UBWA 4JZBA 3ACXA 2PS6A 3P8LA 1N20A 4LUUA 2PS5A 5JV1F 4NG6A 2E91A 5EAUA 2PS7A 4P0VA 3P41A 2AETA 5EROA 5A0IA 3N3LF 5IMNA 1HXCA 5IM1A 2RAHA 4FJQA 3RYWA 3N0FA 4GA3A 3RBMA 5ILJA 2F94F 4GP2A 3S9VA 2O1OA 4LTVA 3G4DA 3M01A 1HM4A 2E8XA 3WJNA 4KUXA 4DZWA 5B00A 1HXGA 3ZCDA 2OPMA 1YJ4A 3KRAA 3TFNA 4MC3A 4OKMA 4Q23A 2Q80A 4EA0A 1N23A 3WCAA 4XQTF 5IVGA 1YYTA 4EA1A 5DHKA 2ZCSA 4H5DF 2F8CF 4RXAA 4E9ZA 3WCHA 4JXNA 3P5RA 4RXDA 3P8RA 5DJVF 3VJ9A 5JV0F 4LFEA 2AZKA 3WCMA 3LGZB 2E90A 3VJDA 5ER8A 1KIZA 5IKHA 3QQVA 3KB9A 5E8LA 3KRCA 4H5EF 3VJBA 3TFVA 5DJRF 2Q9ZA 3B7LA 1VG6A 2AEKA 4LLSA 3KRFA 3V1XA 3OABA 4ZQ8A 3ACWA 4PVXF 3SAEA 1YYUA 5B01A 3Q1OA 3LEEA 5KSXF 3OYRA 4K10A 5JA0F 3ICMA 3ADZA 4OMGA 2H8OA 5HN8A 3VJAA 2ZCRA 3PYAA 4RXEA 3ASXA 3VJCA 3WCFA 4KWDA 2ZEUA 4MC8A 4FP4A 5DZ2A 2PS8A 3G4FA 5DGMF 1HM7A 2E93A 3LDWA 3WJKA 3ICZA 3LMDA 3LK5A 5AYPA 2FTZA 5IMIA 2Z52A 3KRPB 3M9UA 3LZ9A 3LJIA 1YYQA 3VJEA 1WY0A 4E1EA 3QKCA 1V4EA 3WCIA 4OKZA 2J1PA 3N49F 5ILHA 5B0MA 2Z4YA 4P0XA 3V1VA 4JZXA 3DYGA 3OACA 5JV2F 2E92A 4F62A 3APZA 3N6KF 5IK0A 3WEKA 4MC0A 1N1ZA 2DH4A 4OMHA 3MAVA 5H9DA 5HN9A 5IK9A 5JUZF 3WC9A 2AELA 2ZEVA 4WK5A 3AQCB 5EASA 2Z50A 5A0JA 2ZCOA 2FORA 3UCAA 1WL3A 3SDRA 4LPGF 3N1VF 4JVJF 4KVWA 3WCDA 4JXYA 3NRIA 1N24A 1RQIA 1KIYA 3Q30A 5C05A 4H5CF 1V4KA 2E8VA 5AFXA 3NPRA 3N1WF 3TFPA 4QPFA 2E8WA 3BNXA 5EATA 3KBKA 3WCBA 1YYSA 2VF6A 5B0IA 2Z78A 5B03A 3ACYA 1VG7A 3ZL6A 4F6VA 3MZVA 4HD1A 4DEMF 4NFJF 3TC1A 2AZJA 5I1UA 3RMGA 5IL8A 2E95A 2E8UA 4XQSF 4LTZA 4DI5A 5HNAA 1WL0A 5ILIA 4QXSF 1V4JA 3ICKA 3WSAA 5HN7A 3NPKA 4XQRF 3LGKA 5B0JA 3EZ3A 2Z4WA
chains in the Genus database with same CATH superfamily
5DIQF 4RXCA 3IPIA 4LZ3A 4JYXA 2QISA 3N46F 3LLWA 3WSBA 3N5JF 3DYFA 3CC9A 3KROA 5CG6A 4RNQA 3DYHA 3VJ8A 5IKAA 3N0GA 3KRPA 3KRCB 4GP1A 2Z4XA 3PKOA 2F8ZF 1DI1A 3WEGA 1N22A 3KRFB 4NUAA 1HXAA 3CP6A 3OABB 4LXWA 4LZ0A 1V4IA 5E8KA 1WL2A 1UBXA 4KQSA 2EWGA 2F9KF 3ICNA 3WEFA 4LZCA 3IBAA 1YHLA 3WCGA 5AHUB 3WE9A 4LA6A 5ILDA 3W7FA 4N9UA 4GAXA 3WCJA 1YV5A 3TS7A 4NKFA 1WMWA 3BNYA 2E4OA 3N45F 2P1CA 1UBYA 3AE0A 4KVYA 3SDQA 3ID0A 4KVIA 4LFVF 4EA2A 2OGDA 5ILKA 3EGTA 4RYPA 4KVDA 3AQBB 3CKEA 4KQUA 4KPDA 1WL1A 2OA6A 3SDUA 4PVYF 3OACB 3M02A 3WCCA 4KKMA 3WEJA 1ZW5A 2Z4ZA 3N3DA 3SDVA 4LIXA 2E94A 3ZMBA 5DW7A 5CG5A 1VG4A 2J1OA 3RYEA 3M00A 4DWGA 1VG3A 1UBVA 3WEIA 2Z7IA 5IMPA 5IL3A 2Z7HA 3KRAB 3LG5A 2J5CA 1HX9A 2ONHA 5DHIA 5IN8A 1RTRA 2Z4VA 4DXJA 1JFGA 2F7MF 5ILZA 5B0KA 2PS4A 4F6XA 1RQJA 3PH7A 4E9UA 3PYBA 3ZOUA 3Q2QA 4OGUA 3WJOA 2ONGA 3LVSA 3EFQA 5E8HA 4KK2A 2I19A 5DGNF 4KQ5A 3S4JA 5B02A 3M0GA 1FPSA 3ZMCA 1N1BA 2Q58A 3V66A 4LFGA 5ERMA 