4NGCA

Structure of human dicer platform-paz-connector helix cassette in complex with 12-mer sirna having ua-3' ends (2.1 angstrom resolution)
Total Genus 71
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
71
sequence length
299
structure length
276
Chain Sequence
DQPCYLYVIGMVLTTPLPDELNFRRRKLYPPEDTTRCFGILTAKPIPQIPHFPVYTRSGEVTISIELAASGFMLSLQMLELITRLHQYIFSHILRLEKPALYCVLPLNVVSSTLDIDFKFMEDIEKSEARIGIPSTKYTKETPFVFKLEDYQDAVIIPRYRNFDQPHRFYVADVYTDLTPLSKFPSPEYETFAEYYKTKYNLDLTNLNQPLLDVDHTSSRLNLLTPLSSAEKRKAKWESLQNKQILVPELCAIHPIPASLWRKAVCLPSILYRLHC
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title A Phosphate-Binding Pocket within the Platform-PAZ-Connector Helix Cassette of Human Dicer.
pubmed doi rcsb
molecule tags Hydrolase/rna
source organism Homo sapiens
molecule keywords Endoribonuclease Dicer
total genus 71
structure length 276
sequence length 299
ec nomenclature ec 3.1.26.3: Ribonuclease III.
pdb deposition date 2013-11-01

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02170 PAZ PAZ domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.260.10 Mainly Beta Beta Complex paz domain paz domain 4ngcA02
4NH5A 4W5QA 3QIRA 2QVWA 4Z4CA 5KI6A 1T2RA 2FFLA 4NGGA 1T2SA 4Z4IA 3MJ0A 4OLAA 4KRFA 5JS1A 3O7VX 4NGFA 1VYNA 4Z4GA 1SI2A 4NHAA 1SI3A 4NGCA 3O3IX 4Z4FA 4NGBA 4NH3A 2XFMA 4W5TA 1R6ZA 3O6EX 4W5OA 2L5DA 5JS2A 1R4KA 4OLBA 4Z4EA 4Z4HA 4F3TA 4NH6A 4W5RA 4W5NA 5T7BA 3O7XA 2L5CA 4KREA 4NGDA
chains in the Genus database with same CATH superfamily
4NH5A 4W5QA 3QIRA 2QVWA 4Z4CA 5KI6A 1T2RA 2FFLA 4NGGA 1T2SA 4Z4IA 3DA5A 3HM9A 3MJ0A 4OLAA 4KRFA 5JS1A 3O7VX 4NGFA 1VYNA 4Z4GA 1SI2A 4NHAA 1SI3A 4NGCA 3HO1A 3O3IX 4Z4FA 4NGBA 3F73A 4NH3A 4L1UA 2XFMA 4W5TA 1R6ZA 2DB9A 3O6EX 3U1UA 1U04A 3HJFA 3HK2A 4W5OA 2L5DA 5JS2A 1R4KA 4OLBA 4Z4EA 3HVRA 4Z4HA 2BZEA 4F3TA 4NH6A 1Z25A 4W5RA 3DLHA 4W5NA 5T7BA 4L1PA 3O7XA 3DLBA 1Z26A 2L5CA 4KREA 4NGDA
chains in the Genus database with same CATH topology
4NH5A 4W5QA 3QIRA 2QVWA 4Z4CA 5KI6A 1T2RA 2FFLA 4NGGA 1T2SA 4Z4IA 3DA5A 3HM9A 3MJ0A 4OLAA 4KRFA 5JS1A 3O7VX 4NGFA 1VYNA 4Z4GA 1SI2A 4NHAA 1SI3A 4NGCA 3HO1A 3O3IX 4Z4FA 4NGBA 3F73A 4NH3A 4L1UA 2XFMA 4W5TA 1R6ZA 2DB9A 3O6EX 3U1UA 1U04A 3HJFA 3HK2A 4W5OA 2L5DA 5JS2A 1R4KA 4OLBA 4Z4EA 3HVRA 4Z4HA 2BZEA 4F3TA 4NH6A 1Z25A 4W5RA 3DLHA 4W5NA 5T7BA 4L1PA 3O7XA 3DLBA 1Z26A 2L5CA 4KREA 4NGDA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4NH5 A;  4W5Q A;  3QIR A;  2QVW A;  4Z4C A;  5KI6 A;  1T2R A;  2FFL A;  4NGG A;  1T2S A;  4Z4I A;  3MJ0 A;  4OLA A;  4KRF A;  5JS1 A;  3O7V X;  4NGF A;  1VYN A;  4Z4G A;  1SI2 A;  4NHA A;  1SI3 A;  4NGC A;  3O3I X;  4Z4F A;  4NGB A;  4NH3 A;  2XFM A;  4W5T A;  1R6Z A;  3O6E X;  4W5O A;  2L5D A;  5JS2 A;  1R4K A;  4OLB A;  4Z4E A;  4Z4H A;  4F3T A;  4NH6 A;  4W5R A;  4W5N A;  5T7B A;  3O7X A;  2L5C A;  4KRE A;  4NGD A; 
#chains in the Genus database with same CATH topology
 4NH5 A;  4W5Q A;  3QIR A;  2QVW A;  4Z4C A;  5KI6 A;  1T2R A;  2FFL A;  4NGG A;  1T2S A;  4Z4I A;  3DA5 A;  3HM9 A;  3MJ0 A;  4OLA A;  4KRF A;  5JS1 A;  3O7V X;  4NGF A;  1VYN A;  4Z4G A;  1SI2 A;  4NHA A;  1SI3 A;  4NGC A;  3HO1 A;  3O3I X;  4Z4F A;  4NGB A;  3F73 A;  4NH3 A;  4L1U A;  2XFM A;  4W5T A;  1R6Z A;  2DB9 A;  3O6E X;  3U1U A;  1U04 A;  3HJF A;  3HK2 A;  4W5O A;  2L5D A;  5JS2 A;  1R4K A;  4OLB A;  4Z4E A;  3HVR A;  4Z4H A;  2BZE A;  4F3T A;  4NH6 A;  1Z25 A;  4W5R A;  3DLH A;  4W5N A;  5T7B A;  4L1P A;  3O7X A;  3DLB A;  1Z26 A;  2L5C A;  4KRE A;  4NGD A; 
#chains in the Genus database with same CATH homology
 4NH5 A;  4W5Q A;  3QIR A;  2QVW A;  4Z4C A;  5KI6 A;  1T2R A;  2FFL A;  4NGG A;  1T2S A;  4Z4I A;  3DA5 A;  3HM9 A;  3MJ0 A;  4OLA A;  4KRF A;  5JS1 A;  3O7V X;  4NGF A;  1VYN A;  4Z4G A;  1SI2 A;  4NHA A;  1SI3 A;  4NGC A;  3HO1 A;  3O3I X;  4Z4F A;  4NGB A;  3F73 A;  4NH3 A;  4L1U A;  2XFM A;  4W5T A;  1R6Z A;  2DB9 A;  3O6E X;  3U1U A;  1U04 A;  3HJF A;  3HK2 A;  4W5O A;  2L5D A;  5JS2 A;  1R4K A;  4OLB A;  4Z4E A;  3HVR A;  4Z4H A;  2BZE A;  4F3T A;  4NH6 A;  1Z25 A;  4W5R A;  3DLH A;  4W5N A;  5T7B A;  4L1P A;  3O7X A;  3DLB A;  1Z26 A;  2L5C A;  4KRE A;  4NGD A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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