3WCLA 3NF2A 4LOBA 4DWBA 2F89F 5DJPF 4KFAA 1WKZA 2F92F 1YHMA 3PDEA 4NKEA 2E8TA 4KPJA 4LPHF 3WEHA 1YHKA 2OPNA 1DGPA 4NFIF 5ERNA 4DHDA 1EZFA 1YQ7A 2ZY1A 3LOMA 4LLTA 5DGSF 5A0KA 4P0WA 2Q9YA 1YYRA 3AQ0A 3Q2ZA 5ILYA 4LA5A 3P5PA 3N5HF 1JFAA 3LSNA 2AZLA 4NFKF 4N1ZF 3KROB 4L2XF 4UMJA 5IK6A 1V4HA 3SDTA 1N21A 5B0LA 5AELA 3WCEA 1VG2A 2ZCQA 1PS1A 1UBWA 4JZBA 3ACXA 2PS6A 3P8LA 1N20A 4LUUA 2PS5A 5JV1F 4NG6A 2E91A 5EAUA 2PS7A 4P0VA 3P41A 2AETA 5EROA 5A0IA 3N3LF 5IMNA 1HXCA 5IM1A 2RAHA 4FJQA 3RYWA 3N0FA 4GA3A 3RBMA 5ILJA 2F94F 4GP2A 3S9VA 2O1OA 4LTVA 3G4DA 3M01A 1HM4A 2E8XA 3WJNA 4KUXA 4DZWA 5B00A 1HXGA 3ZCDA 2OPMA 1YJ4A 3KRAA 3TFNA 4MC3A 4OKMA 4Q23A 2Q80A 4EA0A 1N23A 3WCAA 4XQTF 5IVGA 1YYTA 4EA1A 5DHKA 2ZCSA 4H5DF 2F8CF 4RXAA 4E9ZA 3WCHA 4JXNA 3P5RA 4RXDA 3P8RA 5DJVF 3VJ9A 5JV0F 4LFEA 2AZKA 3WCMA 3LGZB 2E90A 3VJDA 5ER8A 1KIZA 5IKHA 3QQVA 3KB9A 5E8LA 3KRCA 4H5EF 3VJBA 3TFVA 5DJRF 2Q9ZA 3B7LA 1VG6A 2AEKA 4LLSA 3KRFA 3V1XA 3OABA 4ZQ8A 3ACWA 4PVXF 3SAEA 1YYUA 5B01A 3Q1OA 3LEEA 5KSXF 3OYRA 4K10A 5JA0F 3ICMA 3ADZA 4OMGA 2H8OA 5HN8A 3VJAA 2ZCRA 3PYAA 4RXEA 3ASXA 3VJCA 3WCFA 4KWDA 2ZEUA 4MC8A 4FP4A 5DZ2A 2PS8A 3G4FA 5DGMF 1HM7A 2E93A 3LDWA 3WJKA 3ICZA 3LMDA 3LK5A 5AYPA 2FTZA 5IMIA 2Z52A 3KRPB 3M9UA 3LZ9A 3LJIA 1YYQA 3VJEA 1WY0A 4E1EA 3QKCA 1V4EA 3WCIA 4OKZA 2J1PA 3N49F 5ILHA 5B0MA 2Z4YA 4P0XA 3V1VA 4JZXA 3DYGA 3OACA 5JV2F 2E92A 4F62A 3APZA 3N6KF 5IK0A 3WEKA 4MC0A 1N1ZA 2DH4A 4OMHA 3MAVA 5H9DA 5HN9A 5IK9A 5JUZF 3WC9A 2AELA 2ZEVA 4WK5A 3AQCB 5EASA 2Z50A 5A0JA 2ZCOA 2FORA 3UCAA 1WL3A 3SDRA 4LPGF 3N1VF 4JVJF 4KVWA 3WCDA 4JXYA 3NRIA 1N24A 1RQIA 1KIYA 3Q30A 5C05A 4H5CF 1V4KA 2E8VA 5AFXA 3NPRA 3N1WF 3TFPA 4QPFA 2E8WA 3BNXA 5EATA 3KBKA 3WCBA 1YYSA 2VF6A 5B0IA 2Z78A 5B03A 3ACYA 1VG7A 3ZL6A 4F6VA 3MZVA 4HD1A 4DEMF 4NFJF 3TC1A 2AZJA 5I1UA 3RMGA 5IL8A 2E95A 2E8UA 4XQSF 4LTZA 4DI5A 5HNAA 1WL0A 5ILIA 4QXSF 1V4JA 3ICKA 3WSAA 5HN7A 3NPKA 4XQRF 3LGKA 5B0JA 3EZ3A 2Z4WA
chains in the Genus database with same CATH topology
5DIQF 4RXCA 3IPIA 4LZ3A 4JYXA 2QISA 3N46F 3LLWA 3WSBA 3N5JF 3DYFA 3CC9A 3KROA 5CG6A 4RNQA 3DYHA 3VJ8A 5IKAA 3N0GA 3KRPA 3KRCB 4GP1A 2Z4XA 3PKOA 2F8ZF 1DI1A 3WEGA 1N22A 3KRFB 4NUAA 1HXAA 3CP6A 3OABB 4LXWA 4LZ0A 1V4IA 5E8KA 1WL2A 1UBXA 4KQSA 2EWGA 2F9KF 3ICNA 3WEFA 4LZCA 3IBAA 1YHLA 3WCGA 5AHUB 3WE9A 4LA6A 5ILDA 3W7FA 4N9UA 4GAXA 3WCJA 1YV5A 3TS7A 4NKFA 1WMWA 3BNYA 2E4OA 3N45F 2P1CA 1UBYA 3AE0A 4KVYA 3SDQA 3ID0A 4KVIA 4LFVF 4EA2A 2OGDA 5ILKA 3EGTA 4RYPA 4KVDA 3AQBB 3CKEA 4KQUA 4KPDA 1WL1A 2OA6A 3SDUA 4PVYF 3OACB 3M02A 3WCCA 4KKMA 3WEJA 1ZW5A 2Z4ZA 3N3DA 3SDVA 4LIXA 2E94A 3ZMBA 5DW7A 5CG5A 1VG4A 2J1OA 3RYEA 3M00A 4DWGA 1VG3A 1UBVA 3WEIA 2Z7IA 5IMPA 5IL3A 2Z7HA 3KRAB 3LG5A 2J5CA 1HX9A 2ONHA 5DHIA 5IN8A 1RTRA 2Z4VA 4DXJA 1JFGA 2F7MF 5ILZA 5B0KA 2PS4A 4F6XA 1RQJA 3PH7A 4E9UA 3PYBA 3ZOUA 3Q2QA 4OGUA 3WJOA 2ONGA 3LVSA 3EFQA 5E8HA 4KK2A 2I19A 5DGNF 4KQ5A 3S4JA 5B02A 3M0GA 1FPSA 3ZMCA 1N1BA 2Q58A 3V66A 4LFGA 5ERMA 3WCLA 3NF2A 4LOBA 4DWBA 2F89F 5DJPF 4KFAA 1WKZA 2F92F 1YHMA 3PDEA 4NKEA 2E8TA 4KPJA 4LPHF 3WEHA 1YHKA 2OPNA 1DGPA 4NFIF 5ERNA 4DHDA 1EZFA 1YQ7A 2ZY1A 3LOMA 4LLTA 5DGSF 5A0KA 4P0WA 2Q9YA 1YYRA 3AQ0A 3Q2ZA 5ILYA 4LA5A 3P5PA 3N5HF 1JFAA 3LSNA 2AZLA 4NFKF 4N1ZF 3KROB 4L2XF 4UMJA 5IK6A 1V4HA 3SDTA 1N21A 5B0LA 5AELA 3WCEA 1VG2A 2ZCQA 1PS1A 1UBWA 4JZBA 3ACXA 2PS6A 3P8LA 1N20A 4LUUA 2PS5A 5JV1F 4NG6A 2E91A 5EAUA 2PS7A 4P0VA 3P41A 2AETA 5EROA 5A0IA 3N3LF 5IMNA 1HXCA 5IM1A 2RAHA 4FJQA 3RYWA 3N0FA 4GA3A 3RBMA 5ILJA 2F94F 4GP2A 3S9VA 2O1OA 4LTVA 3G4DA 3M01A 1HM4A 2E8XA 3WJNA 4KUXA 4DZWA 5B00A 1HXGA 3ZCDA 2OPMA 1YJ4A 3KRAA 3TFNA 4MC3A 4OKMA 4Q23A 2Q80A 4EA0A 1N23A 3WCAA 4XQTF 5IVGA 1YYTA 4EA1A 5DHKA 2ZCSA 4H5DF 2F8CF 4RXAA 4E9ZA 3WCHA 4JXNA 3P5RA 4RXDA 3P8RA 5DJVF 3VJ9A 5JV0F 4LFEA 2AZKA 3WCMA 3LGZB 2E90A 3VJDA 5ER8A 1KIZA 5IKHA 3QQVA 3KB9A 5E8LA 3KRCA 4H5EF 3VJBA 3TFVA 5DJRF 2Q9ZA 3B7LA 1VG6A 2AEKA 4LLSA 3KRFA 3V1XA 3OABA 4ZQ8A 3ACWA 4PVXF 3SAEA 1YYUA 5B01A 3Q1OA 3LEEA 5KSXF 3OYRA 4K10A 5JA0F 3ICMA 3ADZA 4OMGA 2H8OA 5HN8A 3VJAA 2ZCRA 3PYAA 4RXEA 3ASXA 3VJCA 3WCFA 4KWDA 2ZEUA 4MC8A 4FP4A 5DZ2A 2PS8A 3G4FA 5DGMF 1HM7A 2E93A 3LDWA 3WJKA 3ICZA 3LMDA 3LK5A 5AYPA 2FTZA 5IMIA 2Z52A 3KRPB 3M9UA 3LZ9A 3LJIA 1YYQA 3VJEA 1WY0A 4E1EA 3QKCA 1V4EA 3WCIA 4OKZA 2J1PA 3N49F 5ILHA 5B0MA 2Z4YA 4P0XA 3V1VA 4JZXA 3DYGA 3OACA 5JV2F 2E92A 4F62A 3APZA 3N6KF 5IK0A 3WEKA 4MC0A 1N1ZA 2DH4A 4OMHA 3MAVA 5H9DA 5HN9A 5IK9A 5JUZF 3WC9A 2AELA 2ZEVA 4WK5A 3AQCB 5EASA 2Z50A 5A0JA 2ZCOA 2FORA 3UCAA 1WL3A 3SDRA 4LPGF 3N1VF 4JVJF 4KVWA 3WCDA 4JXYA 3NRIA 1N24A 1RQIA 1KIYA 3Q30A 5C05A 4H5CF 1V4KA 2E8VA 5AFXA 3NPRA 3N1WF 3TFPA 4QPFA 2E8WA 3BNXA 5EATA 3KBKA 3WCBA 1YYSA 2VF6A 5B0IA 2Z78A 5B03A 3ACYA 1VG7A 3ZL6A 4F6VA 3MZVA 4HD1A 4DEMF 4NFJF 3TC1A 2AZJA 5I1UA 3RMGA 5IL8A 2E95A 2E8UA 4XQSF 4LTZA 4DI5A 5HNAA 1WL0A 5ILIA 4QXSF 1V4JA 3ICKA 3WSAA 5HN7A 3NPKA 4XQRF 3LGKA 5B0JA 3EZ3A 2Z4WA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5DIQ F;  4RXC A;  3IPI A;  4LZ3 A;  4JYX A;  2QIS A;  3N46 F;  3LLW A;  3WSB A;  3N5J F;  3DYF A;  3CC9 A;  3KRO A;  5CG6 A;  4RNQ A;  3DYH A;  3VJ8 A;  5IKA A;  3N0G A;  3KRP A;  3KRC B;  4GP1 A;  2Z4X A;  3PKO A;  2F8Z F;  1DI1 A;  3WEG A;  1N22 A;  3KRF B;  4NUA A;  1HXA A;  3CP6 A;  3OAB B;  4LXW A;  4LZ0 A;  1V4I A;  5E8K A;  1WL2 A;  1UBX A;  4KQS A;  2EWG A;  2F9K F;  3ICN A;  3WEF A;  4LZC A;  3IBA A;  1YHL A;  3WCG A;  5AHU B;  3WE9 A;  4LA6 A;  5ILD A;  3W7F A;  4N9U A;  4GAX A;  3WCJ A;  1YV5 A;  3TS7 A;  4NKF A;  1WMW A;  3BNY A;  2E4O A;  3N45 F;  2P1C A;  1UBY A;  3AE0 A;  4KVY A;  3SDQ A;  3ID0 A;  4KVI A;  4LFV F;  4EA2 A;  2OGD A;  5ILK A;  3EGT A;  4RYP A;  4KVD A;  3AQB B;  3CKE A;  4KQU A;  4KPD A;  1WL1 A;  2OA6 A;  3SDU A;  4PVY F;  3OAC B;  3M02 A;  3WCC A;  4KKM A;  3WEJ A;  1ZW5 A;  2Z4Z A;  3N3D A;  3SDV A;  4LIX A;  2E94 A;  3ZMB A;  5DW7 A;  5CG5 A;  1VG4 A;  2J1O A;  3RYE A;  3M00 A;  4DWG A;  1VG3 A;  1UBV A;  3WEI A;  2Z7I A;  5IMP A;  5IL3 A;  2Z7H A;  3KRA B;  3LG5 A;  2J5C A;  1HX9 A;  2ONH A;  5DHI A;  5IN8 A;  1RTR A;  2Z4V A;  4DXJ A;  1JFG A;  2F7M F;  5ILZ A;  5B0K A;  2PS4 A;  4F6X A;  1RQJ A;  3PH7 A;  4E9U A;  3PYB A;  3ZOU A;  3Q2Q A;  4OGU A;  3WJO A;  2ONG A;  3LVS A;  3EFQ A;  5E8H A;  4KK2 A;  2I19 A;  5DGN F;  4KQ5 A;  3S4J A;  5B02 A;  3M0G A;  1FPS A;  3ZMC A;  1N1B A;  2Q58 A;  3V66 A;  4LFG A;  5ERM A;  3WCL A;  3NF2 A;  4LOB A;  4DWB A;  2F89 F;  5DJP F;  4KFA A;  1WKZ A;  2F92 F;  1YHM A;  3PDE A;  4NKE A;  2E8T A;  4KPJ A;  4LPH F;  3WEH A;  1YHK A;  2OPN A;  1DGP A;  4NFI F;  5ERN A;  4DHD A;  1EZF A;  1YQ7 A;  2ZY1 A;  3LOM A;  4LLT A;  5DGS F;  5A0K A;  4P0W A;  2Q9Y A;  1YYR A;  3AQ0 A;  3Q2Z A;  5ILY A;  4LA5 A;  3P5P A;  3N5H F;  1JFA A;  3LSN A;  2AZL A;  4NFK F;  4N1Z F;  3KRO B;  4L2X F;  4UMJ A;  5IK6 A;  1V4H A;  3SDT A;  1N21 A;  5B0L A;  5AEL A;  3WCE A;  1VG2 A;  2ZCQ A;  1PS1 A;  1UBW A;  4JZB A;  3ACX A;  2PS6 A;  3P8L A;  1N20 A;  4LUU A;  2PS5 A;  5JV1 F;  4NG6 A;  2E91 A;  5EAU A;  2PS7 A;  4P0V A;  3P41 A;  2AET A;  5ERO A;  5A0I A;  3N3L F;  5IMN A;  1HXC A;  5IM1 A;  2RAH A;  4FJQ A;  3RYW A;  3N0F A;  4GA3 A;  3RBM A;  5ILJ A;  2F94 F;  4GP2 A;  3S9V A;  2O1O A;  4LTV A;  3G4D A;  3M01 A;  1HM4 A;  2E8X A;  3WJN A;  4KUX A;  4DZW A;  5B00 A;  1HXG A;  3ZCD A;  2OPM A;  1YJ4 A;  3KRA A;  3TFN A;  4MC3 A;  4OKM A;  4Q23 A;  2Q80 A;  4EA0 A;  1N23 A;  3WCA A;  4XQT F;  5IVG A;  1YYT A;  4EA1 A;  5DHK A;  2ZCS A;  4H5D F;  2F8C F;  4RXA A;  4E9Z A;  3WCH A;  4JXN A;  3P5R A;  4RXD A;  3P8R A;  5DJV F;  3VJ9 A;  5JV0 F;  4LFE A;  2AZK A;  3WCM A;  3LGZ B;  2E90 A;  3VJD A;  5ER8 A;  1KIZ A;  5IKH A;  3QQV A;  3KB9 A;  5E8L A;  3KRC A;  4H5E F;  3VJB A;  3TFV A;  5DJR F;  2Q9Z A;  3B7L A;  1VG6 A;  2AEK A;  4LLS A;  3KRF A;  3V1X A;  3OAB A;  4ZQ8 A;  3ACW A;  4PVX F;  3SAE A;  1YYU A;  5B01 A;  3Q1O A;  3LEE A;  5KSX F;  3OYR A;  4K10 A;  5JA0 F;  3ICM A;  3ADZ A;  4OMG A;  2H8O A;  5HN8 A;  3VJA A;  2ZCR A;  3PYA A;  4RXE A;  3ASX A;  3VJC A;  3WCF A;  4KWD A;  2ZEU A;  4MC8 A;  4FP4 A;  5DZ2 A;  2PS8 A;  3G4F A;  5DGM F;  1HM7 A;  2E93 A;  3LDW A;  3WJK A;  3ICZ A;  3LMD A;  3LK5 A;  5AYP A;  2FTZ A;  5IMI A;  2Z52 A;  3KRP B;  3M9U A;  3LZ9 A;  3LJI A;  1YYQ A;  3VJE A;  1WY0 A;  4E1E A;  3QKC A;  1V4E A;  3WCI A;  4OKZ A;  2J1P A;  3N49 F;  5ILH A;  5B0M A;  2Z4Y A;  4P0X A;  3V1V A;  4JZX A;  3DYG A;  3OAC A;  5JV2 F;  2E92 A;  4F62 A;  3APZ A;  3N6K F;  5IK0 A;  3WEK A;  4MC0 A;  1N1Z A;  2DH4 A;  4OMH A;  3MAV A;  5H9D A;  5HN9 A;  5IK9 A;  5JUZ F;  3WC9 A;  2AEL A;  2ZEV A;  4WK5 A;  3AQC B;  5EAS A;  2Z50 A;  5A0J A;  2ZCO A;  2FOR A;  3UCA A;  1WL3 A;  3SDR A;  4LPG F;  3N1V F;  4JVJ F;  4KVW A;  3WCD A;  4JXY A;  3NRI A;  1N24 A;  1RQI A;  1KIY A;  3Q30 A;  5C05 A;  4H5C F;  1V4K A;  2E8V A;  5AFX A;  3NPR A;  3N1W F;  3TFP A;  4QPF A;  2E8W A;  3BNX A;  5EAT A;  3KBK A;  3WCB A;  1YYS A;  2VF6 A;  5B0I A;  2Z78 A;  5B03 A;  3ACY A;  1VG7 A;  3ZL6 A;  4F6V A;  3MZV A;  4HD1 A;  4DEM F;  4NFJ F;  3TC1 A;  2AZJ A;  5I1U A;  3RMG A;  5IL8 A;  2E95 A;  2E8U A;  4XQS F;  4LTZ A;  4DI5 A;  5HNA A;  1WL0 A;  5ILI A;  4QXS F;  1V4J A;  3ICK A;  3WSA A;  5HN7 A;  3NPK A;  4XQR F;  3LGK A;  5B0J A;  3EZ3 A;  2Z4W A; 
#chains in the Genus database with same CATH topology
 5DIQ F;  4RXC A;  3IPI A;  4LZ3 A;  4JYX A;  2QIS A;  3N46 F;  3LLW A;  3WSB A;  3N5J F;  3DYF A;  3CC9 A;  3KRO A;  5CG6 A;  4RNQ A;  3DYH A;  3VJ8 A;  5IKA A;  3N0G A;  3KRP A;  3KRC B;  4GP1 A;  2Z4X A;  3PKO A;  2F8Z F;  1DI1 A;  3WEG A;  1N22 A;  3KRF B;  4NUA A;  1HXA A;  3CP6 A;  3OAB B;  4LXW A;  4LZ0 A;  1V4I A;  5E8K A;  1WL2 A;  1UBX A;  4KQS A;  2EWG A;  2F9K F;  3ICN A;  3WEF A;  4LZC A;  3IBA A;  1YHL A;  3WCG A;  5AHU B;  3WE9 A;  4LA6 A;  5ILD A;  3W7F A;  4N9U A;  4GAX A;  3WCJ A;  1YV5 A;  3TS7 A;  4NKF A;  1WMW A;  3BNY A;  2E4O A;  3N45 F;  2P1C A;  1UBY A;  3AE0 A;  4KVY A;  3SDQ A;  3ID0 A;  4KVI A;  4LFV F;  4EA2 A;  2OGD A;  5ILK A;  3EGT A;  4RYP A;  4KVD A;  3AQB B;  3CKE A;  4KQU A;  4KPD A;  1WL1 A;  2OA6 A;  3SDU A;  4PVY F;  3OAC B;  3M02 A;  3WCC A;  4KKM A;  3WEJ A;  1ZW5 A;  2Z4Z A;  3N3D A;  3SDV A;  4LIX A;  2E94 A;  3ZMB A;  5DW7 A;  5CG5 A;  1VG4 A;  2J1O A;  3RYE A;  3M00 A;  4DWG A;  1VG3 A;  1UBV A;  3WEI A;  2Z7I A;  5IMP A;  5IL3 A;  2Z7H A;  3KRA B;  3LG5 A;  2J5C A;  1HX9 A;  2ONH A;  5DHI A;  5IN8 A;  1RTR A;  2Z4V A;  4DXJ A;  1JFG A;  2F7M F;  5ILZ A;  5B0K A;  2PS4 A;  4F6X A;  1RQJ A;  3PH7 A;  4E9U A;  3PYB A;  3ZOU A;  3Q2Q A;  4OGU A;  3WJO A;  2ONG A;  3LVS A;  3EFQ A;  5E8H A;  4KK2 A;  2I19 A;  5DGN F;  4KQ5 A;  3S4J A;  5B02 A;  3M0G A;  1FPS A;  3ZMC A;  1N1B A;  2Q58 A;  3V66 A;  4LFG A;  5ERM A;  3WCL A;  3NF2 A;  4LOB A;  4DWB A;  2F89 F;  5DJP F;  4KFA A;  1WKZ A;  2F92 F;  1YHM A;  3PDE A;  4NKE A;  2E8T A;  4KPJ A;  4LPH F;  3WEH A;  1YHK A;  2OPN A;  1DGP A;  4NFI F;  5ERN A;  4DHD A;  1EZF A;  1YQ7 A;  2ZY1 A;  3LOM A;  4LLT A;  5DGS F;  5A0K A;  4P0W A;  2Q9Y A;  1YYR A;  3AQ0 A;  3Q2Z A;  5ILY A;  4LA5 A;  3P5P A;  3N5H F;  1JFA A;  3LSN A;  2AZL A;  4NFK F;  4N1Z F;  3KRO B;  4L2X F;  4UMJ A;  5IK6 A;  1V4H A;  3SDT A;  1N21 A;  5B0L A;  5AEL A;  3WCE A;  1VG2 A;  2ZCQ A;  1PS1 A;  1UBW A;  4JZB A;  3ACX A;  2PS6 A;  3P8L A;  1N20 A;  4LUU A;  2PS5 A;  5JV1 F;  4NG6 A;  2E91 A;  5EAU A;  2PS7 A;  4P0V A;  3P41 A;  2AET A;  5ERO A;  5A0I A;  3N3L F;  5IMN A;  1HXC A;  5IM1 A;  2RAH A;  4FJQ A;  3RYW A;  3N0F A;  4GA3 A;  3RBM A;  5ILJ A;  2F94 F;  4GP2 A;  3S9V A;  2O1O A;  4LTV A;  3G4D A;  3M01 A;  1HM4 A;  2E8X A;  3WJN A;  4KUX A;  4DZW A;  5B00 A;  1HXG A;  3ZCD A;  2OPM A;  1YJ4 A;  3KRA A;  3TFN A;  4MC3 A;  4OKM A;  4Q23 A;  2Q80 A;  4EA0 A;  1N23 A;  3WCA A;  4XQT F;  5IVG A;  1YYT A;  4EA1 A;  5DHK A;  2ZCS A;  4H5D F;  2F8C F;  4RXA A;  4E9Z A;  3WCH A;  4JXN A;  3P5R A;  4RXD A;  3P8R A;  5DJV F;  3VJ9 A;  5JV0 F;  4LFE A;  2AZK A;  3WCM A;  3LGZ B;  2E90 A;  3VJD A;  5ER8 A;  1KIZ A;  5IKH A;  3QQV A;  3KB9 A;  5E8L A;  3KRC A;  4H5E F;  3VJB A;  3TFV A;  5DJR F;  2Q9Z A;  3B7L A;  1VG6 A;  2AEK A;  4LLS A;  3KRF A;  3V1X A;  3OAB A;  4ZQ8 A;  3ACW A;  4PVX F;  3SAE A;  1YYU A;  5B01 A;  3Q1O A;  3LEE A;  5KSX F;  3OYR A;  4K10 A;  5JA0 F;  3ICM A;  3ADZ A;  4OMG A;  2H8O A;  5HN8 A;  3VJA A;  2ZCR A;  3PYA A;  4RXE A;  3ASX A;  3VJC A;  3WCF A;  4KWD A;  2ZEU A;  4MC8 A;  4FP4 A;  5DZ2 A;  2PS8 A;  3G4F A;  5DGM F;  1HM7 A;  2E93 A;  3LDW A;  3WJK A;  3ICZ A;  3LMD A;  3LK5 A;  5AYP A;  2FTZ A;  5IMI A;  2Z52 A;  3KRP B;  3M9U A;  3LZ9 A;  3LJI A;  1YYQ A;  3VJE A;  1WY0 A;  4E1E A;  3QKC A;  1V4E A;  3WCI A;  4OKZ A;  2J1P A;  3N49 F;  5ILH A;  5B0M A;  2Z4Y A;  4P0X A;  3V1V A;  4JZX A;  3DYG A;  3OAC A;  5JV2 F;  2E92 A;  4F62 A;  3APZ A;  3N6K F;  5IK0 A;  3WEK A;  4MC0 A;  1N1Z A;  2DH4 A;  4OMH A;  3MAV A;  5H9D A;  5HN9 A;  5IK9 A;  5JUZ F;  3WC9 A;  2AEL A;  2ZEV A;  4WK5 A;  3AQC B;  5EAS A;  2Z50 A;  5A0J A;  2ZCO A;  2FOR A;  3UCA A;  1WL3 A;  3SDR A;  4LPG F;  3N1V F;  4JVJ F;  4KVW A;  3WCD A;  4JXY A;  3NRI A;  1N24 A;  1RQI A;  1KIY A;  3Q30 A;  5C05 A;  4H5C F;  1V4K A;  2E8V A;  5AFX A;  3NPR A;  3N1W F;  3TFP A;  4QPF A;  2E8W A;  3BNX A;  5EAT A;  3KBK A;  3WCB A;  1YYS A;  2VF6 A;  5B0I A;  2Z78 A;  5B03 A;  3ACY A;  1VG7 A;  3ZL6 A;  4F6V A;  3MZV A;  4HD1 A;  4DEM F;  4NFJ F;  3TC1 A;  2AZJ A;  5I1U A;  3RMG A;  5IL8 A;  2E95 A;  2E8U A;  4XQS F;  4LTZ A;  4DI5 A;  5HNA A;  1WL0 A;  5ILI A;  4QXS F;  1V4J A;  3ICK A;  3WSA A;  5HN7 A;  3NPK A;  4XQR F;  3LGK A;  5B0J A;  3EZ3 A;  2Z4W A; 
#chains in the Genus database with same CATH homology
 5DIQ F;  4RXC A;  3IPI A;  4LZ3 A;  4JYX A;  2QIS A;  3N46 F;  3LLW A;  3WSB A;  3N5J F;  3DYF A;  3CC9 A;  3KRO A;  5CG6 A;  4RNQ A;  3DYH A;  3VJ8 A;  5IKA A;  3N0G A;  3KRP A;  3KRC B;  4GP1 A;  2Z4X A;  3PKO A;  2F8Z F;  1DI1 A;  3WEG A;  1N22 A;  3KRF B;  4NUA A;  1HXA A;  3CP6 A;  3OAB B;  4LXW A;  4LZ0 A;  1V4I A;  5E8K A;  1WL2 A;  1UBX A;  4KQS A;  2EWG A;  2F9K F;  3ICN A;  3WEF A;  4LZC A;  3IBA A;  1YHL A;  3WCG A;  5AHU B;  3WE9 A;  4LA6 A;  5ILD A;  3W7F A;  4N9U A;  4GAX A;  3WCJ A;  1YV5 A;  3TS7 A;  4NKF A;  1WMW A;  3BNY A;  2E4O A;  3N45 F;  2P1C A;  1UBY A;  3AE0 A;  4KVY A;  3SDQ A;  3ID0 A;  4KVI A;  4LFV F;  4EA2 A;  2OGD A;  5ILK A;  3EGT A;  4RYP A;  4KVD A;  3AQB B;  3CKE A;  4KQU A;  4KPD A;  1WL1 A;  2OA6 A;  3SDU A;  4PVY F;  3OAC B;  3M02 A;  3WCC A;  4KKM A;  3WEJ A;  1ZW5 A;  2Z4Z A;  3N3D A;  3SDV A;  4LIX A;  2E94 A;  3ZMB A;  5DW7 A;  5CG5 A;  1VG4 A;  2J1O A;  3RYE A;  3M00 A;  4DWG A;  1VG3 A;  1UBV A;  3WEI A;  2Z7I A;  5IMP A;  5IL3 A;  2Z7H A;  3KRA B;  3LG5 A;  2J5C A;  1HX9 A;  2ONH A;  5DHI A;  5IN8 A;  1RTR A;  2Z4V A;  4DXJ A;  1JFG A;  2F7M F;  5ILZ A;  5B0K A;  2PS4 A;  4F6X A;  1RQJ A;  3PH7 A;  4E9U A;  3PYB A;  3ZOU A;  3Q2Q A;  4OGU A;  3WJO A;  2ONG A;  3LVS A;  3EFQ A;  5E8H A;  4KK2 A;  2I19 A;  5DGN F;  4KQ5 A;  3S4J A;  5B02 A;  3M0G A;  1FPS A;  3ZMC A;  1N1B A;  2Q58 A;  3V66 A;  4LFG A;  5ERM A;  3WCL A;  3NF2 A;  4LOB A;  4DWB A;  2F89 F;  5DJP F;  4KFA A;  1WKZ A;  2F92 F;  1YHM A;  3PDE A;  4NKE A;  2E8T A;  4KPJ A;  4LPH F;  3WEH A;  1YHK A;  2OPN A;  1DGP A;  4NFI F;  5ERN A;  4DHD A;  1EZF A;  1YQ7 A;  2ZY1 A;  3LOM A;  4LLT A;  5DGS F;  5A0K A;  4P0W A;  2Q9Y A;  1YYR A;  3AQ0 A;  3Q2Z A;  5ILY A;  4LA5 A;  3P5P A;  3N5H F;  1JFA A;  3LSN A;  2AZL A;  4NFK F;  4N1Z F;  3KRO B;  4L2X F;  4UMJ A;  5IK6 A;  1V4H A;  3SDT A;  1N21 A;  5B0L A;  5AEL A;  3WCE A;  1VG2 A;  2ZCQ A;  1PS1 A;  1UBW A;  4JZB A;  3ACX A;  2PS6 A;  3P8L A;  1N20 A;  4LUU A;  2PS5 A;  5JV1 F;  4NG6 A;  2E91 A;  5EAU A;  2PS7 A;  4P0V A;  3P41 A;  2AET A;  5ERO A;  5A0I A;  3N3L F;  5IMN A;  1HXC A;  5IM1 A;  2RAH A;  4FJQ A;  3RYW A;  3N0F A;  4GA3 A;  3RBM A;  5ILJ A;  2F94 F;  4GP2 A;  3S9V A;  2O1O A;  4LTV A;  3G4D A;  3M01 A;  1HM4 A;  2E8X A;  3WJN A;  4KUX A;  4DZW A;  5B00 A;  1HXG A;  3ZCD A;  2OPM A;  1YJ4 A;  3KRA A;  3TFN A;  4MC3 A;  4OKM A;  4Q23 A;  2Q80 A;  4EA0 A;  1N23 A;  3WCA A;  4XQT F;  5IVG A;  1YYT A;  4EA1 A;  5DHK A;  2ZCS A;  4H5D F;  2F8C F;  4RXA A;  4E9Z A;  3WCH A;  4JXN A;  3P5R A;  4RXD A;  3P8R A;  5DJV F;  3VJ9 A;  5JV0 F;  4LFE A;  2AZK A;  3WCM A;  3LGZ B;  2E90 A;  3VJD A;  5ER8 A;  1KIZ A;  5IKH A;  3QQV A;  3KB9 A;  5E8L A;  3KRC A;  4H5E F;  3VJB A;  3TFV A;  5DJR F;  2Q9Z A;  3B7L A;  1VG6 A;  2AEK A;  4LLS A;  3KRF A;  3V1X A;  3OAB A;  4ZQ8 A;  3ACW A;  4PVX F;  3SAE A;  1YYU A;  5B01 A;  3Q1O A;  3LEE A;  5KSX F;  3OYR A;  4K10 A;  5JA0 F;  3ICM A;  3ADZ A;  4OMG A;  2H8O A;  5HN8 A;  3VJA A;  2ZCR A;  3PYA A;  4RXE A;  3ASX A;  3VJC A;  3WCF A;  4KWD A;  2ZEU A;  4MC8 A;  4FP4 A;  5DZ2 A;  2PS8 A;  3G4F A;  5DGM F;  1HM7 A;  2E93 A;  3LDW A;  3WJK A;  3ICZ A;  3LMD A;  3LK5 A;  5AYP A;  2FTZ A;  5IMI A;  2Z52 A;  3KRP B;  3M9U A;  3LZ9 A;  3LJI A;  1YYQ A;  3VJE A;  1WY0 A;  4E1E A;  3QKC A;  1V4E A;  3WCI A;  4OKZ A;  2J1P A;  3N49 F;  5ILH A;  5B0M A;  2Z4Y A;  4P0X A;  3V1V A;  4JZX A;  3DYG A;  3OAC A;  5JV2 F;  2E92 A;  4F62 A;  3APZ A;  3N6K F;  5IK0 A;  3WEK A;  4MC0 A;  1N1Z A;  2DH4 A;  4OMH A;  3MAV A;  5H9D A;  5HN9 A;  5IK9 A;  5JUZ F;  3WC9 A;  2AEL A;  2ZEV A;  4WK5 A;  3AQC B;  5EAS A;  2Z50 A;  5A0J A;  2ZCO A;  2FOR A;  3UCA A;  1WL3 A;  3SDR A;  4LPG F;  3N1V F;  4JVJ F;  4KVW A;  3WCD A;  4JXY A;  3NRI A;  1N24 A;  1RQI A;  1KIY A;  3Q30 A;  5C05 A;  4H5C F;  1V4K A;  2E8V A;  5AFX A;  3NPR A;  3N1W F;  3TFP A;  4QPF A;  2E8W A;  3BNX A;  5EAT A;  3KBK A;  3WCB A;  1YYS A;  2VF6 A;  5B0I A;  2Z78 A;  5B03 A;  3ACY A;  1VG7 A;  3ZL6 A;  4F6V A;  3MZV A;  4HD1 A;  4DEM F;  4NFJ F;  3TC1 A;  2AZJ A;  5I1U A;  3RMG A;  5IL8 A;  2E95 A;  2E8U A;  4XQS F;  4LTZ A;  4DI5 A;  5HNA A;  1WL0 A;  5ILI A;  4QXS F;  1V4J A;  3ICK A;  3WSA A;  5HN7 A;  3NPK A;  4XQR F;  3LGK A;  5B0J A;  3EZ3 A;  2Z4W A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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